TWI486174B - Peroxide-stable oral care compositions - Google Patents

Description

Peroxide-stabilized oral health care composition

The present invention discloses an oral health care composition comprising (i) a whitening complex comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, and (ii) comprising lithium magnesium niobate or sodium magnesium niobate or a combination thereof Hydrogen peroxide stabilizer for clay.

Formulations containing peroxide-containing dentifrice are known and used to cleanse and whiten teeth. Peroxides can bleach teeth, remove plaque, and kill cariogenic bacteria. However, peroxides have a relatively high activity and are therefore quite difficult to formulate. In addition, the peroxide can be automatically decomposed to form oxygen (O ₂ ) and water, so when stored, the dentifrice container may swell, burst or leak, and the remaining formulation will not have enough peroxide residue for effective cleaning. And whitening teeth. The portion initially contains a very high amount of peroxide which decomposes over time, so the actual peroxide content output during use can vary and depends primarily on how long and the conditions the dentifrice is stored.

However, known whitening dentifrice compositions containing peroxides may exhibit unacceptable levels of peroxide breakdown and loss of whitening efficacy as they are sold or previously stored by the user.

Therefore, there is a need for an improved whitening oral health care containing peroxide. Compositions, such as dentifrice compositions, exhibit improved cosmetic stability of the peroxide and are therefore chemically stable for long term storage and suitable for everyday consumer use without significant loss of whitening efficacy. Particular embodiments of the invention are directed, at least in part, to meeting these needs.

Overview

The present invention is also directed to providing a single-phase whitening oral health care composition which not only exhibits cosmetic stability of peroxide, but also can be stably stored for a long period of time and is suitable for daily consumption, and more effectively whiten using a bleaching mechanism. tooth.

Accordingly, the present invention provides an oral care composition comprising (i) a whitening complex comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, and (ii) comprising lithium and magnesium bismuth citrate A calcium hydrogen peroxide stabilizer for sodium magnesium silicate.

Optionally, the clay is lithium magnesium niobate.

Optionally, the clay is sodium magnesium citrate.

Optionally, the clay is sodium lithium magnesium silicate.

Optionally, the clay is Laponite ^® , such as Laponite ^® XLG.

Optionally, the clay contains from 55% to 65% by weight SiO ₂ , from 22% to 32% by weight MgO, from 0.5% to 1.5% by weight Li ₂ O, and from 2% to 4% by weight Na ₂ O, which is based on the dry weight of the clay.

Optionally, the clay is present in an amount from 0.1% to 10% by weight, more optionally from 1% to 5% by weight, more optionally from 1% to 4% by weight, and more optionally from 1 From 5% by weight to 3% by weight, more optionally from 1.5% by weight to 2.5% by weight, based on the weight of the composition.

Optionally, the composition contains a polyvinylpyrrolidone thickener. With Desirably, the polyvinylpyrrolidone thickener is present in an amount from 1% to 5% by weight, more optionally from 1% to 4% by weight, and more optionally from 1% to 3% by weight, Still more arbitrarily from 1.5% by weight to 2.5% by weight, based on the weight of the composition.

Optionally, the composition further comprises an ethylene oxide, propylene oxide block copolymer having an average molecular weight greater than 5000 Da, substantially free of ethylene oxide, propylene oxide block copolymer having an average molecular weight of less than 5000 Da.

Optionally, the ethylene oxide, propylene oxide block copolymer contains (ethylene oxide) _x - (propylene oxide) _y where x is an integer from 80 to 150 and y is an integer from 30 to 80.

Optionally, the ethylene oxide, propylene oxide block copolymer is present in an amount from 5% by weight to 10% by weight, based on the weight of the composition.

Optionally, the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount from 0.5% to 20% by weight, more optionally from 6% to 16% by weight, and more optionally from 9% by weight. From 1% to 13% by weight, still more optionally from 10% to 12% by weight, based on the weight of the composition.

Optionally, the whitening complex contains from 10% to 30% by weight hydrogen peroxide and from 5% to 15% by weight total nitrogen, based on the weight of the whitening complex.

Optionally, the total amount of hydrogen peroxide is from 0.5% to 4.5% by weight, based on the weight of the composition. Optionally, the total amount of hydrogen peroxide is from more than 1.1% by weight to less than 3% by weight, based on the weight of the composition. Optionally, the total amount of hydrogen peroxide is from 1.5% to 2.5% by weight, based on the weight of the composition.

Optionally, the composition also contains an abrasive. The abrasive can be selected from At least one calcined alumina, ceria, zirconia, calcium pyrophosphate, dicalcium phosphate, and precipitated calcium carbonate, or any mixture of two or more thereof.

Optionally, the abrasive is, or contains, a calcium abrasive such as calcium pyrophosphate.

Optionally, the abrasive is present in an amount from 10% to 20% by weight, more optionally from 13% to 17% by weight, based on the weight of the composition.

Optionally, the composition further comprises at least one humectant selected from the group consisting of glycerin and propylene glycol, or mixtures thereof. Optionally, the at least one humectant is present in an amount from 30% to 70% by weight, more optionally from 40% to 60% by weight, based on the weight of the composition. Optionally, the composition contains propylene glycol in an amount from 20% to 40% by weight, more optionally from 25% to 35% by weight, and more optionally from 25% to 30% by weight, based on the composition The weight of the object. Optionally, the composition contains glycerin in an amount from 15% to 30% by weight, more optionally from 20% to 30% by weight, and more optionally from 20% to 25% by weight, depending on the composition The weight of the object.

Optionally, the composition also contains polyethylene glycol having an average molecular weight of from 400 to 800 Da. Optionally, the polyethylene glycol is present in an amount from 1% to 5% by weight, based on the weight of the composition.

Optionally, the composition contains less than 3% by weight water, based on the weight of the composition. Optionally, the composition is, or substantially free of water.

Optionally, the composition contains the following ingredients by weight, based on the weight of the composition:

Optionally, the composition is a single phase composition.

Optionally, the composition is a toothpaste.

In some embodiments, the composition further contains an anionic surfactant in an amount of from 0.5 to 3% by weight based on the weight of the composition.

In a preferred embodiment of the present invention, the oral care composition exhibits cosmetic stability of the peroxide, and thus can be stably stored for a long period of time and is suitable for daily consumption, and uses a bleaching mechanism to have high efficacy of whitening teeth.

Prior to the present invention, the theoretical addition of clay to a formulation containing a peroxide would increase the pH of the formulation and would therefore destabilize the peroxide. Accordingly, those skilled in the art will have no incentive to consider adding clay to this formulation.

However, the present inventors have found to be particularly expected in the field of lithium is selected from magnesium silicate and sodium magnesium silicate clays, such as Laponite ^® XLG, significantly increases the stability of the peroxide dentifrices. Accordingly, in the dentifrice containing this specially selected clay, the peroxide content or concentration is increased while maintaining the stability of the peroxide, thereby increasing the degree of whitening of the teeth using the dentifrice. .

The invention also provides a method of whitening teeth comprising administering the invention The composition is to the surface of the mammalian tooth.

Other specific examples of the invention will be apparent from the detailed description and examples.

Detailed description

As used throughout the text, each and every value in the range is expressed in a simplified manner. Any value within the range can be selected as the boundary of the range.

In some embodiments, the present invention provides an oral care composition comprising (i) a whitening complex comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, and (ii) comprising an acid selected from the group consisting of tannic acid A hydrogen peroxide stabilizer for clay of magnesium lithium and sodium magnesium silicate.

The oral care composition is typically a single phase composition, such as a toothpaste.

In some embodiments, the present invention provides an oral care composition comprising (i) a source of peroxide, and (ii) a hydrogen peroxide stabilizer comprising a clay selected from the group consisting of lithium magnesium niobate and sodium magnesium niobate. . In some embodiments, the peroxide source is selected from the group consisting of hydrogen peroxide, sodium percarbonate, urea peroxide, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, and combinations of two or more thereof.

In some embodiments, the peroxide source is present at a concentration effective to provide from about 0.1% to about 10% hydrogen peroxide.

In some embodiments, the present invention provides a toothpaste containing an abrasive, such as a calcium abrasive. In other embodiments, the invention provides a gel free of abrasives.

In the oral care composition of the present invention, the whitening complex contains a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide.

In some embodiments, the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount from 0.5% by weight to 20% by weight based on the weight of the composition.

In some embodiments, the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount from 6% by weight to 16% by weight based on the weight of the composition.

In some embodiments, the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount from 9% by weight to 13% by weight based on the weight of the composition.

In some embodiments, the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount from 10% to 12% by weight, based on the weight of the composition.

Typically, the whitening complex contains from 10% to 30% by weight hydrogen peroxide and from 5% to 15% by weight total nitrogen, based on the weight of the whitening complex. Typically, the whitening complex contains from 15% to about 25% by weight, such as from about 17% to about 22% by weight hydrogen peroxide and from about 7% to about 12% by weight total nitrogen.

In some embodiments, the total amount of hydrogen peroxide is from 0.5% by weight to 4% by weight, based on the weight of the composition. In some embodiments, the total amount of hydrogen peroxide is greater than 1.1% by weight based on the weight of the composition. In some embodiments, the total amount of hydrogen peroxide is less than 3% by weight based on the weight of the composition. In some embodiments, the total amount of hydrogen peroxide is from 1.5% to 2.5% by weight, based on the weight of the composition. In some embodiments, the total amount of hydrogen peroxide is from 2% to 2.5% by weight, based on the weight of the composition.

In the oral care composition of the present invention, the hydrogen peroxide stabilizer contains a clay selected from the group consisting of lithium magnesium niobate and sodium magnesium niobate.

In some embodiments, the clay is lithium magnesium niobate. In some embodiments, the clay is sodium magnesium citrate.

In some embodiments, the clay contains from 55% to 65% by weight SiO ₂ , from 12% to 30% by weight MgO, from 0.01% to 1.5% by weight Li ₂ O, and from 2% to 10% % by weight Na ₂ O, based on the dry weight of the clay.

Typically, the clay is lithium lithium magnesium citrate. In particular part of one embodiment, the clay is Laponite ^®, e.g. Laponite ^® XLG.

The experimental formula of Laponite XLG is: Na ⁺ _0.7 [(Si ₈ Mg _5.5 Li _0.3 )O ₂₀ (OH) ₄ ] ^-0.7 .

In some embodiments, the clay is present in an amount from 0.1% by weight to 10% by weight based on the weight of the composition. In some embodiments, the clay is present in an amount from 1% to 5% by weight, based on the weight of the composition. In some embodiments, the clay is present in an amount from 1% to 4% by weight, based on the weight of the composition. In some embodiments, the clay is present in an amount from 1% to 3% by weight based on the weight of the composition. In some embodiments, the clay is present in an amount from 1.5% to 2.5% by weight, based on the weight of the composition. In some embodiments, the clay is present in an amount of about 2% by weight based on the weight of the composition.

In some embodiments, the clay contains particles having a d50 of about 25 nm. In some embodiments, the clay contains particles having a thickness greater than about 1 nanometer.

In some embodiments, the composition contains a thickening system. Typically, the thickening system contains a polyvinylpyrrolidone thickener.

In some embodiments, the polyvinylpyrrolidone thickener is present in an amount from 1% to 5% by weight, based on the weight of the composition. In some embodiments, the polyvinylpyrrolidone thickener is present in an amount from 1% to 4% % by weight, based on the weight of the composition. In some embodiments, the polyvinylpyrrolidone thickener is present in an amount from 1% to 3% by weight based on the weight of the composition. In some embodiments, the polyvinylpyrrolidone thickener is present in an amount from 1.5% to 2.5% by weight, based on the weight of the composition. In some embodiments, the polyvinylpyrrolidone thickener is present in an amount of about 2% by weight based on the weight of the composition.

The compositions of the present invention may optionally contain other orally acceptable thickening agents selected from one or more, but not limited to, carbomers, also known as carboxyvinyl polymers, carrageenans, also known as carrageenans. Irish moss and more precisely carrageenan (iota-carrageenan), high molecular weight polyethylene glycol (eg CARBOWAX ^® , available from The Dow Chemical Company), cellulosic polymers such as hydroxyethyl cellulose, carboxymethyl fibers CMC and its salts such as sodium CMC, natural gums such as karaya gum, xanthan gum, gum arabic and tragacanth, and colloidal magnesium aluminum citrate and mixtures thereof. Optionally, the total amount of such other thickening agent is from about 0.1% to about 50% by weight, such as from about 0.1% to about 35% or from about 1% to about 15% or from about 1% to about 5% by weight, based on the weight of the composition.

Some specific examples also contain an abrasive. In other embodiments, an oral care composition comprising from about 10 to about 20 weight percent abrasive is provided, for example from about 13 to about 17 weight percent, based on the weight of the composition.

The average particle size in the presence of the abrasive is typically from about 0.1 to about 30 microns, such as from about 1 to about 20 or from about 5 to about 15 microns.

The abrasive is generally selected from the group consisting of at least one calcined alumina, ceria, zirconia, calcium phosphate, calcium pyrophosphate, dicalcium phosphate, dicalcium orthophosphate, tricalcium phosphate, calcium polymetaphosphate and precipitated calcium carbonate, Or a mixture of two or more thereof.

The abrasive may comprise a calcium abrasive such as a calcium phosphate salt such as calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, and/or calcium polymetaphosphate. In a typical embodiment, the calcium abrasive comprises calcium pyrophosphate. In another typical embodiment, the calcium abrasive comprises calcium carbonate.

In some embodiments, the composition is a toothpaste containing a calcium pyrophosphate abrasive. The calcium pyrophosphate is present in an amount from 10% by weight to 20% by weight, for example from 13% by weight to 17% by weight, based on the weight of the composition.

In some embodiments, the composition further comprises a polymeric thickener selected from the group consisting of (i) polyethylene glycol, (ii) a polyethylene glycol-polypropylene glycol block copolymer having a molecular weight of at least 5,000, and Iii) a composition thereof.

In some embodiments, the composition comprises an ethylene oxide, propylene oxide block copolymer of the formula (ethylene oxide) _x -(propylene oxide) _y , wherein x is an integer from 80 to 150, for example 100-130, such as about 118, and y is an integer from 30-80, such as from about 60-70, such as about 66, having an average molecular weight greater than 5,000, such as from 8,000 to 13,000 Da, such as about 9,800.

In some embodiments, the composition comprises an ethylene oxide, propylene oxide block copolymer having an average molecular weight greater than 5000 Da, substantially free of ethylene oxide, propylene oxide block copolymer having an average molecular weight of less than 5000 Da. . The ethylene oxide, propylene oxide block copolymer is present in an amount from 5% by weight to 10% by weight based on the weight of the composition. Block copolymers of ethylene oxide/propylene oxide are quite useful, but higher molecular weights such as > 5000 Da are preferred, including, for example, PLURACARE® L1220 (available from BASF, Wyandotte, Mich., United States of America).

In some embodiments, the composition further comprises polyethylene glycol having an average molecular weight of from 400 to 800 Da, such as about 600 Da. Low or moderate molecular weight polyethylene glycol For example, PEG 400, PEG 600, PEG 800, PEG 1000, and mixtures thereof can be used in the compositions of some embodiments of the present invention.

The polyethylene glycol may be present in an amount from 1% by weight to 5% by weight, based on the weight of the composition. The polyethylene glycol may be present in an amount from 2% to 4% by weight, such as 3% by weight, based on the weight of the composition.

In some embodiments, the oral care composition may additionally contain an amount of other linear polyvinylpyrrolidone.

The compositions of the present invention may also contain various dentifrice ingredients to modify the rheology and feel of the composition, such as humectants, surfactants, and/or gels.

In some embodiments, the oral care composition contains a vehicle for the active ingredient. The vehicle may include a humectant, for example selected from the group consisting of glycerin, propylene glycol, or mixtures or combinations thereof.

In some embodiments, the oral care composition contains from about 30 to about 70% by weight, for example from about 40 to about 60% by weight, of a humectant, depending on the weight of the composition.

In some embodiments, the composition contains propylene glycol in an amount from 20% to 40% by weight, such as from 25 to 35% by weight or from 25 to 30% by weight, based on the weight of the composition.

In some embodiments, the composition contains glycerin in an amount from 15% to 30% by weight, such as from 20 to 30% by weight or from 20 to 25% by weight, based on the weight of the composition.

The typical composition of the present invention contains "low water" amount, which means the total concentration of water, including any free water and all water contained in any component, is less than about 5%, preferably less than 3%. Still more preferably less than 2% water.

Optionally, the composition contains less than 3% by weight water, based on the weight of the composition. In some embodiments, the oral care composition contains less than 2% by weight water, such as less than 1% by weight water, based on the weight of the composition. In some embodiments, the composition is substantially anhydrous.

The vehicle component particularly provides a dentifrice having a viscosity of from about 10,000 CPS to about 700,000 CPS, more preferably from about 30,000 CPS to about 300,000 CPS.

It will be understood by those skilled in the art that the oral compositions of the present invention optionally include other materials such as anti-caries agents, desensitizing agents, viscosity modifiers, diluents, surface active agents such as surfactants, emulsifiers, and foam conditioning. Agents, pH adjusters, abrasives, in addition to those listed above, are also humectants, mouth feel agents, sweeteners, flavoring agents, colorants, preservatives, and combinations thereof. It is understood that the general properties of each of the above categories of substances may vary, there may be some common attributes and any given substance may serve multiple purposes in two or more such classes of matter. Preferably, the carrier is selected to be compatible with the other ingredients of the composition.

A flavoring agent, a sweetener, a coloring agent, a foaming regulator, a mouthfeel, and other additives may be included in the composition, if necessary.

The composition of the present invention may contain a surface active agent (surfactant). Suitable surfactants include, but are not limited to, water-soluble salts of esters of C _8-20 alkyl sulfates, sulfonated C _8-20 fatty acids, monoglycerides of, sarcosinates, taurates, sodium lauryl sulfate , cocoa hydroxy hydroxymonoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl hydroxyethyl disulfonate, sodium lauryl polyoxyethyl ether carboxylate and dodecyl benzene sulfonate Sodium, and cocoamidopropyl betaine.

In some embodiments, the composition may further comprise an anionic surfactant such as sodium lauryl sulfate (SLS). In some specific examples, the composition can The amount further contains an anionic surfactant such as SLS in an amount of from 0.5 to 3% by weight based on the weight of the composition.

The compositions of the present invention optionally contain one or more other active substances which are operable to prevent or treat conditions or diseases of the oral hard or soft tissues, to prevent or treat physiological conditions or conditions, or to provide a cosmetic benefit.

In various embodiments of the invention, the oral care composition comprises an anticalculus (tartar control) agent. Generally, tartar control agents are classified as being incompatible with some whitening agents, but specific examples of the present invention incorporate tartar control agents and whitening agents in single phase whitening compositions.

Suitable anticalculus agents include, but are not limited to, phosphates and polyphosphates (eg, pyrophosphate), polyaminopropanesulfonic acid (AMPS), hexametaphosphate, zinc citrate trihydrate, polypeptides, polyolefin sulfonates Acid esters, polyolefin phosphates, diphosphates. Typically, the anticalculus agent is present in an amount from about 0.1% to about 30% by weight, based on the weight of the composition.

The oral composition can comprise a mixture of different anticalculus agents.

In some embodiments, the composition further comprises a tartar control agent, for example selected from the group consisting of tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP). In some embodiments, the composition contains TSPP in an amount from 1% to 3% by weight based on the weight of the composition.

In a preferred embodiment, tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used. The anticalculus agent contains from about 1-2% TSPP and from about 7% to about 10% STPP, each depending on the weight of the composition.

The oral care composition can optionally comprise at least one orally acceptable source of fluoride ions. Anyone known or to be developed in the art can be used. Fluorine Suitable sources include fluorides, monofluorophosphates and fluoroantimonate. One or more fluoride ion-releasing compounds are optionally present in amounts ranging from about 100 to about 20,000 ppm, from about 200 to about 5,000 ppm, or from about 500 to about 2,500 ppm of fluoride ions, depending on the composition The weight of the object.

The composition can comprise a source of stannous or stannous ions. Suitable stannous ion sources include, but are not limited to, stannous fluoride, other stannous halides such as stannous chloride dihydrate, stannous pyrophosphate, organo stannous carboxylates such as stannous acid salt, acetate, and hydrochloric acid. Sodalate, lactate, tartrate, oxalate, malonate and citrate, ethylene glycol stannous, and the like. One or more sources of stannous ions are optionally and illustratively present in a total amount of from about 0.01% to about 10%, such as from about 0.1% to about 7% or from about 1% to about 5%, each by weight of the composition. .

In some embodiments, the compositions of the present invention optionally contain an antimicrobial (e.g., antimicrobial) agent, such as triclosan. Other illustrative lists of antibacterial agents that can be used are provided, for example, in the U.S. Pat. No. 5,776,435, the disclosure of which is incorporated herein by reference. The one or more antimicrobial agents are optionally present in an antimicrobially effective total amount, typically from about 0.05% to about 10%, such as from about 0.1% to about 3%, each by weight of the composition.

In some embodiments, the compositions of the present invention optionally contain an antioxidant. Any orally acceptable antioxidant can be used, including butylated hydroxyanisole (BHA), butylhydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal resistance Oxidants, chlorophyll, melatonin, and mixtures thereof.

The composition of the present invention may optionally contain a stimulant or saliva stimulating agent, an antiplaque agent, an anti-inflammatory agent, and/or a desensitizing agent.

Although the ingredients are sometimes distinguished by category, such as humectants, antioxidants, thickeners, etc., the identification is for convenience and clarity, but is not intended to be limiting. All of the ingredients in the composition may have functions other than their primary function and may contribute to the overall properties of the composition, including its stability, effectiveness, consistency, mouthfeel, taste, odor, and the like.

In some embodiments, the compositions of the present invention comprise the following ingredients by weight, each depending on the weight of the composition:

The composition may optionally comprise any or all of the following ingredient classes and/or specific ingredients by weight, each depending on the weight of the composition:

A method of whitening an oral surface in a human or animal individual is provided, which comprises storing a stable form of the composition of the invention and contacting the composition with the oral surface. As used herein, "animal individual" includes higher non-human mammals such as large, cat, and horse. The oral care composition is in contact with the oral surface of a mammalian subject, thereby whitening the teeth in a highly effective manner, without any negative effects between the whitening agent, the peroxide incompatible abrasive and other ingredients.

In various embodiments, it is preferred to apply the oral care composition and contact the oral surface. The dentifrice prepared according to a particular embodiment of the invention is preferably applied to the oral surface on a regular basis, preferably daily, for at least once a day for several days, but may also be administered once every two or three days. The oral care composition is preferably applied to the oral surface from 1 to 3 times per day for at least 2 weeks to 8 weeks, or from 4 months to 3 years, or for life.

The invention is illustrated in the following non-limiting examples.

Comparison examples 1 to 5

Rather than according to the invention, a dentifrice was prepared according to Comparative Examples 1 to 5. The composition contains the ingredients listed in Table 1 below, in an amount of % by weight:

The dentifrice of Comparative Example 1 comprises a whitening complex comprising a composite of crosslinked polyvinylpyrrolidone and hydrogen peroxide. The hydrogen peroxide comprises about 2% by weight of the total weight of the dentifrice. The dentifrice contains a substantially anhydrous vehicle comprising PEG ₁₁₈ /PPG ₆₆ copolymer (Pluracare L1220F), glycerin, propylene glycol and PEG 600.

Each of the dentifrice compositions of Comparative Examples 2 to 5 contained clay to replace part of the propylene glycol of Comparative Example 1.

More specifically, the dentifrice compositions of Comparative Examples 2 and 3 contained the same dentifrice composition as Comparative Example 1, except that in Comparative Examples 2 and 3, the composition contained 2% by weight of bentonite and 28% by weight. Propylene glycol, while Comparative Example 1 contained no bentonite and contained 30% by weight of propylene glycol. The dentifrice of Comparative Example 4 contained the same dentifrice composition as Comparative Example 1, except that in Comparative Example 4, the composition contained 2% by weight of montmorillonite and 28% by weight of propylene glycol, and Comparative Example 1 did not contain Desoiled and contained 30% by weight of propylene glycol. The dentifrice of Comparative Example 5 contained the same dentifrice composition as Comparative Example 1, except that in Comparative Example 5, the composition contained 2% by weight of kaolin and 28% by weight of propylene glycol, and Comparative Example 1 contained no kaolin and contained 30% by weight of propylene glycol.

The stability of hydrogen peroxide in each of the dentifrice of Comparative Examples 1 to 5 was evaluated using a test method for evaluating the chemical stability of hydrogen peroxide in a dentifrice.

Hydrogen peroxide decomposes into water and oxygen decomposition products, and 2 moles of hydrogen peroxide produces 1 mole of oxygen. However, 1 mole of oxygen occupies a larger volume than 2 moles of hydrogen peroxide, so when hydrogen peroxide is decomposed, significant pressure builds up in the dentifrice sealing tube.

In each of Comparative Examples 1 to 5, about 95 g of each dentifrice composition was filled in the same conventional elastic, elastic, polymer tetrasens (4 oz.) toothpaste tube at room temperature and The tubes are sealed with conventional closure caps. The tubes used in Comparative Examples 1 to 5 were measured at room temperature on the day of filling the tube and recorded the circumference of the tube at about the middle portion of the two longitudinal ends (hereinafter referred to as "tube waist") and adjacent The circumference of the closed end portion of the pipe (hereinafter referred to as the "pipe end").

After the tube was accelerated and aged at 60 ° C for 7 days, the expansion of the dentifrice containing hydrogen peroxide in Examples 1 to 5 due to decomposition of hydrogen peroxide was obtained by measuring the waist and the tube ends again. As the tube is inflated due to internal pressure generated by oxygen, the circumference of the tube at its waist and tube ends increases accordingly.

Table 2 lists the time function of the increase in the circumference of the tubes and tube ends of the dentifrice compositions of Comparative Examples 1 to 5 at 60 °C.

It can be seen that in Comparative Example 1, the circumference of the tube at the waist of the tube and the circumference of the tube at the tube end were significantly increased, indicating that a large amount of hydrogen peroxide was decomposed during the accelerated aging test.

Moreover, it can be seen that during the accelerated aging test, the tubes of Comparative Examples 2 to 5 burst after the accelerated aging test, resulting in the tubes of Comparative Examples 2 to 5 being unmeasurable after the accelerated aging test (in the "change" of Table 2) Called "N/A" means the pipe bursts). This indicates that during the accelerated aging test, there is a large amount of hydrogen peroxide decomposition, It is likely that the decomposition of hydrogen peroxide during the accelerated aging test is much larger in Comparative Example 1 during the accelerated aging test.

Obviously, hydrogen peroxide had poor chemical stability in the accelerated aging test of Comparative Examples 1 to 5. Moreover, the addition of one of clay, bentonite, montmorillonite and kaolin shows a deterioration in the chemical stability of hydrogen peroxide. These results support the theory prior to the present invention that the addition of clay to a formulation containing a peroxide increases the pH of the formulation, thereby destabilizing the hydrogen peroxide.

Example 1

A dentifrice according to the present invention was produced according to Example 1. The composition contains the ingredients listed in Table 3 below, wherein the amount is % by weight:

The dentifrice composition of Example 1 contained the same dentifrice composition as Comparative Example 1, except that in Example 1, the composition contained 2% by weight of clay containing lithium magnesium citrate and 28% by weight of propylene glycol, and the comparison was made. Example 1 contained no lithium lithium magnesium silicate and contained 30% by weight of propylene glycol.

The stability of hydrogen peroxide in the dentifrice was evaluated using the same test method as Comparative Examples 1 to 5 above. The same volume of conventional elastomeric polymer four oz. 4oz. toothpaste tube was filled with the same volume (about 95 grams) of the dentifrice of Example 1 and the tube was sealed with various conventional closure caps. Again, the circumference of the tube waist and tube ends of the tube were measured at room temperature on the day the tube was filled and recorded, and again after the tube was accelerated aging at 60 ° C for 7 days.

Table 4 lists the time function of the tube used for the dentifrice of Example 1 at its tube waist and tube end circumference at 60 °C.

Table 4 shows the time function of the dentifrice of Example 1 at 60 ° C, and the tube has no change in the circumference of the tube waist and tube ends. That is, for the dentifrice of Example 1, there was no sign of swelling.

From the comparison of the data obtained in Example 1 with Comparative Examples 1 to 5, it can be seen that the addition of the clay containing lithium magnesium niobate to the dentifrice of Example 1 is surprisingly and significantly reduces the composition of the hydrogen peroxide in the dentifrice. Decomposition in the material, thus significantly increasing the chemical stability of the dentifrice.

In summary, the data set forth in the examples demonstrate the inclusion of a whitening complex comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide and a hydrogen peroxide stabilizer comprising a clay containing sodium magnesium niobate, according to the invention. The chemical stability of the dental agent has been unexpectedly improved.

While the invention has been shown and described with reference to the specific embodiments of the invention

Claims (33)

An oral health care composition comprising (i) a whitening complex comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, (ii) a clay comprising lithium magnesium niobate or sodium magnesium niobate or a combination thereof a hydrogen peroxide stabilizer, and (iii) from 1% by weight to 5% by weight of a crosslinked polyvinylpyrrolidone, wherein the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount of from 5 From % by weight to 20% by weight, based on the weight of the composition. The composition of claim 1, wherein the clay comprises lithium magnesium niobate. The composition of claim 1, wherein the clay comprises sodium magnesium citrate. The composition of claim 1, wherein the clay comprises lithium lithium magnesium citrate. The composition according to claim 4, wherein the clay comprises from 55% by weight to 65% by weight of SiO ₂ , from 22% by weight to 32% by weight of MgO, from 0.5% by weight to 1.5% by weight of Li ₂ O, and from 2% by weight to 4% by weight of Na ₂ O, based on the dry weight of the clay. The composition according to any one of claims 1 to 5, wherein the clay is present in an amount of from 0.1% by weight to 10% by weight based on the weight of the composition. The composition according to claim 6 wherein the clay is present in an amount of from 0.5% by weight to 5% by weight based on the weight of the composition. The composition according to item 7 of the patent application, wherein the clay is present in an amount of from 1% by weight to 3% by weight, based on the weight of the composition. The composition according to any one of claims 1 to 5, which further comprises an ethylene oxide or propylene oxide block copolymer having an average molecular weight of more than 5000 Da, substantially free of epoxy B having an average molecular weight of less than 5000 Da. Alkane, propylene oxide block copolymer. The composition according to claim 9 wherein the ethylene oxide and propylene oxide block copolymer comprises (ethylene oxide) _x -(propylene oxide) _y wherein x is an integer of 80-150 and y It is an integer of 30-80. The composition according to any one of claims 1 to 5, wherein the ethylene oxide or propylene oxide block copolymer is present in an amount of from 5% by weight to 10% by weight based on the composition The weight. The composition according to any one of claims 1 to 5, wherein the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount of from 6% by weight to 16% by weight, based on the The weight of the composition. The composition according to claim 12, wherein the crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide is present in an amount of from 9 to 13% by weight, based on the weight of the composition. The composition according to any one of claims 1 to 5, wherein the whitening composite comprises 10% by weight to 30% by weight of hydrogen peroxide and from 5 to 15% by weight of total nitrogen, based on a whitening complex The weight. The composition according to any one of claims 1 to 5, wherein the total amount of the hydrogen peroxide is from 0.1% by weight to 4% by weight based on the weight of the composition. The composition according to claim 15 wherein the total amount of the hydrogen peroxide is from more than 0.5% by weight to less than 3% by weight based on the composition The weight of the object. The composition according to any one of claims 1 to 5, further comprising an abrasive. The composition according to claim 17, wherein the abrasive is selected from the group consisting of at least one calcined alumina, ceria, zirconia, calcium pyrophosphate, dicalcium phosphate, and precipitated calcium carbonate, or two or more thereof Any mixture of them. The composition according to claim 17, wherein the abrasive is a calcium abrasive. The composition according to claim 19, wherein the abrasive is calcium pyrophosphate. The composition according to claim 17, wherein the abrasive is present in an amount of from 10% by weight to 20% by weight based on the weight of the composition. The composition according to any one of claims 1 to 5, further comprising at least one humectant selected from the group consisting of glycerin and propylene glycol, or a mixture thereof. The composition according to claim 22, wherein the at least one humectant is present in an amount of from 30% by weight to 70% by weight, based on the weight of the composition. The composition according to claim 23, wherein the at least one humectant is present in an amount of from 40% by weight to 60% by weight, based on the weight of the composition. The composition according to item 22 of the patent application, which comprises propylene glycol in an amount of from 20% by weight to 40% by weight, based on the weight of the composition. According to the composition of claim 22, the amount of glycerin is 15% by weight to 30% by weight, based on the weight of the composition. The composition according to any one of claims 1 to 5, which further comprises polyethylene glycol having an average molecular weight of 400 to 800 Da. The composition according to claim 27, wherein the polyethylene glycol is present in an amount of from 1% by weight to 5% by weight, based on the weight of the composition. The composition according to any one of claims 1 to 5, which contains less than 3% by weight of water, based on the weight of the composition. The composition according to any one of claims 1 to 5, which contains the following components by weight, each according to the weight of the composition: The composition according to any one of claims 1 to 5, which is a single phase composition. A composition according to any one of claims 1 to 5, which is a toothpaste. Use of a composition according to any one of claims 1 to 32 for the manufacture of an oral health care product for whitening teeth.