FR2567406A1 - Sterile connector in particular for medical tubes. - Google Patents

Sterile connector in particular for medical tubes. Download PDF

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Publication number
FR2567406A1
FR2567406A1 FR8411071A FR8411071A FR2567406A1 FR 2567406 A1 FR2567406 A1 FR 2567406A1 FR 8411071 A FR8411071 A FR 8411071A FR 8411071 A FR8411071 A FR 8411071A FR 2567406 A1 FR2567406 A1 FR 2567406A1
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FR
France
Prior art keywords
discs
tubes
nozzles
connector
sterile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8411071A
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French (fr)
Other versions
FR2567406B1 (en
Inventor
Gerard Jean-Marie Charpentier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monoplast SA France
Original Assignee
Monoplast SA France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monoplast SA France filed Critical Monoplast SA France
Priority to FR8411071A priority Critical patent/FR2567406B1/en
Publication of FR2567406A1 publication Critical patent/FR2567406A1/en
Application granted granted Critical
Publication of FR2567406B1 publication Critical patent/FR2567406B1/en
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/001—Joining in special atmospheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/16—Tube connectors; Tube couplings having provision for disinfection or sterilisation
    • A61M39/18—Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B29C65/565—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits involving interference fits, e.g. force-fits or press-fits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5221—Joining tubular articles for forming coaxial connections, i.e. the tubular articles to be joined forming a zero angle relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2023/00—Tubular articles
    • B29L2023/005—Hoses, i.e. flexible
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Sterilisable connector for making a sterile connection between two tubes or pipes for medical use. According to the present invention, two rotating discs 2, 3 are mounted on a body 1 whose middle part is fitted with blades 8 and tips 6 intended to receive the ends of the pipes truncated by the blades 8. Applications: transfusions, perfusions, etc.

Description

CONNECTEUR STERILE POUR TUBULURES MEDICALES
La présente invention a pour objet un connecteur stérile destiné en particulier, mais non exclusivement, à raccorder deux tubulures ou conduits de prélèvement ou d'injection lors de traitements médicaux tels que transfusions, perfusions etc..., nécessitant d'une part une poche ou réserve et, d'autre part des moyens de pénétration dans l'organisme tels qu'aiguilles ou cathéters, en évitant la transmission accidentelle de germes pathogènes
On sait que, dans un souci d'asepsie, les appareils et instruments utilisés en médecine ou en chirurgie sont stérilisés avant leur utilisation, par étuvage, par irradiation aux ultraviolets, par exemple, afin de détruire les souches pathogènes susceptibles soit d'aggraver le mal soigné, soit d'introduire de nouvelles contaminations, ces précautions étant d'autant plus nécessaires que, dans les hôpitaux de nombreux malades sont en contact direct. Enfin, les liquides transportés par les tubulures sont injectés ou prélevés directement dans l'organisme de sorte que les mécanismes immunitaires ne jouent pas leur rôle habituel.STERILE CONNECTOR FOR MEDICAL TUBES
The subject of the present invention is a sterile connector intended in particular, but not exclusively, to connect two tubes or tubes for sampling or injection during medical treatments such as transfusions, infusions, etc., requiring on the one hand a pocket. or reserve and, on the other hand means of penetration into the body such as needles or catheters, avoiding accidental transmission of pathogenic germs
It is known that, for the sake of asepsis, the apparatuses and instruments used in medicine or in surgery are sterilized before their use, by steaming, by ultraviolet irradiation, for example, in order to destroy the pathogenic strains liable either to aggravate the ill-treated, that is to introduce new contaminations, these precautions being all the more necessary since, in hospitals, many patients are in direct contact. Finally, the liquids transported by the tubes are injected or withdrawn directly in the body so that the immune mechanisms do not play their usual role.

C'est pour cette raison que les conditions d'aseptie sont draconiennes sur les matériels utilisés. Toutefois, elles sont , dans une certaine mesure, illusoires si l'on ne dispose pas de moyens permettant un raccordement stérile de canalisations elles-mêmes stériles. Il y a, à ce niveau, une rupture de la chaîne stérile permettant l'introduction de souches pathogènes dans l'organisme. En effet, le raccordement des deux canalisations devrait être effectué sous atmosphère stérile ce qui s'avère pratiquement difficile.It is for this reason that the aseptic conditions are draconian on the materials used. However, they are, to a certain extent, illusory if one does not have means allowing a sterile connection of pipes themselves sterile. At this level, there is a break in the sterile chain allowing the introduction of pathogenic strains into the body. Indeed, the connection of the two pipes should be carried out in a sterile atmosphere which is practically difficult.

Différents dispositifs de connexion de tubulures stériles ont déjà été proposés. Ils incluent pour la plupart un élément mâle et un élément femelle isolés, avant leur réunion, par des films pouvant être perforés ou par des diaphragmes mobiles. Various devices for connecting sterile tubing have already been proposed. They include for the most part a male element and a female element isolated, before their meeting, by films which can be perforated or by movable diaphragms.

Un tel connecteur est décrit, par exemple, dans le Brevet
US-A-4 187 846 dans lequel il est prévu de mettre en regard les deux tubulures par une rotation relative des élements mâle et femelle. Tous ces dispositifs sont compliqués, d'une mise en oeuvre délicate et d'une fiabilité relative.Such a connector is described, for example, in the patent
US-A-4,187,846 in which it is intended to bring the two pipes opposite by a relative rotation of the male and female elements. All these devices are complicated, delicate to use and relatively reliable.

La présente invention a pour objet un connecteur qui assure effectivement la stérilité des tubulures raccordées, dont le prix soit assez bas pour qu'il puisse être jeté après un seul usage et qui contienne ses propres moyens de stérilisation.The present invention relates to a connector which effectively ensures the sterility of the connected tubes, the price of which is low enough so that it can be discarded after a single use and which contains its own means of sterilization.

Selon la présente invention, le connecteur stérile est caractérisé en ce qu'il comprend un corps aux extrêmités duquel sont montés deux disques pivotants sur le corps, les disques étant munis d'ajutages pour le passage de tubulures, la partie médiane du corps étant pourvue d'une cloison portant deux embouts alignés, un couteau étant muni de deux lames radiales disposées de part et d'aure de la cloison à une distance supérieure à la longueur des embouts.According to the present invention, the sterile connector is characterized in that it comprises a body at the ends of which are mounted two pivoting discs on the body, the discs being provided with nozzles for the passage of tubing, the middle part of the body being provided a partition carrying two aligned ends, a knife being provided with two radial blades arranged on either side of the partition at a distance greater than the length of the ends.

Selon une autre caractéristique de la présente invention le connecteur est muni de bornes traversant le corps, reliées à une résistance électrique s'étendant le long de la paroi. Il suffit ainsi de réunir les bornes à une source de tension électrique appropriée, pendant le temps nécessaire pour que la température interne au corps atteigne un niveau où les souches pathogènes sont détruites.According to another characteristic of the present invention, the connector is provided with terminals passing through the body, connected to an electrical resistance extending along the wall. It is therefore sufficient to bring the terminals together to an appropriate source of electrical voltage, for the time necessary for the internal temperature of the body to reach a level where the pathogenic strains are destroyed.

Selon encore une autre caractéristique de l'invention, les ajutages sont montés excentrés sur les disques et seule une rotation effectuée après la stérilisation assure d'une part le tronçonnage des extrêmités des tubulures à la longueur voulue et, d'autre part, leur alignement avec les embouts.Les tubulures ne seront ainsi effectivement reliées qu'après que le connecteur ait été stérilisé.According to yet another characteristic of the invention, the nozzles are mounted eccentrically on the discs and only one rotation carried out after sterilization ensures on the one hand the cutting of the ends of the tubes to the desired length and, on the other hand, their alignment The tubing will only be effectively connected after the connector has been sterilized.

D'autres caractéristiques et avantages de la présente invention apparattront au cours de la description qui va suivre d'un mode particulier de réalisation donné uniquement à titre d'exemple non limitatif, en regard des dessins qui représentent: - La Fig.1, une vue en perspective avec arrachement partiel
d'un connecteur selon l'invention; - La Fig.2, un schéma montrant la position des éléments avant
connexion des tubulures; - La Fig.3 un schéma identique après réunion des tubulures.Other characteristics and advantages of the present invention will become apparent during the following description of a particular embodiment given solely by way of non-limiting example, with reference to the drawings which represent: - Fig.1, a perspective view with partial cutaway
a connector according to the invention; - Fig. 2, a diagram showing the position of the front elements
connection of tubing; - Fig.3 an identical diagram after joining the tubes.

Sur la Fig.1, le corps 1 du connecteur est cylindrique et creux. Il est fermé à ses deux extrêmités par deux disques 2 et 3 pouvant tourner autour du corps 1 et avantageusement pourvues de moletages périphériques. Le disque 2 porte un ajutage 4 cylindrique formé en position excentrée sur le disque 2. Cet ajutage est destiné à 11 introduction au guidage et au maintien d'une tubulure 12 (Fig.2) généralement en matériau élastique. De même, le disque 3 porte un ajutage 5.In Fig.1, the body 1 of the connector is cylindrical and hollow. It is closed at its two ends by two discs 2 and 3 which can rotate around the body 1 and advantageously provided with peripheral knurls. The disc 2 carries a cylindrical nozzle 4 formed in an eccentric position on the disc 2. This nozzle is intended for introduction to the guidance and the maintenance of a tube 12 (FIG. 2) generally made of elastic material. Likewise, the disc 3 carries a nozzle 5.

Les disques 2 et 3 sont montés sur le corps 1 au moyen de joints de profil annelé (non représentés) et destinés à assurer l'étanchéité de l'intérieur du corps 1 qui forme une enceinte. La partie de raccordement proprement dite est constituée par une cloison médiane 7 portant des embouts ou noix de raccordement 6 sur lesquels viendront s assujetir lors de la mise en service les extrémités des tubulures.The discs 2 and 3 are mounted on the body 1 by means of corrugated profile seals (not shown) and intended to seal the interior of the body 1 which forms an enclosure. The connection part proper consists of a central partition 7 carrying end pieces or connection nuts 6 on which the ends of the pipes will come to subject themselves.

De part et d'autre de la paroi médiane 7 s'étendent radialement deux lames de couteau 8 dont la distance est sensiblement égale à la distance des extrémités des embouts 6. Le long d'une génératrice du cylindre constituant le corps 1, s'étend une résistance électrique 10 dont les extrémités sont reliées à deux bornes 9 étanches et traversant la paroi du corps 1. Une encoche est prévue dans la paroi circulaire 7 pour éviter que la résistance ne touche ce disque.On either side of the middle wall 7 extend radially two knife blades 8 whose distance is substantially equal to the distance from the ends of the end pieces 6. Along a generatrix of the cylinder constituting the body 1, s' extends an electrical resistance 10 whose ends are connected to two sealed terminals 9 and crossing the wall of the body 1. A notch is provided in the circular wall 7 to prevent the resistance from touching this disc.

Le mode opératoire est le suivant : comme représenté sur la
Fig.2, deux tubulures à raccorder 11 et 12 sont introduites dans le corps 1 par les ajutages 5 et 4 respectivement jusqu'à venir en butée contre la paroi 7 ou contre les embouts 6. Les jupes internes des ajutages sont de préférence réalisées dans une matière souple de manière à ce que l'introduction des tubulures obture entièrement l'enceinte constituée par le corps du connecteur, les tubulures étant fermées à leurs secondes extrêmités ou raccordées à un organe stérilisé.The operating mode is as follows: as shown in the
Fig.2, two pipes to be connected 11 and 12 are introduced into the body 1 through the nozzles 5 and 4 respectively until they come into abutment against the wall 7 or against the end pieces 6. The internal skirts of the nozzles are preferably produced in a flexible material so that the introduction of the tubes completely closes off the enclosure formed by the body of the connector, the tubes being closed at their second ends or connected to a sterilized member.

L'enceinte close est alors stérilisée ainsi que les extrêmités des tubulures par branchement de la résistance 10, par l'intermédiaire des bornes 9 à une source convenable de tension. La température à atteindre est de l'ordre de 220 à 240 OC et elle est obtenue au bout d'un temps d'environ une à deux minutes. De préférence, l'alimentation est commandée par une minuterie qui coupe le courant au bout d'un temps déterminé.The closed enclosure is then sterilized as well as the ends of the tubes by connection of the resistor 10, via the terminals 9 to a suitable source of voltage. The temperature to be reached is of the order of 220 to 240 ° C. and it is obtained after a time of approximately one to two minutes. Preferably, the supply is controlled by a timer which cuts the current after a determined time.

Lorsque la stérilisation est terminée, on fait tourner les disques 2 et 3. Les tubulures 11 et 12 tournent avec les disques à travers lesquels elles sont passées. Au cours de ce mouvement de rotation, elles viennent en contact avec les lames 8 des couteaux et sont coupées de manière à ce que leurs nouvelles extrêmités soient au niveau des extrêmités des embouts 6. La poursuite de la rotation amène les butées 13 portées par les deux disques 2 et 3 contre une butée fixe 14 solidaire du corps 1. A ce moment, comme celà apparat sur la Fig.3, les ajutages 4 et 5, et par suite les tubulures 11 et 12 sont alignés avec les embouts 6. Les tubulures sont alors enfoncées sur les embouts 6 et la connexion stérile est réalisée.When sterilization is complete, the discs 2 and 3 are rotated. The tubes 11 and 12 rotate with the discs through which they have passed. During this rotational movement, they come into contact with the blades 8 of the knives and are cut so that their new ends are at the ends of the end pieces 6. The continuation of the rotation brings the stops 13 carried by the two discs 2 and 3 against a fixed stop 14 integral with the body 1. At this time, as appears in FIG. 3, the nozzles 4 and 5, and consequently the pipes 11 and 12 are aligned with the end pieces 6. The tubes are then pressed onto the end pieces 6 and the sterile connection is made.

Il va de soi que de nombreuses variantes peuvent être introduites, notamment par substitution de moyens techniquement équivalents, en particulier pour la stérilisation,sans sortir pour celà du cadre de l'invention.  It goes without saying that many variants can be introduced, in particular by substitution of technically equivalent means, in particular for sterilization, without thereby departing from the scope of the invention.

Claims (4)

REVENDICATIONS 10 Connecteur stérile pour le raccordement de deux tubulures10 Sterile connector for connecting two tubes caractérisé en ce qu'il comprend un corps (1) aux characterized in that it comprises a body (1) with extrêmités duquel sont montés deux disques (2,3) pivotants ends of which are mounted two pivoting discs (2,3) sur le corps (1), les disques (2,3) étant munis d'ajutages on the body (1), the discs (2,3) being provided with nozzles (4,5) pour le passage de tubulures (11,12), la partie (4,5) for the passage of tubing (11,12), the part médiane du corps (1) étant pourvue d'une cloison (7) middle of the body (1) being provided with a partition (7) portant deux embouts (6) alignés, un couteau étant muni de carrying two aligned ends (6), a knife being provided with deux lames radiales (8) disposées de part et d'autre de la two radial blades (8) arranged on either side of the cloison (7) à une distance supérieure à la longueur des partition (7) at a distance greater than the length of the embouts (6). end caps (6). 20 Connecteur selon la revendication 1, caractérisé en ce 20 connector according to claim 1, characterized in that qu'il est muni de bornes (9) traversant le corps (1) that it is provided with terminals (9) passing through the body (1) reliées à une résistance électrique (10) s'étendant le connected to an electrical resistance (10) extending the long de la paroi (1). along the wall (1). 30 Connecteur selon l'une des revendications 1 ou 2,30 Connector according to one of claims 1 or 2, caractérisé en ce que les ajutages (4,5) sont excentrés characterized in that the nozzles (4,5) are offset sur les disques (2,3). on the discs (2,3). 40 Connecteur selon l'une quelconque des revendications40 connector according to any one of claims précédentes, caractérisé en ce que la paroi interne du previous, characterized in that the inner wall of the corps (1) est munie d'une butée (14) fixe, les disques body (1) is provided with a fixed stop (14), the discs (2,3) portant chacun une butée (13) de sorte le contact (2,3) each carrying a stop (13) so that the contact des butées (13) sur la butée (14) corresponde à stops (13) on the stop (14) correspond to l'alignement des ajutages (4,5) et des embouts (6).  the alignment of the nozzles (4,5) and the nozzles (6).
FR8411071A 1984-07-12 1984-07-12 STERILE CONNECTOR ESPECIALLY FOR MEDICAL TUBING Expired FR2567406B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8411071A FR2567406B1 (en) 1984-07-12 1984-07-12 STERILE CONNECTOR ESPECIALLY FOR MEDICAL TUBING

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8411071A FR2567406B1 (en) 1984-07-12 1984-07-12 STERILE CONNECTOR ESPECIALLY FOR MEDICAL TUBING

Publications (2)

Publication Number Publication Date
FR2567406A1 true FR2567406A1 (en) 1986-01-17
FR2567406B1 FR2567406B1 (en) 1986-12-19

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FR8411071A Expired FR2567406B1 (en) 1984-07-12 1984-07-12 STERILE CONNECTOR ESPECIALLY FOR MEDICAL TUBING

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062820A3 (en) * 1999-04-20 2001-03-08 Baxter Int Method and apparatus for manipulating pre-sterilized components in an active sterile field
WO2003106266A1 (en) * 2002-06-14 2003-12-24 Scilog, Inc. Single-use manifold for automated, aseptic transfer of soulutions in bioprocessing applications
US9700844B2 (en) 2002-06-14 2017-07-11 Parker-Hannifin Corporation Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications
USRE49221E1 (en) 2002-06-14 2022-09-27 Parker Intangibles, Llc Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030494A (en) * 1973-11-05 1977-06-21 Francis Tenczar Fluid connectors
EP0104718A1 (en) * 1982-07-06 1984-04-04 E.I. Du Pont De Nemours And Company Sterile docking process, apparatus and system for thermoplastic resin tubes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030494A (en) * 1973-11-05 1977-06-21 Francis Tenczar Fluid connectors
EP0104718A1 (en) * 1982-07-06 1984-04-04 E.I. Du Pont De Nemours And Company Sterile docking process, apparatus and system for thermoplastic resin tubes

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062820A3 (en) * 1999-04-20 2001-03-08 Baxter Int Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7264771B2 (en) 1999-04-20 2007-09-04 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7655198B2 (en) 1999-04-20 2010-02-02 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
WO2003106266A1 (en) * 2002-06-14 2003-12-24 Scilog, Inc. Single-use manifold for automated, aseptic transfer of soulutions in bioprocessing applications
US7052603B2 (en) 2002-06-14 2006-05-30 Scilog, Inc. Single-use manifold for automated, aseptic transfer of soulutions in bioprocessing applications
US9700844B2 (en) 2002-06-14 2017-07-11 Parker-Hannifin Corporation Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications
USRE49221E1 (en) 2002-06-14 2022-09-27 Parker Intangibles, Llc Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications

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