JPS57145891A - Optically active diphosphine ligand - Google Patents

Optically active diphosphine ligand

Info

Publication number
JPS57145891A
JPS57145891A JP56030544A JP3054481A JPS57145891A JP S57145891 A JPS57145891 A JP S57145891A JP 56030544 A JP56030544 A JP 56030544A JP 3054481 A JP3054481 A JP 3054481A JP S57145891 A JPS57145891 A JP S57145891A
Authority
JP
Japan
Prior art keywords
optically active
amino acid
diphosphine ligand
formulai
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56030544A
Other languages
Japanese (ja)
Other versions
JPS642119B2 (en
Inventor
Iwao Oshima
Tetsuo Kogure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP56030544A priority Critical patent/JPS57145891A/en
Publication of JPS57145891A publication Critical patent/JPS57145891A/en
Publication of JPS642119B2 publication Critical patent/JPS642119B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

NEW MATERIAL:An optically active diphosphine ligand shown by the formulaI (R1 and R2 are substituted or unsubstituted aryl; R3 is H, alkyl, etc.; R4 is H, amino acid residue, peptide residue; X is H, amino-protecting group; R3 and R4 are capable of forming substituted or unsubstituted polymethylene group; * is optically active point).
EXAMPLE: (2S, 4S)-N-(N'-Benzyloxycarbonyl-L-phenylalanyl)-4-diphenylphosphino- 2-diphenylphosphinomethylpyrrolidine.
USE: Forming a complex (e.g., rhodium complex) serving as an asymmetric catalyst useful in preparing an optically active α-amino acid or peptides.
PROCESS: An optically active pyrrolidinodiphosphine shown by the formula II is reacted with an amino acid shown by the formula II or peptide in the presence of a binder (e.g., dicyclohexylcarbodiimide), to give a ligand shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56030544A 1981-03-05 1981-03-05 Optically active diphosphine ligand Granted JPS57145891A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56030544A JPS57145891A (en) 1981-03-05 1981-03-05 Optically active diphosphine ligand

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56030544A JPS57145891A (en) 1981-03-05 1981-03-05 Optically active diphosphine ligand

Publications (2)

Publication Number Publication Date
JPS57145891A true JPS57145891A (en) 1982-09-09
JPS642119B2 JPS642119B2 (en) 1989-01-13

Family

ID=12306727

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56030544A Granted JPS57145891A (en) 1981-03-05 1981-03-05 Optically active diphosphine ligand

Country Status (1)

Country Link
JP (1) JPS57145891A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620013A (en) * 1982-02-05 1986-10-28 Hoffmann-La Roche Inc. Chiral phosphines
JP2008534495A (en) * 2005-03-25 2008-08-28 オブシェストヴォス オグラニチェンノイ オトヴェツトヴェンノスティユ “ファルメンテルプリセス” Phenyl-N-acyl derivatives of amines and amino acids, methods for their preparation, their pharmaceutical compositions and uses

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620013A (en) * 1982-02-05 1986-10-28 Hoffmann-La Roche Inc. Chiral phosphines
JP2008534495A (en) * 2005-03-25 2008-08-28 オブシェストヴォス オグラニチェンノイ オトヴェツトヴェンノスティユ “ファルメンテルプリセス” Phenyl-N-acyl derivatives of amines and amino acids, methods for their preparation, their pharmaceutical compositions and uses

Also Published As

Publication number Publication date
JPS642119B2 (en) 1989-01-13

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