FR2412545A1 - Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties - Google Patents
Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic propertiesInfo
- Publication number
- FR2412545A1 FR2412545A1 FR7739028A FR7739028A FR2412545A1 FR 2412545 A1 FR2412545 A1 FR 2412545A1 FR 7739028 A FR7739028 A FR 7739028A FR 7739028 A FR7739028 A FR 7739028A FR 2412545 A1 FR2412545 A1 FR 2412545A1
- Authority
- FR
- France
- Prior art keywords
- isoquinoline
- imino
- thiazolo
- isoquinolino
- antiinflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Abstract
Isoquinolines derivs. of formula (I) in their (R) and (S) forms, and mixtures of these, and their acid addn. salts, are new. In (I) R is straight or branched 1-10C alkyl. A typical prod. is 3- (3-methyl-5-isoquinolyl)imino 1,5,10,10a-tetrahydro thiazolo 3,4-b (S)-isoquinoline, m. pt. 181 degrees C. In an example this was pred. from 5-amino-3-methyl isoquinoline and 3-methylthio-1,5 10, 10a-tetrahydro thiazolo 3, 4-b S-isoquinolinium iodide in pyridine at 20 degrees C.
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7739028A FR2412545A1 (en) | 1977-12-23 | 1977-12-23 | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
NL7800383A NL7800383A (en) | 1977-01-20 | 1978-01-12 | NEW ISOQUEINOLINE DERIVATIVES, THEIR PREPARATION AND PREPARATIONS CONTAINING THE ISOQUEINOLINE DERIVATIVES. |
CS785983A CS195350B2 (en) | 1977-01-20 | 1978-01-17 | Method of producing 3-alkyl-5-isoquinolyliminothiazolo/3,4-b/isoquinolines |
CS78323A CS195349B2 (en) | 1977-01-20 | 1978-01-17 | Method of producing 3-alkyl-5-isoquinolyliminothiazolo/3,4-b/isoquinolines |
OA56380A OA05859A (en) | 1977-01-20 | 1978-01-17 | New isoquinoline derivatives and their preparation process. |
GR55196A GR61726B (en) | 1977-01-20 | 1978-01-18 | Preparation process of novel isoquinoleine derivatives |
IL53841A IL53841A (en) | 1977-01-20 | 1978-01-18 | 3-(3-alkylisoquinol-5-yl)imino)-1,5,10,10a-tetrahydrothiazolo(3,4-b)isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them |
DK27178A DK143343C (en) | 1977-01-20 | 1978-01-19 | ANALOGY PROCEDURE FOR PREPARATION OF 1,5,10,10A-TETRAHYDROTHIAZOLO (3,4-B) -ISOQUINOLINE DERIVATIVES |
PT67545A PT67545B (en) | 1977-01-20 | 1978-01-19 | NOVEL DERIVATIVES OF ISOQUINOLINE PREPARATION AND COMPOSITIONS CONTAINING SAME |
GB2241/78A GB1574281A (en) | 1977-01-20 | 1978-01-19 | 3-imino-1,5,10,10a-tetrahydro-thiazolo (3,4-b)isoquinoline derivatives |
SU782567352A SU730309A3 (en) | 1977-01-20 | 1978-01-19 | Method of preparing 3-alkyl-5-isoquinolyliminothiazolo-/3,4-b/isoquinolines or their or optical isomers, or mixtures of their optical isomers, or their salts |
CA295,296A CA1091674A (en) | 1977-01-20 | 1978-01-19 | Isoquinolein derivatives, preparation process and composition thereof |
CH56178A CH633010A5 (en) | 1977-01-20 | 1978-01-19 | ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM. |
HU78RO958A HU174219B (en) | 1977-01-20 | 1978-01-19 | Process for preparing new triazolo-quinoline derivatives |
AT39378A AT361481B (en) | 1977-01-20 | 1978-01-19 | METHOD FOR PRODUCING NEW 3-ALKYL- -ISOCHINOLYL-5-IMINOTHIAZOLE (3,4-B) ISOCHINOLIN-DERIVATIVES AND THEIR ACID ADDITION SALTS |
SE7800681A SE7800681L (en) | 1977-01-20 | 1978-01-19 | PROCEDURE FOR THE PREPARATION OF NEW ISOKINOLIN DERIVATIVES |
NO780202A NO780202L (en) | 1977-01-20 | 1978-01-19 | PROCEDURE FOR PREPARING NEW ISOKINOLIN DERIVATIVES |
LU78895A LU78895A1 (en) | 1977-01-20 | 1978-01-19 | NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
AU32611/78A AU510044B2 (en) | 1977-01-20 | 1978-01-20 | Thiazolo (3, 4-b) isoquinoline compounds |
US05/871,136 US4153698A (en) | 1977-01-20 | 1978-01-20 | Isoquinoline derivatives and pharmaceutical compositions containing them |
ES466192A ES466192A1 (en) | 1977-01-20 | 1978-01-20 | Isoquinoline derivatives and pharmaceutical compositions containing them |
DE2802453A DE2802453C3 (en) | 1977-01-20 | 1978-01-20 | Derivatives of 3 - [(3-alkyl-5-isoquinolyl) -imino] -1,5,10,10a-tetrahydro-thiazolo [3,4-b] isoquinoline, their preparation and the compositions containing them |
JP53005113A JPS5914037B2 (en) | 1977-01-20 | 1978-01-20 | Isoquinoline derivatives, their production methods and pharmaceutical compositions containing them |
NZ186282A NZ186282A (en) | 1977-01-20 | 1978-01-20 | 3-((3-alkylisoquinol-5-yl)-imino)-1,5,10,10a-tetrahydro-thiazolo-(4,3-b)isoquinolines |
IE126/78A IE46375B1 (en) | 1977-01-20 | 1978-01-20 | 3-imino-1,5,10,10a-tetrahydrothiazolo(3,4-b)isoquinoline derivatives |
AR270785A AR217460A1 (en) | 1977-01-20 | 1978-01-20 | PROCEDURE FOR PREPARING DERIVATIVES OF ((ALKYL-3-ISOQUINOLYL-5) -IMINO) -3-TETRAHYDRO-1, 5, 10,10A-THIAZOL- (3,4-B) -ISOQUINOLEIN AND ITS SALTS |
FI780182A FI62314C (en) | 1977-01-20 | 1978-01-20 | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ANALYSIS 3 - ((3-ALKYLISOKINOL-5-YL) IMINO) -1,5,10,10A-TETRAHYDROTIA ZOO (3,4-B) ISOKINOLINER |
ES468630A ES468630A1 (en) | 1977-01-20 | 1978-04-07 | Isoquinoline derivatives and pharmaceutical compositions containing them |
AR275407A AR219963A1 (en) | 1977-01-20 | 1979-02-05 | PROCEDURE FOR PREPARING NEW DERIVATIVES OF (ALCOIL (C1-C10) -3-ISOQUINOLIL-5-IMINO) -3-TETRAHYDRO-1,5,10,10A-THIAZOL (3,4-B) - ISOQUINOLEIN |
SU792720496A SU776560A3 (en) | 1977-01-20 | 1979-02-08 | Method of preparing 3-/(3-alkyl-5-isoquinolyl)imino/-1,5,10.10a-tetrahydrothiazolo/3,4-b/isoquinolyls in the form of individual isomers or their mixtures or their acid-additive salts |
FR7911707A FR2456098A2 (en) | 1977-12-23 | 1979-05-09 | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
AT574979A AT359504B (en) | 1977-01-20 | 1979-08-28 | METHOD FOR PRODUCING NEW 3-ALKYL- -ISOCHINOLYL-5-IMINOTHIAZOLE (3,4-B) ISOCHINOLIN-DERIVATIVES AND THEIR ACID ADDITION SALTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7739028A FR2412545A1 (en) | 1977-12-23 | 1977-12-23 | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2412545A1 true FR2412545A1 (en) | 1979-07-20 |
FR2412545B1 FR2412545B1 (en) | 1980-08-22 |
Family
ID=9199290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7739028A Granted FR2412545A1 (en) | 1977-01-20 | 1977-12-23 | Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2412545A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2456098A2 (en) * | 1977-12-23 | 1980-12-05 | Rhone Poulenc Ind | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2635516A1 (en) * | 1975-08-06 | 1977-02-17 | Rhone Poulenc Ind | NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM |
-
1977
- 1977-12-23 FR FR7739028A patent/FR2412545A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2635516A1 (en) * | 1975-08-06 | 1977-02-17 | Rhone Poulenc Ind | NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2456098A2 (en) * | 1977-12-23 | 1980-12-05 | Rhone Poulenc Ind | Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. |
Also Published As
Publication number | Publication date |
---|---|
FR2412545B1 (en) | 1980-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |