FR2470773A1 - - Google Patents

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Publication number
FR2470773A1
FR2470773A1 FR7929289A FR7929289A FR2470773A1 FR 2470773 A1 FR2470773 A1 FR 2470773A1 FR 7929289 A FR7929289 A FR 7929289A FR 7929289 A FR7929289 A FR 7929289A FR 2470773 A1 FR2470773 A1 FR 2470773A1
Authority
FR
France
Prior art keywords
fragment
iib
thiolated
toxin
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7929289A
Other languages
English (en)
French (fr)
Other versions
FR2470773B1 (https=
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Priority to FR7929289A priority Critical patent/FR2470773B1/fr
Priority to ES497182A priority patent/ES8202831A1/es
Priority to CA000365671A priority patent/CA1152493A/en
Priority to DE8080401708T priority patent/DE3064161D1/de
Priority to EP80401708A priority patent/EP0030496B1/fr
Priority to DE8282105526T priority patent/DE3070438D1/de
Priority to JP16683380A priority patent/JPS5690097A/ja
Priority to EP82105526A priority patent/EP0065320B1/fr
Publication of FR2470773A1 publication Critical patent/FR2470773A1/fr
Priority to ES507625A priority patent/ES507625A0/es
Application granted granted Critical
Publication of FR2470773B1 publication Critical patent/FR2470773B1/fr
Priority to CA000425262A priority patent/CA1178949A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR7929289A 1979-11-28 1979-11-28 Expired FR2470773B1 (https=)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7929289A FR2470773B1 (https=) 1979-11-28 1979-11-28
CA000365671A CA1152493A (en) 1979-11-28 1980-11-27 Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for obtaining and its applications
ES497182A ES8202831A1 (es) 1979-11-28 1980-11-27 Procedimiento para la obtencion del compuesto polipeptidico tiolado constituido por el fragmento b-iib de la toxina te- tanica
EP80401708A EP0030496B1 (fr) 1979-11-28 1980-11-28 Composé polypeptidique thiolé provenant d'un fragment de la toxine tétanique, son procédé d'obtention et ses applications
DE8080401708T DE3064161D1 (en) 1979-11-28 1980-11-28 Thiolated polypeptidic compound coming from a fragment of tetanic toxine, process for obtaining it and its applications
DE8282105526T DE3070438D1 (en) 1979-11-28 1980-11-28 Coupling process of a medicament to a thiolated polypeptidic compound coming from a fragment of the tetanic toxine, and its uses
JP16683380A JPS5690097A (en) 1979-11-28 1980-11-28 Novel thinated polypeptide compound*its manufacture and its use
EP82105526A EP0065320B1 (fr) 1979-11-28 1980-11-28 Procédé de couplage d'un médicament avec un composé polypeptidique thiolé provenant d'un fragment de la toxine tétanique et ses applications
ES507625A ES507625A0 (es) 1979-11-28 1981-12-01 Procedimiento de copulacion de un compuesto polipeptido tiolado con una sustancia activa.
CA000425262A CA1178949A (en) 1979-11-28 1983-04-05 Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for obtaining and its applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7929289A FR2470773B1 (https=) 1979-11-28 1979-11-28

Publications (2)

Publication Number Publication Date
FR2470773A1 true FR2470773A1 (https=) 1981-06-12
FR2470773B1 FR2470773B1 (https=) 1983-01-28

Family

ID=9232177

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7929289A Expired FR2470773B1 (https=) 1979-11-28 1979-11-28

Country Status (5)

Country Link
EP (2) EP0030496B1 (https=)
JP (1) JPS5690097A (https=)
CA (1) CA1152493A (https=)
ES (2) ES8202831A1 (https=)
FR (1) FR2470773B1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479940A (en) * 1981-01-22 1984-10-30 Institut Pasteur Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for its obtention and its applications

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
WO1992019646A1 (en) * 1991-05-03 1992-11-12 The Rockefeller University Analog of endothelial leukocyte adhesion molecule (elam)
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
DK1049712T3 (da) * 1997-08-14 2007-05-29 Pasteur Institut Hybrid-tetanus-toxoid-proteiner der retrogradt og transsynaptisk migrerer ind i CNS
US7923015B2 (en) 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3171831A (en) * 1961-02-14 1965-03-02 Schwarz Biores Inc Thiolation of proteins by reaction with homocysteine thiolactone in the presence of tertiary amine
DE1617880A1 (de) * 1966-10-06 1971-07-22 Karl Dr Med Theurer Verfahren zur Gewinnung von organotropen,bioaktiven Wirkstoffen,insbesondere von Arzneimitteln
FR2270891A2 (en) * 1974-05-15 1975-12-12 Anvar Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria
FR2334954A1 (fr) * 1975-12-12 1977-07-08 Dainippon Pharmaceutical Co Reactif convenant pour la determination immunologique enzymatique
GB1492445A (en) * 1974-10-14 1977-11-16 All India Inst Med Immunochemically purified derivatives of human chorionic gonadotropin
FR2366569A1 (fr) * 1976-09-29 1978-04-28 Mochida Pharm Co Ltd Procede immunochimique et reactifs pour le dosage d'haptene
GB2013690A (en) * 1978-02-06 1979-08-15 Research Corp Antigen for early pregnancy test and contraceptive vaccine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3171831A (en) * 1961-02-14 1965-03-02 Schwarz Biores Inc Thiolation of proteins by reaction with homocysteine thiolactone in the presence of tertiary amine
DE1617880A1 (de) * 1966-10-06 1971-07-22 Karl Dr Med Theurer Verfahren zur Gewinnung von organotropen,bioaktiven Wirkstoffen,insbesondere von Arzneimitteln
FR2270891A2 (en) * 1974-05-15 1975-12-12 Anvar Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria
GB1492445A (en) * 1974-10-14 1977-11-16 All India Inst Med Immunochemically purified derivatives of human chorionic gonadotropin
FR2334954A1 (fr) * 1975-12-12 1977-07-08 Dainippon Pharmaceutical Co Reactif convenant pour la determination immunologique enzymatique
FR2366569A1 (fr) * 1976-09-29 1978-04-28 Mochida Pharm Co Ltd Procede immunochimique et reactifs pour le dosage d'haptene
GB2013690A (en) * 1978-02-06 1979-08-15 Research Corp Antigen for early pregnancy test and contraceptive vaccine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1977 *
EXBK/78 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479940A (en) * 1981-01-22 1984-10-30 Institut Pasteur Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for its obtention and its applications

Also Published As

Publication number Publication date
FR2470773B1 (https=) 1983-01-28
ES497182A0 (es) 1982-03-01
ES8400460A1 (es) 1983-10-16
CA1152493A (en) 1983-08-23
EP0065320A1 (fr) 1982-11-24
EP0065320B1 (fr) 1985-04-03
ES8202831A1 (es) 1982-03-01
ES507625A0 (es) 1983-10-16
EP0030496A1 (fr) 1981-06-17
EP0030496B1 (fr) 1983-07-13
JPS5690097A (en) 1981-07-21

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Legal Events

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ST Notification of lapse