FR2504532A1 - Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique Download PDF

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Publication number
FR2504532A1
FR2504532A1 FR8108226A FR8108226A FR2504532A1 FR 2504532 A1 FR2504532 A1 FR 2504532A1 FR 8108226 A FR8108226 A FR 8108226A FR 8108226 A FR8108226 A FR 8108226A FR 2504532 A1 FR2504532 A1 FR 2504532A1
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France
Prior art keywords
sep
formula
compounds
group
preparation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
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FR8108226A
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English (en)
French (fr)
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FR2504532B1 (enrdf_load_stackoverflow
Inventor
Jean-Francois Ancher
Patrick Guerret
Michel Langlois
Jacky Tisne-Versailles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8108226A priority Critical patent/FR2504532A1/fr
Priority to CH2230/82A priority patent/CH653021A5/fr
Priority to SE8202363A priority patent/SE449612B/sv
Priority to GB8211125A priority patent/GB2097790B/en
Priority to ZA822640A priority patent/ZA822640B/xx
Priority to US06/370,064 priority patent/US4459296A/en
Priority to LU84099A priority patent/LU84099A1/fr
Priority to CA000401373A priority patent/CA1186308A/en
Priority to GR67966A priority patent/GR76078B/el
Priority to ES512259A priority patent/ES8402300A1/es
Priority to IT8220889A priority patent/IT1190787B/it
Priority to DE19823215269 priority patent/DE3215269A1/de
Priority to JP57067509A priority patent/JPS5823664A/ja
Priority to NL8201708A priority patent/NL8201708A/nl
Priority to AU82981/82A priority patent/AU552345B2/en
Priority to BE0/207910A priority patent/BE892950A/fr
Publication of FR2504532A1 publication Critical patent/FR2504532A1/fr
Priority to ES524976A priority patent/ES524976A0/es
Application granted granted Critical
Publication of FR2504532B1 publication Critical patent/FR2504532B1/fr
Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8108226A 1981-04-24 1981-04-24 Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique Granted FR2504532A1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR8108226A FR2504532A1 (fr) 1981-04-24 1981-04-24 Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique
CH2230/82A CH653021A5 (fr) 1981-04-24 1982-04-13 Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
SE8202363A SE449612B (sv) 1981-04-24 1982-04-15 Piperidin-, piperazin- och homopiperazinderivat, deras framstellningssett och farmaceutisk komposition derav
GB8211125A GB2097790B (en) 1981-04-24 1982-04-16 Piperidine piperazine and homopiperazine derivatives
ZA822640A ZA822640B (en) 1981-04-24 1982-04-19 New piperidino,piperazino and homopiperazino derivatives,n-substituted by an aromatic heterocyclic group,the process for preparing same and their use in therapeutics
US06/370,064 US4459296A (en) 1981-04-24 1982-04-20 Piperazines and homopiperazines, N-substituted by an aromatic heterocyclic group, and their use in therapeutics
LU84099A LU84099A1 (fr) 1981-04-24 1982-04-20 Nouveaux derives piperidino,piperazino et homopiperazino,n-substitues par un groupe heterocyclique aromatique,leur procede de preparation et leur application en therapeutique
CA000401373A CA1186308A (en) 1981-04-24 1982-04-21 Piperidino, piperazino and homopiperazino derivatives, n-substituted by an aromatic heterocyclic group, the process for preparing same and their use in therapeutics
GR67966A GR76078B (enrdf_load_stackoverflow) 1981-04-24 1982-04-22
ES512259A ES8402300A1 (es) 1981-04-24 1982-04-23 "procedimiento para la preparacion de nuevos derivados piperidinicos piperacinicos y homopiperacinicos".
IT8220889A IT1190787B (it) 1981-04-24 1982-04-23 Derivati piperidino,piperazino e omopiperazino n-sostituiti da un gruppo eterociclico aromatico,loro procedimento di preparazione e loro applicazione in terapia
DE19823215269 DE3215269A1 (de) 1981-04-24 1982-04-23 Durch eine heterocyklisch-aromatische gruppe n-substituierte, neuartige piperidin-, piperazin- und homopiperazin-derivate, ihr herstellungsverfahren und ihre anwendung in der therapie
JP57067509A JPS5823664A (ja) 1981-04-24 1982-04-23 新規ｎ−芳香族異環基置換ピペリジン、ピペラジン及びホモピペラジン誘導体、その製造法並びにこれを含有する薬剤
NL8201708A NL8201708A (nl) 1981-04-24 1982-04-23 Nieuwe piperidino-, piperazino- en homopiperazinoverbindingen, die met een aromatische heterocyclische groep n-gesubstitueerd zijn, alsmede werkwijze ter bereiding van deze verbindingen en de therapeutische toepassing daarvan.
AU82981/82A AU552345B2 (en) 1981-04-24 1982-04-23 N-heterocyclyl piperidines, piperazines and homopiperazines
BE0/207910A BE892950A (fr) 1981-04-24 1982-04-23 Nouveaux derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique leur procede de preparation et leur application en therapeutique
ES524976A ES524976A0 (es) 1981-04-24 1983-08-16 Procedimiento para la preparacion de nuevos derivados piperidinicos, piperacinicos y homopiperacinicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8108226A FR2504532A1 (fr) 1981-04-24 1981-04-24 Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2504532A1 true FR2504532A1 (fr) 1982-10-29
FR2504532B1 FR2504532B1 (enrdf_load_stackoverflow) 1984-03-16

Family

ID=9257756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8108226A Granted FR2504532A1 (fr) 1981-04-24 1981-04-24 Nouveaux derives heterocycliques du type benzimidazole, indole et purine, leur procede de preparation et leur application en therapeutique

Country Status (5)

Country Link
JP (1) JPS5823664A (enrdf_load_stackoverflow)
BE (1) BE892950A (enrdf_load_stackoverflow)
FR (1) FR2504532A1 (enrdf_load_stackoverflow)
GR (1) GR76078B (enrdf_load_stackoverflow)
ZA (1) ZA822640B (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
JP4730574B2 (ja) * 2001-05-18 2011-07-20 山田化学工業株式会社 ベンズイミダゾール化合物、アゾベンズイミダゾール化合物とそのキレート化合物
KR20070027584A (ko) * 2004-06-17 2007-03-09 와이어쓰 고나도트로핀 방출 호르몬 수용체 길항제
JP4745645B2 (ja) * 2004-11-16 2011-08-10 住化バイエルウレタン株式会社 樹脂原液櫛型注入装置および樹脂成型体の製造方法

Also Published As

Publication number Publication date
FR2504532B1 (enrdf_load_stackoverflow) 1984-03-16
GR76078B (enrdf_load_stackoverflow) 1984-08-03
BE892950A (fr) 1982-10-25
ZA822640B (en) 1983-03-30
JPS5823664A (ja) 1983-02-12

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