FR2613618A2 - New cosmetic or dermatological compositions containing an extract of Silybum marianum fruits combined with essential fatty acids - Google Patents

New cosmetic or dermatological compositions containing an extract of Silybum marianum fruits combined with essential fatty acids Download PDF

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Publication number
FR2613618A2
FR2613618A2 FR8705089A FR8705089A FR2613618A2 FR 2613618 A2 FR2613618 A2 FR 2613618A2 FR 8705089 A FR8705089 A FR 8705089A FR 8705089 A FR8705089 A FR 8705089A FR 2613618 A2 FR2613618 A2 FR 2613618A2
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FR
France
Prior art keywords
weight
silybum marianum
extract
mixture
fatty acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8705089A
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French (fr)
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FR2613618B2 (en
Inventor
Elisabeth Papaconstantin
Philippe Lepage
Pascale Frerejouand
Jean-Pierre Marty
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Parfums Rochas SAS
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Parfums Rochas SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR878705089A priority Critical patent/FR2613618B2/en
Application filed by Parfums Rochas SAS filed Critical Parfums Rochas SAS
Priority to DE8888400098T priority patent/DE3869442D1/en
Priority to IE12388A priority patent/IE60704B1/en
Priority to AU10364/88A priority patent/AU602947B2/en
Priority to ES198888400098T priority patent/ES2032574T3/en
Priority to EP88400098A priority patent/EP0278809B1/en
Priority to CA000556735A priority patent/CA1334006C/en
Priority to KR1019880000424A priority patent/KR880008797A/en
Publication of FR2613618A2 publication Critical patent/FR2613618A2/en
Priority to US07/499,552 priority patent/US4997649A/en
Application granted granted Critical
Publication of FR2613618B2 publication Critical patent/FR2613618B2/en
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

The invention relates to new cosmetic compositions comprising: a. A Silymarin-rich extract of Silybum marianum fruits. b. One or more polyunsaturated essential fatty acids containing 18 to 22 carbon atoms, present only: - either in free form 1, - or in the form of salts of an alkali metal or ammonium salts 2, - or in the form of triglycerides 3, or present in the form of a mixture consisting of 2 of the 3 forms 1, 2 and 3 or of the three forms 1, 2 and 3. t

Description

Dans la demande de brevet principal déposée en France le 19 Janvier 1987 sous le na 8700550, la demanderesse a décrit de nouvelles compositions cosmétiques ou dermatologiques renfermant un extrait des fruits de Silybum Marianum riche en silymarine associe à des acides gras essentiels. In the main patent application filed in France on January 19, 1987 under na 8700550, the applicant described new cosmetic or dermatological compositions containing an extract of the fruits of Silybum Marianum rich in silymarin combined with essential fatty acids.

Ces compositions sont caractérisées en ce qu'elles renferment comme constituant principat le mélange comprenant
A/. Un extrait de fruits de Silybum Marianum riche en silymarine.These compositions are characterized in that they contain as a principal constituent the mixture comprising
AT/. A fruit extract from Silybum Marianum rich in silymarin.

B/. Un ou plusieurs acides gras essentiels polyinsaturés contenant 18 à 22 atomes de carbone presents uniquement : - soit sous forme libre (1), - soit sous forme de sels d'un métal alcalin ou d'ammonium (2), - soit sous forme de triglycérides (3) ou présents sous forme d'un méLange constitué par 2 des 3 formes (1), (2) et (3) ou par les trois formes (1) (2) et (3).B /. One or more polyunsaturated essential fatty acids containing 18 to 22 carbon atoms present only: - either in free form (1), - or in the form of salts of an alkali metal or ammonium (2), - or in the form of triglycerides (3) or present in the form of a mixture consisting of 2 of the 3 forms (1), (2) and (3) or by the three forms (1) (2) and (3).

La demande de brevet principal revole L'intérêt d'associer le composé A, piégeur de radicaux Libres très efficace, aux acides gras essentiels polyinsaturés. Cette association, en assurant un apport constant en acides gras essentiels et en facilitant la destruction des radicaux libres, maintient les membranes cellulaires épidermiques fluides et fonctionnelles. The main patent application overrides the advantage of associating compound A, a very effective free radical scavenger, with essential polyunsaturated fatty acids. This association, by ensuring a constant supply of essential fatty acids and by facilitating the destruction of free radicals, keeps the epidermal cell membranes fluid and functional.

La demande de brevet principal a aussi pour objet des compositions telles que définies ci-dessus, caractérisées en ce qu'elles renferment aussi des terpènes d'huiles essentielles, des flavono1des, et de l'alpha-tocopherol.  The main patent application also relates to compositions as defined above, characterized in that they also contain terpenes of essential oils, flavonoids, and alpha-tocopherol.

La présente demande de certificat d'addition a pour objet des compositions telles que définies dans la demande de brevet principal et plus particulièrement caractérisées en ce qu'elles renferment comme constituant principal 0,5 X à 10 X en poids du mélange comprenant : - 10 à 30 X en poids d'un extrait sec à 5 % dans du polyéthylène glycol de fruits délipidés de Silybum Marianum, - 5 à 15 X en poids de terpènes d'huiles essentielles, - 5 à 15 Z en poids de ftavonoides, - 5 à 20 Z en poids d'alpha-tocophérol, - 25 à 40 Z d'huile d'onagre ou bourrache, - 10 à 25 Z d'acide gamma-linolénique sous forme libre et sous forme de sels d'un métal alcalin ou d'ammonium. The present application for a certificate of addition relates to compositions as defined in the main patent application and more particularly characterized in that they contain, as main constituent, 0.5 X to 10 X by weight of the mixture comprising: - 10 at 30 X by weight of a dry extract at 5% in polyethylene glycol of delipidated fruits of Silybum Marianum, - 5 to 15 X by weight of terpenes of essential oils, - 5 to 15 Z by weight of ftavonoids, - 5 to 20 Z by weight of alpha-tocopherol, - 25 to 40 Z of evening primrose oil or borage, - 10 to 25 Z of gamma-linolenic acid in free form and in the form of salts of an alkali metal or ammonium.

Le mélange tel que défini ci-dessus contenant 25 à 40 X d'huile de bourrache est deposé sous Le nom de marque SKINAVENGER
Dans ces compositions, l'acide gamma-linolenique sous forme de sels d'un métal alcalin ou d'ammonium provient de préférence de la saponification de l'huile d'onagre.The mixture as defined above containing 25 to 40 X of borage oil is deposited under the brand name SKINAVENGER
In these compositions, gamma-linolenic acid in the form of salts of an alkali metal or of ammonium preferably comes from the saponification of evening primrose oil.

La présente demande concerne aussi des compositions caractérisés en ce qu'elles renferment comme constituant principal le mélange comprenant
- 1 à 10 X en poids d'huile d'onagre, et - 1 à 10 X en poids du mélange lui-même constitué
d'un extrait sec à 5 Z de fruits delipidés de Silybum Marianum,
et de 0,05 X à 2Z en poids d'alpha-tocopherol, dans du polyethylene
glycol.The present application also relates to compositions characterized in that they contain as main constituent the mixture comprising
- 1 to 10 X by weight of evening primrose oil, and - 1 to 10 X by weight of the mixture itself
a 5 Z dry extract of delipidated fruits of Silybum Marianum,
and from 0.05 X to 2Z by weight of alpha-tocopherol, in polyethylene
glycol.

La'présente demande a plus particulierement pour objet des compositions caractérisées en ce qu'elles renferment comme constituant principal le mélange comprenant :
- 5 Z en poids d'huile d'onagre,
- 5 X én poids du mélange lui-même constitué :
d'un extrait sec à 5 Z de fruits délipides de Silybum Marianum
et de IZ en poids d'alpha tocophérol dans du polyethylene glycol ; et - 1 Z à 10 Z en poids de filtres solaires UVA-UVB, et - 1 Z à 10 Z en poids d'extrait de rate.The present application relates more particularly to compositions characterized in that they contain as main constituent the mixture comprising:
- 5% by weight of evening primrose oil,
- 5 X en weight of the mixture itself:
a 5 Z dry extract of delipid fruits from Silybum Marianum
and 1% by weight of alpha tocopherol in polyethylene glycol; and - 1 Z to 10 Z by weight of UVA-UVB sunscreens, and - 1 Z to 10 Z by weight of spleen extract.

Le mélange constitue d'un extrait sec à 5 Z de fruits délipidés de
Silybum Marianum et de 1 Z en poids d'alpha-tocophérol dans du polyéthylène glycol est déposé sous Le nom de marque FLAVOPHEROL#. The mixture consists of a dry extract containing 5% of delipidated fruits of
Silybum Marianum and 1% by weight of alpha-tocopherol in polyethylene glycol is registered under the brand name FLAVOPHEROL #.

L'invention concerne les compositions cosmetiques ou dermatologiques telles que définies ci-dessus caractérisées en ce qu'elles se présentent sous forme de creme, gel, Lait, lotion pour la peau et tout particulièrement, des compositions cosmetiques ou dermatologiques, caractérisées en ce que leurs excipients sont adaptés à l'application sur le visage et sur le co.  The invention relates to cosmetic or dermatological compositions as defined above, characterized in that they are provided in the form of a cream, gel, milk, skin lotion and very particularly, cosmetic or dermatological compositions, characterized in that their excipients are suitable for application on the face and on the co.

En effet, pour chaque forme, on a recours à des excipients appropriés. Ces excipients doivent avoir toutes les qualités habituellement demandées. Ils doivent être doués d'une grande affinité pour la peau, être parfaitement bien tolérés, stables, présenter une consistance adequate permettant une utilisation facile et agréable. Indeed, for each form, use is made of suitable excipients. These excipients must have all the qualities usually required. They must have a great affinity for the skin, be perfectly tolerated, stable, have an adequate consistency allowing easy and pleasant use.

A titre d'exemples d'excipients pouvant être utilisés, on peut citer, Le stéarate de glycérol, le propylène glycol, les derivés palmitates, stéarates, la lanoline, la glycerine, l'alcool cétylique, polyol, les huiles animales, minerales, les cires, les mouillants, Les épaissisants, les stabilisants, les émulsionnants couramment utilisés. As examples of excipients which can be used, there may be mentioned, glycerol stearate, propylene glycol, palmitate derivatives, stearates, lanolin, glycerine, cetyl alcohol, polyol, animal oils, minerals, waxes, wetting agents, thickeners, stabilizers, emulsifiers commonly used.

Les différentes formes cosmétiques mentionnées ci-dessus sont obtenues selon les méthodes usuelles utilisées dans ce domaine. The various cosmetic forms mentioned above are obtained according to the usual methods used in this field.

Les exemples donnés ci-dessous illustrent l'invention sans toutefois la limiter. The examples given below illustrate the invention without however limiting it.

Exemple 1 :
GEL FLUIDE Polymere carboxyvinylique neutralisé 0,25 à 0,65 g
Carboxyméthyl cellulose sel de Na 0,02 à 0,5 9
Propylène Glycol 1,- à 5,- g
Gel de polyglycérylmethacrylate 5,- à 10,- g
Perhydrosqualène 1,- à 5,- 9
α Orizanol 0,05 à 2,- 9
α Bizabolol 0,05 à 0,1 g
Skinavenger > 1,- à 5,- 9
Peptides de'haut poids moléculaire 1,- à 5,- g
Acide hyaluronique 0,01 à 0,05 9
Conservateurs q.s.Example 1:
FLUID GEL Neutralized carboxyvinyl polymer 0.25 to 0.65 g
Carboxymethyl cellulose Na salt 0.02 to 0.5 9
Propylene Glycol 1, - to 5, - g
Polyglycerylmethacrylate gel 5, - to 10, - g
Perhydrosqualene 1, - to 5, - 9
α Orizanol 0.05 to 2, - 9
α Bizabolol 0.05 to 0.1 g
Skinavenger> 1, - to 5, - 9
High molecular weight peptides 1, - to 5, - g
Hyaluronic acid 0.01 to 0.05 9
Preservatives qs

Parfum q.s.Perfume q.s.

Colorants q.s.Dyes q.s.

Eau purifiee q.s.p 100 g
Exemple 2 :
EMULSION FLUIDE HIE
Acide stéarique 0,5 - 2,5 g
Acide gras de propylène glycol 1 - 5 g
Perhydrosqualène 1 - 5 g
Beurre de Karité ou Cacao 1 - 5 g
Polypeptides d'origine animale 0,1 - 1 g
Esters gras ramifiés 2 - 12 g
Filtre UVA/UVB 0,5 - 1,5 g
cl Bisabolol 0,05 - 1 g
Huile végétale 1 - 5 9
α Orizanol 0,05 - 0,5 g
Skinavenger R 1 5 g
Acide Hyaluronique 0,01 - 0,05 g
Carboxymethylcellulose neutralisee 0,1 - 1 g
Propylène glycol 3 - 12 g
Urée 0,5 - 5 g
Conservateurs q.s.Purified water qs 100 g
Example 2:
HIE FLUID EMULSION
Stearic acid 0.5 - 2.5 g
Propylene glycol fatty acid 1 - 5 g
Perhydrosqualene 1 - 5 g
Shea or Cocoa Butter 1 - 5 g
Polypeptides of animal origin 0.1 - 1 g
Branched fatty esters 2 - 12 g
UVA / UVB filter 0.5 - 1.5 g
cl Bisabolol 0.05 - 1 g
Vegetable oil 1 - 5 9
α Orizanol 0.05 - 0.5 g
Skinavenger R 1 5 g
Hyaluronic acid 0.01 - 0.05 g
Carboxymethylcellulose neutralized 0.1 - 1 g
Propylene glycol 3 - 12 g
Urea 0.5 - 5 g
Preservatives qs

Parfum q.s.Perfume q.s.

Eau purifiée q.s.p. 100 g
Exemple 3 :
CREME H/E
Emulgateur type :
Ester gras P.0.E. )
Sucres P.O.E. ) 2 à 7 g
Phospholipides )
Huile de silicone 0,5 à 5 9
Cire végétale 0,2 à 1 g
Perhydrosqualène 1 à 5 9
Filtres UVA/UVB 0,5 à 1,5 g
Alcool cetylique 0,2 à 1 g
Huile végétale 1 à 5 9
Phytostérols 1 à 2,5 g
α Orizanol 0,05 à 0,5 9
Triéthanolamine 0,3 à 2 9
Protéine d'origine animale 1 à 5 g Skinavenger 1 à 5 g
Acide hyaluronique 0,01 à 0,05 g
Polymèrecarboxyvinylique neutralisé 0,3 à 0,8 g
Urée 0,5 à 5 g
Conservateurs q.s.Purified water qs 100 g
Example 3:
M / E CREAM
Typical emulsifier:
Fatty ester P.0.E. )
POE sugars) 2 to 7 g
Phospholipids)
Silicone oil 0.5 to 5 9
Vegetable wax 0.2 to 1 g
Perhydrosqualene 1 to 5 9
UVA / UVB filters 0.5 to 1.5 g
Cetyl alcohol 0.2 to 1 g
Vegetable oil 1 to 5 9
Phytosterols 1 to 2.5 g
α Orizanol 0.05 to 0.5 9
Triethanolamine 0.3 to 2 9
Animal protein 1 to 5 g Skinavenger 1 to 5 g
Hyaluronic acid 0.01 to 0.05 g
Carboxyvinyl neutralized polymer 0.3 to 0.8 g
Urea 0.5 to 5 g
Preservatives qs

Parfum q.s.Perfume q.s.

Eau purifiée q.s.p. 100 g
Exemple 4 :
CREME E/H Isostearate de glycérol et du sorbitan 10 - 12 9
Perhydrosqualéne 10 - 15 g
Succinate de 2-éthyl hexyle 10 - 15 g
Huile d'avocat 3 - 6 g
Cire d'abeille blanche 3 - 5 g
α Orizanol 0,05 - 0,5 g
Cire micro cristalline 1,- 3,- g
Skinavenger @ 1,- 5,- g
Acide hyaluronique 0,01 - 0,03 g
Glycérine 2 à 5 9
Sulfate de magnésium (Mg, S04, 7H20) 0,7 g
Conservateur q.s.Purified water qs 100 g
Example 4:
W / O CREAM Glycerol and sorbitan isostearate 10 - 12 9
Perhydrosqualene 10 - 15 g
2-ethyl hexyl succinate 10 - 15 g
Avocado oil 3 - 6 g
White beeswax 3 - 5 g
α Orizanol 0.05 - 0.5 g
Micro crystalline wax 1, - 3, - g
Skinavenger @ 1, - 5, - g
Hyaluronic acid 0.01 - 0.03 g
Glycerin 2 to 5 9
Magnesium sulfate (Mg, S04, 7H20) 0.7 g
Conservative qs

Parfum q.s.Perfume q.s.

Eau purifiée q.s.p. 100 g
Exemple 5 :
CREME DE JOUR/SOIN VISAGE
Palmitate de sorbitan 6.0 g
Glycérides d'acides gras 13.0 g
Vaseline 4.0 g
Oxybenzone 1.0 g
Huile d'onagre 5.0 g
Sorbitol 3.0 g
Polymère carboxyvinylique neutralisé 0.5 g
Extrait tissulaire de Rate 3.0 g Flavophérol 5.0 g
Conservateurs q.s.Purified water qs 100 g
Example 5:
DAY CREAM / FACE CARE
Sorbitan palmitate 6.0 g
Fatty acid glycerides 13.0 g
Vaseline 4.0 g
Oxybenzone 1.0 g
Evening primrose oil 5.0 g
Sorbitol 3.0 g
0.5 g neutralized carboxyvinyl polymer
Spleen tissue extract 3.0 g Flavopherol 5.0 g
Preservatives qs

Composition aromatique q.s.Aromatic composition q.s.

Eau purifiée q.s.p 100 g
Exemple 6 :
CREME DE JOUR HYDRATANTE
Ether cétylique POE 3,5 9
Stéarate de sorbitan 3,5 g
Triglycérides d'acides gras 5 g Perhydrosqualène 2 g
Lanoline hydrogénee 5 g
Huile d'onagre 5 g
Filtre solaire UVA et UVB 2 g Propylene glycol 5 g Flavophérol > 3 g
Pyrrolidone carboxylate de sodium 2 g
Polymère carboxyvinylique neutralise 1 g
Conservateurs q.s.Purified water qs 100 g
Example 6:
MOISTURIZING DAY CREAM
Cetyl ether POE 3.5 9
Sorbitan stearate 3.5 g
Triglycerides of fatty acids 5 g Perhydrosqualene 2 g
Hydrogenated lanolin 5 g
Evening primrose oil 5 g
UVA and UVB sunscreen 2 g Propylene glycol 5 g Flavopherol> 3 g
Sodium pyrrolidone carboxylate 2 g
Carboxyvinyl polymer neutralizes 1 g
Preservatives qs

Composition aromatique q.s.Aromatic composition q.s.

Eau purifiée q.s.p. 100 g
Exemple 7 :
CREME DE SOIN
Stéarate de glycol et de PEG 100 6 g
Beurre de Karite 5 g
Huile d'onagre 5 g
Alcool cétylique 2 g
Triglycerides d'acides gras 8 g
Vitamine A 0,5 g
Extrait biologique 5 g Flavophérol # 5 g
Glycérine 5 g
Polymère carboxyvinylique neutralisé 1 9
Conservateurs q.s.Purified water qs 100 g
Example 7:
CARE CREAM
Glycol and PEG 100 stearate 6 g
Shea butter 5 g
Evening primrose oil 5 g
Cetyl alcohol 2 g
Triglycerides of fatty acids 8 g
Vitamin A 0.5 g
Organic extract 5 g Flavopherol # 5 g
Glycerin 5 g
Neutralized carboxyvinyl polymer 1 9
Preservatives qs

Composition aromatique q.s.Aromatic composition q.s.

Eau purifiee q.s.p. 100 g
Exemple 8
GEL POUR LE VISAGE
AGE sous forme de liposomes 0,5 g Flavophérol # 3 g
Pyrrolidone carboxylate de sodium 2 g
Conservateur q.s.Purified water qs 100 g
Example 8
FACE GEL
AGE in the form of liposomes 0.5 g Flavopherol # 3 g
Sodium pyrrolidone carboxylate 2 g
Conservative qs

Composition aromatique q.s.Aromatic composition q.s.

Polymere carboxyvinylique neutralisé 1,5 g
Propylène glycol 5 g
Eau purifiée q.s.p. 100 g
Exemple 9
CREME ANTISOLAIRE
Huile de vaseline 5 g
Huile de silicone 1 g
Ester d'acides gras 5 g
Dérivé de lanoline 8 g
Stéarate de glycol et de PEG100 6 g
Filtre solaire UVA et UVB 5 g
Huile d'onagre 3 9
Sorbitol 5 g Flavophérol # 3 g
Pigments minéraux inorganiques 5 g
Polymère carboxyvinylique neutralisé 1 g
Conservateurs q.s.1.5 g neutralized carboxyvinyl polymer
Propylene glycol 5 g
Purified water qs 100 g
Example 9
ANTISOLAR CREAM
Vaseline oil 5 g
Silicone oil 1 g
Ester of fatty acids 5 g
Lanolin derivative 8 g
Glycol and PEG100 stearate 6 g
UVA and UVB sunscreen 5 g
Evening primrose oil 3 9
Sorbitol 5 g Flavopherol # 3 g
Inorganic mineral pigments 5 g
1 g neutralized carboxyvinyl polymer
Preservatives qs

Composition aromatique q.s.Aromatic composition q.s.

Eau purifiée q.s.p. 100 g Purified water q.s.p. 100g

Claims (4)

REVENDICATIONS 1/. Compositions cosmétiques ou dermatologiques pour les soins de la peau, telles que définies à la revendication 1 de la demande de brevet principal, caracterisees en ce qu'elles renferment comme constituant principal 0,5 X à 10 Z en poids du mélange comprenant : - 10 à 30 Z en poids d'un extrait sec à 5 X dans du polyéthylène glycol de fruits délipides de Silybum Marianum, - 5 à 15 X en poids de terpenes d'huiles essentielles, - 5 à 15 X en poids de flavonoides, - 5 à 20 X en poids d'alpha-tocophérol, - 25 à 40 Z d'huile d'onagre ou de bourrache, - 10 à 25 X d'acide gamma-linolénique sous forme libre et sous forme de sels d'un métal alcalin ou d'ammonium. CLAIMS 1 /. Cosmetic or dermatological compositions for skin care, as defined in claim 1 of the main patent application, characterized in that they contain as main constituent 0.5 X to 10 Z by weight of the mixture comprising: - 10 at 30% by weight of a dry extract at 5% in polyethylene glycol of delipid fruits from Silybum Marianum, - 5 to 15% by weight of terpenes of essential oils, - 5 to 15% by weight of flavonoids, - 5 to 20% by weight of alpha-tocopherol, - 25 to 40% of evening primrose or borage oil, - 10 to 25% of gamma-linolenic acid in free form and in the form of salts of an alkali metal or ammonium. 2/. Compositions cosmetiques ou dermatologiques pour les soins de la peau telles que définies à la revendication 1 de la demande de brevet principal, caractérisées en ce qu'elles renferment comme constituant principal le mélange comprenant :2 /. Cosmetic or dermatological compositions for skin care as defined in claim 1 of the main patent application, characterized in that they contain as main constituent the mixture comprising: - 1 à 10 Z en poids d'huile d'onagre, et - 1 à 10 X en poids du mélange lui-meme constitué - 1 to 10% by weight of evening primrose oil, and - 1 to 10% by weight of the mixture itself d'un extrait sec à 5 Z de fruits délipidés de Silybum Marianum, a 5 Z dry extract of delipidated fruits of Silybum Marianum, et de 0,05 Z à 2 Z en poids d'alpha-tocopherol, dans du polyéthylène and from 0.05 Z to 2 Z by weight of alpha-tocopherol, in polyethylene glycol. glycol. 3/. Compositions telles que definies à la revendication 2, caractérisées en ce qu'elles renferment comme constituant principal Le melange comprenant :3 /. Compositions as defined in claim 2, characterized in that they contain as main constituent The mixture comprising: - 5 Z en poids d'huile d'onagre, et - 5 X en poids du mélange lui-même constitué - 5% by weight of evening primrose oil, and - 5% by weight of the mixture itself d'un extrait sec à 5 Z de fruits délipidés de Silybum Marianum 5 Z dry extract of delipidated fruit from Silybum Marianum et de 1X en poids d'alpha tocophérol, dans du polyéthylene  and 1X by weight of alpha tocopherol, in polyethylene glycol ; et - 1 b à 10 Z en poids de filtres solaires UVA-UVB, et - 1 % à 10 Z en poids d'extrait de rate. glycol; and - 1% to 10% by weight of UVA-UVB sunscreens, and - 1% to 10% by weight of spleen extract. 4/. Compositions telles que définies aux revendications 1 à 3, caractérisées en ce qu'elles se présentent sous forme de creme, gel, lait pour la peau. 4 /. Compositions as defined in claims 1 to 3, characterized in that they are in the form of cream, gel, milk for the skin.
FR878705089A 1987-01-19 1987-04-10 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS ASSOCIATED WITH ESSENTIAL FATTY ACIDS Expired - Lifetime FR2613618B2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR878705089A FR2613618B2 (en) 1987-04-10 1987-04-10 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS ASSOCIATED WITH ESSENTIAL FATTY ACIDS
IE12388A IE60704B1 (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum sillybum rich in sillymarine associated with essential fatty acids
AU10364/88A AU602947B2 (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum silybum rich in silymarine associated with essential fatty acids
ES198888400098T ES2032574T3 (en) 1987-01-19 1988-01-18 NEW COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF FRUITS OF "SILYBUM MARIANUM", RICH IN SILIMARINE, ASSOCIATED WITH ESSENTIAL FATTY ACIDS. (RESERVATION OF ART. 167.2 CPE).
DE8888400098T DE3869442D1 (en) 1987-01-19 1988-01-18 COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING AN EXTRACT OF THE FRUIT OF THE SILYBUM MARIANUM WITH A HIGH SYLIMARINE CONTENT WITH ESSENTIAL FATTY ACIDS.
EP88400098A EP0278809B1 (en) 1987-01-19 1988-01-18 Cosmetic or dermatologic compositions containing a silybum marianum fruit extract rich in sylimarin together with essential fatty acids
CA000556735A CA1334006C (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum silybum rich in silymarine associated with essential fatty acids
KR1019880000424A KR880008797A (en) 1987-01-19 1988-01-19 Skin care composition containing silymarin
US07/499,552 US4997649A (en) 1987-01-19 1990-03-26 Cosmetic and dermatological compositions including an extract of Silybum marianum rich in silymarine associated with essential fatty acids

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FR878705089A FR2613618B2 (en) 1987-04-10 1987-04-10 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS ASSOCIATED WITH ESSENTIAL FATTY ACIDS

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FR2613618A2 true FR2613618A2 (en) 1988-10-14
FR2613618B2 FR2613618B2 (en) 1991-03-22

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2820635A1 (en) * 2001-02-09 2002-08-16 Genevrier Lab Preparation of water-in-oil emulsions containing hyaluronic acid, useful for the topical treatment of venous ulcers
DE102005048780A1 (en) * 2005-10-10 2007-04-12 Beiersdorf Ag Hydrous cosmetic preparation with dissolved flavonolignans

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180505A1 (en) * 1984-10-19 1986-05-07 C L A R I N S Cosmetic preparation to arrest the ageing of the skin, and application process
EP0236218A1 (en) * 1986-02-24 1987-09-09 Claude Bonne Cosmetic compositions containing an extract of Silybum Marianum fruits

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180505A1 (en) * 1984-10-19 1986-05-07 C L A R I N S Cosmetic preparation to arrest the ageing of the skin, and application process
EP0236218A1 (en) * 1986-02-24 1987-09-09 Claude Bonne Cosmetic compositions containing an extract of Silybum Marianum fruits

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2820635A1 (en) * 2001-02-09 2002-08-16 Genevrier Lab Preparation of water-in-oil emulsions containing hyaluronic acid, useful for the topical treatment of venous ulcers
DE102005048780A1 (en) * 2005-10-10 2007-04-12 Beiersdorf Ag Hydrous cosmetic preparation with dissolved flavonolignans

Also Published As

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