FR2479818A1 - 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione - Google Patents

2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione Download PDF

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Publication number
FR2479818A1
FR2479818A1 FR8007545A FR8007545A FR2479818A1 FR 2479818 A1 FR2479818 A1 FR 2479818A1 FR 8007545 A FR8007545 A FR 8007545A FR 8007545 A FR8007545 A FR 8007545A FR 2479818 A1 FR2479818 A1 FR 2479818A1
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FR
France
Prior art keywords
pro
gly
leu
formula
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8007545A
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English (en)
French (fr)
Other versions
FR2479818B1 (enrdf_load_stackoverflow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8007545A priority Critical patent/FR2479818A1/fr
Publication of FR2479818A1 publication Critical patent/FR2479818A1/fr
Application granted granted Critical
Publication of FR2479818B1 publication Critical patent/FR2479818B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8007545A 1980-04-03 1980-04-03 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione Granted FR2479818A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8007545A FR2479818A1 (en) 1980-04-03 1980-04-03 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8007545A FR2479818A1 (en) 1980-04-03 1980-04-03 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione

Publications (2)

Publication Number Publication Date
FR2479818A1 true FR2479818A1 (en) 1981-10-09
FR2479818B1 FR2479818B1 (enrdf_load_stackoverflow) 1984-10-19

Family

ID=9240506

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8007545A Granted FR2479818A1 (en) 1980-04-03 1980-04-03 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione

Country Status (1)

Country Link
FR (1) FR2479818A1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012547A3 (en) * 1998-09-01 2000-06-15 Innogenetics Nv Benzodiazepines and benzothiazepines derivatives and hbsag peptides binding to annexins, their compositions and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285890A1 (fr) * 1974-09-11 1976-04-23 Hoffmann La Roche Derives de diazepine
FR2300569A1 (fr) * 1975-02-15 1976-09-10 Roussel Uclaf Nouvelles imidazolobenzodiazepines et

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285890A1 (fr) * 1974-09-11 1976-04-23 Hoffmann La Roche Derives de diazepine
FR2300569A1 (fr) * 1975-02-15 1976-09-10 Roussel Uclaf Nouvelles imidazolobenzodiazepines et

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/78 *
EXBK/80 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012547A3 (en) * 1998-09-01 2000-06-15 Innogenetics Nv Benzodiazepines and benzothiazepines derivatives and hbsag peptides binding to annexins, their compositions and use

Also Published As

Publication number Publication date
FR2479818B1 (enrdf_load_stackoverflow) 1984-10-19

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