KR20150087845A

KR20150087845A - Oral care whitening compositions

Info

Publication number: KR20150087845A
Application number: KR1020157014436A
Authority: KR
Inventors: 샹 첸; 토마스 제이. 보이드
Original assignee: 콜게이트-파아므올리브캄파니
Priority date: 2012-11-27
Filing date: 2012-11-27
Publication date: 2015-07-30

Abstract

A whitening agent represented by the formula R ¹ -OOR ² ; And an aliphatic ketone wherein R ¹ and R ² are independently selected from hydrogen, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ carbonyl, SO ₃ and phenyl Composition; And methods of making and using the same are described.

Description

[0001] ORAL CARE WHITENING COMPOSITIONS [0002]

Dentifrice formulations containing a variety of tooth whitening agents are known to be useful for tooth cleaning and whitening. A known tooth whitening agent is hydrogen peroxide. Hydrogen peroxide can bleach teeth, remove stains, and kill dental caries bacteria. To deliver good whitening efficacy over the acceptable use time, the dentifrice composition is formulated with a high peroxide content, usually at least 1 wt% of the composition. However, peroxide compounds are highly reactive, and in many countries there are strict regulations limiting the concentration of hydrogen peroxide.

Thus, there is a need for an improved single-part oral whitening composition, such as a dentifrice composition, which contains other whitening agents besides hydrogen peroxide and which can deliver enhanced whitening performance compared to known compositions.

The present invention is intended, at least in part, to meet at least one of these needs.

According to some embodiments, the present invention relates to a whitening agent represented by the formula R ¹ -OOR ² ; And an aliphatic ketone wherein R ¹ and R ² are independently selected from the group consisting of hydrogen, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ carbonyl, SO ₃ , Phenyl and naphthyl.

In some aspects, the invention provides an oral care composition comprising peroxodisulfate whitening agent and an aliphatic ketone.

Optionally, the peroxodisulfate whitening agent is in the acid or salt form thereof.

Optionally, the whitening agent is selected from the group consisting of peroxodi < RTI ID = 0.0 > di < / RTI > selected from at least one of sodium peroxodisulfate, potassium peroxodisulfate, ammonium peroxodisulfate, lithium peroxodisulfate, calcium peroxodisulfate and magnesium peroxodisulfate Sulfate salts, or mixtures of any two or more of these peroxodisulfate salts.

Optionally, the whitening agent comprises sodium peroxodisulfate.

Optionally, the composition is an aqueous composition and the peroxodisulfate whitening agent is present in an amount of 0.01M to 0.05M, based on the weight of the composition.

Optionally, the composition is an aqueous composition and the peroxodisulfate whitening agent is present in an amount of from 0.1 to 10 wt%, generally from 0.7 to 3.5 wt%, or from 0.24 to 1.2 wt%, based on the weight of the composition, do.

Optionally, the composition is a substantially anhydrous composition containing less than 5 wt% water and the peroxodisulfate whitening agent is present in an amount of 0.1 to 45 wt%, more preferably 0.7 to 20 wt%, more preferably 3.5 To 10 wt%, generally from 5 to 8 wt% or from 0.24 to 1.2 wt%, based on the weight of the composition.

Optionally, the aliphatic ketone is a ketone represented by the formula R.CO.R 'wherein R is a C ₁ to C ₄ alkyl group, R' is a C ₁ to C ₄ alkyl group, and R and R 'are the same Or may be different.

Optionally, R is a methyl group and R 'is a C ₂ to C ₄ alkyl group.

Optionally, R 'is an ethyl group.

Optionally, the composition is an aqueous composition and the aliphatic ketone is present in an amount from 0.01M to 0.05M, based on the weight of the composition.

Optionally, the composition is an aqueous composition, wherein the aliphatic ketone is present in an amount of from 0.02 to 1.5 wt%, generally from 0.05 to 0.8 wt%, based on the weight of the composition.

Optionally, the composition is a substantially anhydrous composition containing less than 5 wt% water, wherein the aliphatic ketone is present in an amount of from 0.03 to 6 wt%, generally from 1.3 to 4.7 wt%, or from 0.06 to 4.7 wt% 0.7 wt%.

Optionally, the peroxodisulphate whitening agent and the aliphatic ketone are added to the composition in a molar ratio of from 0.5: 1 to 1: 0.5, optionally in a molar ratio of from 0.75: 1 to 1: 0.75, 1. &Lt; / RTI >

In some cases, the composition is in the form of a dentifrice, a cream toothpaste, a mouthwash, a strip, or a solid or liquid gel.

The present invention also provides a tooth whitening method comprising applying the composition of the present invention to the surface of a mammalian tooth.

According to a preferred embodiment of the present invention, the oral hygiene composition is stable during long-term storage and remains effective for tooth cleaning and whitening, and the oral hygiene composition has acceptable whitening agents under the regulations in force in many countries around the world.

Further aspects of the present invention will become apparent from the detailed description and the embodiments.

As used throughout this specification, a range is an abbreviation for representing each and every value within this range. Any value within this range can be selected as the end value of the range.

Some embodiments of the present invention include a whitening agent represented by the formula R ¹ -OOR ² ; And an aliphatic ketone, wherein R < ¹ ^> And R ² are independently selected from hydrogen, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ carbonyl, SO ₃ , phenyl and naphthyl. In some aspects, R ¹ and R ² are SO ₃ .

In some aspects, the invention provides an oral care composition comprising a peroxodisulfate whitening agent and an aliphatic ketone.

In some embodiments, the peroxodisulfate whitening agent is in the acid or salt form thereof. Generally, the whitening agent is selected from the group consisting of peroxodisulfate selected from at least one of sodium peroxodisulfate, potassium peroxodisulfate, ammonium peroxodisulfate, lithium peroxodisulfate, calcium peroxodisulfate and magnesium peroxodisulfate, Or a mixture of any two or more of these peroxodisulfate salts. In one particularly preferred composition, the whitening agent comprises sodium peroxodisulfate.

In some embodiments, the composition is an aqueous composition and the peroxodisulfate whitening agent is present in an amount of 0.01M to 0.05M, based on the weight of the composition, and / or in an amount of 0.1 to 10 wt%, based on the weight of the composition . Generally, the composition is an aqueous composition and the peroxodisulfate whitening agent is present in an amount of 0.24 to 3.5 wt%, alternatively 0.7 to 3.5 wt% or 0.24 to 1.2 wt%, based on the weight of the composition.

In some alternative embodiments, the composition is a substantially anhydrous composition containing less than 5 wt% water, wherein the peroxodisulfate whitening agent is present in an amount of from 0.1 to 45 wt%, or from 0.24 to 1.2 wt%, more preferably, 0.7 to 20 wt%, more preferably 3.5 to 10 wt%, generally in an amount of 5 to 8 wt% based on the weight of the composition.

The present invention is based on the discovery by the present inventors that the whitening efficacy of peroxodisulfate whitening agents can be unexpectedly improved, at least by combining aliphatic ketones with peroxodisulfate whitening agents.

In some embodiments, the aliphatic ketone is a ketone represented by the formula R.CO.R 'wherein R is a C ₁ to C ₄ alkyl group, R' is a C ₁ to C ₄ alkyl group, and R and R ' May be the same or different. Generally, R is a methyl group, R 'is a C ₂ to C ₄ alkyl group, such as an ethyl group, and the ketone is methyl ethyl ketone.

In some embodiments, the composition is an aqueous composition and the aliphatic ketone is present in an amount of 0.01M to 0.05M, based on the weight of the composition, and / or in an amount of 0.02 to 1.5 wt%, based on the weight of the composition. Generally, the composition is an aqueous composition and the aliphatic ketone is present in an amount of 0.05 to 0.8 wt%, based on the weight of the composition.

In some alternative embodiments, the composition is a substantially anhydrous composition containing less than 5 wt% water, wherein the aliphatic ketone is present in an amount of from 0.03 to 6 wt%, generally from 1.3 to 4.7 wt%, based on the weight of the composition, Or 0.06 to 0.7 wt%.

In some embodiments, the composition is an aqueous composition or a substantially anhydrous composition wherein the peroxodisulfate whitening agent and the aliphatic ketone are present in the composition in a molar ratio of from 0.5: 1 to 1: 0.5, in other cases from 0.75: 1 to 1: 0.75, and in some cases about 1: 1.

In some embodiments, the composition is in the form of a dentifrice, a cream toothpaste, a mouthwash, a strip, or a solid or liquid gel. In some aspects, the cream toothpaste may contain an abrasive, such as a calcium abrasive. In other aspects, the cream toothpaste may contain a non-abrasive gel.

The compositions of the present invention may optionally contain additional orally acceptable thickening agents, including, but not limited to, polyvinylpyrrolidone, which may be silica, linear or crosslinkable, carbomers, also known as carboxyvinyl polymers, Carrageenan, also known as i-carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (e.g. CARBOWAX®, available from The Dow Chemical Company), also known as Irish moss, cellulosic polymers such as hydroxyethylcellulose, (CMC) and its salts such as CMC sodium, natural gums such as karaya, xanthan gum arabic and tragacanth, and colloidal magnesium aluminum silicate and mixtures thereof. have. Optionally, such additional thickeners are present in a total amount of from about 0.1 wt% to about 50 wt%, such as from about 0.1 wt% to about 35 wt%, or from about 1 wt% to about 15 wt%, based on the weight of the composition.

In some aspects, the composition further comprises a polymer thickener selected from (i) polyethylene glycol, (ii) a polyethylene glycol-polypropylene glycol block copolymer having a molecular weight of at least 5000, and (iii) a combination thereof.

In some embodiments, the composition contains an ethylene oxide, propylene oxide block copolymer, represented by the formula (ethylene oxide) _x- (propylene oxide) _y with an average molecular weight greater than 5000, such as 8000 to 13000 Da, Where x is an integer from 80 to 150, such as from 100 to 130, such as about 118, and y is an integer from 30 to 80, such as from about 60 to 70,

In some embodiments, the composition contains an ethylene oxide, propylene oxide block copolymer having an average molecular weight of greater than 5000 Da, substantially free of ethylene oxide, propylene oxide block copolymer, having an average molecular weight of less than 5000 Da. Optionally, the ethylene oxide, propylene oxide block copolymer is present in an amount of from 5 wt% to 10 wt%, based on the weight of the composition. Ethylene oxide / propylene oxide block copolymers are useful, but preferably have a high molecular weight, e.g.> 5000 Da, such as PLURACARE L1220 (available from BASF, Michigan, USA).

In some embodiments, the composition further comprises a polyethylene glycol having an average molecular weight of 400 to 800 Da, such as about 600 Da. Low molecular weight or medium molecular weight polyethylene glycols such as PEG 400, PEG 600, PEG 800, PEG 1000 and mixtures thereof are useful in compositions of some embodiments of the present invention.

In addition, polyethylene glycol may optionally be present in an amount of from 5 wt% to 15 wt%, based on the weight of the composition.

Some embodiments further comprise an abrasive. Another embodiment provides an oral care composition comprising about 5 to about 15 wt% of an abrasive, based on the weight of the composition.

When abrasive is present, the average particle size is generally from about 0.1 to about 30 microns, such as from about 1 to about 20 microns, or from about 5 to about 15 microns.

The abrasive may contain a calcium abrasive, such as a calcium phosphate salt, such as calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, and / or calcium polymetaphosphate. In a general aspect, the calcium abrasive contains calcium pyrophosphate. According to another aspect, the calcium abrasive contains calcium carbonate.

Optionally, the composition is a cream toothpaste containing a calcium pyrophosphate abrasive. Also optionally, the calcium pyrophosphate is present in an amount of from 10 wt% to 20 wt%, based on the weight of the composition.

The compositions of the present invention may also contain a variety of toothpaste ingredients that modulate the rheology and feel of the composition, such as wetting agents, surface active agents, or gelling agents.

In some embodiments, the oral care composition contains a vehicle for the active ingredient. The mediator may contain a humectant, such as a wetting agent selected from glycerin, propylene glycol or combinations thereof.

In some embodiments, the oral care composition contains about 20 to about 60 wt% wetting agent, based on the weight of the composition.

In some embodiments, the composition further comprises propylene glycol in an amount of 10 wt% to 20 wt%, based on the weight of the composition.

In some embodiments, the composition further contains glycerin in an amount of 25 wt% to 40 wt%, based on the weight of the composition.

A typical composition of the present invention can be a substantially anhydrous composition and has a "low moisture" content, which means that the total concentration of any water contained in any free water and any ingredients is less than about 5 wt% , Preferably less than 3 wt%, preferably less than 2 wt%.

Optionally, the composition contains less than 3 wt% water based on the weight of the composition. In some embodiments, the oral care composition contains less than 2 wt% water, such as less than 1 wt% water. In some embodiments, the composition is a substantially anhydrous composition.

Preferably, the medicament component provides a toothpaste having a viscosity of from about 10,000 CPS to about 700,000 CPS, preferably from about 30,000 CPS to about 300,000 CPS.

As will be appreciated by those skilled in the art, the oral compositions of the present invention may optionally contain other materials such as dental caries inhibitors, desensitizing agents, viscosity modifiers, diluents, surface active agents such as surfactants, emulsifiers and foam modulators ), pH adjusting agents, abrasives other than those mentioned above, wetting agents, mouth-feel agents, sweeteners, flavors, coloring agents, preservatives and combinations thereof. The materials of the above category may have different common properties, but may have some common properties, and any material presented may serve multiple purposes within two or more of the above categories of materials. Preferably, the carrier is selected according to compatibility with other components of the composition.

Flavoring agents, sweeteners, coloring agents, foam control agents, oral toughening agents, and the like may be further included in the composition if desired.

The composition of the present invention may contain a surface active agent (surfactant). A suitable surfactant include, but are not limited to, C ₈ _-20-soluble salts of alkyl sulfates, C ₈ during installation the monoglycerides, sulfonated sarcoidosis _-20 fatty acid sulfonates, taurates, sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate Sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate and sodium dodecylbenzene sulfonate, and cocoamidopropyl betaine. In some embodiments, the composition may additionally contain a surfactant, such as sodium laurylsulfate (SLS).

The compositions of the present invention may optionally contain one or more additional ingredients that may act to prevent or treat the condition or disorder of the hard or soft tissue of the mouth, to prevent or treat a physiological disorder or condition, or to provide a cosmetic benefit Contains the active substance (s).

In various aspects of the invention, the oral composition contains an anti-tartar (anti-tartar) agent. In general, the dental calculus inhibitor is classified as incompatible with some whitening agents, although aspects of the present invention incorporate the dental calculus inhibitor and whitening agent into a single daily whitening composition.

Suitable anticalculus agents include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphate), polyaminopropane sulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, Lt; / RTI > Generally, anticalculus agents are present from about 0.1 wt% to about 30 wt%, based on the weight of the composition.

The oral composition may comprise a mixture of various anti-calculus agents.

In some embodiments, the composition further comprises a tartar inhibitor, for example, selected from tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP).

According to one preferred embodiment, tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used. The anticalculus agent contains about 1-2 wt% TSPP and about 7 wt% to about 10 wt% STPP, respectively, based on the weight of the composition.

The oral care composition may optionally contain fluoride ions of at least one oral tolerable source. Anything known or being developed in the art can be used. Suitable sources of fluoride ions include fluorides, monofluorophosphates and fluorosilicate salts. The at least one fluoride ion-releasing compound is optionally present in an amount to provide a total of from about 100 to about 20,000 ppm, from about 200 to about 5,000 ppm, or from about 500 to about 2,500 ppm of fluoride ions, respectively, based on the weight of the composition .

The composition may comprise a stannous ion or a primary tin ion source. Suitable tin ion sources include, but are not limited to, tin fluoride, other tin halides such as tin chloride monohydrate, tin pyrophosphate, organic tin carboxylate salts such as ferric stannate, Tin gluconate, ferric tin lactate, ferric tin tartrate, ferric oxalate, ferric malonic acid tin and ferric citrate, ferric tin ethylene glycol oxide and the like. The one or more primary tin ion sources are optionally present in an amount of from about 0.01% to about 10 wt%, such as from about 0.1 wt% to about 7 wt%, or from about 1 wt% to about 5 wt%, respectively, do.

In some embodiments, the compositions of the present invention optionally contain an antimicrobial (e.g., an antimicrobial) agent, such as triclosan. A further exemplary list of useful antimicrobial agents is provided, for example, as described in U.S. Patent 5,776,435 (Gaffar et al., The disclosure of which is incorporated herein by reference). The one or more antimicrobial agents are each optionally present in an amount of from about 0.05 wt% to about 10 wt%, such as from about 0.1 wt% to about 3 wt%, based on the weight of the composition, of the antimicrobial effective total amount.

In some embodiments, the compositions of the present invention optionally contain an antioxidant. Any oral tolerated antioxidant may be used, examples of which include butyric hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbates Acids, herb antioxidants, chlorophyll, melatonin and mixtures thereof.

The composition of the present invention may optionally contain a saliva secretagogue or a saliva-stimulating agent, an anti-plaque agent, an anti-inflammatory agent, and / or a sensitizer.

The ingredients are sometimes referred to herein as categories, such as wetting agents, antioxidants, thickeners, etc., but these are for convenience and clarity, and are not intended to be limiting. All ingredients contained in the composition may perform additional functions on their primary function and contribute to the overall properties of the composition, such as stability, efficacy, consistency, mouth feel, taste, smell, and the like.

In some embodiments, the composition contains the following ingredients, each based on the weight of the composition:

Peroxodisulfate salt 0.2 to 10%, optionally 1.5 to 3.5%

Aliphatic ketone 0.03 to 6%, and optionally 0.06 to 0.4%

Polyvinylpyrrolidone 5 to 15%

glycerin 25 to 35%

Propylene glycol 12 to 18%

Ethylene oxide, propylene

Oxide block copolymer, average MW > 5 kDa 5 to 10%

Polyethylene glycol 600 5 to 15%

Calcium pyrophosphate 10 to 20%

The composition may optionally contain, in addition to the peroxodisulfate whitening agent, generally in an amount of 0.2 to 1.5 wt% or 3.5 to 10 wt%, and the aliphatic ketone whitening enhancer, generally in the amount of 0.06 to 0.4 wt% or 0.03 to 6 wt% Or all of the component classes and / or the components of the ingredients, based on the weight of the composition, on a weight basis:

35 to 60% wetting agent such as

glycerin 25 to 40%, such as about 25 to 35%

Propylene glycol 10 to 20%, such as about 12 to 18%

Thickening agents such as

Polyvinylpyrrolidone 5 to 15%, such as about 8 to 12%

From 10 to 25% polymer,

Ethylene oxide, propylene oxide

Block copolymer, average MW > 5 kDa 5 to 10%, such as about 7 to 8%

Polyethylene glycol 600 5% to 15%, such as about 10%

Abrasive, 5-25%, e.g.

Calcium pyrophosphate 10% to 20%, such as about 15%

Fluoride, 0 to 1%, e.g.

Sodium monofluorophosphate 0.5 to 1%, such as about 0.76%

Surfactants such as SLS 0 to 3%

Tartar inhibitors, such as TSPP 0.5 to 5%, such as about 2%

Antioxidants, 0.01 to 5%, such as

BHT 0.03%

Flavor 0.1 to 5%

water <3%

Peroxodisulfate whitening agents and aliphatic ketones may be used in whitening strips prepared to be activated by water or saliva when placed against teeth in the mouth. The strip may be a two-layer strip or a monolayer soluble strip comprising a final backing layer to prevent loss of active ingredients and a front adhesive layer made of a peroxodisulphate whitening agent and an aliphatic ketone. Alternatively, the peroxodisulfate whitening agent and the aliphatic ketone may be located on the surface of the monolayer or bilayer strip.

The monolayer strips comprise 10 to 15 wt% of high molecular weight homopolymers and / or copolymers of acrylic acid crosslinked by polyalkenyl polyethers (e.g., those readily available as Carbopol polymers), polyvinyl alcohol (PVA, available as Kollicoat , 5 to 10 wt% of hydroxypropyl methylcellulose, 5 to 15 wt% of propylene glycol, 5 to 10 wt% of Tween 80, 0.5 to 15 wt% of sodium peroxodisulfate and 0.1 to 5 wt% of methyl ethyl ketone can do.

The two-layered strip is applied to the adhesive layer in an amount of 10 to 15 wt% Carbopol polymer, 50 to 60 wt% polyvinyl alcohol (PVA, available as Kollicoat), 5 to 10 wt% hydroxypropyl methylcellulose, 5 to 15 wt% propylene glycol, 10 wt% non-ionic surfactants and polyethoxylated sorbitan and oleic acid-derived emulsifiers (e.g. Polysorbate 80, available as Tween 80), 0.5-15 wt% sodium peroxodisulfate and 0.1-5 wt% methyl ethyl ketone And the backside layer may contain 80 to 90 wt% polyvinyl alcohol (PVA, available as Kollicoat), 5 to 15 wt% propylene glycol, and 5 to 10 wt% Tween 80.

There is provided a method of whitening the oral surface of a human or animal specimen, including storing the composition of the present invention in a stable form and contacting the composition with the oral surface. As used herein, an "animal sample" includes higher mammals other than humans, such as dogs, cats and horses. The oral care composition is in contact with the oral surface of the mammalian sample to whiten the teeth in a highly effective manner without any adverse interaction between the whitening agent, the peroxide non-fusing abrasive, and other ingredients.

In various embodiments, the oral care composition is preferably applied to and contacted with the oral surface. The toothpaste produced in accordance with certain aspects of the present invention is preferably applied to the oral surface regularly, preferably on a daily basis, more than once a day for a few days, but alternatively every two or three days It is possible. Preferably, the oral composition is applied to the oral surface for at least 2 weeks up to 8 weeks, 4 months to 3 years, or especially 1 to 3 times a day for a maximum life.

The following examples further illustrate and demonstrate exemplary embodiments within the scope of the present invention. The embodiments are for illustrative purposes only and various modifications are possible without departing from the spirit and scope of the invention, and are not to be construed as limiting the invention. Various modifications of the invention in addition to those shown and described herein will be readily apparent to those skilled in the art and are intended to be within the scope of the following claims.

Example

Example One

An in vitro test model is used to study the whitening performance exhibited by the combination of sodium peroxodisulfate and methyl ethyl ketone. 0.05M sodium peroxodisulfate and 0.05M methyl ethyl ketone solution were prepared in deionized (DI) water.

An artificially colored small tooth is prepared so that the starting L value is between about 62 and 68 (L is an index of tooth whiteness), and the reference L, a and b values of tooth whiteness are specially designed to measure tooth color, Lt; RTI ID = 0.0 > SpectroShade < / RTI > spectrophotometer. This measures the initial tooth whiteness before the whitening treatment using the sodium peroxodisulfate / methyl ethyl ketone solution according to some embodiments of the present invention.

The small teeth are then immersed in a sodium peroxodisulfate / methyl ethyl ketone solution for 30 minutes.

The teeth are then removed from the solution and the whiteness is measured again by measuring the L ^* , a ^* , and b ^* values with a SpectroShade ™ spectrophotometer.

△ increased mibaekdo shown as E is calculated from △ L, △ a and △ b as shown L ^*, a ^*, and change in the b ^* value, and so ^{△ E = (△ L 2 +} △ a 2 + △ b 2) . The higher the value of ΔE, the higher the whiteness is.

As shown in Table 1 illustrating the value of DELTA E in Example 1, DELTA E was observed to be 2.82. This represents high whiteness.

Comparative Example 1, 2, and 3

Using the same in vitro test model as in Example 1, the whitening performance of the following solutions was studied: 0.05 M sodium peroxodisulfate solution in Comparative Example 1, 0.05 M methyl ethyl ketone deion (DI) in Comparative Example 2, Aqueous solution and a 0.05 M aqueous solution of hydrogen peroxide (DI) in Comparative Example 3.

The corresponding value of? E was calculated in each of Comparative Examples 1 to 3. Also, as shown in Fig. 1 illustrating ΔE values of Comparative Examples 1 to 3, it was found that Comparative Example 1 ΔE was 1.21, Comparative Example 2 ΔE was 0.74, and Comparative Example 3 ΔE was 1.67 .

Comparison of the results of Example 1 and Comparative Examples 1 and 2 suggests that the combination of sodium peroxodisulphate and methyl ethyl ketone unexpectedly provided a significant and synergistic increase in whitening when expressed as ΔE relative to each component do. The whitening effect of the aliphatic ketone when used alone was not good, but the aliphatic ketone significantly improved the whitening effect of the peroxodisulfate whitening agent.

In addition, the results of Example 1 and Comparative Example 3 show that the combination of sodium peroxodisulfate and methyl ethyl ketone unexpectedly provided a significant whitening increase when compared to an equivalent amount of hydrogen peroxide as a whitening agent.

Example 2 and Comparative Example 4

The substantially anhydrous toothpaste was prepared according to Example 2. This composition contains the following components in the amount of wt% specified in Table 1 below.

Since the toothpaste of Example 2 is substantially anhydrous, a higher concentration of peroxodisulfate whitening agent can be used without the problem of excessive premature decomposition.

Example 3

Again, the in vitro test model was used to study the whitening performance by the combination of different molar concentrations of sodium peroxodisulphate and methyl ethyl ketone.

Composition (a) contained a solution of 0.01 M sodium peroxodisulfate and 0.01 M methyl ethyl ketone in deionized (DI) water.

Composition (b) contained a solution of 0.01 M sodium peroxodisulfate and 0.05 M methyl ethyl ketone in deionized (DI) water.

Composition (c) contained a solution of 0.05 M sodium peroxodisulfate and 0.01 M methyl ethyl ketone in deionized (DI) water.

Composition (d) contained a solution of 0.05M sodium peroxodisulfate and 0.05M methyl ethyl ketone in deionized (DI) water.

Artificially colored small teeth are prepared so that the starting L value is between about 62 and 68 (L is an index of tooth whiteness), and the baseline L, a and b values of tooth whiteness were measured using a SpectroShade ™ spectrophotometer. Thus, the initial tooth whitening degree is measured before the whitening treatment using the sodium peroxodisulfate / methyl ethyl ketone solution according to the present invention.

The small teeth are then immersed in each of the four sodium peroxodisulfate / methyl ethyl ketone solutions (a), (b), (c) and (d) for 30 minutes.

Next, the teeth are taken out from each solution, and the whiteness is measured again by measuring the L, a, and b values with a SpectroShade ™ spectrophotometer.

The increase in whiteness shown as? W is calculated from the change in L, a and b values shown as? L,? A and? B, and the expression of the initial and final whiteness W values

Respectively. The more negative the ΔW value, the greater the whitening effect.

Table 2 shows the values of DELTA W of each of the compositions (a), (b), (c) and (d).

In the case of compositions (a) and (d), when sodium peroxodisulfate and methyl ethyl ketone are both at the same molar concentration (0.01 M in composition (a) or 0.05 M in composition (d) It can be observed that the increase of the whiteness is large. This suggests that methyl ethyl ketone improves the whitening efficacy of sodium peroxodisulfate when both sodium peroxodisulfate and methyl ethyl ketone are in a molar concentration of 0.01 M to 0.05 M and a particularly preferred molar ratio of 1: .

While particular embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the scope of the invention as defined in the following claims.

Claims

A whitening agent represented by the formula R ¹ -OOR ² ; And an aliphatic ketone, wherein R &^lt; ¹ > And R ² are independently selected from hydrogen, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ carbonyl, SO _3, and phenyl.

The composition of claim 1, wherein the whitening agent is a peroxodisulfate whitening agent.

3. The composition of claim 1 or 2, wherein the whitening agent is in the acid or salt form thereof.

4. The method of any one of claims 1 to 3 wherein the whitening agent is selected from the group consisting of sodium peroxodisulfate, potassium peroxodisulfate, ammonium peroxodisulfate, lithium peroxodisulfate, calcium peroxodisulfate, and magnesium peroxodi Sulfates, or a mixture of any two or more of such peroxodisulfate salts.

5. The composition of claim 4, wherein the whitening agent comprises sodium peroxodisulfate.

6. The process according to any one of claims 1 to 5, wherein the aliphatic ketone is a ketone represented by the formula R.CO.R 'wherein R is a C ₁ to C ₄ alkyl group and R' is a C ₁ to C ₄ Alkyl group, and R and R 'may be the same or different.

The method of claim 6, wherein, R is a methyl group and R 'is a C ₂ to C ₄ alkyl group composition.

8. The composition of claim 7 wherein R ' is an ethyl group.

9. The composition according to any one of claims 1 to 8, wherein the aqueous composition is a composition wherein the peroxodisulfate whitening agent is present in an amount of 0.01M to 0.05M, based on the weight of the composition.

9. The composition according to any one of claims 1 to 8, wherein the aqueous composition is a composition wherein the peroxodisulfate whitening agent is present in an amount of 0.1 to 10 wt%, based on the weight of the composition.

11. The composition of claim 10 wherein the peroxodisulfate whitening agent is present in an amount of 0.24 to 3.5 wt%, based on the weight of the composition.

12. The composition according to any one of claims 1 to 11, wherein the aqueous composition and the aliphatic ketone are present in an amount of from 0.01M to 0.05M, based on the weight of the composition.

12. The composition according to any one of claims 1 to 11, wherein the aqueous composition is present in an amount of from 0.02 to 1.5 wt%, based on the weight of the composition, of the aliphatic ketone.

14. The composition of claim 13, wherein the aliphatic ketone is present in an amount of 0.05 to 0.8 wt%, based on the weight of the composition.

9. The composition according to any one of claims 1 to 8, wherein the composition is a substantially anhydrous composition containing less than 5 wt% water, wherein the peroxodisulfate whitening agent is present in an amount of 0.1 to 45 wt%, based on the weight of the composition.

16. The composition of claim 15, wherein the peroxodisulfate whitening agent is present in an amount of generally from 0.24 to 8 wt%, based on the weight of the composition.

17. A composition according to any one of claims 1 to 8, 15 and 16 wherein the composition is a substantially anhydrous composition containing less than 5 wt% water and wherein the aliphatic ketone is present in an amount of from 0.03 to 6 wt% &Lt; / RTI >

18. The composition of claim 17, wherein the aliphatic ketone is present in an amount of generally 0.06 to 4.7 wt%, based on the weight of the composition.

19. The composition according to any one of claims 1 to 18, wherein the peroxodisulfate whitening agent and the aliphatic ketone are present in the composition in a molar ratio of from 0.5: 1 to 1: 0.5.

20. The composition of claim 19 wherein the peroxodisulfate whitening agent and the aliphatic ketone are present in the composition in a molar ratio of 0.75: 1 to 1: 0.75.

21. The composition of claim 20, wherein the peroxodisulfate whitening agent and aliphatic ketone are present in the composition in a molar ratio of about 1: 1.

22. The composition according to any one of claims 1 to 21, wherein the composition is present in a form selected from a cream toothpaste, a mouthwash, a strip and a solid or liquid gel.

22. A tooth whitening method comprising applying the composition of any one of claims 1 to 22 to a tooth surface of a mammal.