FR2527928B1 - Procede de preparation d'anticorps monoclonaux conjugues avec un chelate metallique et solution les contenant - Google Patents

Procede de preparation d'anticorps monoclonaux conjugues avec un chelate metallique et solution les contenant

Info

Publication number
FR2527928B1
FR2527928B1 FR8309437A FR8309437A FR2527928B1 FR 2527928 B1 FR2527928 B1 FR 2527928B1 FR 8309437 A FR8309437 A FR 8309437A FR 8309437 A FR8309437 A FR 8309437A FR 2527928 B1 FR2527928 B1 FR 2527928B1
Authority
FR
France
Prior art keywords
preparation
solution containing
monoclonal antibodies
metal chelate
antibodies conjugated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8309437A
Other languages
English (en)
French (fr)
Other versions
FR2527928A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/386,110 external-priority patent/US4472509A/en
Priority claimed from US06/386,109 external-priority patent/US4454106A/en
Application filed by Individual filed Critical Individual
Publication of FR2527928A1 publication Critical patent/FR2527928A1/fr
Application granted granted Critical
Publication of FR2527928B1 publication Critical patent/FR2527928B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Radiation-Therapy Devices (AREA)
FR8309437A 1982-06-07 1983-06-07 Procede de preparation d'anticorps monoclonaux conjugues avec un chelate metallique et solution les contenant Expired FR2527928B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/386,110 US4472509A (en) 1982-06-07 1982-06-07 Metal chelate conjugated monoclonal antibodies
US06/386,109 US4454106A (en) 1982-06-07 1982-06-07 Use of metal chelate conjugated monoclonal antibodies

Publications (2)

Publication Number Publication Date
FR2527928A1 FR2527928A1 (fr) 1983-12-09
FR2527928B1 true FR2527928B1 (fr) 1989-09-22

Family

ID=27011278

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8309437A Expired FR2527928B1 (fr) 1982-06-07 1983-06-07 Procede de preparation d'anticorps monoclonaux conjugues avec un chelate metallique et solution les contenant

Country Status (5)

Country Link
JP (1) JP2599705B2 (zh)
CA (1) CA1225930A (zh)
DE (1) DE3320560A1 (zh)
FR (1) FR2527928B1 (zh)
GB (1) GB2122641B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
ES2054678T5 (es) * 1986-08-18 1997-09-16 Dow Chemical Co Conjugados estrella.
AU619218B2 (en) * 1987-11-06 1992-01-23 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
JPH01176000A (ja) * 1987-12-30 1989-07-12 Nippon Mejifuijitsukusu Kk 放射性医薬品とその調製用高分子化合物
US5639624A (en) * 1989-03-14 1997-06-17 Board Of Regents Of The University Of Nebraska Monoclonal antibodies specific for metallic cations and method therefor
US5972656A (en) * 1989-03-14 1999-10-26 Bionebraska, Inc. Mercury binding polypeptides and nucleotides coding therefore
EP0493526A4 (en) * 1989-09-22 1992-08-26 Neorx Corporation Stable therapeutic radionuclide compositions and methods for preparation thereof
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
US6111079A (en) * 1995-06-05 2000-08-29 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefore
ATE223237T1 (de) * 1996-11-15 2002-09-15 Euratom Ex-corpore verfahren zur behändlung von blut- zellen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583036A5 (zh) * 1972-05-12 1976-12-31 Hoffmann La Roche
JPS5857149B2 (ja) * 1975-12-25 1983-12-19 スギウラ マモル エル − アミノサンサンカコウソノセイセイホウ
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
GB2109407B (en) * 1981-10-27 1985-12-18 Hybritech Inc Tumour imaging with radiolabelled monoclonal antibodies
US4666697A (en) * 1982-12-08 1987-05-19 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent

Also Published As

Publication number Publication date
JPS5946227A (ja) 1984-03-15
FR2527928A1 (fr) 1983-12-09
GB8315483D0 (en) 1983-07-13
JP2599705B2 (ja) 1997-04-16
GB2122641A (en) 1984-01-18
GB2122641B (en) 1986-08-06
DE3320560A1 (de) 1984-02-09
DE3320560C2 (zh) 1993-09-16
CA1225930A (en) 1987-08-25

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse