FR2497665A1 - Capsule molle gastro-resistante de fluorure de sodium a haute dose, et procede d'obtention d'une telle capsule - Google Patents
Capsule molle gastro-resistante de fluorure de sodium a haute dose, et procede d'obtention d'une telle capsule Download PDFInfo
- Publication number
- FR2497665A1 FR2497665A1 FR8100430A FR8100430A FR2497665A1 FR 2497665 A1 FR2497665 A1 FR 2497665A1 FR 8100430 A FR8100430 A FR 8100430A FR 8100430 A FR8100430 A FR 8100430A FR 2497665 A1 FR2497665 A1 FR 2497665A1
- Authority
- FR
- France
- Prior art keywords
- sodium fluoride
- sodium
- oil
- capsules
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 title claims abstract description 46
- 239000002775 capsule Substances 0.000 title claims abstract description 30
- 239000011775 sodium fluoride Substances 0.000 title claims abstract description 23
- 235000013024 sodium fluoride Nutrition 0.000 title claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 229920000159 gelatin Polymers 0.000 title claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 title claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 title claims description 7
- 239000008273 gelatin Substances 0.000 title claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 title claims description 7
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims abstract description 10
- 235000019483 Peanut oil Nutrition 0.000 claims abstract description 8
- 239000000312 peanut oil Substances 0.000 claims abstract description 8
- 239000007766 cera flava Substances 0.000 claims abstract description 7
- 229920002545 silicone oil Polymers 0.000 claims abstract description 7
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 13
- 239000008173 hydrogenated soybean oil Substances 0.000 claims description 7
- 239000004402 sodium ethyl p-hydroxybenzoate Substances 0.000 claims description 6
- 235000010226 sodium ethyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 239000004404 sodium propyl p-hydroxybenzoate Substances 0.000 claims description 6
- 235000010230 sodium propyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 claims description 6
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 claims description 6
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- 235000019482 Palm oil Nutrition 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- 239000002540 palm oil Substances 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 208000001132 Osteoporosis Diseases 0.000 abstract description 3
- 206010033103 otosclerosis Diseases 0.000 abstract description 3
- 210000004051 gastric juice Anatomy 0.000 abstract description 2
- 239000001828 Gelatine Substances 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 abstract 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002702 enteric coating Substances 0.000 description 2
- 238000009505 enteric coating Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 125000005498 phthalate group Chemical class 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8100430A FR2497665A1 (fr) | 1981-01-09 | 1981-01-09 | Capsule molle gastro-resistante de fluorure de sodium a haute dose, et procede d'obtention d'une telle capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8100430A FR2497665A1 (fr) | 1981-01-09 | 1981-01-09 | Capsule molle gastro-resistante de fluorure de sodium a haute dose, et procede d'obtention d'une telle capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2497665A1 true FR2497665A1 (fr) | 1982-07-16 |
| FR2497665B1 FR2497665B1 (cs) | 1984-08-31 |
Family
ID=9254044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8100430A Granted FR2497665A1 (fr) | 1981-01-09 | 1981-01-09 | Capsule molle gastro-resistante de fluorure de sodium a haute dose, et procede d'obtention d'une telle capsule |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2497665A1 (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859467A (en) * | 1986-09-25 | 1989-08-22 | Colgate-Palmotive Company | Sustained release fluoride composition |
| US4861590A (en) * | 1986-09-25 | 1989-08-29 | Colgate-Palmolive Company | Sustained release fluoride and calcium composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1135709A (en) * | 1966-11-09 | 1968-12-04 | Merck Ag E | Stabilised pharmaceutical preparations containing bromelain |
| FR1599474A (cs) * | 1968-12-27 | 1970-07-15 | ||
| FR2383661A1 (fr) * | 1977-03-19 | 1978-10-13 | Blendax Werke Schneider Co | Produit pour soins dentaires et buccaux |
-
1981
- 1981-01-09 FR FR8100430A patent/FR2497665A1/fr active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1135709A (en) * | 1966-11-09 | 1968-12-04 | Merck Ag E | Stabilised pharmaceutical preparations containing bromelain |
| FR1599474A (cs) * | 1968-12-27 | 1970-07-15 | ||
| FR2383661A1 (fr) * | 1977-03-19 | 1978-10-13 | Blendax Werke Schneider Co | Produit pour soins dentaires et buccaux |
Non-Patent Citations (2)
| Title |
|---|
| DR. B. HELWIG et al: "MODERNE ARZNEIMITTEL", édition 5, 1980, Wissenschaftliche Verlagsgesellschaft mbH, STUTTGART (DE) * |
| w. KERN et al.: "HAGERS HANDBUCH DER PHARMAZEUTISCHEN PRAXIS", vol. 7, partie A, 1971, Springer Verlag, BERLIN (DE) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859467A (en) * | 1986-09-25 | 1989-08-22 | Colgate-Palmotive Company | Sustained release fluoride composition |
| US4861590A (en) * | 1986-09-25 | 1989-08-29 | Colgate-Palmolive Company | Sustained release fluoride and calcium composition |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2497665B1 (cs) | 1984-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |