FR2453875A1 - Fractions d'heparine presentant des activites anticoagulantes accrues, leur preparation et leurs utilisations therapeutiques - Google Patents
Fractions d'heparine presentant des activites anticoagulantes accrues, leur preparation et leurs utilisations therapeutiquesInfo
- Publication number
- FR2453875A1 FR2453875A1 FR8008228A FR8008228A FR2453875A1 FR 2453875 A1 FR2453875 A1 FR 2453875A1 FR 8008228 A FR8008228 A FR 8008228A FR 8008228 A FR8008228 A FR 8008228A FR 2453875 A1 FR2453875 A1 FR 2453875A1
- Authority
- FR
- France
- Prior art keywords
- heparin
- preparation
- therapeutic uses
- fractions
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 3
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 239000002565 heparin fraction Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 5
- 229960002897 heparin Drugs 0.000 abstract 5
- 229920000669 heparin Polymers 0.000 abstract 5
- 239000008366 buffered solution Substances 0.000 abstract 3
- 238000010828 elution Methods 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7912691 | 1979-04-11 | ||
| GB7924816 | 1979-07-17 | ||
| GB8009585 | 1980-03-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2453875A1 true FR2453875A1 (fr) | 1980-11-07 |
| FR2453875B3 FR2453875B3 (OSRAM) | 1982-03-12 |
Family
ID=27260704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8008228A Granted FR2453875A1 (fr) | 1979-04-11 | 1980-04-11 | Fractions d'heparine presentant des activites anticoagulantes accrues, leur preparation et leurs utilisations therapeutiques |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE3014076A1 (OSRAM) |
| FR (1) | FR2453875A1 (OSRAM) |
| GB (1) | GB2051103A (OSRAM) |
| IT (1) | IT1141273B (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058397A3 (en) * | 1981-02-12 | 1984-01-04 | Eisai Co., Ltd. | Anticoagulant and the use thereof |
| EP2314632A2 (en) | 2004-03-24 | 2011-04-27 | Aventis Pharma S.A. | Oligosaccharidic compounds derived from heparin |
| WO2021007429A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104817651A (zh) * | 2015-05-26 | 2015-08-05 | 苏州鸿洋医药科技有限公司 | 肝素钠的精制工艺 |
| CN113484262B (zh) * | 2021-07-06 | 2023-04-07 | 青岛科技大学 | 一种肝素钠含量测定的方法 |
-
1980
- 1980-04-10 GB GB8011927A patent/GB2051103A/en not_active Withdrawn
- 1980-04-11 IT IT21337/80A patent/IT1141273B/it active
- 1980-04-11 DE DE19803014076 patent/DE3014076A1/de not_active Withdrawn
- 1980-04-11 FR FR8008228A patent/FR2453875A1/fr active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058397A3 (en) * | 1981-02-12 | 1984-01-04 | Eisai Co., Ltd. | Anticoagulant and the use thereof |
| EP2314632A2 (en) | 2004-03-24 | 2011-04-27 | Aventis Pharma S.A. | Oligosaccharidic compounds derived from heparin |
| WO2021007429A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| US11542534B2 (en) | 2019-07-09 | 2023-01-03 | Optimvia, Llc | Methods for synthesizing anticoagulant polysaccharides |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2051103A (en) | 1981-01-14 |
| IT8021337A0 (it) | 1980-04-11 |
| IT1141273B (it) | 1986-10-01 |
| FR2453875B3 (OSRAM) | 1982-03-12 |
| DE3014076A1 (de) | 1980-10-30 |
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