BE899612A - DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. - Google Patents

DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES.

Info

Publication number
BE899612A
BE899612A BE0/212897A BE212897A BE899612A BE 899612 A BE899612 A BE 899612A BE 0/212897 A BE0/212897 A BE 0/212897A BE 212897 A BE212897 A BE 212897A BE 899612 A BE899612 A BE 899612A
Authority
BE
Belgium
Prior art keywords
derivatives
alpha
vitamin
preparation
intermediate products
Prior art date
Application number
BE0/212897A
Other languages
French (fr)
Inventor
H Deluca
H Schnoes
R Sicinski
Y Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE899612A publication Critical patent/BE899612A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne de nouveaux dérivés de la vitamine D2 et plus particulièrement les composés 1-alpha, 25-dihydroxylés de la famille des vitamines D. Elle concerne également un procédé de préparation de ces dérivés et également un procédé pour certains produits intermédiaires utilisés dans ce procédé. La présente invention permet d'obtenir les dérivés 1-alpha, 25-dihydroxyvitamine D2 et leurs acylates (I). Application de ces dérivés comme remplaçants des vitamines D3 ou D2 pour corriger les troubles du métabolisme du calcium et traiter les maladies des os qui y sont associées.The present invention relates to new derivatives of vitamin D2 and more particularly the 1-alpha, 25-dihydroxylated compounds of the family of vitamins D. It also relates to a process for the preparation of these derivatives and also a process for certain intermediate products used in this process. The present invention makes it possible to obtain the 1-alpha, 25-dihydroxyvitamin D2 derivatives and their acylates (I). Application of these derivatives as substitutes for vitamins D3 or D2 to correct disorders of calcium metabolism and treat bone diseases associated therewith.

BE0/212897A 1983-05-09 1984-05-09 DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. BE899612A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09

Publications (1)

Publication Number Publication Date
BE899612A true BE899612A (en) 1984-08-31

Family

ID=23957917

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/212897A BE899612A (en) 1983-05-09 1984-05-09 DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES.

Country Status (5)

Country Link
JP (1) JPS60501261A (en)
BE (1) BE899612A (en)
FR (1) FR2545824B1 (en)
GB (3) GB2139627B (en)
IE (1) IE58277B1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
JP2608322B2 (en) * 1988-04-11 1997-05-07 日清製粉株式会社 Method for producing 1α, 25-dihydroxyvitamin D
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
ATE322477T1 (en) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-EPI-VITAMIN D2 COMPOUNDS AND THEIR APPLICATIONS
WO1998051678A1 (en) 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
WO2002030430A1 (en) * 2000-10-06 2002-04-18 Abbott Laboratories Use of vitamin d2 compounds for alopecia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL188286C (en) * 1978-01-16 1992-05-18 Wisconsin Alumni Res Found PROCESS FOR PREPARING A 1-ALFA-HYDROXYVITAMINE D COMPOUND
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

Also Published As

Publication number Publication date
IE58277B1 (en) 1993-08-25
GB2158442B (en) 1987-02-04
FR2545824B1 (en) 1987-11-20
GB2139627A (en) 1984-11-14
JPS60501261A (en) 1985-08-08
GB8507475D0 (en) 1985-05-01
GB8507474D0 (en) 1985-05-01
FR2545824A1 (en) 1984-11-16
GB2139627B (en) 1987-02-04
GB8411794D0 (en) 1984-06-13
IE841149L (en) 1984-11-09
JPH0364498B2 (en) 1991-10-07
GB2158443A (en) 1985-11-13
GB2158442A (en) 1985-11-13
GB2158443B (en) 1987-02-04

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Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20030531