FR2564845B1 - Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique - Google Patents

Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique

Info

Publication number
FR2564845B1
FR2564845B1 FR858507862A FR8507862A FR2564845B1 FR 2564845 B1 FR2564845 B1 FR 2564845B1 FR 858507862 A FR858507862 A FR 858507862A FR 8507862 A FR8507862 A FR 8507862A FR 2564845 B1 FR2564845 B1 FR 2564845B1
Authority
FR
France
Prior art keywords
mercaptocycloalkylcarbonyl
mercaptoarylcarbonyl
dipeptides
therapeutic action
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR858507862A
Other languages
English (en)
Other versions
FR2564845A1 (fr
Inventor
Harold N Weller Iii
Eric M Gordon
Norma G Delaney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2564845A1 publication Critical patent/FR2564845A1/fr
Application granted granted Critical
Publication of FR2564845B1 publication Critical patent/FR2564845B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR858507862A 1984-05-25 1985-05-24 Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique Expired - Fee Related FR2564845B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/614,090 US4560506A (en) 1984-05-25 1984-05-25 Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

Publications (2)

Publication Number Publication Date
FR2564845A1 FR2564845A1 (fr) 1985-11-29
FR2564845B1 true FR2564845B1 (fr) 1990-04-27

Family

ID=24459829

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858507862A Expired - Fee Related FR2564845B1 (fr) 1984-05-25 1985-05-24 Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique

Country Status (7)

Country Link
US (1) US4560506A (fr)
JP (1) JPH0762029B2 (fr)
CA (1) CA1269496A (fr)
DE (1) DE3518817A1 (fr)
FR (1) FR2564845B1 (fr)
GB (1) GB2159160B (fr)
IT (1) IT1183677B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
DE3889726T2 (de) * 1987-03-17 1994-10-13 Res Corp Technologies Inc Synthetische inhibitoren von säugetier-collagenase.
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
CA1337400C (fr) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibiteurs de l'endopeptidase neutre
US4849525A (en) * 1987-09-21 1989-07-18 E. R. Squibb & Sons, Inc. Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
US5117335A (en) * 1989-12-28 1992-05-26 Koito Manufacturing Co., Ltd. Headlight for vehicle
EP0723451B1 (fr) * 1993-10-13 1999-08-25 Karla Lehmann Utilisation de composes de lithium en combinaison avec des inhibiteurs de l'ace et/ou des antagonistes du recepteur a angiotensin-ii pour traiter l'hypertension
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
WO2003014062A1 (fr) * 2001-08-03 2003-02-20 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Compositions d'acylthiol et de thiol utilisees en tant qu'agents anti-hiv et en tant qu'agents anti-retroviraux
PT1966130E (pt) 2005-12-23 2014-01-30 Zealand Pharma As Compostos miméticos de lisina modificados
DK2468724T3 (en) 2006-12-21 2016-02-22 Zealand Pharma As Synthesis of pyrrolidine compounds
DK3618847T3 (da) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
GR75019B (fr) * 1980-09-17 1984-07-12 Univ Miami
US4440941A (en) * 1980-12-22 1984-04-03 Usv Pharmaceutical Corporation Aroyl-aminoacids, amides and esters thereof
IT1195287B (it) * 1981-11-05 1988-10-12 Ausonia Farma Srl Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
EP0127124A3 (fr) * 1983-05-23 1987-04-08 Usv Pharmaceutical Corporation Composés pour le traitement de l'hypertension

Also Published As

Publication number Publication date
IT1183677B (it) 1987-10-22
GB2159160A (en) 1985-11-27
FR2564845A1 (fr) 1985-11-29
JPS617295A (ja) 1986-01-13
CA1269496C (fr) 1990-05-22
GB2159160B (en) 1987-10-28
IT8520872A0 (it) 1985-05-24
DE3518817A1 (de) 1985-11-28
CA1269496A (fr) 1990-05-22
US4560506A (en) 1985-12-24
JPH0762029B2 (ja) 1995-07-05
GB8513178D0 (en) 1985-06-26

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Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse