FR2526798B1 - Derives de peneme, leur procede de preparation et compositions therapeutiques les contenant - Google Patents

Derives de peneme, leur procede de preparation et compositions therapeutiques les contenant

Info

Publication number
FR2526798B1
FR2526798B1 FR8308085A FR8308085A FR2526798B1 FR 2526798 B1 FR2526798 B1 FR 2526798B1 FR 8308085 A FR8308085 A FR 8308085A FR 8308085 A FR8308085 A FR 8308085A FR 2526798 B1 FR2526798 B1 FR 2526798B1
Authority
FR
France
Prior art keywords
penema
derivatives
preparation
compositions containing
therapeutic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8308085A
Other languages
English (en)
Other versions
FR2526798A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2526798A1 publication Critical patent/FR2526798A1/fr
Application granted granted Critical
Publication of FR2526798B1 publication Critical patent/FR2526798B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8308085A 1982-05-14 1983-05-16 Derives de peneme, leur procede de preparation et compositions therapeutiques les contenant Expired FR2526798B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57081067A JPS58198486A (ja) 1982-05-14 1982-05-14 ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法

Publications (2)

Publication Number Publication Date
FR2526798A1 FR2526798A1 (fr) 1983-11-18
FR2526798B1 true FR2526798B1 (fr) 1985-10-04

Family

ID=13736043

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8308085A Expired FR2526798B1 (fr) 1982-05-14 1983-05-16 Derives de peneme, leur procede de preparation et compositions therapeutiques les contenant

Country Status (8)

Country Link
US (1) US4613595A (fr)
JP (1) JPS58198486A (fr)
CH (1) CH659072A5 (fr)
DE (1) DE3317742A1 (fr)
ES (2) ES8407053A1 (fr)
FR (1) FR2526798B1 (fr)
GB (1) GB2121792B (fr)
IT (1) IT1164226B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
CA1339860C (fr) * 1985-06-17 1998-05-12 Tsunehiko Soga Derives de peneme
US4751297A (en) * 1987-03-20 1988-06-14 Pfizer Inc. Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
ES2067534T3 (es) * 1988-04-01 1995-04-01 Sankyo Co Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos.
WO1994014811A1 (fr) * 1992-12-21 1994-07-07 Chong Kun Dang Corp. Derives 2-(2-substitues pyrrolidin-4-yl)thio-carbapeneme
WO2023235456A1 (fr) * 2022-06-01 2023-12-07 The Johns Hopkins University Agents antibactériens à base de pénèmes dirigés contre des pathogènes mycobactériens et d, d- et l, d transpeptidases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003960B1 (fr) * 1978-02-02 1983-06-29 Ciba-Geigy Ag Composés thia-aza substitués en position 6, leur préparation et compositions pharmaceutiques les contenant
EP0008514B1 (fr) * 1978-08-25 1982-01-20 Beecham Group Plc Dérivés antibactériens de bêta-lactames, compositions les contenant et un procédé pour leur préparation
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0041768B1 (fr) * 1980-04-24 1987-11-11 Beecham Group Plc Composés de bêta-lactame, leur préparation et application
EP0046363B1 (fr) * 1980-08-16 1984-11-14 Beecham Group Plc Procédé de préparation de dérivés de 2-thio penème et les intermédiaires
JPS57176988A (en) * 1981-04-09 1982-10-30 Sankyo Co Ltd Penam-3-carboxylic acid derivative and its preparation
AU8605382A (en) * 1981-07-15 1983-01-20 Sumitomo Chemical Company, Limited Penicillins and azetidinones
US4435412A (en) * 1982-11-29 1984-03-06 Schering Corporation 5R,6S,8R-2-(1-Methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid

Also Published As

Publication number Publication date
GB2121792B (en) 1986-01-08
CH659072A5 (de) 1986-12-31
FR2526798A1 (fr) 1983-11-18
ES528491A0 (es) 1985-05-01
IT1164226B (it) 1987-04-08
GB8313399D0 (en) 1983-06-22
JPS58198486A (ja) 1983-11-18
ES522389A0 (es) 1984-08-16
DE3317742A1 (de) 1983-11-17
DE3317742C2 (fr) 1991-08-29
US4613595A (en) 1986-09-23
ES8504815A1 (es) 1985-05-01
GB2121792A (en) 1984-01-04
IT8321084A1 (it) 1984-11-13
JPH0318638B2 (fr) 1991-03-13
ES8407053A1 (es) 1984-08-16
IT8321084A0 (it) 1983-05-13

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Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse