FR2609630A1 - New cosmetic or dermatological compositions containing an extract of Silybum marianum fruits which is rich in silymarin combined with essential fatty acids - Google Patents

New cosmetic or dermatological compositions containing an extract of Silybum marianum fruits which is rich in silymarin combined with essential fatty acids Download PDF

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Publication number
FR2609630A1
FR2609630A1 FR8700550A FR8700550A FR2609630A1 FR 2609630 A1 FR2609630 A1 FR 2609630A1 FR 8700550 A FR8700550 A FR 8700550A FR 8700550 A FR8700550 A FR 8700550A FR 2609630 A1 FR2609630 A1 FR 2609630A1
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Prior art keywords
fatty acids
defined according
essential fatty
triglycerides
alkali metal
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FR8700550A
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FR2609630B1 (en
Inventor
Elisabeth Papaconstantin
Philippe Lepage
Pascale Frerejouand
Jean-Pierre Marty
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Parfums Rochas SAS
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Parfums Rochas SAS
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Priority to FR8700550A priority Critical patent/FR2609630B1/en
Priority to ZA88222A priority patent/ZA88222B/en
Priority to IE12388A priority patent/IE60704B1/en
Priority to DE8888400098T priority patent/DE3869442D1/en
Priority to CA000556735A priority patent/CA1334006C/en
Priority to ES198888400098T priority patent/ES2032574T3/en
Priority to AU10364/88A priority patent/AU602947B2/en
Priority to EP88400098A priority patent/EP0278809B1/en
Priority to KR1019880000424A priority patent/KR880008797A/en
Priority to JP63009436A priority patent/JPS63239208A/en
Publication of FR2609630A1 publication Critical patent/FR2609630A1/en
Priority to US07/499,552 priority patent/US4997649A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

The invention relates to new cosmetic or dermatological compositions containing an extract of Silybum marianum fruits which is rich in silymarin combined with essential fatty acids.

Description

L'invention a pour objet de nouvelles compositions cosmétiques ou dermatologiques renfermant un extrait des fruits de Silybum Marianum riche en Silymarine associé à des acides gras essentiels.  The subject of the invention is new cosmetic or dermatological compositions containing an extract of the fruits of Silybum Marianum rich in Silymarin associated with essential fatty acids.

L'extrait de Silybum Marianum, appelé "Absolu d'Epine Blanche" est une substance bloquant la formation des radicaux Libres. Un radical libre est un atome ou une molécule qui a acquis transitoirement un électron "célibataire". Cet électron non apparié à un autre de spin inverse, confére au radical une tries grande réactivité, c'est-à-dire une grande capacité à réagir avec les molécules environnantes qui vont à leur tour devenir des radicaux Libres. Silybum Marianum extract, called "White Thorn Absolute" is a substance that blocks the formation of free radicals. A free radical is an atom or a molecule which has transiently acquired a "celibate" electron. This unpaired electron with another of opposite spin, gives the radical a great reactivity, that is to say a great capacity to react with the surrounding molecules which will in turn become Free radicals.

Ce mécanisme permet d'expliquer la très grande toxicité de ces "molécules excitees". C'est ainsi que les radicaux libres vont s'attaquer aux éléments clés de la cellule tels que le noyau, les protéines et plus particulièrement à la membrane. This mechanism explains the very high toxicity of these "excited molecules". This is how free radicals will attack key elements of the cell such as the nucleus, proteins and more particularly the membrane.

Or, les acides gras essentiels sont les constituants des phospholipides membranaires et sont particulièrement vulnérables aux radicaux Libres, au niveau de leurs doubles liaisons. However, essential fatty acids are the constituents of membrane phospholipids and are particularly vulnerable to Free radicals, at the level of their double bonds.

Rappelons que ces doubles liaisons carbone-carbone assurent la structure et la solidité membranaire ; L'intervention des radicaux libres va introduire des cassures, des modifications d'angulation rendant la membrane moins solide, moins fluide et moins capable d'assurer la régulation des mouvements ioniques. Let us recall that these carbon-carbon double bonds ensure the structure and the membrane solidity; The intervention of free radicals will introduce breaks, changes in angulation making the membrane less solid, less fluid and less capable of regulating ionic movements.

Ces altérations membranaires vont pertuber le métabolisme de la cellule. Moins bien protégée, moins bien oxygénée et moins bien nourrie, la cellule va peu à peu perdre ses fonctions de multiplication, se scléroser puis mourir. C'est ainsi que les radicaux libres et les processus de peroxydation qu'ils engendrent, jouent un rôle significatif dans le vieillissement des cellules et consécutivement de la peau. These membrane alterations will disturb the metabolism of the cell. Less well protected, less well oxygenated and less well nourished, the cell will gradually lose its multiplication functions, become sclerotic and then die. This is how free radicals and the peroxidation processes they generate play a significant role in the aging of cells and, consequently, of the skin.

Il est donc particulièrement intéressant d'associer dans une composition cosmétique ou dermatologique "L'Absolu d'Epine Blanche" piègeur des radicaux libres particulièrement efficace, ayant un rôle préventif, à des acides gras essentiels ayant un rôle réparateur. It is therefore particularly advantageous to combine in a cosmetic or dermatological composition "L'Absolu d'Epine Blanche" free radical scavenger, which is particularly effective, having a preventive role, with essential fatty acids having a repairing role.

L'invention a donc pour objet des compositions cosmétiques ou dermatologiques pour tes soins de la peau, caractérisées en ce qu'elles renferment comme constituant principal le mélange comprenant
A) Un extrait de fruits de Silybum Marianum riche en Silymarine appelé "Absolu d'Epine Blanche".The subject of the invention is therefore cosmetic or dermatological compositions for your skin care, characterized in that they contain as main constituent the mixture comprising
A) A Silybum Marianum fruit extract rich in Silymarin called "White Thorn Absolute".

B) Un ou plusieurs acides gras essentiels polyinsaturés contenant 18 à 22 atomes de carbone présents uniquement - soit sous forme libre (1) - soit sous forme de sels d'un métal alcalin ou d'ammonium (2) - soit sous forme de triglycérides (3) ou présents sous forme d'un mélange constitué par 2 des 3 formes (1) (2) et (3) ou par les 3 formes (1) (2) et (3).B) One or more polyunsaturated essential fatty acids containing 18 to 22 carbon atoms present only - either in free form (1) - or in the form of alkali metal or ammonium salts (2) - or in the form of triglycerides (3) or present in the form of a mixture constituted by 2 of the 3 forms (1) (2) and (3) or by the 3 forms (1) (2) and (3).

L'invention a plus particulièrement pour objet des compositions, caractérisées en ce que le composant B) est constitué d'acides gras essentiels polyinsaturés contenant de 18 à 22 atomes de carbone présents à la fois sous forme libre (1) et sous forme de triglycérides (3) et sous forme de sels d'un métal alcalin ou d'ammonium (2) provenant de la saponification de tout ou partie des triglycérides (3). A more particular subject of the invention is compositions, characterized in that component B) consists of polyunsaturated essential fatty acids containing from 18 to 22 carbon atoms present both in free form (1) and in the form of triglycerides (3) and in the form of salts of an alkali metal or of ammonium (2) originating from the saponification of all or part of the triglycerides (3).

Par ailleurs, il est particulierement judicieux d'ajouter au constituant A) des compositions de l'invention d'autres substances dites piègeurs de radicaux libres pour renforcer l'action de 'l'Ahsolu d'Epine Blanche". Furthermore, it is particularly advisable to add to component A) of the compositions of the invention other substances known as free radical scavengers to enhance the action of "White Spine Ahsolu".

Ces substances sont par exemple des terpènes d'huiles essentielles olefiniques, acycliques ou cycliques et leurs alcools dérivés et des flavonoides. La structure moléculaire de ces composés permet d'expliquer leur rôle de piègeurs de radicaux libres. These substances are for example terpenes of olefinic, acyclic or cyclic essential oils and their derived alcohols and flavonoids. The molecular structure of these compounds explains their role as scavengers for free radicals.

On peut rajouter également par exemple de la vitamine E ou alphatocophérol dont les propriétés anti-oxydants et anti-radicalaires sont largement décrites. One can also add for example vitamin E or alphatocopherol whose antioxidant and anti-radical properties are widely described.

L'invention concerne donc tout particulièrement des compositions caractérisées en ce que le constituant A) renferme en outre des terpènes d'huiles essentielles, des flavonoides, de l'alpha-tocophérol. The invention therefore relates very particularly to compositions characterized in that component A) also contains terpenes of essential oils, flavonoids, alpha-tocopherol.

L'invention a pour objet des compositions caractérisées en ce qu'elles renferment : - 10 à 30X en poids de l'extrait de Silybum Marianum, - 5 à 15X en poids de terpènes d'huiles essentielles, - 5 à 15X en poids de flavonoides, - 5 à 20X en poids d'alpha-tocophérol, - 25 à 40X en poids de triglycérides d'acides gras essentiels (3), - 10 à 25X d'acides gras essentiels sous forme libre (1) et sous forme de sels d'un métal alcalin ou d'ammonium (2) provenant de tout ou partie de la saponification des triglycérides (3). The subject of the invention is compositions characterized in that they contain: - 10 to 30X by weight of the extract of Silybum Marianum, - 5 to 15X by weight of terpenes of essential oils, - 5 to 15X by weight of flavonoids, - 5 to 20X by weight of alpha-tocopherol, - 25 to 40X by weight of triglycerides of essential fatty acids (3), - 10 to 25X of essential fatty acids in free form (1) and in the form of salts of an alkali metal or ammonium (2) originating from all or part of the saponification of triglycerides (3).

Les compositions telles que définies ci-dessus ont L'avantage d'associer aussi bien dans le constituant A que dans le constituant B, certaines substances solubles dans une phase huileuse et d'autres substances solubles dans une phase aqueuse. The compositions as defined above have the advantage of combining both in component A and in component B, certain substances soluble in an oily phase and other substances soluble in an aqueous phase.

Ainsi, 'l'Absolu d'Epine Blanche" est soluble dans l'eau, les terpènes, les flavonoides et I'alpha-tocophérol étant solubles dans L'huile. De même, les triglycérides d'acides gras essentiels sont solubles dans l'huile, alors que les acides gras essentiels libres ou sous forme de sels sont solubles dans l'eau. Thus, the "White Thorn Absolute" is soluble in water, the terpenes, flavonoids and alpha-tocopherol being soluble in Oil. Likewise, the triglycerides of essential fatty acids are soluble in the oil, while free essential fatty acids or in the form of salts are soluble in water.

Dans le composant B, les triglycérides des acides gras essentiels sont Les triglycérides banals de synthèse. Ces triglycérides peuvent être apportés par l'intermédiaire d'une j plusieurs sources les renfermant à L'état naturel. De telles sources sont essentiellement les huiles végétales. In component B, the triglycerides of essential fatty acids are the common synthetic triglycerides. These triglycerides can be supplied via a number of sources containing them in the natural state. Such sources are mainly vegetable oils.

On peut citer, par exemple, l'huile de germe de blé, d'olive, de mais, de tournesol, d'amande douce, d'onagre, de bourrache, de pépins de cassis. Toutes ces huiles contiennent des proportions tres variables d'un ou plusieurs acides gras essentiels. We can cite, for example, wheat germ oil, olive oil, corn, sunflower, sweet almond, evening primrose, borage, blackcurrant seeds. All these oils contain very variable proportions of one or more essential fatty acids.

La saponification des triglycérides s'effectue par des methodes très usuelles, notamment par un hydroxyde de métal alcalin (soude ou potasse). The saponification of the triglycerides is carried out by very usual methods, in particular by an alkali metal hydroxide (soda or potash).

Cette saponification s'effectue en présence d'un anti-oxydant compte tenu de la grande facilité d'oxydation des acides gras polyinsaturés. This saponification takes place in the presence of an antioxidant, taking into account the great ease of oxidation of polyunsaturated fatty acids.

Les acides gras polyinsaturés présente sous forme d'un sel de métal alcalin, contenus dans le constituant B, sont de préférence des sels de sodium ou de potassium. The polyunsaturated fatty acids present in the form of an alkali metal salt, contained in component B, are preferably sodium or potassium salts.

Il existe deux familles d'acides polyinsaturés indispensables, la famille gamma-linolénique et la famille linoléique. There are two families of essential polyunsaturated acids, the gamma-linolenic family and the linoleic family.

Les acides gras essentiels les plus abondants au niveau cutané ont pour précurseur l'acide linoléique métabolisé suivant le schéma suivant
C18 : 2

Figure img00030001
The most abundant essential fatty acids in the skin are precursors of linoleic acid metabolized according to the following scheme
C18: 2
Figure img00030001

C18 : 3

Figure img00030002
C18: 3
Figure img00030002

C20 : 3

Figure img00030003
C20: 3
Figure img00030003

C20 : 4
Acide
Linoléique
Acide gamma linolénique
Acide di homo gamma-tinolénique
Acide arachidonique
Tous ces acides sont donc particulièrement indispensables à la croissance normale et à L'activité physiologique des tissus.C20: 4
Acid
Linoleic
Gamma linolenic acid
Homo gamma-tinolenic acid
Arachidonic acid
All these acids are therefore particularly essential for normal growth and physiological activity of the tissues.

Les huiles riches en acides gras essentiels sous forme de triglycérides cités cidessus sont L'huile de tournesol (57X acide linoléique), L'huile de mais (40% acide linoléique), L'huile d'onagre (71X acide linoléique 9% d'acide gamma-linolénique), l'huile de bourrache,
L'huile de pépins de cassis.The oils rich in essential fatty acids in the form of the triglycerides mentioned above are Sunflower oil (57X linoleic acid), Corn oil (40% linoleic acid), Evening primrose oil (71X linoleic acid 9% d 'gamma-linolenic acid), borage oil,
Blackcurrant seed oil.

Chez L'homme, la conversion de l'acide linoléique en acide linolénique est une étape limitante, rendue plus inopérante par de nombreuses influences extérieures. En particulier, cette étape est déficiente au cours du vieillissement. In humans, the conversion of linoleic acid to linolenic acid is a limiting step, made more ineffective by many external influences. In particular, this stage is deficient during aging.

Parmi les acides gras essentiels cités précédemment, l'acide linolénique est donc particulièrement intéressant. Among the essential fatty acids mentioned above, linolenic acid is therefore particularly interesting.

L'invention a donc notamment pour objet des compositions caractérisées en ce que le composant B) est un mélange constitué d'acide gamma-linolénique sous forme libre (1), d'une huile obtenue à partir d'une source riche en acide gamma-linolénique (3) et d'acide gamma-linolénique sous forme de sels de métal alcalin ou d'ammonium (2) provenant de la saponification de (3). A subject of the invention is therefore in particular compositions characterized in that component B) is a mixture consisting of gamma-linolenic acid in free form (1), of an oil obtained from a source rich in gamma acid -linolenic (3) and gamma-linolenic acid in the form of alkali metal or ammonium salts (2) originating from the saponification of (3).

L'huile d'onagre extraite des graines de plantes Oenothera Bienis ou
Oenothera Lamark iana, L'huile de bourrache et l'huile de pépins de cassis sont les trois principales huiles végétales riches en acide gammalinolénique.Evening primrose oil extracted from seeds of Oenothera Bienis plants or
Oenothera Lamark iana, Borage oil and blackcurrant seed oil are the three main vegetable oils rich in gammalinolenic acid.

Parmi les huiles contenant de l'acide gamma-linolénique, utilisables dans les compositions de l'invention, on peut citer également L'huile obtenue par extraction de champignons siphomycètes, de spirulines, de graine d'érable, de houblon. Among the oils containing gamma-linolenic acid, which can be used in the compositions of the invention, mention may also be made of oil obtained by extraction of siphomycete fungi, spirulina, maple seed, hops.

On peut utiliser bien entendu tout autre huile extraite d'une source naturelle d'acide gamma-linolénique. Any other oil extracted from a natural source of gamma-linolenic acid can of course be used.

La présente invention a tout particulièrement pour objet des compositions caractérisées en ce que le composant B) est un mélange constitué d'acide gamma-linolénique sous forme libre (1), d'huile d'onagre (3) et de sel de métal alcalin de l'acide gamma-linolénique (2) provenant de la saponification de (3). The present invention relates very particularly to compositions characterized in that component B) is a mixture consisting of gamma-linolenic acid in free form (1), evening primrose oil (3) and alkali metal salt gamma-linolenic acid (2) from the saponification of (3).

Les compositions selon l'invention peuvent renfermer éventuellement toutes les substances connues comme ayant des propriétes bienfaisantes sur la peau, telles que le collagène, l'élastine, l'acide hyaluronique, des humectants tels que l'urée, l'acide pyrrolidone carboxylique et ses sels, des extraits vitaminés, des parfums, des conservateurs, des colorants, des extraits de rate ou de thymus, de l'huile de jojoba, du beurre de karité, du gamma-oryzanol. The compositions according to the invention may optionally contain all the substances known to have beneficial properties on the skin, such as collagen, elastin, hyaluronic acid, humectants such as urea, pyrrolidone carboxylic acid and its salts, vitamin extracts, perfumes, preservatives, dyes, spleen or thymus extracts, jojoba oil, shea butter, gamma-oryzanol.

Elles peuvent contenir aussi de petites quantités de filtres ou écrans des radiations solaires à cause de l'importance des rayonnements UV sur la formation des radicaux libres de la peau. Il s'agit par exemple de filtres des radiations UVA et UVB tels que par exemple, l'hydroxy 2 - méthoxy 4 benzophène, L'acide diméthoxy 3,4-phényl glyoxylique sous forme de sel de sodium. They can also contain small quantities of filters or screens of solar radiations because of the importance of UV radiation on the formation of free radicals of the skin. These are, for example, filters for UVA and UVB radiation such as, for example, hydroxy 2 - methoxy 4 benzophene, dimethoxy 3,4-phenyl glyoxylic acid in the form of sodium salt.

Les compositions, selon l'invention, peuvent se présenter sous toutes les formes utilisées en cosmétologie crème ou gel en pots ou en tubes,
Lait, lotion en flacon de verre ou de plastique et éventuellement en flacon doseur ou flacon muni d'un compte-gouttes, ou encore en ampoules ou en bombe aérosol.The compositions according to the invention can be in any form used in cream or gel cosmetology in jars or tubes,
Milk, lotion in a glass or plastic bottle and possibly in a dosing bottle or a bottle fitted with a dropper, or in ampoules or aerosol can.

L'invention concerne donc des compositions cosmétiques ou dermatologiques caractérisées en ce qu'elles se présentent sous forme de crème, gel, lait, pains dermatologiques, lot ion pour la peau et tout particulièrement, des compositions cosmétiques ou dermatologiques, caractérisées en ce que leurs excipients sont adaptés à l'application sur le visage et sur le cou. The invention therefore relates to cosmetic or dermatological compositions characterized in that they are in the form of cream, gel, milk, dermatological breads, lot ion for the skin and very particularly, cosmetic or dermatological compositions, characterized in that their excipients are suitable for application on the face and on the neck.

En effet, pour chaque forme, on a recours à des excipients appropriés. Indeed, for each form, use is made of suitable excipients.

Ces excipients doivent avoir toutes les qualités habituellement demandées.These excipients must have all the qualities usually required.

Ils doivent être doués d'une grande affinité pour la peau, être parfaitement bien tolérées, stables, présenter une consistance adéquate permettant une utilisation facile et agréable.They must have a great affinity for the skin, be perfectly tolerated, stable, have an adequate consistency allowing easy and pleasant use.

A titre d'exemples d'excipients pouvant être utilisés, on peut citer, le stéarate de glycérol, le propylène glycol, les dérivés palmitates, stéarates, la lanoline, la glycérine , l'alcool cétylique, polyol, les huiles animales, minérales, les cires, les mouillants, les épaississants, les stabilisants, les émulsionnants couramment utilisés. As examples of excipients which can be used, there may be mentioned, glycerol stearate, propylene glycol, palmitate derivatives, stearates, lanolin, glycerin, cetyl alcohol, polyol, animal and mineral oils, waxes, wetting agents, thickeners, stabilizers, emulsifiers commonly used.

Les différentes formes cosmétiques mentionnées ci-dessus sont obtenues selon les méthodes usuelles utilisées dans ce domaine. The various cosmetic forms mentioned above are obtained according to the usual methods used in this field.

Les composants A et B de la présente invention seront incorporés aux excipients et aux substances présentant des bienfaits pour la peau mentionnée ci-dessus en tenant compte de leur affinité pour les phases huiles ou eau. The components A and B of the present invention will be incorporated into the excipients and the substances having benefits for the skin mentioned above, taking into account their affinity for the oil or water phases.

Les composants B seront incorporés normalement des le début de L'émulsification.  Components B will be incorporated normally from the start of the emulsification.

Les composants A ne seront incorporés qu'en fin d'émulsion à une température n'excédant pas 35nu.  Components A will only be incorporated at the end of the emulsion at a temperature not exceeding 35nu.

Claims (9)

REVENDICATIONS 1.- Compositions cosmétiques ou dermatologiques pour les soins de la peau, caractérisées en ce qu'elles renferment comme constituant principal le mélange comprenant :1.- Cosmetic or dermatological compositions for skin care, characterized in that they contain as main constituent the mixture comprising: A) Un extrait de fruits de Silybum Marianum riche en Silymarine appelé "Absolu d'Epine Blanche".A) A Silybum Marianum fruit extract rich in Silymarin called "White Thorn Absolute". B) Un ou plusieurs acides gras essentiels polyinsaturés contenant 18 à 22 atomes de carbone présents uniquement - soit sous forme libre (1) - soit sous forme de sels d'un métal alcalin ou d' ammonium (2) - soit sous forme de triglycérides (3) ou présents sous forme d'un mélange constitué par 2 des 3 formes (1) (2) et (3) ou par les 3 formes (1) (2) et (3).B) One or more polyunsaturated essential fatty acids containing 18 to 22 carbon atoms present only - either in free form (1) - or in the form of alkali metal or ammonium salts (2) - or in the form of triglycerides (3) or present in the form of a mixture constituted by 2 of the 3 forms (1) (2) and (3) or by the 3 forms (1) (2) and (3). 2.- Compositions définies selon la revendication 1, caractérisées en ce que le composant B) est constitué d'acides gras essentiels polyinsaturés contenant de 18 à 22 atomes de carbone présents à la fois sous forme libre (1) et sous forme de triglycérides (3) et sous forme de sels d'un métal alcalin ou d'ammonium (2) provenant de la saponification de tout ou partie des triglycérides (3).2.- Compositions defined according to claim 1, characterized in that component B) consists of polyunsaturated essential fatty acids containing from 18 to 22 carbon atoms present both in free form (1) and in the form of triglycerides ( 3) and in the form of alkali metal or ammonium salts (2) originating from the saponification of all or part of the triglycerides (3). 3.- Compositions définies selon les revendications 1 et 2, caractérisées en ce que le composant A) renferme en outre des terpènes d'huiles essentielles.3.- Compositions defined according to claims 1 and 2, characterized in that component A) also contains terpenes of essential oils. 4.- Compositions définies selon les revendications 1 à 3, caractérisées en ce que le composant A) renferme en outre des flavonoides.4.- Compositions defined according to claims 1 to 3, characterized in that component A) also contains flavonoids. 5.- Compositions définies selon les revendications 1 à 4, caractérisées en ce que le composant A) renferme en outre de L'alpha-tocophérol. 5.- Compositions defined according to claims 1 to 4, characterized in that component A) also contains alpha-tocopherol. 6.- Compositions définies selon les revendications 1 à 5, caractérisées en ce qu'elles renferment : - 10 à 30% en poids de l'extrait de Silybum Marianum, - 5 à 15X en poids de terpenes d'huiles essentielles, - 5 à 15X en poids de flavono;des, - 5 à 20X en poids d'alpha-tocophérol, - 25 à 40X en poids de triglycérides d'acides gras essentiels (3), - 10 à 25X d'acides gras essentiels sous forme libre (1) et sous forme de sels d'un métal alcalin ou d'ammonium (2) provenant de tout ou partie de la saponification des trîglycérides (3).6.- Compositions defined according to Claims 1 to 5, characterized in that they contain: - 10 to 30% by weight of the extract of Silybum Marianum, - 5 to 15X by weight of terpenes of essential oils, - 5 to 15X by weight of flavono; from, - 5 to 20X by weight of alpha-tocopherol, - 25 to 40X by weight of triglycerides of essential fatty acids (3), - 10 to 25X of essential fatty acids in free form (1) and in the form of salts of an alkali metal or of ammonium (2) originating from all or part of the saponification of the triglycerides (3). 7.- Compositions définies selon Les revendications 1 à 6, caractérisées en ce que le composant B) est un mélange constitué d'acide gamma-linolénique sous forme libre (1), d'une huile obtenue à partir d'une source riche en acide gamma-linolénique (3) et d'acide gamma-linolénique sous forme de sels de métal alcalin d'ammonium (2) provenant de la saponification de (3).7.- Compositions defined according to Claims 1 to 6, characterized in that component B) is a mixture consisting of gamma-linolenic acid in free form (1), of an oil obtained from a source rich in gamma-linolenic acid (3) and gamma-linolenic acid in the form of alkali metal ammonium salts (2) from the saponification of (3). 8.- Compositio s définies selon les revendications 1 à 7, caractérisées en ce que le com@@@ant B) est un mélange constitué d'acide gamma-linolénique sous forme 'i (1), d'huile d'onagre (3) et de sel de métal alcalin de l'acide gammalinolénique (2) provenant de la saponification de (3).8.- Compositio s defined according to claims 1 to 7, characterized in that the com @@@ ant B) is a mixture consisting of gamma-linolenic acid in form 'i (1), evening primrose oil ( 3) and the alkali metal salt of gammalinolenic acid (2) from the saponification of (3). 9.- ComCot;+ions définies selon revendications 1 à 8, caractérisées en ce qu'elles se @@@sentent sous forme de crème, gel, lait, lotion pour la peau. 9.- ComCot; + ions defined according to claims 1 to 8, characterized in that they are felt in the form of cream, gel, milk, skin lotion.
FR8700550A 1987-01-19 1987-01-19 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS RICH IN SILYMARINE ASSOCIATED WITH ESSENTIAL FATTY ACIDS Expired - Fee Related FR2609630B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR8700550A FR2609630B1 (en) 1987-01-19 1987-01-19 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS RICH IN SILYMARINE ASSOCIATED WITH ESSENTIAL FATTY ACIDS
ZA88222A ZA88222B (en) 1987-01-19 1988-01-13 Cosmetic and dermatological compositions including an extract of marianum silybum rich in silymarine associated with essential fatty acids
EP88400098A EP0278809B1 (en) 1987-01-19 1988-01-18 Cosmetic or dermatologic compositions containing a silybum marianum fruit extract rich in sylimarin together with essential fatty acids
CA000556735A CA1334006C (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum silybum rich in silymarine associated with essential fatty acids
ES198888400098T ES2032574T3 (en) 1987-01-19 1988-01-18 NEW COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF FRUITS OF "SILYBUM MARIANUM", RICH IN SILIMARINE, ASSOCIATED WITH ESSENTIAL FATTY ACIDS. (RESERVATION OF ART. 167.2 CPE).
AU10364/88A AU602947B2 (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum silybum rich in silymarine associated with essential fatty acids
IE12388A IE60704B1 (en) 1987-01-19 1988-01-18 Cosmetic and dermatological compositions including an extract of marianum sillybum rich in sillymarine associated with essential fatty acids
DE8888400098T DE3869442D1 (en) 1987-01-19 1988-01-18 COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING AN EXTRACT OF THE FRUIT OF THE SILYBUM MARIANUM WITH A HIGH SYLIMARINE CONTENT WITH ESSENTIAL FATTY ACIDS.
KR1019880000424A KR880008797A (en) 1987-01-19 1988-01-19 Skin care composition containing silymarin
JP63009436A JPS63239208A (en) 1987-01-19 1988-01-19 Beauty or skin composition containing silymarine-rich extract of silybum marianum fruit and essential fatty acid
US07/499,552 US4997649A (en) 1987-01-19 1990-03-26 Cosmetic and dermatological compositions including an extract of Silybum marianum rich in silymarine associated with essential fatty acids

Applications Claiming Priority (1)

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FR8700550A FR2609630B1 (en) 1987-01-19 1987-01-19 NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING AN EXTRACT OF SILYBUM MARIANUM FRUITS RICH IN SILYMARINE ASSOCIATED WITH ESSENTIAL FATTY ACIDS

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FR2609630A1 true FR2609630A1 (en) 1988-07-22
FR2609630B1 FR2609630B1 (en) 1991-01-04

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JP (1) JPS63239208A (en)
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
US5196448A (en) * 1991-01-22 1993-03-23 Stiefel Laboratories, Inc. Antiinflammatory compositions and method of use
EP0615753A1 (en) * 1993-03-19 1994-09-21 Scotia Holdings Plc Formulation for use in smokers
DE102005048780A1 (en) * 2005-10-10 2007-04-12 Beiersdorf Ag Hydrous cosmetic preparation with dissolved flavonolignans

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Publication number Priority date Publication date Assignee Title
JPH0495008A (en) * 1990-08-10 1992-03-27 Kanebo Ltd Skin aging inhibitor and skin cosmetic containing the same
JP3687277B2 (en) 1997-06-10 2005-08-24 サンスター株式会社 Whitening cosmetics
FR2860434B1 (en) * 2003-10-06 2006-10-27 Dermo Cosmetique Animale L D C DERMO COSMETIC COMPOSITION FOR PETS.
JP6415156B2 (en) * 2014-07-23 2018-10-31 小林製薬株式会社 Composition for external use

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0180505A1 (en) * 1984-10-19 1986-05-07 C L A R I N S Cosmetic preparation to arrest the ageing of the skin, and application process
EP0236218A1 (en) * 1986-02-24 1987-09-09 Claude Bonne Cosmetic compositions containing an extract of Silybum Marianum fruits

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0180505A1 (en) * 1984-10-19 1986-05-07 C L A R I N S Cosmetic preparation to arrest the ageing of the skin, and application process
EP0236218A1 (en) * 1986-02-24 1987-09-09 Claude Bonne Cosmetic compositions containing an extract of Silybum Marianum fruits

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196448A (en) * 1991-01-22 1993-03-23 Stiefel Laboratories, Inc. Antiinflammatory compositions and method of use
EP0615753A1 (en) * 1993-03-19 1994-09-21 Scotia Holdings Plc Formulation for use in smokers
US5562913A (en) * 1993-03-19 1996-10-08 Scotia Holdings Plc Formulation for use in smokers
DE102005048780A1 (en) * 2005-10-10 2007-04-12 Beiersdorf Ag Hydrous cosmetic preparation with dissolved flavonolignans

Also Published As

Publication number Publication date
FR2609630B1 (en) 1991-01-04
JPS63239208A (en) 1988-10-05
ZA88222B (en) 1988-09-28

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