FR2456098A2 - Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. - Google Patents
Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.Info
- Publication number
- FR2456098A2 FR2456098A2 FR7911707A FR7911707A FR2456098A2 FR 2456098 A2 FR2456098 A2 FR 2456098A2 FR 7911707 A FR7911707 A FR 7911707A FR 7911707 A FR7911707 A FR 7911707A FR 2456098 A2 FR2456098 A2 FR 2456098A2
- Authority
- FR
- France
- Prior art keywords
- isoquinoline
- antipyretic
- derivs
- rboxamide
- thiazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Isoquilins derivs. of formula (I) (in the (R)- or (S)- form or mixts. and their acid addn. salts are new: In (I), R' is -(CH2)n-OR2 in which R2 is 1-8C alkyl and n is 1 or 2. (I) have analgesic, anti-inflammatory and antipyretic activie. The (S)-isomers also have antiviral activity (esp. against rhinoviruses). Acute toxicity is low.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7911707A FR2456098A2 (en) | 1977-12-23 | 1979-05-09 | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
GB8014441A GB2048880A (en) | 1979-05-09 | 1980-05-01 | Isoquinoline derivatives |
NL8002540A NL8002540A (en) | 1979-05-09 | 1980-05-01 | NEW ISOCHINOLINE DERIVATIVES, METHODS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW DERIVATIVES. |
JP5988280A JPS55151591A (en) | 1979-05-09 | 1980-05-06 | Isoquinoline derivative and its manufacture |
US06/147,248 US4287197A (en) | 1979-05-09 | 1980-05-06 | Antiviral isoquinoline derivatives |
BE0/200532A BE883191A (en) | 1979-05-09 | 1980-05-08 | NOVEL ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE19803017895 DE3017895A1 (en) | 1979-05-09 | 1980-05-09 | NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
IT21956/80A IT1130588B (en) | 1979-05-09 | 1980-05-09 | ISOKINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7739028A FR2412545A1 (en) | 1977-12-23 | 1977-12-23 | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
FR7911707A FR2456098A2 (en) | 1977-12-23 | 1979-05-09 | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2456098A2 true FR2456098A2 (en) | 1980-12-05 |
FR2456098B2 FR2456098B2 (en) | 1982-05-21 |
Family
ID=26220364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7911707A Granted FR2456098A2 (en) | 1977-12-23 | 1979-05-09 | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2456098A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2802453A1 (en) * | 1977-01-20 | 1978-07-27 | Rhone Poulenc Ind | NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM |
FR2378030A1 (en) * | 1977-01-20 | 1978-08-18 | Rhone Poulenc Ind | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
FR2412545A1 (en) * | 1977-12-23 | 1979-07-20 | Rhone Poulenc Ind | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
-
1979
- 1979-05-09 FR FR7911707A patent/FR2456098A2/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2802453A1 (en) * | 1977-01-20 | 1978-07-27 | Rhone Poulenc Ind | NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM |
FR2378030A1 (en) * | 1977-01-20 | 1978-08-18 | Rhone Poulenc Ind | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
FR2412545A1 (en) * | 1977-12-23 | 1979-07-20 | Rhone Poulenc Ind | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
Also Published As
Publication number | Publication date |
---|---|
FR2456098B2 (en) | 1982-05-21 |
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