BE899612A - DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. - Google Patents
DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES.Info
- Publication number
- BE899612A BE899612A BE0/212897A BE212897A BE899612A BE 899612 A BE899612 A BE 899612A BE 0/212897 A BE0/212897 A BE 0/212897A BE 212897 A BE212897 A BE 212897A BE 899612 A BE899612 A BE 899612A
- Authority
- BE
- Belgium
- Prior art keywords
- derivatives
- alpha
- vitamin
- preparation
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne de nouveaux dérivés de la vitamine D2 et plus particulièrement les composés 1-alpha, 25-dihydroxylés de la famille des vitamines D. Elle concerne également un procédé de préparation de ces dérivés et également un procédé pour certains produits intermédiaires utilisés dans ce procédé. La présente invention permet d'obtenir les dérivés 1-alpha, 25-dihydroxyvitamine D2 et leurs acylates (I). Application de ces dérivés comme remplaçants des vitamines D3 ou D2 pour corriger les troubles du métabolisme du calcium et traiter les maladies des os qui y sont associées.The present invention relates to new derivatives of vitamin D2 and more particularly the 1-alpha, 25-dihydroxylated compounds of the family of vitamins D. It also relates to a process for the preparation of these derivatives and also a process for certain intermediate products used in this process. The present invention makes it possible to obtain the 1-alpha, 25-dihydroxyvitamin D2 derivatives and their acylates (I). Application of these derivatives as substitutes for vitamins D3 or D2 to correct disorders of calcium metabolism and treat bone diseases associated therewith.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49286383A | 1983-05-09 | 1983-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE899612A true BE899612A (en) | 1984-08-31 |
Family
ID=23957917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/212897A BE899612A (en) | 1983-05-09 | 1984-05-09 | DERIVATIVES 1 ALPHA, 25-DIHYDROXILES OF VITAMIN D2 AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS60501261A (en) |
BE (1) | BE899612A (en) |
FR (1) | FR2545824B1 (en) |
GB (3) | GB2139627B (en) |
IE (1) | IE58277B1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769181A (en) * | 1983-11-07 | 1988-09-06 | Wisconsin Alumni Research Foundation | 1,25-dihydroxyvitamin D2 compounds |
JP2608322B2 (en) * | 1988-04-11 | 1997-05-07 | 日清製粉株式会社 | Method for producing 1α, 25-dihydroxyvitamin D |
US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
AU6247194A (en) * | 1993-02-19 | 1994-09-14 | Wisconsin Alumni Research Foundation | Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders |
AU743514B2 (en) | 1997-05-16 | 2002-01-24 | Women & Infants Hospital | Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof |
WO1998051664A1 (en) * | 1997-05-16 | 1998-11-19 | Women & Infants Hospital | 3-epi vitamin d2 compounds and uses thereof |
WO2002030430A1 (en) * | 2000-10-06 | 2002-04-18 | Abbott Laboratories | Use of vitamin d2 compounds for alopecia |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
NL188286C (en) * | 1978-01-16 | 1992-05-18 | Wisconsin Alumni Res Found | PROCESS FOR PREPARING A 1-ALFA-HYDROXYVITAMINE D COMPOUND |
US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
US4264513A (en) * | 1979-05-21 | 1981-04-28 | Wisconsin Alumni Research Foundation | 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same |
-
1984
- 1984-05-09 GB GB08411794A patent/GB2139627B/en not_active Expired
- 1984-05-09 IE IE114984A patent/IE58277B1/en not_active IP Right Cessation
- 1984-05-09 BE BE0/212897A patent/BE899612A/en not_active IP Right Cessation
- 1984-05-09 FR FR8407155A patent/FR2545824B1/en not_active Expired
- 1984-05-09 JP JP59502223A patent/JPS60501261A/en active Granted
-
1985
- 1985-03-22 GB GB08507475A patent/GB2158443B/en not_active Expired
- 1985-03-22 GB GB08507474A patent/GB2158442B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE841149L (en) | 1984-11-09 |
IE58277B1 (en) | 1993-08-25 |
GB8411794D0 (en) | 1984-06-13 |
GB2139627B (en) | 1987-02-04 |
FR2545824B1 (en) | 1987-11-20 |
GB8507475D0 (en) | 1985-05-01 |
GB2158443A (en) | 1985-11-13 |
GB2158443B (en) | 1987-02-04 |
GB8507474D0 (en) | 1985-05-01 |
GB2158442B (en) | 1987-02-04 |
GB2158442A (en) | 1985-11-13 |
JPH0364498B2 (en) | 1991-10-07 |
GB2139627A (en) | 1984-11-14 |
FR2545824A1 (en) | 1984-11-16 |
JPS60501261A (en) | 1985-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Effective date: 20030531 |