FR2270891A2 - Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria - Google Patents

Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria

Info

Publication number
FR2270891A2
FR2270891A2 FR7416936A FR7416936A FR2270891A2 FR 2270891 A2 FR2270891 A2 FR 2270891A2 FR 7416936 A FR7416936 A FR 7416936A FR 7416936 A FR7416936 A FR 7416936A FR 2270891 A2 FR2270891 A2 FR 2270891A2
Authority
FR
France
Prior art keywords
vaccines
product
glutaraldehyde
diphtheria
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7416936A
Other languages
French (fr)
Other versions
FR2270891B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7416936A priority Critical patent/FR2270891A2/en
Publication of FR2270891A2 publication Critical patent/FR2270891A2/en
Application granted granted Critical
Publication of FR2270891B2 publication Critical patent/FR2270891B2/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

General method for prepn. of vaccines is new in which the toxic product is treated with glutaraldehyde to detoxify the product and retain or increase its antigenic potency characterized by the glutaraldehyde treatment polymerizing the product to cause a chain of a limited number of molecules of toxic product, thereby detoxifying the product to give a non-toxic highly active vaccine. Spefic. claimed are vaccines prepared by this process contg. molecules of at least two antigen or hapten molecules mutually linked in a copolymer.
FR7416936A 1974-05-15 1974-05-15 Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria Granted FR2270891A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7416936A FR2270891A2 (en) 1974-05-15 1974-05-15 Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7416936A FR2270891A2 (en) 1974-05-15 1974-05-15 Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria

Publications (2)

Publication Number Publication Date
FR2270891A2 true FR2270891A2 (en) 1975-12-12
FR2270891B2 FR2270891B2 (en) 1978-05-26

Family

ID=9138897

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7416936A Granted FR2270891A2 (en) 1974-05-15 1974-05-15 Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria

Country Status (1)

Country Link
FR (1) FR2270891A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470773A1 (en) * 1979-11-28 1981-06-12 Pasteur Institut
EP0037522A2 (en) * 1980-04-04 1981-10-14 Smith Kline - RIT Société anonyme dite: Derivatives of the heat stable enterotoxin of Escherichia coli, and their preparation
FR2532850A1 (en) * 1982-09-15 1984-03-16 Pasteur Institut Immunogenic conjugates between a hapten and a carrier molecule derived from a toxin, vaccines comprising them and method for obtaining them
WO1997002838A1 (en) * 1995-07-12 1997-01-30 Francisco Javier Martin Oncina Polymerized vaccines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470773A1 (en) * 1979-11-28 1981-06-12 Pasteur Institut
EP0030496B1 (en) * 1979-11-28 1983-07-13 Institut Pasteur Thiolated polypeptidic compound coming from a fragment of tetanic toxine, process for obtaining it and its applications
EP0037522A2 (en) * 1980-04-04 1981-10-14 Smith Kline - RIT Société anonyme dite: Derivatives of the heat stable enterotoxin of Escherichia coli, and their preparation
JPS56152495A (en) * 1980-04-04 1981-11-26 Smith Kline Rit E.coli fever stable entrotoxin drrivative and manufacture
EP0037522A3 (en) * 1980-04-04 1982-05-19 Smith Kline - Rit Societe Anonyme Dite: Derivatives of the heat stable enterotoxin of escherichia coli, and their preparation
FR2532850A1 (en) * 1982-09-15 1984-03-16 Pasteur Institut Immunogenic conjugates between a hapten and a carrier molecule derived from a toxin, vaccines comprising them and method for obtaining them
WO1997002838A1 (en) * 1995-07-12 1997-01-30 Francisco Javier Martin Oncina Polymerized vaccines
ES2108614A1 (en) * 1995-07-12 1997-12-16 Oncina Fco Javier Martin Polymerized vaccines

Also Published As

Publication number Publication date
FR2270891B2 (en) 1978-05-26

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Legal Events

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TP Transmission of property