FR2495933A1 - WATERPROOFING COMPOSITION CONTAINING ALUMINUM CHLORHYDRATE, ALUMINUM CHLORIDE, AND A COMPLEX ALUMINUM AND ZIRCONIUM POLYCHLORHYDRATE AND METHOD OF USING THE SAME - Google Patents

Abstract

The invention relates to a composition against perspiration. THE COMPOSITION OF THE INVENTION, BUFFERED AT A PH OF APPROXIMATELY 2.5 TO ABOUT 4.5, CONTAINS AS ACTIVE INGREDIENTS A FORMED ASSOCIATION OF ALUMINUM HYDROCHLORIDE, ALUMINUM CHLORIDE AND A COMPLEX OF POLYCHLORIDE D '. ALUMINUM AND ZIRCONUM; AN ADDITIONAL BUFFERING AGENT, PREFERABLY GLYCINE, MAY BE INCORPORATED IN THE COMPOSITION. THE COMPOSITION OF THE INVENTION IS VERY EFFICIENT, IT SLIGHTLY IRRITATES THE SKIN AND OR IT DOES NOT DAMAGE THE TISSUES.

Description

The present invention relates to compositions against perspiration.

  It more particularly relates to compositions against perspiration which are

  incorporated aluminum chlorohydrate, aluminum chloride,

  minium, a polyhydrochloride complex of aluminum and

  zirconium and a buffering agent, for example glycine.

  It has been known for many years that aluminum chlorohydrate (ACH) is a safe and effective agent against perspiration. Nevertheless, this product leaves much to be desired and research is constantly pursued to find more effective materials against perspiration. It has also been known for some time in the prior art that aluminum chloride and

  zirconium salts are exceptional substances

  nally effective against perspiration. However, solutions of aluminum chloride hexahydrate and oxychloride or zirconium hydroxychloride are very acidic and, consequently, they are not widely used alone because of their irritating power and the great danger they present for tissues. As a result, various efforts have been focused on raising the pH to a value of 3-4 through the use of less acidic aluminum salts and the incorporation of organic compounds.

containing nitrogen.

  U.S. Patent Nos. 2,814,584, 2,814,585 and 2,854,382 have shown that when

  zirconium oxychloride or zirconium hydroxychloride

  conium were buffered with ACH and glycine, the efficacy against sweating was greater than when ACH was used alone. Since then, the combination of aluminum chlorohydrate, zirconium hydroxychloride and glycine has been widely used as very

  effective against sweating.

  U.S. Patent No. 3,792,068 discloses a method for preparing a composition

  against perspiration, which consists of spray drying

  a solution containing, for example, ACII, zirconyl hydroxychloride and glycine. It is claimed that this association has superior characteristics that it does not possess when the components

  are dried separately and combined by simple physical blending

  than. The British patent N0? 347,950 discloses the use of an association between ACH and chloride

  of aluminum as an effective material against perspiration.

  This combination has been particularly useful in an aerosol composition. However, as in the case of other perspiration materials known in

  the prior art, it still leaves something to be desired.

  Other perspiration compositions containing aluminum and zirconium salts have been reported, for example in US Pat. Nos. 2,906,668, 3,979,510, 3,981,896, 599, No. 3,407,254, No. 3,970,748, No. 4,202,879, etc. The activity against perspiration of all these salts described in the aforementioned patents has not been clearly claimed to be superior to that of compositions containing

  zirconium hydroxychloride, ACH and glycine.

  Although it has been suggested to use indivi-

  aluminum chloride, aluminum hydrochloride,

  Zirconylhydrochloride chloride and certain chlorhy-

  complexes of aluminum and zirconium as anti-perspiration materials, in the prior art, and that it has

  It has been suggested to use aluminum chloride together

  and aluminum chlorohydrate, on the one hand, and

  aluminum chlorohydrate and zirconium hydroxychloride

  As an active antiperspirant composition, it has unexpectedly been found that the combination of aluminum chloride, aluminum chlorohydrate, aluminum complex polyhydrochloride and zirconium as defined more particularly hereinafter, produced an effect

  synergistic and showed, at the same concentration of

  these actives, a higher degree of activity against the trans-

  It may not be expected from the level of activity of the individual ingredients or certain combinations of ingredients which are known in the prior art. In combination with a buffering agent such as glycine, these materials are a very effective agent against perspiration, having a low power of irritation of the skin.

  skin and / or tissue damage.

  The present invention therefore aims to find

  very effective compositions against perspiration.

  The purpose of the invention is also to find

  a method for inhibiting perspiration on the skin of

  by the application to the skin surface of

  perspiration positions indicated above.

  Other features and advantages of the

  will appear from the detailed description which will

to follow.

  In the following description, unless specified

  contrary, the percentages are expressed by weight

  port to the total weight of the composition.

  The aluminum chloride which is incorporated in the compositions of the present invention may be aluminum chloride hydrated to varying degrees. However, aluminum chloride hexahydrate (AlCl 3 · 6H 2 O) has been shown to be very effective and is therefore preferred for the purpose of the present invention. The amount of aluminum chloride that can be incorporated into the composition of the invention may vary

  slightly. In general, aluminum chloride is incor-

  to these compositions in a proportion of about 0.5 to about

  6% by weight on an anhydrous basis relative to the total weight of the composition. In the form of hexahydrate (AlCl3.6H2O), it is incorporated at a concentration of about 0.9 to about 11% by weight based on the total weight of the composition, the preferred range being from about 2 to about 6% on the

same basis.

  Aluminum chloride hexahydrate is usually

  incorporated in the composition of the invention in the form of a 50% aqueous solution. When selected in this form, it is used in a proportion of about 1.8 to about 22% by weight of the composition based on the weight

total of the latter.

  Aluminum chlorohydrate (sometimes referred to as aluminum chlorohydroxide) can also be incorporated into

  variable amounts to the composition of the invention.

  Typically, it is used in a proportion ranging from about 1 to about 15% by weight on an anhydrous basis, based on the total weight of the composition, the preferred proportion being in the range of about 2 to about% by weight on the weight basis train. Aluminum chlorohydrate is also presented as a 50% aqueous solution. When used in this form, it is at a concentration of about 2.6 to about

  38% by weight based on the total weight of the composition.

  ACH and aluminum chloride may be added to this composition in whole or in part in the form of a powder mixture as described in British Patent No. 1,347,950. This mixture can be prepared by drying a aqueous solution of aluminum chloride

  hexahydrate and ACH using standard techniques

  drying, for example oven drying, drying at

  vacuum oven, spray drying or freeze-drying

  tion. These compositions are characterized in that the molar ratio of aluminum to chloride is in a range from about 0.8: 1 to about 1.95: 1, with the preferred range being about 1.2: 1 at about 1.5: 1. When the molar ratio of aluminum to chloride is less than 1, the addition of larger amounts of buffering agent, for example glycine, may be necessary to reduce

  Irritancy and tissue damage

  The complex polychlorhydrates of aluminum and zirconium which can be incorporated into the composition

  of the present invention may be defined by the

  general mule: (I) AlxZr (OH) yCIz. nCH2COOH. MH20

NH2

  wherein: (a) x is a number from 2 to 10; (b) Z is a number from 3 to 8; (c) X is (3x + 4) - Z; (d) the summation y + Z is a number from 10 to 34; (e) m is a number from 0 to 12; (fn is a number from 0 to 3, x being normally from about 5 to about 29. As is evident from formula I, glycine may be complex-bound or may be absent. glycine in the complex determines the amount of unbound glycine or other buffer that can be incorporated into the composition to raise the pH to about 2.5 to about 4.5

  or at the preferred pH value of about 2.8 to about 3.8.

  Several aluminum and zirconium complex polychlorhydrates known in the prior art can be used for the purposes of the invention. As an example, we can mention the following, which we also give the

  crude formulas: aluminum tetrachlorohydrate and zinc

  conium (Al4Zr (OH) 12Cl4); glycine tetrachlorohydrate

  and zirconium (Wickenol N E-369) (Al4Zr (OH) 12C14.

  NH2CH2COOH); aluminum trihydrochloride and zirconium (Al4Zr (OH) 13Cl3); glycine-trihydrochloride of aluminum and zirconium (Al4Zr (OH) 13Cl3 .NH2CH2COOH); pentachlorohydrate

  aluminum and zirconium (Al10Zr (OH) 29Cl5); glycine

  aluminum and zirconium pentachlorohydrate (Al10Zr (OH) 29C15.NH2CH2COOH); aluminum and zirconium octachlorohydrate (Al6Zr (OH) 14C18); glycineoctachlorhydrate

  aluminum and zirconium (Al6Zr (OH) 14C18.NH2CH2COOH).

  The complex aluminum zirconium polychlorhydrate can be individually blended with ACH and AlCl3.6H2O in solution or as a powder or in various combinations. The Food and Drug Administration's OTC team appreciating the antiperspirant compositions has adopted a certain nomenclature and standards for various aluminum and zirconium polychlorhydrates which are useful in the present invention. The following Table A summarizes the following: Nomenclature adopted by the working group Aluminum trihydrochloride and zirconium tetrachlorohydrate of luminium and zirconium Pentachlorhydr.It of aluliniumi and zirconium Aluminum octachlorhydrate e-zirconium Plusiurs and zirconium qu!

TABLE A

  Range of metal-halide ratios 2.1 to 1.571 not included

1.5 to 0.951

  included 2.1 to 1.5: 1 not included n1.5! 0, D m. 1Cc 7lmS Range of Al / Zr ratios 2.0 to 6.0: 1 not included 2.0 to 6.0: 1. not included

6.0 to 10.0: 1

ic read

6.0 to 10.0: 1

  Included aluminum complex polychlorhydrates are useful in the present invention are commercially available. The Reheis Chemical Company, based on the trademark "ZAL3", is sold under the trademark "ZAL3".

  several of these products and indicates their characteristics.

c:

1 "REZAL 36G"

2 "REZAL 36"

3 "REZAL 67"

4 "REZAL 67"

TABLE I

  Glycine-aluminum tetrachlorohydrate complex (solution) aluminum and zirconium trihydrochloride (powder) aluminum and zirconium pentachlorohydrate (solution) aluminum and zirconium pentachlorohydrate (powder) Al / Zr ratio apprcximative 3, 6: 1 Ratio metal / Cl approx 1.4: 1 Concentration of solids iv 35% Aluminum (Ai) 5.0% -5.7% Zirconium (Zr) 4.4% -5.7% Glycine 3.6 % -4,7% Chloride (Cl) 5, 9% -6,7% Iron (Fe) NM 50 ppm Heavy metals expressed in Pb) NSl 10 ppm Particle diameter passing through a 44-μm sieve

mesh) -

3.6: 1 1.6: 1%

16.3% -17.7%

13.8% -15.2%

16.0% -19.0%

Pon 6.7: 1 1.7: 1 ov40%

7.6% -8.4%

3.7% -4.3%

6.5% -7.2%

NM! 50 ppm NMT 20 pp NMT 10 ppmn

> 97% min ---

6.7: 1 1.7: 1%

19.0% -21.0%

9.2% -10.8%

16.2% -18.0%

  NRT 100 ppm NMtT 20 ppm> 97% min Similar products are sold by Wickhen Products, Inc. and by Comet Chemical Corporation. The amount of any complex polychlorhydrate

  of aluminum and zirconium which are incorporated into

  The position of the present invention may also vary to some extent. Usually, it is used at a concentration in the range of about 5 to about 16% by weight on an anhydrous basis based on the total weight

  of the composition. In the recommended forms of the invention

  concentrations are in the range of about 8 to about 14% by weight on an anhydrous basis relative to

total weight of the composition.

  The preferred complex aluminum and zirconium polychlorhydrate according to the invention is the complex

  glycine and aluminum tetrachlorohydrate and zinc

  Conium. It is usually used at a concentration of

  5 to about 16% by weight on an anhydrous basis relative to the total weight of the composition, the preferred concentration being in the range of about 8 to about 14% on the

  same weight basis. The glycine and tetra-complex

  Aluminum chlorohydrate and zirconium is presented as a 35% aqueous solution. When using it

  in this form, it is usually incorporated into the

  of the present invention in a range of from about 18 to about 60% by weight based on

of the total weight of the composition.

  Glycine, which is the preferred buffering agent, is

  an important component of the composition of the invention.

  It can be incorporated as free glycine or as part of the aluminum polyhydrochloride complex and

  zirconium or both. In general, total glycine

  of these compositions (i.e. free glycine, complexed glycine or a mixture of both) is in the range of about 0.5 to about 5% by weight.

  weight based on the total weight of the composition. Toute-

  times, the preferred range of total glycine ranges from about 1.5

  at about 3% on the same weight basis.

  Other buffering or complexing agents, in addition to glycine, may also be used in the present invention. For example, other amino acids or their salts

  (such as sodium glycinate, dihydroxy glycinate

  aluminum), urea, a nitrogen-containing organic base, a hydroxide, carbonate and metal oxide containing an alkali metal or alkaline earth metal (Mg (OH) 2, Na2CO3, ZnO, etc.). These buffering agents may be used alone or together with glycine to give the composition a pH in the range of 2.5 to 4.5 (preferably

2.8 to 3.8).

  These complexing agents and buffering agents serve

  to reduce the irritating power and the alteration of the tissues.

  They also have the effect of stabilizing the composition

against perspiration.

  The compositions of the present invention can affect various forms containing active doses. Thus, they may be emulsion products or clear products

  hydro-alcoholic or aqueous applied using a ball.

  Aqueous solutions of ammonium chloride, ACH, aluminum polyhydrochloride complex and zirconium and a buffering agent such as glycine can be spray dried into an impalpable powder. We can

  use them as is or incorporate them into sticks

  cators, suspensions, powders or products

applied with a ball.

  Although the compositions of the present invention may affect various forms, they are found to be very effective in a system that contains a relatively high amount of water. They may affect the form of a solution or emulsion in which the active ingredients (i.e., aluminum chloride, ACH, aluminum zirconium polychlorhydrate complex, and buffer ) are contained in the aqueous phase. These aqueous emulsion systems are appreciated because they give more elegant compositions from the point of view

  organoleptic. These emulsion systems are usually

  oil-in-water type, o the active ingredients

  are present in the continuous aqueous phase.

  The amount of water that can be contained in

  these compositions may vary to some extent.

  Usually it is from about 40 to about 80% by weight based on the total weight of the composition, the preferred range being from about 60 to about 75% on the

same weight basis.

  The emulsion-type products of the present invention may also contain other ingredients ordinarily found in the lotion-like or emulsion-type perspiration composition. They include components such as emollients, surfactants, sequestering agents, perfumes, dyestuffs, etc. As a representative example of the emollients which can be used in accordance with the invention, mention may be made of fatty acid esters (isopropyl myristate, isopropyl palmitate) 3; diesters of dicarboxylic acids (adipate diisopropyl),

  polyoxyalkyl esters (glycols (polyolefin mono-oleate)

  propylene glycol 2f000) - diesters of propylene glycol of fatty acids with short chain (C8-C10) ("Neobee M-20"); polyoxyethylene ethers, polyoxyethylene ethers, ethylbenzyl ethers, pyrrolidone ethers, ethylene glycol ethers and the like, a mono-propoxy alcohol. ## STR2 ## ("Fluid AP"), a fatty aloe-alcohol (eg, d) ethyl alcohol), silicone oils (di.n. the viscosity range is 105 to 2.10-3 m 2 / s), e ..

  7207 and 7158-Union. DTD: C-arethoxy-naphthalene-polyoxypropylidene

  that 'Prorety': 'U ..'., odified, "-i7conol APES" .. Liquids not po. above-mentioned. You are alone, in the midst of the ends of the invention. the above-mentioned menoils are organic oily fluids of the type ## STR1 ## having air at a vapor point at atmospheric pressure of less than about 120 ° C;

  (b) a density of between 0.7 and 1.6, preferably

between 0.7 and 1.2.

  The amount of emollient used varies to a certain extent, with the concentration typically being in the range of about 1 to about 30% by weight based on the total weight of the coating. composition. Preferably, this amount is in the range of about 2 to about 15%

  by weight on the weight basis rame.

  Various surfactants and various combinations of surfactants can also be used in the preparation of the products of the invention of the lotion or emulsion type. These are materials such as surfactants

  nonionic, cationic and amphoteric materials that can be

  to be used in emulsion systems against perspiration.

  Examples are given below: I. Nonionic Surfactants 1. Polyoxyethylene fatty ethers - "Brij 30", "Brij 35", "Brij 72", "Brij 78", etc.

  2. Polyoxypropylene-polyoxy-fatty ethers

  Ethylenic - "Procetyl AWS", "Witconol APEM", "Witconol APES", etc.

  3. Polyoxyethylenic alkyl and phenyl ethers -

"Igepal CO 530", etc.

  4. Polyoxyethylene fatty acid esters

  sorbitan - "Tween 20", "Tween 80", etc. 5. Fatty acid esters of sorbitan - "Span 60", "Span 85", etc. 6. Lanolin ethers - "Laneto 50", "Solulan 98", etc.

  7. Fatty alcohols and polyoxyethylene fatty ethers

  - "Promulgen G", "Polawax", etc. II. Cationic surfactants

  N- (lauryl-colamino-formylmethyl) chloride

pyridinium ("Emcol E607L").

III. Amphoteric surfactants

  Imidazoline of coconut ("Monateric CA" -

%) IV. Auxiliary surfactants

  1. Glyceryl esters of fatty acids - mono-

glyceryl stearate.

  2. Fatty acid amides - "Witcamide 70" (Witco

Chem. Co.).

  3. Fatty alcohols - stearyl alcohol.

  As in the case of emollients, the quantity

  used may vary to some extent. The most

  this amount is in a range of about 1 to about 10% by weight on an anhydrous basis relative to the total weight of the composition, the preferred range being from about

  2 to about 6% on the same weight basis.

  As indicated above, one of the classical systems

  The antiperspirants used in the prior art are a complex of glycine and aluminum and zirconium hydrochloride. The system of the invention offers the following advantages over this conventional system:

  1. Low price of ingredients. The classical system

  The above is much more expensive than AlC13.6H20 or ACH. 2. Better stability of the emulsion and more

  great ease of manufacture. Systems that are directly

  of glycine and Al / Zr polychlorhydrate are

  difficult to stabilize and produce in the form of emul-

sions.

  3. Low ability to stain tissue. generation

  Al / Zr glycine and polyhydrochloride salts are

  stain more than aluminum salts.

  Other details of the invention emerge from the following examples. However, it should be noted that

  the invention is not limited to these examples.

EXAMPLE i

  Formula 1908 Ingredients% by weight PPG-11 and stearyl ether 2.25 Polyoxyethylene (2) and stearyl ether 1.65 Polyoxyethylene (20) and stearyl ether 0.60 Perfume 0.30 Disodium edetate dihydrate 0 Deionized Water 35.40 50% Aluminum Chlorhydroxide 18.00 50% Aluminum Chloride Hexahydrate Solution 6.00 Amino Acetic Acid (Glycine Crystal USP) 0.50 Glycine Complex Solution and of 35% aluminum tetrachlorohydrate and 35% zirconium 35.00 FD & C N 1 blue dye (0.1% aqueous solution) 0.20, 00 Appearance: homogeneous opaque lotion Color: pale blue pH: 3.3 + 0, 3 Viscosity: spindle N 3 at 20 rpm, 15 seconds

  Viscosity after resting during the night: 500-1500 mPa.s.

  Procedure: 1. In a suitable stainless steel container,

  melting together polyoxypropylene ethers of

  fatty cools, polyoxyethylene (2) -stearyl ether and polyoxyethylene (20) -stearyl ether by heating to 60 C. Add the perfume and shake just before step 3. 2. In a separate stainless steel container, dissolve edetate disodium in water and heat to

60 C.

  3. Slowly add the oil phase to the aqueous phase (both at 60 C) using a blender

  Lightnin, at low stirring speed. Maintain the weather

  at 60 ° C. for 15 minutes.

  4. Working at 60 ° C, slowly add to the mixture with slow stirring a solution of aluminum chlorhydroxide, aluminum chloride hexahydrate, glycine

  and glycine-aluminum tetrachlorohydrate complex solution

  minium and zirconium which has been previously heated to

  C. Continue shaking and cool the mixture to 51.7 ° C.

  Shake for 15 minutes, keeping the temperature of the

mixture at 49r51.7 C.

  5. Cool the mixture to 40.5 C, add it.

  dye solution and continue stirring with

health.

  6. When the temperature of the mixture reaches

  26.7-29.4 ° C, discontinue agitation and possibly compensate for

loss of water.

EXAMPLE 2

  The composition and the procedure of Example 1 are used, with the difference that instead of the PPG-11 and stearyl ether, the product "Arlamol

  ESP "(PPG-15 and stearyl ether).

EXAMPLE 3

  Formula 1956 Following the procedure of Example 1, the following composition is prepared: Ingredients Ether PPG-11 and Stearyl Ether Polyoxyethylene (2) and Stearyl Ether Polyoxyethylene (20) and Stearyl -e Perfume Edetate disodium dihydrate Deionized water

Butylated hydroxytoluene -

  50% Aluminum Chlorhydroxide 50% Solution Aluminum Chloride Hexahydrate Amino Acetic Acid (Glycine Crystal USP)

Glycine complex solution

  aluminum and red zirconium tetrachloride D & C N0 19 (aqueous solution

at 0.1%)

Yellow D & C N 10 (aqueous solution

at 0.1%)

  % by weight 2,25 1,65 0,60 0,32 0,10, 13 0,05 18,00 6,00 0,50, 00 0,08 0, 32, 00 Appearance: opaque homogeneous lotion Color: pink pH: 3.3 + 0.3 Viscosity: spindle N 3 at 20 rpm, 15 seconds

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 4

  The composition and the procedure of Example 3 are adopted, with the difference that the PPG-11 and stearyl ether is replaced by the product "Arlamol ESP" (ether

PPG-15 and stearyl).

EXAMPLE 5

  The procedure of Example 1 is followed to prepare the following composition: Ingredients Ether of PPG-11 and stearyl Ether of polyoxyethylene (2) and stearyl Ether of polyoxyethylene (20) and stearyl Perfume Edetate disodium dihydrate Water Deionized 50% Aluminum Chlorhydroxide 50% Ammonium Chloride Solution 50% Amino Acetic Acid (Glycine Crystal USP)

Glycine complex solution

* Aluminum and zirconium tetrachlorohydrate, 35% Blue FD & C N 1 (aqueous solution

at 0.1%)

% by weight 2.25 1.65 0.60

0.30 -

  0.10 31.40 12.00 6.00 0.50, 00 0.20, 00 Appearance: homogeneous, opaque lotion Color: pale blue pH: 3.3 + 0.3 Viscosity: N 3 spindle at 20 rpm min, 15 seconds

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 6

  The procedure and the composition of Example 5 are adopted, except that the PPG-11 and stearyl ether is replaced by the product "Arlamol ESP" (ether

PPG-15 and stearyl).

EXAMPLE 7

  Formula 1979 The procedure of Example 1 is followed to prepare the following composition: Ingredients Ether of PPG-11 and Stearyl Ether of Polyoxyethylene (2) and Stearyl Ether of Polyoxyethylene (20) and Stearyl Perfume Disodium Edetate Hydrate Deionized Water 50% Aluminum Chlorhydroxide 50% Aluminum Chloride Solution 50% Amino Acetic Acid (Glycine Crystal USP)

Glycine complex solution

  aluminum and zirconium tetrachlorohydrate, 35% Blue FD & C N0 1 (aqueous solution

at 0.1%)

  % by weight 2,25 1,65 0,60 0,30 0,10, 40, 50 8,00 1,00, 00 0,20, 00 Appearance: homogeneous opaque lotion Color: pale blue pH: 3,3 + 0.3 Viscosity: spindle N0 3 at 20 rpm, 15 seconds

  Viscosity after resting overnight: 500-2000 mPa.s.

EXAMPLE 8

  The composition and the procedure of Example 7 are adopted, except that the PPG-11 and stearyl ether is replaced by the product "Arlamol ESP" (ether

PPG-15 and stearyl).

3C EXAMPLE 9

  Formula 1991 The procedure of Example 1 was followed to prepare the following composition: -17 Ingredients Ether of PPG-11 and Stearyl Ether Polyoxyethylene (2) and Stearyl Ether Polyoxyethylene (20) and stearyl Perfume Disodium edetate dihydrate Deionized water 50% aluminum chlorhydroxide 50% aluminum chloride hexahydrate solution Amino acetic acid (Glycine Crystal USP)

Glycine complex solution

  35% aluminum and zirconium tetrachloride Blue FD & C N 1 (aqueous solution

at 0.1%)

  % by weight 2,25 1,65 0,60 0,30 0,10 31,40, 00 8,00 0,50, 00 0,20, 00 Appearance: lotion opaque, homogeneous Color: pale blue pH: 3, 3 + 0.3 Viscosity: spindle N 3 at 20 rpm, 15 seconds

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 10

  The composition and the procedure of Example 9 are adopted, except that the PPG-11 and stearyl ether is replaced by the product "Arlamol ESP" (ether

PPG-15 and stearyl).

EXAMPLE 11

  Formula 1955 The procedure of Example 1 is followed to prepare the following composition: Ingredients Ether of PPG-11 and Stearyl Ether of Polyoxyethylene (2) and

of stearyl -

  Polyoxyethylene (20) and Stearyl Ether Fragrance Disodium Edetate Dihydrate Deionized Water 50% Aluminum Chlorhydroxide 50% Aluminum Chloride Solution 50% Amino Acetic Acid (Glycine Crystal USP)

Glycine complex solution

  aluminum tetrachlorohydrate and zirconium% by weight 2,25 1,65 0,60 0, 30 0,10, 60 18,00 6,00 0,50, 00, 00 Appearance: lotion opaque, homogeneous Color: white pH : 3.3 + 0.3 Viscosity: spindle N 3 at 20 rpm, 15 seconds

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 12

  The composition and the procedure of Example 11 are adopted, except that the PPG-11 and stearyl ether is replaced by the product "Arlamol ESP".

(PPG-15 and stearyl ether).

EXAMPLE 13

  Formula BA 1810-64 Aluminum trihydrochloride is used and

  zirconium powder. The number following the term

  In this example as well as in the others, the hydrochloride represents the Al / Zr molar ratio in the compound.

  for example, 31 denotes an Al / Zr molar ratio of 3/1.

  Elemental Emulsion A Ether of PPG-11 and Stearyl Ether of Polyoxyethylene (2) and Stearyl Ether of Polyoxyethylene (20) and Stearyl Perfume Disodium Edetate Dihydrate FD & C Blue N 1 (aqueous solution at 0, 1%) Deionized water Ingredients Trihydrochloride 31 Al / Zr powder 50% ACH solution 50% AlCl3.6H20 solution Glycine Deionized water Primary emulsion A, sufficient for% by weight, 56 4, 07 1.48 0.75 0.25 0.49 87.41, 00% by weight, 00 18.00 6.00

1.50 O

24.00, 00 pH: 3.4 + 0.3

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 14

  Formula BA 1810-65 Powdered aluminum and zirconium trihydrochloride (Al / Zr mole ratio = 2/1) are used: Ingredients% by weight Al / Zr trihydrochloride 21 powder 10.00 50% solution ACH 18.00 50% solution of AlCi3.6H20 6.00 Glycine 1.50 Deionized water 24.00 Primary emulsion A, sufficient quantity for 100.00 pH: 3.5 + 0.3

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 15

Formula BA 1810-56

  Powder 81 of glycine-complex is used

  aluminum and zirconium octachlorhydrate (molar ratio Al / Zr = 8/1): Ingredients% by weight A1 / Zr 81 glycine-octachlorhydrate complex powder 15.00 50% AH solution 10.00 Solution of AlCl3.6H20 8.00 Glycine 0.50 Deionized water 26.00 Primary emulsion A, sufficient quantity for 100.00 pH: 3.2 + 0.3

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 16

  Formula BA 1810-57 A solution of aluminum pentachlorohydrate and zirconium (molar ratio Al / Zr = 10/1) is used: Ingredients% by weight 30% solution of A1 / Zr pentachlorohydrate 35.00 50% solution % ACH 10.00 50% AlCl3.6H20 solution 8.00 Glycine 2.00 Deionized water 4.50 Primary emulsion A, sufficient for 100.00 pH: 3.4 + 0.3

  Viscosity after overnight rest: 450-1500 mPa.s.

EXAMPLE 17

  Formula BQ 1856-83 Various buffering agents such as sodium carbonate are used as an additional buffering agent in

this example.

  Primary emulsion B% by weight PPG-11 and stearyl ether 6.43 Polyoxyethylene (2) and stearyl ether 4.71 Polyoxyethylene (20) and stearyl ether 1.71 Fragrance 0.86 Disodium edetate dihydrate 0.29 Blue FD & C N 1 (0.1% aqueous solution) 0.57 Deionized water 85.43, 00 Ingredients

  35% glycine complex solution

  Al / Zr tetrachlorohydrate 50% ACH solution 50% AlCl3 solution. 6H20 Glycine Sodium carbonate monohydrate Deionized water Primary emulsion B, sufficient for% by weight, 00, 00 8.00 1.20 0.50 0, 30.00 pH: 3.4 + 0.3

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 18

  Formula BQ 1856-83 We use magnesium hydroxide as

other buffering agent.

Ingredients% by weight

  35% glycine complex solution

  Al / Zr tetrachlorohydrate 45.00 50% ACH solution 10.00 50% AlCl3.6H20 solution 8.00 Glycine 0.50 Magnesium hydroxide 0.50 Deionized water 1.00 Primary emulsion B, sufficient quantity for 100.00 pH: 3.4 + 0.3

  Viscosity after resting during the night: 500-1500 mPa.s.

EXAMPLE 19

  Formula 1509-61 Ingredients% Polyether PPG-11 and stearyl ether 2.25 Polyoxyethylene (2) and stearyl ether 1.65 Polyoxyethylene (20) and stearyl ether 0.60 Perfume 0.30 Deionized water 41,20 Disodium edetate dihydrate 0,10 Anti-foaming agent DC, AF, 25% 0,10 Al / Zr glycine-tetrahydrochloride complex solution 35% 35,00 50% ACH solution 15,00 Js Ingredients (Continued) 50% solution of AlCl3.6H20 Glycine Blue FD & C N 1 (0.1% aqueous solution)% by weight 3.00 0.60 0.20, 00 pH: 3.4 + 0, 3

  Viscosity after resting during the night: 400-1200 mPa.s.

  To demonstrate that the association between chloride

  aluminum, ACH, aluminum polyhydrochloride and zinc

  conium and glycine exerts a synergistic effect, we have prepared

  several formulas identified in Table II below.

  below. The formula N 1908 is representative of the

this invention.

  Ingredients ACH (% on anhydrous basis) AlC13.6H20 (% on anhydrous basis) Al / Zr tetrachlorohydrate (% on an anhydrous basis) PPG-11 and stearyl Glycine Ether

Polyoxy ether

ethylene- (2) and stearyl

Polyoxy ether

  Ethylene- (20) and Stearyl Edetate Disodium Dihydrate Perfume & Dye

Water, sufficient quantity

  effective for 100 Total Active Ingredients Total Glycine

F N 1052

T A B L E A U II

  % by weight based on total weight

F N 1676 E N 1908

  18.3 7.5 1.7 18.6 2.8 3.0 1.9 1.1 18.3 o0 2.0 1.5 0.6 0.1 18.6 2.8 9.3 1 , 9 2.25 1.65 0.6 0.1 18.5 1.9

F N 1341

  16.2 2.0 2.0 3.5 2.3 1.2 0.1 18.2 2.0 Trade Emulsion applied to the marble

(BR-4504)

  Al / Zr trihydrochloride (% on an anhydrous basis) 19.7 Glycine 4.2 PEG-40 stearate, glyceryl stearate, glycerin, paraffin

refined, iso palmitate

  propyl, Mg / Al silicate and perfume 19.7 total active substances 4, 2 of total glycine w ru -J. w Lu o As we will notice, all these formulas are

  similar, except for the active ingredients that are used

  his. In addition, each contains the total active ingredients essentially at the same concentration, i.e. about 18% on an anhydrous basis. Each of these compositions has been submitted to

  activity tests against perspiration. The operating mode

  The general rule used is that which is described in the Federal Register, volume 43, number 196, of October 10

  1978. It is called a gravimetric test against

  underarms. These are comparative studies in pairs (treated / treated) of the antiperspirant efficacy of

  the emulsion against perspiration.

  The details of the test method are given

below.

  Test method A Statistical Services statistical test model is used, eg if a test substance is evaluated, half of the test group receives the test substance under the armpit left, while the remaining half receives the test substance

  under the right armpit. The opposite armpit serves as a witness.

  If two test substances are evaluated, one-half of the individuals in the group receive product A in the left armpit and product B in the right armpit, while the product / armpit pattern is reversed for people

remaining group.

  The test is conducted for a period of 5 days (Monday to Friday). Sweating is triggered under ambient conditions involving a temperature of

  37.8 + 1.10C and a relative humidity of 40% + 2%.

  Day 1: control measure followed by product application People in the test group wait

  half an hour at room temperature (about 18.3

  26.7 C), after which they enter the test room. They then have under their armpits the unsweetened "Webril" pads (which are folded in half to dimensions of 16 x 5.08 cm). People remain seated in the

  test room during a warm-up period of 40 minutes.

  utes. At the end of this period, warm stamps

  are removed by people and are thrown away.

  The people in the group remove the plastic bags containing the tared collecting pads from manila envelopes. Each of them inserts the pads under the instructions of a technician. The buffers remain

  in place under the armpit for a period of 20 minutes.

  At the end of this period, the persons in the group are asked to remove the tampons and to introduce them into the plastic dobby bags intended for this purpose, which are then

  put back into manila envelopes.

  People from the group leave the test room to deposit their envelopes, then wash their armpits at

  warm water with gauze pads and dry them

  following with the help of a towel. About 1 to 3 minutes

  later, the test material is applied and

  Test group members leave. The plastic bags are removed from the manila envelopes and weighed by a technician. The people in the group must

  produce at least 200 mg of sweat per armpit to

  continue to participate in the working group.

  Day 2 * Product application only People in the group wait for half an hour at room temperature, then wash their underarms with warm water using gas pads and dry them with a towel. About 1 to 3 minutes later, the

  test material is applied and people leave.

  Third day: product application and collection People in the group wait for half an hour at room temperature, after which they wash their underarms as described above. About 1 to 5 minutes later, the test material is applied. The people

  then wait for 1 hour at room temperature.

  They then enter the test room, for a

  a warm-up period of 40 minutes, and place the

  undamaged pons under their armpits. At the end of this

  period, the heated pads are removed and discarded.

  People in the group withdraw from their

  manila bags plastic bags containing tared collecting pads. They inscribe the pads under the instructions of a technician. The pads remain under the armpits for a period of 20 minutes. People are then asked to remove the tampons and

  to introduce them into the plastic bags provided

  for this purpose, which are reintroduced into the envelopes

  of shackle. People leave the test room, depo-

  feel their envelopes and go away. The plastic bags are removed from the manila envelopes and are

weighed by a technician.

  Fourth day: product application only

Like the second day.

  Fifth day Supplication of the product and collection

Like the third day.

  The results of the test are summarized below.

  below: I. Form No. 1908 against Form No. 1052 Results: The results of this study, which included 47 women, were submitted to the Statistical Services Department for

their assessment. -

  In short, their analysis indicated that Form No. 1908 against perspiration, applied to the ball, was significantly more effective than Form No. 1052,

at the dose of 0.01.

  This conclusion is corroborated by the A / B ratio (amount of sweat collected from the armpit treated with product A relative to the armpit treated with product B) for the day of collection corresponding to the final treatment (correction taking into account the control), with an average value of 0.319 which is very different from

equality report 1.0.

  The results above demonstrate that the effectiveness

  The effectiveness of Formula No. 1908 is greater than that of

  Formula No. 1052 in the proportion of about 18%.

  II. Form No. 1908 against Form No. 1676 Results The results of this study, on 46 women, were submitted to the Statistical Services Department for evaluation. In short, their analysis indicated that the effectiveness of the NO 1908 formula was significantly greater than

  that of the formula No. 1676 at the dose of 0.01.

  This conclusion is corroborated by the A / B report, at the final day of collection after treatment (correction taking into account the control) of average value equal to 0.883,

  which differs significantly from the equality ratio of 1.0.

  The above results indicate that the effectiveness of the formula No. 1908 is greater than that of the formula

  No. 1676 in the proportion of about 12%.

  III. Formula No 1908 against formula in emulsion N0 BR 4504 of the trade, applied to the ball Results:

  The results of this study, involving 48 women

  have been submitted to the Statistical Services Department

view of their evaluation.

  In short, their analysis indicates that the effectiveness of Formula No. 1908 is significantly higher than that of the commercial emulsion formula applied to the ball,

at the dose of 0.01.

  This conclusion is corroborated by the report

  A / B on the last day of collection after treatment (correct

  the average value * of 0.881, which is very different from the equality

of 1.0.

  The above results indicate that the effectiveness of the formula No. 1908 is greater than that of the formula

  No. BR 4504 in a proportion of about 12%.

  IV. The formula NO 1341 (see Table II) which contains

  active substances against perspiration, an association

  of ACH and AlCl3.6H20 (at a concentration of

  18.2) appeared, by a similar test, to be less effective

  in the proportion of 9.6% on average, than the commercial emulsion applied to the ball (BR 4504) which contains 19.7% of Al / Zr trihydrochloride as active substances against perspiration (see Table II). ). However, this latter composition also appeared to be less effective than Formula No. 1908 of the present invention, i.e., Formula NM 1908 was more effective in a proportion of about 12% than Formula BR 4505.

(see paragraph III).

  V. The formula NO 1991 (see example 9) appeared, by a similar test, more effective in a proportion of 15% than a commercial suspension applied to the ball,

  called formula NO BR 4751. The latter has the composition

  following composition: Formula N0 BR 4751 Ingredients% by weight Aluminum tetrachlorohydrate and zirconium (on an anhydrous basis) 13.8 Glycine 2.0 Bentone 38 3.25 Cyclomethicone and perfume, sufficient quantity per 100.00 It goes without saying that the present invention has been described for explanatory purposes, but in no way limiting, and that many modifications can be made thereto

without leaving his frame.

Claims (9)

  A perspiration composition, buffered to a pH in a range of about 2.5 to about 4.5, characterized in that it contains as active ingredients aluminum chloride, aluminum chlorohydrate and a complex of aluminum polyhydrochloride and zirconium,   said complex of aluminum polyhydrochloride and zirconium   conium corresponding to the formula: 1 (I) Al x Zr (OH) y Cl 2. nCH2COOH. wherein: (a) x is a number from 2 to 10; (b) Z is a number from 3 to 8; (c) Z has the value (3x + 4) - Z; (d) the sum y + Z is a number from 10 to 34; (e) m is a number from 0 to 12; (f) n is a number from 0 to 3   said active ingredients being incorporated into said compound   in the following proportions (percentages by weight) based on the total weight of said composition and on an anhydrous basis: (1) aluminum chloride, from about 0.5 to about 6% (2) aluminum chlorohydrate from about 1 to about% (3) aluminum polyhydrochloride complex and   zirconium, from about 5 to about 16%.   2. The composition of claim 1, wherein   it contains an additional buffering agent, preferably glycine.   3. The composition of claim 2, wherein   wherein the total amount of glycine in bound form and / or non-lactate form is present in a proportion in the range of about 0.5 to about% by weight based on the total weight of the composition. 4. Composition against buffered sweat   at a pH in the range of about 2.8 to 3.8,   characterized in that it contains as active ingredients aluminum chloride, aluminum chlorohydrate, a complex of polychlorhydrate of aluminum and zirconium and in that it contains water. glycine, the aluminum zirconium polychlorhydrate complex having the formula: wherein: (ta) x is a number from 2 to 10; (b) Z is a number from 3 to 8; (c) y is 3: Z + 4) Z; (d) the sum y + Z is a number from 10 to 34; (e) m is a number from 0 to 12 (f) is a number from t to 3,   said active ingredients being incorporated into the composition   in the following percentages by weight, based on the total weight of the composition and on an anhydrous basis: (1) aluminosilicum, from about 1.5 to about 3%   (2) aluminum chloride hydrochloride, from about 2 to about (3) aluminum polyhydrochloride complex and   zirconium from about 8 to about 14%, -   the total weight percentage of glycine in the bound form and / or in the unbound form being from about 1.5 to about   3% based on the total weight of the composition.   5. Composition according to one of the claims   1 and 3, characterized in that the polyhydrochloride complex   of aluminum and zirconium is the glycine-tetra-   aluminum chlorohydrate and zirconium.   6. Composition according to one of the claims   1 and 4, characterized in that the polychlorhydrate complex   aluminum and zirconium drate is selected from the group consisting of aluminum tetrachlorohydrate and zirconium;   glycine-aluminum tetrachlorohydrate complex and zirconium   conium; aluminum trihydrochloride and zirconium, glycine-trihydrochloride complex of aluminum and zirconium;   aluminum pentachlorohydrate and zirconium, the   aluminum glycine-pentachlorohydrate plexus and zirconium; aluminum octahloride and zirconium; the glycineoctachlorhydrate aluminum and zirconium complex, and mixtures thereof.   7. Composition according to any one of the   1, 3 and 6, characterized in that the chloride   aluminum is incorporated in the form of hexahydrate.   8. Composition according to any one of the   1 to 7, characterized in that it is in the form of an oil-in-water emulsion in which at least a high proportion of the active ingredients and   glycine is contained in the aqueous phase.   9. A method for inhibiting the perspiration of an individual, characterized in that it consists in applying to   the skin of the individual an effective amount of the composi-   according to any one of claims 1 to 7.