FR2523844A1 - PEROXYDIPHOSPHATE-BASED TOOTHPASTE COMPOSITION AND METHOD OF APPLICATION - Google Patents

Abstract

THE INVENTION CONCERNS A TOOTHPASTE COMPOSITION CONTAINING A PEROXIDIPHOSPHATE AND OPTIONALLY AN ANTI-CARIES AGENT PROVIDING FLUORINE AS SUBSTANTIALLY THE ONLY ORAL AGENTS WITH CHEMICAL ACTION, IN COMBINATION WITH A POLISHING MATERIAL AND SPECIAL THICKNESSES.

Description

The present invention relates to composites

  stabilized toothpaste and, in particular, such compositions containing a peroxydiphosphate (PDP), preferably the tetrapotassium salt (KPDP), and possibly an anti-caries agent providing fluorine as almost the only chemically active agents

for the oral route.

  It is known in practice that hydrogen peroxide

  ne and other peroxygen agents are effective against

  caries, plaque, gingivitis, periodon-

  ticks, bad breath, and dental stains In fact, the essential active PDP used in this case has previously been described as an effective deodorant agent in an oral composition. Thus, U.S. Patent No. 4,041,149 describes the efficacy of such oral compositions, PDP being activated by

  saliva phosphates, generating hydrogen peroxide

  drogen and / or active or nascent oxygen which deodorizes

builds up the oral cavity.

  Other oral compositions have been prepared

  in which a PDP is used as an additive for inhi-

  ber the formation of spots that are produced normally

  by the chemically active essential oral agent of the compounds

  More particularly, US Patent No. 4,273,759 describes oral compositions containing PDP to inhibit the formation of spots

  normally produced by anti-plaque antibacterial agents

  cationic nitrogenous materials and United States Patent Application No. 117,410 filed January 31, 1980 in the name of Abdul Gaffar describes oral compositions containing PDP to inhibit the formation of spots normally produced by a gingivitis-fighting agent

of the tranexamic acid type.

  However, it is also known that most peroxides such as hydrogen peroxide and peroxides

  metals such as magnesium peroxide are insta-

  damage to storage, continuously losing their app-

  ability to release active or nascent oxygen over relatively short periods of time, particularly in the presence of various other mineral and organic materials

  incompatible, such as many of the exci-

  usual patients of oral compositions, in particular

  toothpaste compositions (including den-

  therefore in French Patent No. 2,325,304, this

  problem is posed and solved by a relatively different means

  difficult and expensive to prevent the peroxy compound

  dice such as magnesium peroxide to come into contact with an acidic material reacting with it, for example by coating this component and the acidic material with suitable excipients before and until the moment of use in

the oral cavity.

  PDPs are considered to be significantly more

  stable than hydrogen peroxide and ma- peroxide

  gnesium United States Patent No. 4,041,149

  above describes that a 10% aqueous solution of KPDP pre-

  féré does not show a loss of active oxygen after 4 months at 250 C and a loss of 3% after 6 months at 500 C We therefore concluded, and this is indicated in the patent, that "this

  stability allows a long shelf life

  oral positions containing said peroxydiphosphate ".

  However, the above conclusion has been found to be largely unjustified Extensive testing with oral compositions containing KPDP in combination with various common excipients, such as polishing material (dental abrasives), humectants,

  thickeners, flavorings, etc., have revealed

  previously unknown compatibilities resulting in

  storage stability or shelf life ex-

  ceaselessly short, premature loss of active oxygen, impairment of the desired functions of the various components of the compositions and / or of the chemical properties and / or

  unacceptable physical and / or cosmetic components

  tions, etc. The object of the present invention is to provide oral compositions which are not liable to pre-

  feel one or more of the above drawbacks and defects

  Another object of the present invention is to provide

  provide stable compositions containing a PDP and optionally

  an anti-caries compound providing fluorine as just about the only chemically active agents for the pathway

  Another object of the present invention is to provide

  define procedures to promote oral hygiene, use

  health of such compositions Other purposes and advantages

  will emerge from the description which follows.

  In some of its aspects, this

  invention provides a toothpaste composition comprising

  taking: I an oral vehicle, II as substantially the only chemically active agents for the oral route, A O at approximately 2% by weight of an anti-caries compound providing fluorine and

  B about 1 to about 7% by weight of a peroxydiphos-

phate.

  II I about 10 to about 75% by weight of at least one ma-

  polishing agent chosen from silica and hydrated alumina,

  IV about 0.5 to about 10% by weight of at least one thick-

  sissant chosen from colloidal silica, hectorite

  synthetic, poly (methyl ether / vinyl / anhy-

  maleic dride), a carboxyvinyl polymer, the carbon

  xymethylcellulose, hydroxypropyl-methyl-cellulose,

  hydroxybutyl-methyl-cellulose and hydroxyethyl-cellu-

  lose, and V about 5 to about 75% by weight of polyethylene glycol

as a humectant.

  The chemically active components IIA and IIB for the oral route defined above are for example and preferably mineral. These components which include mutually compatible components make it possible to obtain one or more unexpected improvements such as stability in storage. or surprisingly improved shelf life, acceptable chemical and / or physical and / or cosmetic properties, maintenance of the desired functions of the individual components, etc. As used herein, the term "chemically active agent for the oral route "means agents combating cavities, plaque, gingivitis, periodontitis, bad breath, and bleaching, etc., which act chemically on and with respect to teeth, oral tissue and / or the oral environment , unlike the

  polishing material (dental abrasives) which acts physically

  only on the teeth and inert components that deter-

  undermine the properties of the oral composition per se such as thickeners, humectants,

  flavorings, purfactants, sweeteners, colo-

  rants, bleaching agents, optical brightening agents, preservatives, and other conventional excipients The essential PDPs used in the present invention, in particular KPDP, fall into the category

  of each of the chemically active agents for the oral route

  The Above-mentioned Oral compositions of the present invention, for similar reasons, are devoid of the anti-bacterial anti-plaque compositions of United States Patent No. 4,273,759 mentioned above and gingivitis-fighting compositions of the United States patent application.

  U.S. Patent No. 117,410 mentioned above.

  Any of the alkali metal, alkaline earth metal, metallic or ammonium peroxydiphosphates or their corresponding acid salts which are water soluble in the proportion of about 0.001 can be used in the compositions of the present invention.

  percent by weight Examples are peroxydiphos-

  tetrapotassium phate (K 4 P 208), tetralithic peroxydiphosphate (Li 4 P 208), tetrasodium peroxydiphosphate

  that (Na 4 P 208), tripotas monosodium peroxydiphosphate-

  sic (K 3 Na P 208), disodium peroxydiphosphate dipotas-

  sic (K 2 Na 2 P 2082 H 20), trisodium peroxydiphosphate

  monopotassium (K Na 3 P 208), dihydrogen-peroxydiphospha-

  monosodium monopotassium (K Na H 2 P 208), peroxydi-

  trilithic monopotassium phosphate (Li 3 KP 208), pero-

  dilithic dipotassium xydiphosphate (Li 2 K 2 P 208), the per-

  monolithic tripotassium oxidiphosphate (Li K 3 P 208), trilithic monosodium peroxydiphosphate (Li 3 Na P 208), dilithic disodium peroxydiphosphate (Li 2 Na 2 P 208), monolithic trisodium peroxydiphosphate (Li Na 3 P 2 08), monolithic monosodium dihydrogen peroxydiphosphate

  (Li Na H 2 P 208), and the dihydrogen-peroxydiphosphate monopo-

  monolithic tassic (Li KH 2 P 208), in addition to peroxydi-

  di-zinc phosphate (Zn 2 P 208), tetra- peroxydiphosphate

  ammonium dihydrate ((NH 4) 4 P 2082 H 20), and acid salts

  Group II metals, such as dihydrogen peroxide

  barium phosphate (Ba H 2 P 208), dihydrogen-peroxydi-

  calcium phosphate (Ca H 2 P 208), etc. Tetrapotassium peroxydiphosphate (KPDP)

  preferred is a non-hygrosco- crystalline solid

  white spike, free flowing, finely divided, odorless and stable with a molecular weight of 346.35 and an active oxygen content of 4.5% Potassium peroxydiphosphate is water-soluble at 47-51% at 0-61 C, But

  insoluble in common solvents such as acetoni-

  trile, alcohols, ethers, ketones, dimethyl-

  formamide, dimethyl sulfoxide, etc. A 2% aqueous solution has a p H of about 9.6 and its saturated solution has a p H

about 10.9.

  The essential PDP (or a mixture thereof)

  is used in an effective amount to achieve ef-

  whitening, deodorant and therapeutic fet or

  be desired effect, constituting approximately 1 to approximately 7% by weight, preferably approximately 2 to approximately 5% by weight, better still approximately 3% by weight of the oral compositions

of the invention.

  Anti-cavity compounds providing fluorine

  possibly present in these oral preparations may

  may be slightly soluble in water or may be completely soluble in water They are characterized by their ability to release fluoride ions in water and by a significant absence of reaction with the other components of the oral preparation Among these materials mention may be made of mineral fluorides such as the soluble salts of alkali metals, alkaline earth metals and heavy metals, for example sodium fluoride, potassium fluoride, ammonium fluoride, calcium fluoride, a copper fluoride such as

  copper fluoride, zinc fluoride, fluoride

  tin such as stannic fluoride or stannous chlorofluoride, barium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium fluorozirconate, sodium monofluorophosphate, aluminum mono and di-fluorophosphate and pyrophosphate of sodium and fluorinated calcium The alkali metal and tin fluorides are preferred, for example sodium and stannous fluorides, sodium monofluorophosphate (MFP)

and their mixtures.

  The amount of fluorine-providing compound depends to some extent on the type of compound, its solubility, and the type of oral preparation, but this should

  be a non-toxic amount An amount of such a com-

  laid which releases a maximum of about 1% of the fluoride ion based on the weight of the preparation is considered satisfactory Any suitable minimum quantity of this compound can be used, but it is preferable to use a sufficient quantity to release about

  0.005 to 1%, and preferably about 0.1% of fluo- ion

  rure For example, in particular in the case of MFP, alkali metal fluorides and stannous fluoride, this

  component is present in an amount of about 0.01 to

  about 2% by weight, based on the weight of the preparation, and preferably in the range of about 0.05 to about

  1% by weight, in particular about 0.76% by weight.

  To obtain the desired results in this case, component III, which is a polishing material, must

  be chosen from silica, preferably hy-

  dratée (alpha-alumina trihydrate), both being by themselves conventional abrasive polishing materials for teeth having an average particle size of between about 0.1 and about 30 micrometers, of

  preferably between about 1.0 and about 15 microns.

  Examples of some preferred polishing materials

-20 are given below.

  The silica used as a polishing material can be in the form of crystalline silica having a particle size of up to 5 micrometers, an average particle diameter of up to about 1.1 micrometers and a specific surface of up to

  000 cm 2 / g, silica gels, si-based products

  Zeodent brand precipitated runner (e.g. Zeodent 49, 119) from J M Huber Corporation, aluminosilicates from

  complex amorphous alkali metals, etc. The types of abra-

  silica-based dental sifts described in the patent of

  United States of America No. 3,862,307 may be used.

  When using clear looking gels, a

  polishing agent of silica xerogel or silica col-

  loldale, like those sold under the SYLOID trademark (W R Grace and Co for example Syloid 63, 64, 72

  or 74) or under the trademark SANTOCEL, for example-

  ple Santocel 100 and alumino-silicate complexes of

  alkali metals are particularly useful because they pre-

  feel refractive indices close to those of the systems

  gelling agent-liquid temes (including water and / or

  humectant) commonly used in dentin

  frices. Hydrated alumina, in particular hydrated alumina sold by Alcoa under the designation C 333, which has an alumina content of 64.9% by weight, a silica content of 0.008%, a ferric oxide content of 0.003% , and a moisture content of 0.37%, at 110 C, and which has a density of 2.42 and a particle size such that all of the particles have a size of less than 50 micrometers and 84% of the particles have a

  dimension less than 20 micrometers, is particular-

  It has been found that hydrated alumina is the olus compatible polishing material in this case.

  The polishing material is generally pre-

  feels in proportions of between about 10 and about% by weight, preferably between about 35 and 65% by weight, better still between about 45 and about 55% by

  weight in these toothpaste compositions.

  Component IV which is a thickener, useful

  dried in proportions of about 0.5 to about 10, from pre-

  ference of about 1 to about 5% by weight of the compound

  tion, must be constituted by an element of the group above-

  mentioned or by a mixture of such elements A thickened-

  health that is preferred is synthetic hectorite, a

  complex colloidal synthetic clay of metallic silicate

  tal alkali and magnesium available for example under the

  designation La Donite (for example XLG, XLS, D), commercial-

  read by Laporte Industries Limited An analysis of Laponite D reveals approximately 58.00% by weight of Si O 2, 40% by weight of Mg O, 3.05% by weight of Na 20, 0.98% by weight of Li 20, and a little water and metals in the form of traces Its actual density is 2.53 and its density

  apparent (at 8% humidity) is 1.0 g / ml.

  Other thickeners include carboxy-

  methylcellulose, hydroxybutyl-methyl-cellulose, hydro-

  xypropyl-methyl-cellulose, and preferably hydroxyethyl-

  cellulose (for example available under the designation Tatrosol).

  The thickener poly (methyl ether and vi-

  nyle / maleic anhydride) is available for example under

  the designation Gantrez AN 139 (CAF Corporation) and the

  thickening formed by colloidal silica is

  "Syloid" more finely divided (for example 244).

  The carboxyvinyl polymer useful as a thick-

  sissant is for example available under the designation Carbopol (for example 934, 940, 941) These products of BF Goodrich Co, are described in the patents of the United States of America N 2 798 053, N 2 923 692 and N 2 980 655 as being carboxylic polymers

  essentially water-soluble acids forming a solution

  colloidal acrylic acid crosslinked with about 0.75 to about 2.02% of a crosslinking agent of the type

  polyallyl-sucrose or polyallyl-pentaerythritol.

  Component V which is the humectant used

  read in proportions of about 5 to 75, preferably between

  about 10 to 45, better still about 15 to 35% by weight

  toothpaste compositions of the present invention

  tion, is a polyethylene glycol (e.g. 400, 600).

  This relatively low molecular weight component (e.g. from about 300 to about 1000) also often serves as a liquid carrier vehicle, alone or in combination with

water and / or ethanol.

  Any flavoring optionally, but preferably

  rence, used in the toothpaste compositions containing PDP of the present invention should naturally

  also be compatible with PDP.

  The flavoring agent is, for example, incorporated into the oral compositions of the present invention in approximate proportions by weight of 0.01 to 3.0%,

  preferably 0.5 to 2.0%, more preferably 0.75 to 1.0%.

  Examples of compatible flavorings include pulegol, anethole, isoeugenol, guaiacol, creosol, thymol, menthol, cineol, eugenol, clove essence, peppermint extracts and of

  spearmint, carvone, methyl paracresol, euca-

lyptol, safrol, anisol, etc.

  The solid and liquid components of the compounds

  tions of the present invention are present in pro-

  classic portions to form a pasty mass, created

  meuse or gelled which can be delivered or extruded from a pressurized container or from a flexible or compressible container or tube, for example made of alumina,

  lead coated or plastic, etc. The compounds

  may be substantially anhydrous, but in general,

  they contain about 1 to about 25, for example between-

  about 5 to about 20% by weight of water These compositions preferably have a p H measured in the form of a suspension

  20% aqueous from 7.8 to about 10.5, preferably from

  approximately 8.5 to approximately 10.5, in particular approximately 9.5 to, 5, because the PDP, in particular the KPDP, seems to be more stable, that is to say exhibit better conservation of its activity in active oxygen, in these ranges more

  alkaline in the presence of the other components of the compounds

  The p H can be adjusted by incorporating the quan-

  necessary amounts of acidic substances such as citric acid or benzoic acid, basic substances such as sodium hydroxide, and / or buffering agents such as citrate, benzoate, bicarbonate or sodium carbonate , disodium hydrogen phosphate, sodium dihydrogen phosphate, or mixtures thereof It is

  note that the choice of abrasive or polishing material

  correct dental hygiene is important for maintaining the ranges of alkaline p H described above, since most conventional polishing materials cannot be used in the compositions of the invention at such

  ranges of p H For example, when using the metaphos-

  insoluble sodium phate (IMP) abrasive with the other components defined above of these compositions and that the

  p H is adjusted to 9.7, the composition loses significant amounts

  carrying its available oxygen when it is old

  binds to 490 C and the p H goes down to around 7.2 Au contrai-

  re, although the compositions of the present invention

  having silica as a polishing material

  try a poor stability at a p H "of composition as is" of 7.7, the composition is stabilized when the

  p H is adjusted to a higher value, as shown above

  above, for example to 9.7, and the p H does not drop significantly during aging The hydrated alumina constitutes an excellent means in this respect because its p H

  normal is in the ranges above.

  The toothpaste compositions of the pre-

  sente invention may contain an anionic surfactant

  or non-ionic organic sufficiently water-soluble, syn-

  cosmetic, of the non-soap type in general concentrations

  between about 0.05 and about 10, preferably between about 0.5 and about 5 percent by weight, in order to promote the wetting properties,

detergents and foaming.

  U.S. Patent No. 4,041,149

  describes such anionic surfactants suitable for colonization

  ne 4, lines 31-68 and in column 9, lines 1-12, these steps-

  wise men being cited by way of reference in the present brief, surfactants which are not

  ionic "Pluronic" type (block polymers of poly-

  oxyethylene-polyoxyprouylene) such as Pluronic F 108 and

F 127.

  Various other adjuvants or exci Dients classi-

  that for toothpastes can be incorporated, for example bleaching or coloring agents, preservatives, silicones, an ammoniated material such as urea and diammonium phosphate, and sweetening agents in proportions of between approximately 0, 01 and about 5% by weight or more Sweeteners

  suitable include for example Dle sorbitol, xyli-

  tol, sodium cyclamate, perillartin, D-tryp-

  tophane, dihydrochalcones, etc., preferably the sac-

charine.

  In the implementation of this invention

  tion, the toothpastes according to the invention are applied

  regularly in the oral cavity, in particular in the dental enamel, preferably approximately 1 to 3 times per

  day, for durations preferably at least 10 sec-

  approximately, better still at least about 60 seconds

  of, in the usual necessary quantities used

for brushing teeth.

  The following examples illustrate the invention without limiting it. All the quantities and proportions are

  expressed by weight unless otherwise specified.

  In the following example, the stability of KPDP can be estimated by monitoring the active oxygen (O A) contents by the following process: KPDP readily hydrolyzes in an aqueous medium as follows:

  P 208 4 + 2 H 20 + 2 HP 04 2 + H 202

  An excess of ammonium sulphate iron is added.

  to reduce the peroxide: 2 Fe (NH 4) 2 (SO 4) 2 + H 202 + H 2 SO 4, Fe 2 (504) 3 + 2 (NH 4) 2 SO 4 + 2 H 2 Excess d ferrous ion is titrated back with ceric sulfate: 2 Fe (NH 4) 2 (SO 4) 2 + 2 Ce (SO 4) 2 Ce 2 (504) 3 + Fe 2 (504) 3 + 2 (NH 4 ) 25 04

The O A is calculated by difference.

TABLE I

* Water, distilled Laponite XLG

PEG 600

Pluronic F 108 Example (% by weight)

1 2 3

19.69 17.0 18.0

2.4 2.4 2.5

8.7 8.0 7.0

4.3 4.0 4.5

  AI Sodium benzoate Saccharin sodium salt 0.54 0.22 0.5 0.2 0.54 0.22

0.55 0.5

  l Flavoring Water, distilled KPDP Alumina hydrated 7.6 3.0 7.0 3.0 0.55 7.6 6 3.0

53.0 50.0 53.0

  Theoretical Initial at room temperature After aging for 7 weeks at 38 C Active oxygen

0.126 0.126 0.126

0.123 0.130 0.122

0.123 0.131 0.130

TABLE II

  Laponite XLG Laponite XLS Natrosol 250 MR * KPDP Sodium benzoate Sodium salt of saccharin

PEG 600

  Alumina hydrated SLS Aroma Water (p H) -Initial at room temperature After 3 weeks aging

at 49 C

After 6 weeks of aging

at 49 C

After 9 weeks of aging

at 49 C

a Hydroxyethylcellulose

Example (%

  2.0 by weight), 8 0.5 3.0 0.5 0, 2, 0 49.0 1.5 0.5 32.8

(10.0)

  Oxygen 0.124 3.0 0.2.0 37.0 1.5 0.5 37.0

(9.6)

active 0.127

0.130 0.127

0.120 0.112

0.116 0.119

TABLE III

Syloid 244 Zeo 49 (Huber silica)

PEG 600

  KPDP Saccharin sodium salt Sodium benzoate Ti O 2 SLS water Flavor (p H adjusted with 50% Na OH) Initial at room temperature After 3 weeks aging

at 49 C

After 6 weeks of aging

at 49 C

After 9 weeks of aging

at 49 C

Example (%

  7.15 19.36, 6 3.0 0.2 0.5 0.55 17.14 1.0 0.5

(9.7)

  Oxygen 0.125 0.118 0.110 0.108 by weight) 7.3 19.8 51.7 3.4 0.22 0.56 0.56 14.8 1.66

(9.2)

l active 0.148 0.126 0.128 0.132

TABLE IV

Hydroxyethylcellulose

PEG 600

  Sodium benzoate Saccharin sodium salt Hydrated alumina KPDP H 20 SLS aroma Non-ionic surfactant (p H) Example (% by weight)

8 9 10

1.0 1.0 1.0

.0 20.0 20.0

0.5 0.5 0.5

0.2 0.2 0.2

47.0 47.0 48.0

3.0 3.0 3.0

26.05 26.05 25.6

0.75 0.75 0.5

1.5 1.5 -

1.2

(10) (10)

  Active oxygen Initial at room temperature 0.136 0.131 0.130 After 6 weeks aging

at 49 C 0.134 0.133

After 9 weeks of aging

at 49 C 0.130

  Sodium lauryl sulfate * Polvethoxylated sorbitan monoisostearate (20 O E)

  The formulations of the above examples pre-

  feel a stability of the active oxygen during the emma-

  good to excellent gasing On the other hand, the only

  lation of toothpaste described in US Pat. No. 4,041,149, namely Example 1,

  containing incompatible components (glycerin, carbo-

  precipitated calcium nate and dihy- dicalcium phosphate

  draté) has an unacceptable oxygen stability

  active Some of the examples above show the se-

  quence of addition of individual underlined components

or grouped.

  Exudes 11% by weight Natrosol 250 MR 1.0

PEG 600 20.0

Hydrated alumina 52.0

SLS 1.5

  Sodium benzoate 0.5 Saccharin sodium salt 0.2

KPDP 3.0

Deionized water 25.8 (p H at 10.2)

  The above formulation according to the present in-

  vention, stable from the chemical, physical and cos-

  metic, and a control formulation not containing KPDP are evaluated to determine their effectiveness in reducing

  gingivitis and plaque in a 12-week trial

  nes conducted scientifically on groups of 10 beagle dogs (5 males and 5 females) The results (average of dogs) are as follows: Control Example 11 Gingival index Initial 0.85 0.88 Final 0.79 0.47 Plaque index 1 , 22 0.96 These results reveal that the addition of KPDP to the control formulation considerably reduces both the gingival index and the plaque index.

  simultaneous test using a nonaqueous formulation

  containing propylene glycol as a humectant, hy-

  droxypropylcellulose as thickener and Dical as abrasive increases the plaque index and a similar test using a neutral aqueous formulation containing PEG 600 as a humectant, hydroxyethylcellulose as

  thickener and IMP as an abrasive increases both the

  gingival dice and plaque index.

  It has been shown above that the formulations according to the invention containing polyethylene glycol (PEG) as humectant are very stable with regard to the loss of available oxygen The critical nature of the combinations of the components necessary in these formulations, and the mutual effect of the stabilization of these formulations, are, for example, demonstrated by the

  PEG acts on the effectiveness of KPDP and reduces con-

  dramatically the effectiveness of KPDP as a source of oxygen

  available in the absence of other defined components.

  Thus, aqueous solutions of KPDP buffered at p H 7 are stable at 49 ° C. for 9 weeks, but the addition of variable amounts (3%, 15%, 40%) of PEG to solutions at 3% of KPDP (carried out three times) gives, after aging for 9 weeks at 38 ° C. and 49 ° C., the following average results: 3% of PEG% of PEG% of PEG% of available oxygen

Initial 1 se 3 se 6 se 9 se 6 se-

maine maines maines maines

  at 49 C at 49 C at 49 C at 49 C at 38 C

0.126 0.107 0.050 0.041 O 0.086

0.115 0.113 0.066 0.053 0.023 0.088

0.120 0.116 0.091 0.084 0.029 0.091

Average loss (%)

6.7 42.4 50.4 85.2 26.5

9 weeks

at 38 C

0.061 0.066 0.072 44.9

Claims (8)

  1 Composition of toothpaste, characteristic   sée in that it comprises: I an oral vehicle II as substantially the only oral agents with chemically active, A O at approximately 2% by weight of an anti-caries compound providing fluorine and   B about 1 to about 7% by weight of a peroxydiphos- phate,   II I about 10 to about 75% by weight of at least one ma-   polishing agent chosen from silica and hydrated alumina,   IV about 0.5 to about 10% by weight of at least one thick-   sissant selected from colloidal silica, synthetic hectorite, poly (methyl vinyl ether / maleic anhydride), a carboxyvinyl polymer,   carboxymethyl cellulose, hydroxypropyl methyl cell   lose, hydroxybutyl-methyl-cellulose and hydroxy- ethyl cellulose, and   V about 5 to about 75% by weight of a polyethylene- glycol as a humectant.   2 Composition according to claim 1, charac-   terized in that the polishing material comprises hydrated alumina.   3 Composition according to claim 2, charac-   terized in that the thickener comprises synthetic hectorite.   4 Composition according to claim 2, charac-   terized in that the thickener comprises hydroxyethyl-   cellulose. Composition according to Claim 1, characterized in that the polishing material comprises silica.   6 Composition according to any of the   vendications 1 to 5, characterized in that the peroxydi-   phosphate is tetrapotassium peroxydiphosphate.   7 Composition according to claim 6, charac-   terized in that it has a p H of 7.8 to 10.5 approximately.   8 A method characterized in that it consists in applying to the oral cavity a composition according to one   any of claims 1 to 5.   9 A method characterized in that it consists in applying to the oral cavity a composition according to the claim 6.   Process characterized in that it consists in applying to the oral cavity a composition according to the claim 7.