FR2505360A1 - Procede pour degrader une chaine laterale en 17 d'un steroide a l'aide d'un micro-organisme mutant - Google Patents

Procede pour degrader une chaine laterale en 17 d'un steroide a l'aide d'un micro-organisme mutant Download PDF

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Publication number
FR2505360A1
FR2505360A1 FR8208077A FR8208077A FR2505360A1 FR 2505360 A1 FR2505360 A1 FR 2505360A1 FR 8208077 A FR8208077 A FR 8208077A FR 8208077 A FR8208077 A FR 8208077A FR 2505360 A1 FR2505360 A1 FR 2505360A1
Authority
FR
France
Prior art keywords
mutant
compound
side chain
steroids
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8208077A
Other languages
English (en)
French (fr)
Other versions
FR2505360B1 (ja
Inventor
Merle Gene Wovcha
John Costain Knight
Alfred Benjamin Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2505360A1 publication Critical patent/FR2505360A1/fr
Application granted granted Critical
Publication of FR2505360B1 publication Critical patent/FR2505360B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium
    • Y10S435/865—Mycobacterium fortuitum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR8208077A 1981-05-11 1982-05-10 Procede pour degrader une chaine laterale en 17 d'un steroide a l'aide d'un micro-organisme mutant Granted FR2505360A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/262,018 US4429041A (en) 1981-05-11 1981-05-11 Process of producing 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid

Publications (2)

Publication Number Publication Date
FR2505360A1 true FR2505360A1 (fr) 1982-11-12
FR2505360B1 FR2505360B1 (ja) 1984-01-06

Family

ID=22995838

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8208077A Granted FR2505360A1 (fr) 1981-05-11 1982-05-10 Procede pour degrader une chaine laterale en 17 d'un steroide a l'aide d'un micro-organisme mutant

Country Status (11)

Country Link
US (1) US4429041A (ja)
JP (1) JPS57198099A (ja)
CH (1) CH650803A5 (ja)
DD (1) DD202308A5 (ja)
DE (1) DE3215065A1 (ja)
FR (1) FR2505360A1 (ja)
GB (1) GB2098218B (ja)
HU (1) HU189135B (ja)
IE (1) IE53238B1 (ja)
IT (1) IT1189273B (ja)
NL (1) NL8201874A (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510138A1 (fr) * 1981-07-24 1983-01-28 Upjohn Co Procede de production du 9-hydroxy-3-oxo-4,17 (20)-pregnadiene-20-carboxaldehyde par fermentation et produit obtenu

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids
US4444884A (en) * 1982-05-25 1984-04-24 Wisconsin Alumni Research Foundation Process for preparing steroids
IL94272A (en) * 1989-05-11 1994-04-12 Richter Gedeon Vegyeszet History of A9 Acids - Hydroxy - 3 - Oxo - 4, 42) 52 (- Stigmestadian 62 - Oai, process for their preparation and pharmaceutical preparations containing them
WO1992003465A1 (de) * 1990-08-18 1992-03-05 Schering Aktiengesellschaft Berlin Und Bergkamen 20-METHYL-5,7-PREGNADIEN-3β,21-DIOL-DERIVATIVE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029549A (en) * 1976-03-26 1977-06-14 The Upjohn Company Process of producing 9α-hydroxy-3-ketobisnorchol-4-en-22-oic with mycobacterium fortuitum
EP0011235A1 (en) * 1978-11-08 1980-05-28 Mitsubishi Kasei Corporation 9-Alpha-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester and methods for the microbiological production thereof
US4214051A (en) * 1977-10-21 1980-07-22 The Upjohn Company Process for preparing 9α-OH BN acid methyl ester

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029549A (en) * 1976-03-26 1977-06-14 The Upjohn Company Process of producing 9α-hydroxy-3-ketobisnorchol-4-en-22-oic with mycobacterium fortuitum
US4214051A (en) * 1977-10-21 1980-07-22 The Upjohn Company Process for preparing 9α-OH BN acid methyl ester
EP0011235A1 (en) * 1978-11-08 1980-05-28 Mitsubishi Kasei Corporation 9-Alpha-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester and methods for the microbiological production thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510138A1 (fr) * 1981-07-24 1983-01-28 Upjohn Co Procede de production du 9-hydroxy-3-oxo-4,17 (20)-pregnadiene-20-carboxaldehyde par fermentation et produit obtenu

Also Published As

Publication number Publication date
HU189135B (en) 1986-06-30
IE821109L (en) 1982-11-11
JPH0157960B2 (ja) 1989-12-08
JPS57198099A (en) 1982-12-04
IT1189273B (it) 1988-02-04
GB2098218B (en) 1985-02-27
DE3215065A1 (de) 1983-01-27
IT8248374A0 (it) 1982-05-10
FR2505360B1 (ja) 1984-01-06
CH650803A5 (de) 1985-08-15
GB2098218A (en) 1982-11-17
DD202308A5 (de) 1983-09-07
IE53238B1 (en) 1988-09-14
US4429041A (en) 1984-01-31
NL8201874A (nl) 1982-12-01
DE3215065C2 (ja) 1989-11-30

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