FR2545824B1 - DERIVATIVE 1A, 25-DIHYDROXYLS OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES - Google Patents

DERIVATIVE 1A, 25-DIHYDROXYLS OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES

Info

Publication number
FR2545824B1
FR2545824B1 FR8407155A FR8407155A FR2545824B1 FR 2545824 B1 FR2545824 B1 FR 2545824B1 FR 8407155 A FR8407155 A FR 8407155A FR 8407155 A FR8407155 A FR 8407155A FR 2545824 B1 FR2545824 B1 FR 2545824B1
Authority
FR
France
Prior art keywords
dihydroxyls
vitamin
derivative
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8407155A
Other languages
French (fr)
Other versions
FR2545824A1 (en
Inventor
Hector F Deluca
Heinrich K Schnoes
Rafal R Sicinski
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2545824A1 publication Critical patent/FR2545824A1/en
Application granted granted Critical
Publication of FR2545824B1 publication Critical patent/FR2545824B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dram (AREA)
FR8407155A 1983-05-09 1984-05-09 DERIVATIVE 1A, 25-DIHYDROXYLS OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES Expired FR2545824B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09

Publications (2)

Publication Number Publication Date
FR2545824A1 FR2545824A1 (en) 1984-11-16
FR2545824B1 true FR2545824B1 (en) 1987-11-20

Family

ID=23957917

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8407155A Expired FR2545824B1 (en) 1983-05-09 1984-05-09 DERIVATIVE 1A, 25-DIHYDROXYLS OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES

Country Status (5)

Country Link
JP (1) JPS60501261A (en)
BE (1) BE899612A (en)
FR (1) FR2545824B1 (en)
GB (3) GB2139627B (en)
IE (1) IE58277B1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
JP2608322B2 (en) * 1988-04-11 1997-05-07 日清製粉株式会社 Method for producing 1α, 25-dihydroxyvitamin D
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
JPH08507073A (en) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン Use of 26,26,26,27,27,27-hexafluoro-1alpha, 25-dihydroxycholecalciferol for the treatment of calcium metabolism disorders
US6100294A (en) 1997-05-16 2000-08-08 Women And Infants Hospital Cyclic ether vitamin D3 compounds, 1α(OH) 3-epi-vitamin D3 compounds and uses thereof
ATE322477T1 (en) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-EPI-VITAMIN D2 COMPOUNDS AND THEIR APPLICATIONS
AU2001291239A1 (en) * 2000-10-06 2002-04-22 Abbott Laboratories Use of vitamin d2 compounds for alopecia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL188286C (en) * 1978-01-16 1992-05-18 Wisconsin Alumni Res Found PROCESS FOR PREPARING A 1-ALFA-HYDROXYVITAMINE D COMPOUND
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

Also Published As

Publication number Publication date
GB8507475D0 (en) 1985-05-01
GB8507474D0 (en) 1985-05-01
GB2158443A (en) 1985-11-13
IE58277B1 (en) 1993-08-25
GB2158442B (en) 1987-02-04
IE841149L (en) 1984-11-09
GB2139627A (en) 1984-11-14
GB2158442A (en) 1985-11-13
FR2545824A1 (en) 1984-11-16
JPS60501261A (en) 1985-08-08
BE899612A (en) 1984-08-31
JPH0364498B2 (en) 1991-10-07
GB2139627B (en) 1987-02-04
GB8411794D0 (en) 1984-06-13
GB2158443B (en) 1987-02-04

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Legal Events

Date Code Title Description
ST Notification of lapse