FR2455608A1 - PROTEIN FRACTIONATION PROCEDURE - Google Patents

PROTEIN FRACTIONATION PROCEDURE

Info

Publication number
FR2455608A1
FR2455608A1 FR8009775A FR8009775A FR2455608A1 FR 2455608 A1 FR2455608 A1 FR 2455608A1 FR 8009775 A FR8009775 A FR 8009775A FR 8009775 A FR8009775 A FR 8009775A FR 2455608 A1 FR2455608 A1 FR 2455608A1
Authority
FR
France
Prior art keywords
protein
membrane
solution
controlled
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8009775A
Other languages
French (fr)
Inventor
Grant U Bethel
Richard M Condie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota filed Critical University of Minnesota
Publication of FR2455608A1 publication Critical patent/FR2455608A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/10—Temperature control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A controlled protein fractionation method in which a cold protein-containing solution is circulated in contact with one side of a membrane and the temperature is controlled by circulating a protein precipitant solution in contact with the opposite side of the membrane. The flow rate is increased and back pressure is exerted on the precipitant solution to cause it to penetrate the membrane, mix with the protein solution and precipitate protein in fine particles along an inside membrane wall. The precipitated protein may be concentrated and separated by centrifugation or diafiltration. The membrane is preferably in the form of a plurality of hollow fibers. Control of process variables increases yield and purity, decreases processing time and reduces degree of denaturization. The method is especially applicable to carrying out the Cohn cold alcohol fractionation process.
FR8009775A 1979-05-04 1980-04-30 PROTEIN FRACTIONATION PROCEDURE Withdrawn FR2455608A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3603179A 1979-05-04 1979-05-04

Publications (1)

Publication Number Publication Date
FR2455608A1 true FR2455608A1 (en) 1980-11-28

Family

ID=21886215

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8009775A Withdrawn FR2455608A1 (en) 1979-05-04 1980-04-30 PROTEIN FRACTIONATION PROCEDURE

Country Status (17)

Country Link
EP (1) EP0028246A4 (en)
JP (1) JPS56500442A (en)
AR (1) AR224765A1 (en)
BE (1) BE883099A (en)
CA (1) CA1161368A (en)
DK (1) DK537380A (en)
ES (1) ES491138A0 (en)
FI (1) FI801439A (en)
FR (1) FR2455608A1 (en)
GR (1) GR68187B (en)
IL (1) IL59975A (en)
IT (1) IT1131137B (en)
NO (1) NO803951L (en)
NZ (1) NZ193605A (en)
PT (1) PT71179B (en)
WO (1) WO1980002380A1 (en)
ZA (1) ZA802667B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100004496A1 (en) * 2021-02-25 2022-08-25 Univ Della Calabria RECOVERY OF BIOLOGICAL DRUGS OR THEIR FRAGMENTS FROM IMPURE SOLUTIONS BY CRYSTALLIZATION OR PRECIPITATION WITH MEMBRANE

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2469193A (en) * 1942-02-09 1949-05-03 Research Corp Protein fractionation
US2390074A (en) * 1942-02-09 1945-12-04 Research Corp Protein product and process
US2770616A (en) * 1951-01-29 1956-11-13 Protein Foundation Inc Fractionation of proteinaceous materials in blood plasma and liver tissue
GB1323681A (en) * 1969-03-28 1973-07-18 Nat Res Dev Apparatus for use in the fractionation of solutions of protein aceous materials
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
US3763135A (en) * 1971-11-08 1973-10-02 Baxter Laboratories Inc Gamma globulin production from cohn fraction iii using polyethylene glycol
US4142966A (en) * 1974-04-01 1979-03-06 Monsanto Company Membrane separation of water from aqueous mixtures
DE2444524A1 (en) * 1974-09-18 1976-04-08 Oeser Henning Dr METHOD AND DEVICE FOR EXPLORATION OF HUMAN BLOOD PLASMA COMPONENTS
US3998946A (en) * 1975-04-23 1976-12-21 The Regents Of The University Of Minnesota Fibrinogen-free plasminogen-plasmin-free plasma and method of preparing and using same
SE393535B (en) * 1975-09-11 1977-05-16 Gambro Ab DEVICE FOR DIFFUSION OF THE SUBJECT BETWEEN TWO FLUIDES VIA SEMIPERMEABLE MEMBRANE
US4218312A (en) * 1975-12-01 1980-08-19 Monsanto Company Membrane separation of organics from aqueous solutions
FR2380362A2 (en) * 1976-02-13 1978-09-08 Baxter Travenol Lab Prodn. of dialyser contg. filament bundle - to give improved matrix strength and utilisation of available flow paths
NL7711855A (en) * 1977-02-11 1978-08-15 Baxter Travenol Lab METHOD AND ARRANGEMENT FOR THE MANUFACTURE OF FILAMENT BUNDLES AND DIALYZATORS CONTAINING SUCH BUNDLES.
DE2725757A1 (en) * 1977-06-07 1978-12-21 Fresenius Chem Pharm Ind DEVICE FOR THE CONTINUOUS ANALYSIS OF LOW MOLECULAR COMPONENTS IN FLOWING LIQUIDS
US4136094A (en) * 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin

Also Published As

Publication number Publication date
PT71179B (en) 1982-06-20
FI801439A (en) 1980-11-05
WO1980002380A1 (en) 1980-11-13
DK537380A (en) 1980-12-17
IT8021790A0 (en) 1980-05-02
GR68187B (en) 1981-11-09
EP0028246A1 (en) 1981-05-13
ZA802667B (en) 1981-06-24
AR224765A1 (en) 1982-01-15
PT71179A (en) 1980-07-01
BE883099A (en) 1980-11-03
CA1161368A (en) 1984-01-31
IL59975A (en) 1983-07-31
EP0028246A4 (en) 1982-03-29
JPS56500442A (en) 1981-04-09
IL59975A0 (en) 1980-07-31
NO803951L (en) 1980-12-29
IT1131137B (en) 1986-06-18
ES8107244A1 (en) 1981-05-16
NZ193605A (en) 1983-05-10
ES491138A0 (en) 1981-05-16

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Legal Events

Date Code Title Description
ST Notification of lapse