FR2504009A1 - Topical compsns. contg. arnica extract - together with camphor, menthol and surfactant for topical treatment of inflammations and infections - Google Patents

Abstract

Compsns. contg. an antiinflammatory agent such as arnica extract, a sedative such as camphor, a disinfectant such as menthol, a surfactant or penetrating agent such as triethanolamine, and a lipo-aqueous excipient, such as a major amt. of stearine and a minor amt. of water, are new. The compsns. pref. contain 1-4 g arnica extract, 0.1-0.6 g camphor, 0.01-0.08 g menthol, 0.02-0.08 g triethanolamine and 0.5-2 g excipient. Used for topical treatment of inflammatory and/or infectious states affecting the skin, mucous membranes or teeth such as abcesses, boils, blackheads, fever pustules, eczema, haemorrhoids, pruritis, bad teeth, dental abcesses etc. Synergism between the various components gives the compsns. an improved antiinflammatory local analgesic, and cicatrising effect.

Description

 The present invention relates to a new composition with therapeutic action which is effective, in topical application, in the treatment of a wide variety of skin or other disorders or conditions, of a generally inflammatory and / or infectious character.

 This composition is particularly useful for the topical treatment of ailments such as abscesses, boils, panaris, acne (treatment of more or less infected blackheads and blackheads and paculopustules), anthrax, cold sores, eczema, pruritus, ulcers, etc ...

 It is also active, in topical application, for the treatment of hemorrhoids, toothaches, dental abscesses.

 This composition can be used as the sole agent or therapeutic means against the aforementioned disorders and affections or it can be used in combination with a known drug, in particular a topical drug or a drug which can be administered orally or parenterally, and / or with surgical or similar treatment.

 The duration of treatment can range from a few days to a few months, usually one to several weeks. The daily number of topical applications generally ranges from 1 to 6 times. The visibly sick area, which may or may not be a wound, is usefully treated as well as the surrounding area; it may be useful, to increase the effectiveness of the treatment, to wash the wounds beforehand with a disinfectant solution, for example a sterlane solution.

 In summary, the composition according to the invention exhibits an antimicrobial activity, an anti-inflammatory activity and a local analgesic activity, at the same time as a healing activity, so that it rapidly produces healing effects in a large number of affections, cutaneous or other, of various natures.

The composition according to the invention is essentially aractérisée an what it contains, in synergistic association
- an anti-inflammatory agent such as an extract of arnica t
- a painkiller such as camphor
- a disinfectant such as menthol
- a surfactant or penetration agent such as trietha
nolamine
- a lipo-aqueous excipient.

Conforming to a preferred embodiment of the present invention, this composition contains at least the following active principles and excipient, in the respective proportions indicated below.
- arnica extract 1 to 4 g
- camphor 0.1 to 0.6 g
- menthol 0.01 to 0.08 g
- triethanolamine 0.02 to 0.08 g
- lipo-aqueous excipient 0.5 to 2 g, said lipo-aqueous excipient containing in particular a major proportion of stearin and a minor proportion of water.

 The aforementioned composition further comprises one or more of the following constituents which confer either an additional therapeutic activity, or an action for preserving the composition, or properties making the use of said composition more pleasant or easier: vulnerable alcoholate, essence of geranium, chamomile essence, lavender essence, tincture of horse chestnut, rose water, vaseline oil, glycerin, coumarin, iodinated methyl oarahydroxybenzoate, ethyl paraminobenzoate, butyl paraaminobenzoate, saffron stigmas.

 The extract of arnica used is preferably constituted by a fluid extract of arnica montana which is optionally used in combination with tincture of arnica (low concentrated aqueous solution, less effective than the extract of arnica) .

The composition of the invention corresponds in particular to the more limiting composition below
- fluid extract of arnica montana 1 to 4 g
- alcoholate vulnerable 0 to 3 g
- camphor 0.1 to 0.6 g
- essence of geranium 0 to 0.155 g
- chamomile essence 0 to 0.015 g
- ionone 0 to 0.080 g
- lavender essence 0 to 0.155 g
- menthol 0.01 to 0.08 g
- ethyl paraaminobenzoate 0 to 0.150 g
- butyl paraaminobenzoate 0 to 0.075 g
- tincture of horse chestnut O at 0.100 g
- rose water 0 to 0.155 g
- tincture of arnica O at 0.150 g
- stearin 0.5 to 2 g
- petrolatum oil 0 to 0.750 g
- triethanolamine O at 0.090 g
- coumarin 0 to 0.005 g
- glycerin O at 0.150 g
- sodium methyl parahydroxybenzoate O at 0.090 g
- possibly some stigma
saffron
- distilled water 0.025 to 0.100 g
A particular embodiment of a composition in accordance with the invention is given below, which is in the form of a cream:
- fluid extract of arnica montana about 2,000 g
- alcoholate vulnerable about 1,500 g
- camphor about 0.300 g
- essence of geranium about 0.077 g
- chamomile essence about 0.00? g
- ionone about 0.040 g
- lavender essence about 0.077 a
- menthol about 0.042 g
- ethyl paraaminobenzoate about 0.095 g
- butyl paraaminobenzoate about 0.03? g
- horse chestnut tincture about 0.050 g
- rose water about 0.077 g
- tincture of arnica about 0.075 g
- stearin about 1.050 g
- petrolatum oil about 0.37 g
- triethanolamine about 0.045 g
- coumarin about 0, OC2 g
- glycerin about 0.075 g
- methyl parahydroxybenzoate
soda approx. 0.045 g
- possibly some stigma
saffron
- distilled water about 0.050 g
An example of therapeutic treatment is given below using a composition in accordance with the invention.

A 63-year-old woman had a right leg abscess. This abscess was refractory to conventional medications, none of which had resulted in significant improvement. The cream of the above example was then applied topically, at the rate of 4 to 6 times per day, on the abscess itself and on the surrounding region, a few grams with each application; we noticed that the cream was absorbed spontaneously by the abscess; the abscess opened after the 4th day of treatment; the above-mentioned applications were then continued and, simultaneously, the open abscess (wound) was cleaned several times a day with a disinfectant solution (sterlane solution). The patient did not have a fever, before and selling the treatment, we then continued to apply the cream for a few days, twice a day, while continuing to wash with the disinfectant solution. There was no recurrence of abscess in this area in the first two years following this treatment, i.e.
March 1979 to March 1981 (patient subject to repetitive abscesses).

 Of course, the above examples have been given only by way of non-limiting illustration and all other embodiments, variants or equivalent means, within the reach of ordinary skill in the art, also forms part of the present invention.

Claims (5)

 1. Composition for the tonic treatment of various symptoms of an generally inflammatory and / or infectious nature, affecting in particular the skin, the mucous membranes and the dental apparatus, such as abscesses, boils, oanaris, blackheads, fever blisters, eczema, hemorrhoids , pruritus, toothache, dental abscess or the like, characterized in that it contains, in synergistic association that  - an anti-inflammatory agent such as an extract of arnica  - a painkiller such as camphor  - a disinfectant such as menthol  - a surfactant or penetrating agent such as triethanolamine  - a lipo-aqueous excipient.  2. Composition according to claim 1, characterized in that it contains  - an arnica extract 1 to 4 g  - camphor 0.1 to 0.6 g  - menthol 0.01 to 0.08 g  - triethanolamine 0.02 to 0.08 g  - Excess lipo-aqueous 0.5 to 2 g said lip-aqueous excipient containing in particular a major proportion of stearin and a minor proportion of water.  3. Composition according to claim 1 or 2 characterized in that it also contains one or more of the following constituents: vulnerable alcoholate, geranium essence, chamomile essence, lavender essence, horse chestnut tincture, rose water , petrolatum oil, glycerin, coumarin, iodinated methyl parahydroxybenzoate, ethyl oaraaminobenzoate, butyl oaraaminobenzoate, ionone, saffron stigmas.  4. Composition according to any one of the preceding claims, characterized in that the abovementioned arnica extract consists of a fluid extract of arnica montana which is optionally used in combination with tincture of arnica .  5. Composition according to any one of the preceding claims, characterized in that it corresponds to the following formulation fluid extract of arnica montana 1 to 4 g  (preferably about 2,000 g) alcoholate vulnerable 0 to 3 g Oà3g  (preferably about 1,500 g) - camphor 0.1 to 0.6 g  (preferably about 0.300 g) - essence of geranium O at 0.155 g  (from nreférenae about 0.077 g) - chamomile essence 0 to 0.015 g  (from reference approximately 0.007 g) - ionone 0 to 0.080 g  (preferably about 0.040 g) - lavender essence O at 0.155 g  (preferably about 0.077 g) menthol 0.01 to 0.08 g  (preferably about 0.042 g) - ethyl paraaminobenzoate O to 0.150 g  (preferably about 0.075 g) - butyl paraaminobenzoate O at 0.075 g  (preferably about 0.03? g) - tincture of horse chestnut O at 0.100 g  (reference approximately 0.050 g) - rose water O at 0.155 g  (preferably about 0.077 g) - stearin  0.5 to 2 g  (preferably about 1.050 g) - tincture of arnica O at 0.150 g  (reference approximately 0.095 g) - petrolatum oil 0 to 0.750 g  (preferably about 0.375 g) triethanolamine O at 0.090 g  (preferably about 0.045 g) coumarin 0 to 0.005 g  (preferably about 0.002 g) glycerin 0 to 0.150 g  (preferably about 0.095 g) - sodium methyl parahydroxybenzoate 0 to 0.090 g  (preferably about 0.045 g) - possibly some stigma  saffron - distilled water 0.025 to 0.100 g  (preferably about 0.050 g)