FR2521145B1 - Phosphines chirales, procedes pour leur preparation, produits intermediaires de leur preparation, complexes de rhodium de ces phosphines et utilisation de ces derniers dans des hydrogenations asymetriques - Google Patents
Phosphines chirales, procedes pour leur preparation, produits intermediaires de leur preparation, complexes de rhodium de ces phosphines et utilisation de ces derniers dans des hydrogenations asymetriquesInfo
- Publication number
- FR2521145B1 FR2521145B1 FR8301684A FR8301684A FR2521145B1 FR 2521145 B1 FR2521145 B1 FR 2521145B1 FR 8301684 A FR8301684 A FR 8301684A FR 8301684 A FR8301684 A FR 8301684A FR 2521145 B1 FR2521145 B1 FR 2521145B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- processes
- same
- intermediate products
- rhodium complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000005984 hydrogenation reaction Methods 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003003 phosphines Chemical class 0.000 title 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical class [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
- B01J31/2414—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom comprising aliphatic or saturated rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2495—Ligands comprising a phosphine-P atom and one or more further complexing phosphorus atoms covered by groups B01J31/1845 - B01J31/1885, e.g. phosphine/phosphinate or phospholyl/phosphonate ligands
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
- B01J31/1875—Phosphinites (R2P(OR), their isomeric phosphine oxides (R3P=O) and RO-substitution derivatives thereof)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH711/82A CH651051A5 (en) | 1982-02-05 | 1982-02-05 | Phosphorus compounds |
CH7010/82A CH653338A5 (en) | 1982-12-02 | 1982-12-02 | Phosphorus compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2521145A1 FR2521145A1 (fr) | 1983-08-12 |
FR2521145B1 true FR2521145B1 (fr) | 1986-09-12 |
Family
ID=25685452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8301684A Expired FR2521145B1 (fr) | 1982-02-05 | 1983-02-03 | Phosphines chirales, procedes pour leur preparation, produits intermediaires de leur preparation, complexes de rhodium de ces phosphines et utilisation de ces derniers dans des hydrogenations asymetriques |
Country Status (7)
Country | Link |
---|---|
US (2) | US4539411A (fr) |
AT (1) | AT389312B (fr) |
DE (1) | DE3302697A1 (fr) |
FR (1) | FR2521145B1 (fr) |
GB (1) | GB2114134B (fr) |
IT (1) | IT1175910B (fr) |
NL (1) | NL8300354A (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3574704D1 (de) * | 1984-04-19 | 1990-01-18 | Hoffmann La Roche | Chirale rhodium-diphosphinkomplexe fuer asymmetrische hydrierungen. |
DE3446303A1 (de) * | 1984-12-19 | 1986-06-19 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von optisch aktivem 1-benzyl-3,4-bis-(diphenylphosphino)-pyrrolidin |
DE3685713D1 (de) * | 1985-10-18 | 1992-07-23 | Hoffmann La Roche | Chirale rhodium-diphosphinkomplexe fuer asymmetrische hydrierungen. |
FR2600330B1 (fr) * | 1986-06-23 | 1988-12-16 | Charbonnages Ste Chimique | Procede d'hydrogenation asymetrique de composes carbonyles et composes obtenus |
EP0251164B1 (fr) * | 1986-06-25 | 1992-12-16 | Kazuo Achiwa | Composés chiraux de phosphinopyrrolidine et leur utilisation pour la synthèse asymétrique de composés optiquement actifs |
JP2816555B2 (ja) * | 1988-03-07 | 1998-10-27 | 富士薬品工業株式会社 | 新規なホスフイノピロリジン化合物およびそれを用いる不斉合成法 |
US5036153A (en) * | 1989-05-11 | 1991-07-30 | Braish Tamim F | Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates |
US5286902A (en) * | 1991-04-15 | 1994-02-15 | Koch Industries, Inc. | Process for preparation of 2-(6-methoxy-2-naphthyl)propionic acid and intermediates therefor utilizing 2,6-diisopropylnaphthalene |
AU5191898A (en) * | 1996-11-29 | 1998-06-22 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Novel phosphinopyrrolidine compounds and process for producing the same |
DE19831137A1 (de) * | 1998-07-11 | 2000-01-13 | Studiengesellschaft Kohle Mbh | Asymmetrische katalytische Hydrierung von Olefinen |
US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
TW201109335A (en) | 2009-08-04 | 2011-03-16 | Takeda Pharmaceutical | Heterocyclic compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4119652A (en) * | 1974-08-29 | 1978-10-10 | Monsanto Company | Catalytic asymmetric hydrogenation |
JPS53105421A (en) * | 1977-02-28 | 1978-09-13 | Sagami Chem Res Center | Preparation of optical active alpha-hydroxycarboxylic acid esters acid esters |
US4168381A (en) * | 1977-06-14 | 1979-09-18 | American Cyanamid Company | Enhancement of enantioselectivity by iodide salts of Rh(I) complexes in the reduction of prochiral imidazolinones |
JPS54160365A (en) * | 1978-06-04 | 1979-12-19 | Fuji Yakuhin Kogyo Kk | Phosphine contained pyrrolidine compound and its manufacture |
JPS5639097A (en) * | 1979-09-07 | 1981-04-14 | Sagami Chem Res Center | Optically active n-carbamoylpyrrolidinodiphosphine ligand and its preparation |
JPS57145891A (en) * | 1981-03-05 | 1982-09-09 | Sagami Chem Res Center | Optically active diphosphine ligand |
US4424312A (en) * | 1981-03-16 | 1984-01-03 | Polymer Sciences Corporation | Preparation of amino acids in high optical yield via catalytic hydrogenation |
US4343741A (en) * | 1981-04-22 | 1982-08-10 | Hoffmann-La Roche Inc. | Chiral phosphines |
-
1983
- 1983-01-17 US US06/458,418 patent/US4539411A/en not_active Expired - Fee Related
- 1983-01-20 IT IT19195/83A patent/IT1175910B/it active
- 1983-01-27 DE DE19833302697 patent/DE3302697A1/de not_active Withdrawn
- 1983-01-31 NL NL8300354A patent/NL8300354A/nl not_active Application Discontinuation
- 1983-02-03 FR FR8301684A patent/FR2521145B1/fr not_active Expired
- 1983-02-04 GB GB08303161A patent/GB2114134B/en not_active Expired
- 1983-02-04 AT AT0039383A patent/AT389312B/de not_active IP Right Cessation
-
1985
- 1985-06-14 US US06/744,584 patent/US4620013A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB8303161D0 (en) | 1983-03-09 |
NL8300354A (nl) | 1983-09-01 |
FR2521145A1 (fr) | 1983-08-12 |
GB2114134A (en) | 1983-08-17 |
AT389312B (de) | 1989-11-27 |
ATA39383A (de) | 1989-04-15 |
IT1175910B (it) | 1987-08-12 |
US4539411A (en) | 1985-09-03 |
US4620013A (en) | 1986-10-28 |
GB2114134B (en) | 1985-10-09 |
DE3302697A1 (de) | 1983-08-18 |
IT8319195A0 (it) | 1983-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |