FR2529888B1 - Composes 1a-hydroxyles - Google Patents

Composes 1a-hydroxyles

Info

Publication number
FR2529888B1
FR2529888B1 FR8311299A FR8311299A FR2529888B1 FR 2529888 B1 FR2529888 B1 FR 2529888B1 FR 8311299 A FR8311299 A FR 8311299A FR 8311299 A FR8311299 A FR 8311299A FR 2529888 B1 FR2529888 B1 FR 2529888B1
Authority
FR
France
Prior art keywords
hydroxyl compounds
hydroxyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8311299A
Other languages
English (en)
Other versions
FR2529888A1 (fr
Inventor
Hector F De Luca
Heinrich K Schnoes
David E Hamer
Herbert E Paaren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2529888A1 publication Critical patent/FR2529888A1/fr
Application granted granted Critical
Publication of FR2529888B1 publication Critical patent/FR2529888B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR8311299A 1978-01-16 1983-07-06 Composes 1a-hydroxyles Expired FR2529888B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86944878A 1978-01-16 1978-01-16
US05/914,796 US4195027A (en) 1978-01-16 1978-06-12 Process for preparing 1α-hydroxylated compounds

Publications (2)

Publication Number Publication Date
FR2529888A1 FR2529888A1 (fr) 1984-01-13
FR2529888B1 true FR2529888B1 (fr) 1986-04-04

Family

ID=27128114

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7900990A Granted FR2438035A1 (fr) 1978-01-16 1979-01-16 Procede et intermediaires pour la preparation de derives 1a-hydroxyles de vitamines du groupe d
FR7923987A Withdrawn FR2436140A1 (fr) 1978-01-16 1979-09-26 Derives de 1 a-hydroxy cyclovitamines du groupe d et leur preparation
FR8108368A Granted FR2478631A1 (fr) 1978-01-16 1981-04-27 Nouvelles cyclovitamines 1a-hydroxylees et leur procede de preparation
FR8311299A Expired FR2529888B1 (fr) 1978-01-16 1983-07-06 Composes 1a-hydroxyles

Family Applications Before (3)

Application Number Title Priority Date Filing Date
FR7900990A Granted FR2438035A1 (fr) 1978-01-16 1979-01-16 Procede et intermediaires pour la preparation de derives 1a-hydroxyles de vitamines du groupe d
FR7923987A Withdrawn FR2436140A1 (fr) 1978-01-16 1979-09-26 Derives de 1 a-hydroxy cyclovitamines du groupe d et leur preparation
FR8108368A Granted FR2478631A1 (fr) 1978-01-16 1981-04-27 Nouvelles cyclovitamines 1a-hydroxylees et leur procede de preparation

Country Status (15)

Country Link
US (1) US4195027A (fr)
JP (1) JPS5828876B2 (fr)
AU (1) AU525781B2 (fr)
BE (1) BE873512A (fr)
CA (1) CA1156251A (fr)
CH (2) CH658050A5 (fr)
DE (2) DE2954557C2 (fr)
DK (3) DK147912C (fr)
FR (4) FR2438035A1 (fr)
GB (1) GB2013686B (fr)
IE (1) IE48547B1 (fr)
NL (1) NL188901C (fr)
NZ (1) NZ189388A (fr)
SE (1) SE429971B (fr)
WO (1) WO1979000513A1 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
JPS5626820A (en) * 1979-08-10 1981-03-16 Chugai Pharmaceut Co Ltd Immunosuppressing agent
US4265822A (en) * 1979-09-10 1981-05-05 Wisconsin Alumni Research Foundation Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
EP0070588B1 (fr) * 1981-07-17 1986-05-07 Duphar International Research B.V Procédé de préparation de dérivés de 1 alpha-hydroxy vitamine D ou de 1 alpha-hydroxy prévitamine D et d'adducts de prévitamine D ou de tachysterol avec des diénophiles appropriés
US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
FR2545824B1 (fr) * 1983-05-09 1987-11-20 Wisconsin Alumni Res Found Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
DE3590080T (de) * 1984-03-05 1986-02-20 Wisconsin Alumni Research Foundation, Madison, Wis. 1α-Hydroxyvitamin D↓2↓-Analogverbindungen und Verfahren zu deren Herstellung
US4555364A (en) * 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
DE3666587D1 (en) * 1985-08-02 1989-11-30 Leo Pharm Prod Ltd Novel vitamin d analogues
US5602116A (en) * 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) * 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5321018A (en) * 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5185150A (en) * 1990-08-24 1993-02-09 Wisconsin Alumni Research Fdn. Cosmetic compositions containing 19-nor-vitamin D compounds
HU213471B (en) * 1990-09-21 1997-06-30 Bone Care International Process for producing 1alpha-hydroxy-vitamin d4
US5798345A (en) * 1990-09-21 1998-08-25 Bone Care International, Inc. Method of inhibiting the hyperproliferation of malignant cells
US5763428A (en) * 1990-09-21 1998-06-09 Bone Care International, Inc. Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
US5801164A (en) * 1990-09-21 1998-09-01 Bone Care International, Inc. Methods of treating osteoporosis prophylactically or therapeutically
US6025346A (en) * 1990-09-21 2000-02-15 Bone Care International, Inc. 1α-hydroxy vitamin D4 and novel intermediates and analogues
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6166000A (en) * 1991-01-08 2000-12-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-Dihydroxy vitamin . D.sub2
ES2200238T3 (es) * 1991-01-08 2004-03-01 Bone Care International, Inc. Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2.
US5786348A (en) * 1991-01-08 1998-07-28 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
WO1994005630A1 (fr) * 1992-08-28 1994-03-17 Lunar Corporation PROCEDES DE PREPARATION ET D'UTILISATION DE LA VITAMINE D2 1α,24(S)-DIHYDROXY
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5869472A (en) * 1994-07-18 1999-02-09 Bone Care International, Inc. Synthesis of 1α-hydroxy vitamin D
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6376479B1 (en) 1995-04-03 2002-04-23 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
EP1021401A1 (fr) * 1995-09-21 2000-07-26 Wisconsin Alumni Research Foundation Derives de calcitriol et leurs utilisations
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
PL336231A1 (en) * 1997-02-13 2000-06-19 Bone Care International System for aimed therapeutic delivery of vitamin d compounds
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
EP1064000B1 (fr) * 1998-03-27 2011-07-06 Oregon Health & Science University Vitamine d et ses analogues pour le traitement de tumeurs et d'autres troubles d'hyperproliferation
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
WO2002006218A2 (fr) * 2000-07-18 2002-01-24 Bone Care International, Inc. 1$g(a)hydroxy-vitamine d stabilisée
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20050239756A1 (en) * 2004-04-23 2005-10-27 Bone Care International, Inc. Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7491712B1 (en) 2007-12-10 2009-02-17 Formosa Laboratories, Inc. Process for preparation of paricalcitol and intermediates thereof
WO2010009879A2 (fr) * 2008-07-22 2010-01-28 Azad Pharmaceutical Ingredients Ag Procédés de production de paricalcitol
US20120184514A1 (en) * 2009-07-01 2012-07-19 Vitamin Derivatives Inc. Vitamin d compounds and methods for preparing same
CN114805158B (zh) * 2022-04-24 2023-11-14 浙江花园生物医药股份有限公司 一种制备骨化三醇的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901928A (en) * 1973-01-10 1975-08-26 Robert Henry Hesse 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US3847955A (en) * 1973-07-16 1974-11-12 Wisconsin Alumni Res Found 1,24,25-trihydroxycholecalciferol
CA1034114A (fr) * 1973-12-03 1978-07-04 Wisconsin Alumni Research Foundation Modes de preparation de derives steroides
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US3976636A (en) * 1974-10-10 1976-08-24 The Upjohn Company Process and compounds

Also Published As

Publication number Publication date
NZ189388A (en) 1981-02-11
IE790055L (en) 1979-07-16
DK147912B (da) 1985-01-07
GB2013686A (en) 1979-08-15
AU4339479A (en) 1979-07-26
FR2529888A1 (fr) 1984-01-13
SE7907631L (sv) 1979-09-13
DK374083D0 (da) 1983-08-16
FR2438035B1 (fr) 1984-02-24
CA1156251A (fr) 1983-11-01
DK436182A (da) 1982-10-01
CH658050A5 (de) 1986-10-15
WO1979000513A1 (fr) 1979-08-09
JPS54500080A (fr) 1979-11-29
BE873512A (fr) 1979-05-16
DK374083A (da) 1983-08-16
GB2013686B (en) 1982-04-15
DK169871B1 (da) 1995-03-20
NL188901B (nl) 1992-06-01
DK365079A (da) 1979-08-31
SE429971B (sv) 1983-10-10
FR2478631B1 (fr) 1984-02-24
CH653321A5 (de) 1985-12-31
NL7900331A (nl) 1979-07-18
NL188901C (nl) 1992-11-02
AU525781B2 (en) 1982-12-02
DE2954557C2 (fr) 1991-07-11
IE48547B1 (en) 1985-03-06
DE2933189C2 (fr) 1991-05-29
DK170437B1 (da) 1995-09-04
US4195027A (en) 1980-03-25
FR2438035A1 (fr) 1980-04-30
FR2478631A1 (fr) 1981-09-25
JPS5828876B2 (ja) 1983-06-18
DK147912C (da) 1985-06-17
DE2933189T1 (de) 1980-12-18
FR2436140A1 (fr) 1980-04-11

Similar Documents

Publication Publication Date Title
FR2529888B1 (fr) Composes 1a-hydroxyles
AT379079B (de) Akupunkturgeraet
AT370950B (de) Hoeschenwindel
AT365922B (de) Netzbett
NO149339C (no) Freseverktoey
AT374352B (de) Sportschuh
TR20169A (tr) Pestisid bilesikler
TR19943A (tr) Piridazon bilesikleri
DK15579A (da) Loeftevaerktoej
FI783483A (fi) Lignosulfatderivat
TR20165A (tr) Feniluereler
FI792859A (fi) Vrid-lyftfoenster
FI791113A (fi) Kortback
DK469779A (da) Stoebeasfaltblanding
DK549479A (da) Cephalosporin-analoge forbindelser
FI793167A (fi) Nedboejningsreglervals
FI780346A (fi) Osymmetrisk sekundaerkylning
MA18686A1 (fr) Composes aminothiazoliques
ATA26879A (de) B-ettbank
NO791571L (no) Vel-luktende bicyklooktan-forbindelser
AT368010B (de) Rollskier
TR20414A (tr) Halometil suebtituee dialkoksipiridinler
AR219977A1 (es) Apero subsolador mejorado
DK124979A (da) Substituerede n-iminomethylpiperidiner
IT1125554B (it) Composti ciclopropanici