FR2378030A1 - Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties - Google Patents

Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties

Info

Publication number
FR2378030A1
FR2378030A1 FR7701516A FR7701516A FR2378030A1 FR 2378030 A1 FR2378030 A1 FR 2378030A1 FR 7701516 A FR7701516 A FR 7701516A FR 7701516 A FR7701516 A FR 7701516A FR 2378030 A1 FR2378030 A1 FR 2378030A1
Authority
FR
France
Prior art keywords
isoquinoline
imino
thiazolo
isoquinolino
antiinflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7701516A
Other languages
French (fr)
Other versions
FR2378030B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7701516A priority Critical patent/FR2378030A1/en
Priority to NL7800383A priority patent/NL7800383A/en
Priority to CS78323A priority patent/CS195349B2/en
Priority to OA56380A priority patent/OA05859A/en
Priority to CS785983A priority patent/CS195350B2/en
Priority to GR55196A priority patent/GR61726B/en
Priority to IL53841A priority patent/IL53841A/en
Priority to BE184454A priority patent/BE863083A/en
Priority to NO780202A priority patent/NO780202L/en
Priority to SU782567352A priority patent/SU730309A3/en
Priority to CA295,296A priority patent/CA1091674A/en
Priority to LU78895A priority patent/LU78895A1/en
Priority to GB2241/78A priority patent/GB1574281A/en
Priority to CH56178A priority patent/CH633010A5/en
Priority to SE7800681A priority patent/SE7800681L/en
Priority to AT39378A priority patent/AT361481B/en
Priority to HU78RO958A priority patent/HU174219B/en
Priority to DK27178A priority patent/DK143343C/en
Priority to PT67545A priority patent/PT67545B/en
Priority to AR270785A priority patent/AR217460A1/en
Priority to IE126/78A priority patent/IE46375B1/en
Priority to ES466192A priority patent/ES466192A1/en
Priority to DE2802453A priority patent/DE2802453C3/en
Priority to ZA00780382A priority patent/ZA78382B/en
Priority to JP53005113A priority patent/JPS5914037B2/en
Priority to FI780182A priority patent/FI62314C/en
Priority to US05/871,136 priority patent/US4153698A/en
Priority to NZ186282A priority patent/NZ186282A/en
Priority to AU32611/78A priority patent/AU510044B2/en
Priority to ES468630A priority patent/ES468630A1/en
Publication of FR2378030A1 publication Critical patent/FR2378030A1/en
Priority to AR275407A priority patent/AR219963A1/en
Priority to SU792720496A priority patent/SU776560A3/en
Application granted granted Critical
Publication of FR2378030B1 publication Critical patent/FR2378030B1/fr
Priority to AT574979A priority patent/AT359504B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Abstract

Isoquinolines derivs. of formula (I) in their (R) and (S) forms, and mixtures of these, and their acid addn. salts, are new. In (I) R is straight or branched 1-10C alkyl. A typical prod. is 3- (3-methyl-5-isoquinolyl)imino 1,5,10,10a-tetrahydro thiazolo 3,4-b (S)-isoquinoline, m. pt. 181 degrees C. In an example this was pred. from 5-amino-3-methyl isoquinoline and 3-methylthio-1,5 10, 10a-tetrahydro thiazolo 3, 4-b S-isoquinolinium iodide in pyridine at 20 degrees C.
FR7701516A 1977-01-20 1977-01-20 Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties Granted FR2378030A1 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR7701516A FR2378030A1 (en) 1977-01-20 1977-01-20 Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties
NL7800383A NL7800383A (en) 1977-01-20 1978-01-12 NEW ISOQUEINOLINE DERIVATIVES, THEIR PREPARATION AND PREPARATIONS CONTAINING THE ISOQUEINOLINE DERIVATIVES.
CS78323A CS195349B2 (en) 1977-01-20 1978-01-17 Method of producing 3-alkyl-5-isoquinolyliminothiazolo/3,4-b/isoquinolines
OA56380A OA05859A (en) 1977-01-20 1978-01-17 New isoquinoline derivatives and their preparation process.
CS785983A CS195350B2 (en) 1977-01-20 1978-01-17 Method of producing 3-alkyl-5-isoquinolyliminothiazolo/3,4-b/isoquinolines
IL53841A IL53841A (en) 1977-01-20 1978-01-18 3-(3-alkylisoquinol-5-yl)imino)-1,5,10,10a-tetrahydrothiazolo(3,4-b)isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them
GR55196A GR61726B (en) 1977-01-20 1978-01-18 Preparation process of novel isoquinoleine derivatives
DK27178A DK143343C (en) 1977-01-20 1978-01-19 ANALOGY PROCEDURE FOR PREPARATION OF 1,5,10,10A-TETRAHYDROTHIAZOLO (3,4-B) -ISOQUINOLINE DERIVATIVES
SU782567352A SU730309A3 (en) 1977-01-20 1978-01-19 Method of preparing 3-alkyl-5-isoquinolyliminothiazolo-/3,4-b/isoquinolines or their or optical isomers, or mixtures of their optical isomers, or their salts
CA295,296A CA1091674A (en) 1977-01-20 1978-01-19 Isoquinolein derivatives, preparation process and composition thereof
LU78895A LU78895A1 (en) 1977-01-20 1978-01-19 NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
GB2241/78A GB1574281A (en) 1977-01-20 1978-01-19 3-imino-1,5,10,10a-tetrahydro-thiazolo (3,4-b)isoquinoline derivatives
CH56178A CH633010A5 (en) 1977-01-20 1978-01-19 ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM.
SE7800681A SE7800681L (en) 1977-01-20 1978-01-19 PROCEDURE FOR THE PREPARATION OF NEW ISOKINOLIN DERIVATIVES
AT39378A AT361481B (en) 1977-01-20 1978-01-19 METHOD FOR PRODUCING NEW 3-ALKYL- -ISOCHINOLYL-5-IMINOTHIAZOLE (3,4-B) ISOCHINOLIN-DERIVATIVES AND THEIR ACID ADDITION SALTS
HU78RO958A HU174219B (en) 1977-01-20 1978-01-19 Process for preparing new triazolo-quinoline derivatives
BE184454A BE863083A (en) 1977-01-20 1978-01-19 NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
PT67545A PT67545B (en) 1977-01-20 1978-01-19 NOVEL DERIVATIVES OF ISOQUINOLINE PREPARATION AND COMPOSITIONS CONTAINING SAME
NO780202A NO780202L (en) 1977-01-20 1978-01-19 PROCEDURE FOR PREPARING NEW ISOKINOLIN DERIVATIVES
AU32611/78A AU510044B2 (en) 1977-01-20 1978-01-20 Thiazolo (3, 4-b) isoquinoline compounds
ES466192A ES466192A1 (en) 1977-01-20 1978-01-20 Isoquinoline derivatives and pharmaceutical compositions containing them
AR270785A AR217460A1 (en) 1977-01-20 1978-01-20 PROCEDURE FOR PREPARING DERIVATIVES OF ((ALKYL-3-ISOQUINOLYL-5) -IMINO) -3-TETRAHYDRO-1, 5, 10,10A-THIAZOL- (3,4-B) -ISOQUINOLEIN AND ITS SALTS
ZA00780382A ZA78382B (en) 1977-01-20 1978-01-20 Isoquinoline derivatives
JP53005113A JPS5914037B2 (en) 1977-01-20 1978-01-20 Isoquinoline derivatives, their production methods and pharmaceutical compositions containing them
FI780182A FI62314C (en) 1977-01-20 1978-01-20 PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ANALYSIS 3 - ((3-ALKYLISOKINOL-5-YL) IMINO) -1,5,10,10A-TETRAHYDROTIA ZOO (3,4-B) ISOKINOLINER
US05/871,136 US4153698A (en) 1977-01-20 1978-01-20 Isoquinoline derivatives and pharmaceutical compositions containing them
NZ186282A NZ186282A (en) 1977-01-20 1978-01-20 3-((3-alkylisoquinol-5-yl)-imino)-1,5,10,10a-tetrahydro-thiazolo-(4,3-b)isoquinolines
IE126/78A IE46375B1 (en) 1977-01-20 1978-01-20 3-imino-1,5,10,10a-tetrahydrothiazolo(3,4-b)isoquinoline derivatives
DE2802453A DE2802453C3 (en) 1977-01-20 1978-01-20 Derivatives of 3 - [(3-alkyl-5-isoquinolyl) -imino] -1,5,10,10a-tetrahydro-thiazolo [3,4-b] isoquinoline, their preparation and the compositions containing them
ES468630A ES468630A1 (en) 1977-01-20 1978-04-07 Isoquinoline derivatives and pharmaceutical compositions containing them
AR275407A AR219963A1 (en) 1977-01-20 1979-02-05 PROCEDURE FOR PREPARING NEW DERIVATIVES OF (ALCOIL (C1-C10) -3-ISOQUINOLIL-5-IMINO) -3-TETRAHYDRO-1,5,10,10A-THIAZOL (3,4-B) - ISOQUINOLEIN
SU792720496A SU776560A3 (en) 1977-01-20 1979-02-08 Method of preparing 3-/(3-alkyl-5-isoquinolyl)imino/-1,5,10.10a-tetrahydrothiazolo/3,4-b/isoquinolyls in the form of individual isomers or their mixtures or their acid-additive salts
AT574979A AT359504B (en) 1977-01-20 1979-08-28 METHOD FOR PRODUCING NEW 3-ALKYL- -ISOCHINOLYL-5-IMINOTHIAZOLE (3,4-B) ISOCHINOLIN-DERIVATIVES AND THEIR ACID ADDITION SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7701516A FR2378030A1 (en) 1977-01-20 1977-01-20 Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties

Publications (2)

Publication Number Publication Date
FR2378030A1 true FR2378030A1 (en) 1978-08-18
FR2378030B1 FR2378030B1 (en) 1979-05-11

Family

ID=9185698

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7701516A Granted FR2378030A1 (en) 1977-01-20 1977-01-20 Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties

Country Status (3)

Country Link
BE (1) BE863083A (en)
FR (1) FR2378030A1 (en)
ZA (1) ZA78382B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2443469A1 (en) * 1978-12-07 1980-07-04 Rhone Poulenc Ind Thiazolo-thieno-pyridine derivs. - useful as antiviral, analgesic, antipyretic and antiinflammatory agents
FR2456098A2 (en) * 1977-12-23 1980-12-05 Rhone Poulenc Ind Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.
US4261999A (en) * 1978-12-07 1981-04-14 Rhone-Poulenc Industries Thiazolothienopyridines and anti-viral compositions thereof
EP0030198A1 (en) * 1979-12-04 1981-06-10 Rhone-Poulenc Sante Isoquinoline derivatives, their preparation and pharmaceutical compositions containing them
FR2470772A1 (en) * 1979-12-04 1981-06-12 Rhone Poulenc Ind 3-Substd. imino 1,5,10,10a-tetra:hydro thiazolo(3,4-b)-isoquinoline - antiviral esp. for rhino viruses some of which have analgesic, antiinflammatory and antipyretic activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505340A (en) * 1967-10-05 1970-04-07 Sandoz Ag 1-substituted-3-substituted imino-1,5,6,7,8,8a-hexahydro-3-h-thiazolo (3,4-a) pyridines and intermediates therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505340A (en) * 1967-10-05 1970-04-07 Sandoz Ag 1-substituted-3-substituted imino-1,5,6,7,8,8a-hexahydro-3-h-thiazolo (3,4-a) pyridines and intermediates therefor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456098A2 (en) * 1977-12-23 1980-12-05 Rhone Poulenc Ind Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.
FR2443469A1 (en) * 1978-12-07 1980-07-04 Rhone Poulenc Ind Thiazolo-thieno-pyridine derivs. - useful as antiviral, analgesic, antipyretic and antiinflammatory agents
US4261999A (en) * 1978-12-07 1981-04-14 Rhone-Poulenc Industries Thiazolothienopyridines and anti-viral compositions thereof
EP0030198A1 (en) * 1979-12-04 1981-06-10 Rhone-Poulenc Sante Isoquinoline derivatives, their preparation and pharmaceutical compositions containing them
FR2470772A1 (en) * 1979-12-04 1981-06-12 Rhone Poulenc Ind 3-Substd. imino 1,5,10,10a-tetra:hydro thiazolo(3,4-b)-isoquinoline - antiviral esp. for rhino viruses some of which have analgesic, antiinflammatory and antipyretic activity

Also Published As

Publication number Publication date
BE863083A (en) 1978-07-19
ZA78382B (en) 1979-03-28
FR2378030B1 (en) 1979-05-11

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