FR2539129B1 - Analogues amines des prostaglandines 7-oxabicycloheptane-substitues utiles comme medicaments cardio-vasculaires - Google Patents

Analogues amines des prostaglandines 7-oxabicycloheptane-substitues utiles comme medicaments cardio-vasculaires

Info

Publication number
FR2539129B1
FR2539129B1 FR8400420A FR8400420A FR2539129B1 FR 2539129 B1 FR2539129 B1 FR 2539129B1 FR 8400420 A FR8400420 A FR 8400420A FR 8400420 A FR8400420 A FR 8400420A FR 2539129 B1 FR2539129 B1 FR 2539129B1
Authority
FR
France
Prior art keywords
oxabicycloheptane
cardiovascular drugs
analogs useful
amino analogs
substituted prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8400420A
Other languages
English (en)
Other versions
FR2539129A1 (fr
Inventor
Masami Nakane
Martin F Haslanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2539129A1 publication Critical patent/FR2539129A1/fr
Application granted granted Critical
Publication of FR2539129B1 publication Critical patent/FR2539129B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR8400420A 1983-01-12 1984-01-12 Analogues amines des prostaglandines 7-oxabicycloheptane-substitues utiles comme medicaments cardio-vasculaires Expired FR2539129B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/457,538 US4456617A (en) 1983-01-12 1983-01-12 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction

Publications (2)

Publication Number Publication Date
FR2539129A1 FR2539129A1 (fr) 1984-07-13
FR2539129B1 true FR2539129B1 (fr) 1986-10-24

Family

ID=23817117

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8400420A Expired FR2539129B1 (fr) 1983-01-12 1984-01-12 Analogues amines des prostaglandines 7-oxabicycloheptane-substitues utiles comme medicaments cardio-vasculaires

Country Status (7)

Country Link
US (1) US4456617A (fr)
JP (1) JPS59134793A (fr)
CA (1) CA1199031A (fr)
DE (1) DE3400757A1 (fr)
FR (1) FR2539129B1 (fr)
GB (1) GB2133014B (fr)
IT (1) IT1174463B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588741A (en) * 1985-02-28 1986-05-13 E. R. Squibb & Sons, Inc. Platelet aggregation inhibiting and bronchoconstriction inhibiting thiabicycloheptane substituted amino prostaglandin analog derivatives, compositions, and method of use therefor
US4607048A (en) * 1985-05-16 1986-08-19 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4609671A (en) * 1985-06-27 1986-09-02 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease
US4663336A (en) * 1985-07-01 1987-05-05 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease
US4654356A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs
US4654355A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs
US4632931A (en) * 1985-09-25 1986-12-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs useful in the treatment of thrombotic disease
US4652576A (en) * 1985-10-18 1987-03-24 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs
US4639461A (en) * 1985-10-28 1987-01-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted keto-amide prostaglandin analogs useful in the treatment of thrombotic disease
US4638012A (en) * 1985-11-05 1987-01-20 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane α-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease
US4647573A (en) * 1985-11-22 1987-03-03 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted thioamide-amide prostaglandin analogs
US4656185A (en) * 1985-12-05 1987-04-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs
US4652578A (en) * 1986-02-24 1987-03-24 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide prostaglandin analogs
US4663337A (en) * 1986-04-18 1987-05-05 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease
US4670453A (en) * 1986-05-08 1987-06-02 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease
US4743697A (en) * 1986-06-04 1988-05-10 E. R. Squibb & Sons, Inc. Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists and novel intermediates procuced therein
US4687865A (en) * 1986-06-04 1987-08-18 E. R. Squibb & Sons, Inc. Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
US4851553A (en) * 1986-06-04 1989-07-25 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amido-carboxylic acids
US4958036A (en) * 1986-06-04 1990-09-18 E. R. Squibb & Sons, Inc. Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids
US4816579A (en) * 1986-06-04 1989-03-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
US4734426A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs
US4734424A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. Bicycloheptane substituted diamide and its congener prostaglandin analogs
US4735962A (en) * 1986-10-06 1988-04-05 E. R. Squibb & Sons, Inc. 7-thiabicycloheptane substituted diamide and its congener prostaglandin analogs
US4734425A (en) * 1986-10-17 1988-03-29 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs
US4738978A (en) * 1986-11-10 1988-04-19 E. R. Squibb & Sons, Inc. Bisthioamide-7-oxabicycloheptane prostaglandin analogs
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
US4992581A (en) * 1988-12-13 1991-02-12 National Research Development Corporation Novel methods of manufacturing thromboxane A2 antagonists
US5106870A (en) * 1988-12-13 1992-04-21 National Research Development Corporation Methods for the use of thromboxane A2 antagonists
US4973604A (en) * 1988-12-13 1990-11-27 National Research Development Corporation Thromboxane A2 antagonists and pharmaceutical compositions thereof
US4992563A (en) * 1988-12-13 1991-02-12 National Research Development Corporation Benzopyran intermediates for use in manufacturing thromboxane A2 antagonists
US5055582A (en) * 1988-12-13 1991-10-08 National Research Development Corporation Process for preparing thromboxane A2 antagonists
NO175258C (no) * 1988-12-23 1994-09-21 Squibb & Sons Inc Analogifremgangsmåte for fremstilling av terapeutisk aktive 7-oksabicykloheptyl-substituerte heterocyklisk amidprostaglandinanaloger
US4977174A (en) * 1989-06-12 1990-12-11 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
EP2147679B1 (fr) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions pour le transport de barrière hématoencéphalique
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (fr) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
WO1980001381A1 (fr) * 1979-01-05 1980-07-10 R Jones Bicyclo (2,2,1) heptanes et hep-2-enes substitues
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
US4335537A (en) * 1979-11-28 1982-06-22 Plectrum Pty. Limited Toy aircraft
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease

Also Published As

Publication number Publication date
CA1199031A (fr) 1986-01-07
US4456617A (en) 1984-06-26
GB2133014A (en) 1984-07-18
IT1174463B (it) 1987-07-01
GB8400658D0 (en) 1984-02-15
JPS59134793A (ja) 1984-08-02
IT8419117A0 (it) 1984-01-11
GB2133014B (en) 1986-03-26
FR2539129A1 (fr) 1984-07-13
DE3400757A1 (de) 1984-07-19

Similar Documents

Publication Publication Date Title
FR2539129B1 (fr) Analogues amines des prostaglandines 7-oxabicycloheptane-substitues utiles comme medicaments cardio-vasculaires
IT1161242B (it) Analoghi di prostaglandina 7-ossabicicloeptanidrazone
IT1177013B (it) Analoghi interfenilene di prostaglandina 7-ossa-biciclo eptano sostituiti
IT8324352A0 (it) Analoghi di prostaglandina 7-ossabicicloeptano ammino sostitutivo.
BE896274A (fr) Nouvelle utilisation d'analogues de prostaglandines
MX7527E (es) Procedimiento para la sintesis de un aminoacido de ciclopropilo
GB2133791B (en) 7-oxabicycloheptane substituted carbamate prostaglandin analogs
BE896818A (fr) Nouvelle utilisation d'analogues des prostaglandines.
AU526356B2 (en) Amino acid intermediates for the preparation of prosta- glandin analogues
IT1173442B (it) Analoghi di prostaglandina 7-ossabicicloeptano sostituito
FR2525215B1 (fr) Analogues de la vasopressine
FR2611718B1 (fr) Analogues d'amino prostaglandines 7-oxabicycloheptane substitues, a action therapeutique
BE893162A (fr) Analogues de la mitomycine
IT8620208A0 (it) Eteri del 7-ossabicicloeptano sostituiti quali analoghi di prostaglandine e relative composizioni farmaceutiche.
IT8619557A1 (it) Analoghi di ammino prostaglandine tiabicicloeptano-sostituite
IT1188554B (it) Analoghi di prostaglandina 7-ossabicicloeptano sostitutiti
DK386783A (da) Fremgangsmaade til fremstilling af benzamidderivater eller et farmaceutisk acceptabelt salt deraf
FR2581997B1 (fr) Analogues de prostaglandines a substituant thiabicycloheptane, a proprietes therapeutiques
BE851357A (fr) Analogues des prostaglandines
GB8314355D0 (en) Prostaglandin analogues
IT1194406B (it) Procedimento per la preparazione di 2-idrossi-5-01-idrossi-2-((4-fenil-2-butil)ammino) etil benzammide
IT1197558B (it) Composizioni farmaceutiche somministrabili per via nasale
BR8303003A (pt) Ester etilico de acido n-(metoxi(tiometil)fosfinil)-n,n-dimetil carbamimidotioico
IT1151742B (it) Metodo per la sintesi di analoghi parzialmente retro-invertiti delle encefaline
FR2361362B1 (fr) Analogues des prostaglandines

Legal Events

Date Code Title Description
ST Notification of lapse