FR2453642A1 - Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxine - Google Patents
Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxineInfo
- Publication number
- FR2453642A1 FR2453642A1 FR7909270A FR7909270A FR2453642A1 FR 2453642 A1 FR2453642 A1 FR 2453642A1 FR 7909270 A FR7909270 A FR 7909270A FR 7909270 A FR7909270 A FR 7909270A FR 2453642 A1 FR2453642 A1 FR 2453642A1
- Authority
- FR
- France
- Prior art keywords
- plasticiser
- anionic
- polymers
- ergo
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 title abstract 2
- 125000000129 anionic group Chemical group 0.000 title abstract 2
- 239000004014 plasticizer Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- XLMJRFCCCWFQRE-SJRQCXNHSA-N ecboline Chemical compound C([C@H]1[C@]2(O)O3)CCN1C(=O)CN2C(=O)[C@]3(C(C)C)NC(=O)[C@@H](CN(C)[C@@H]1C2)C=C1C1=C3C2=CNC3=CC=C1 XLMJRFCCCWFQRE-SJRQCXNHSA-N 0.000 title 1
- 239000008187 granular material Substances 0.000 title 1
- 230000002490 cerebral effect Effects 0.000 abstract 2
- QHZUABXEBRGBLP-LKWYKXIFSA-N (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-4-benzyl-9b-hydroxy-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-9b-hydroxy-3,5-dioxo-2,4-di(propan-2-yl)-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,10aR)-N-[(2S,4S,9bS)-9b-hydroxy-4-(2-methylpropyl)-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)C4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2CC(CN(C)[C@@H]2C2)C(=O)N[C@@]3(C(=O)C4[C@@H](C(N5CCCC5[C@@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(C21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 QHZUABXEBRGBLP-LKWYKXIFSA-N 0.000 abstract 1
- 206010065929 Cardiovascular insufficiency Diseases 0.000 abstract 1
- UJYGDMFEEDNVBF-UHFFFAOYSA-N Ergocorninine Natural products C1=CC(C=2C(N(C)CC(C=2)C(=O)NC2(C(=O)N3C(C(N4CCCC4C3(O)O2)=O)C(C)C)C(C)C)C2)=C3C2=CNC3=C1 UJYGDMFEEDNVBF-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- YDOTUXAWKBPQJW-NSLWYYNWSA-N alpha-ergocryptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=CNC3=C1 YDOTUXAWKBPQJW-NSLWYYNWSA-N 0.000 abstract 1
- 229950001817 alpha-ergocryptine Drugs 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 208000015669 capillary disease Diseases 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- XQUUDUKVJKNJNP-OGGGUQDZSA-N ergocornine Chemical compound C([C@H]1N(C)C2)C([C]34)=CN=C4C=CC=C3C1=C[C@H]2C(=O)N[C@@]1(C(C)C)C(=O)N2[C@@H](C(C)C)C(=O)N3CCC[C@H]3[C@]2(O)O1 XQUUDUKVJKNJNP-OGGGUQDZSA-N 0.000 abstract 1
- OWEUDBYTKOYTAD-MKTPKCENSA-N ergocristine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@@H]1C=C2C3=CC=CC4=NC=C([C]34)C[C@H]2N(C)C1)C(C)C)C1=CC=CC=C1 OWEUDBYTKOYTAD-MKTPKCENSA-N 0.000 abstract 1
- HEFIYUQVAZFDEE-UHFFFAOYSA-N ergocristinine Natural products N12C(=O)C(C(C)C)(NC(=O)C3C=C4C=5C=CC=C6NC=C(C=56)CC4N(C)C3)OC2(O)C2CCCN2C(=O)C1CC1=CC=CC=C1 HEFIYUQVAZFDEE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7909270A FR2453642A1 (fr) | 1979-04-12 | 1979-04-12 | Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7909270A FR2453642A1 (fr) | 1979-04-12 | 1979-04-12 | Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2453642A1 true FR2453642A1 (fr) | 1980-11-07 |
| FR2453642B1 FR2453642B1 (enExample) | 1982-05-21 |
Family
ID=9224260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7909270A Granted FR2453642A1 (fr) | 1979-04-12 | 1979-04-12 | Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxine |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2453642A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2477015A1 (fr) * | 1980-03-03 | 1981-09-04 | Fabre Sa Pierre | Composition pharmaceutique a base d'un alcaloide de l'ergot de seigle, a activite regulatrice sur le tonus vasculaire |
| WO1985002114A1 (fr) * | 1983-11-14 | 1985-05-23 | Societe Anonyme Ethypharm | Nouvelles formes galeniques du sulpiride utlisables par voie orale |
| EP0147244A1 (fr) * | 1983-12-23 | 1985-07-03 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Nouvelles formes galéniques du sulpiride utilisables par voie orale |
| WO1986001717A1 (en) * | 1984-09-14 | 1986-03-27 | Pharmatec S.P.A. | Controlled release nifedipine preparation |
| EP0188309A3 (en) * | 1985-01-03 | 1987-09-02 | Connaught Laboratories Limited | Microencapsulation of living cells |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1347413A (fr) * | 1963-01-29 | 1963-12-27 | Italnysco S P A | Sphérules ou globules à action étalée et procédé pour leur préparation |
| GB1175430A (en) * | 1966-04-07 | 1969-12-23 | Sandoz Ltd | Pharmaceutical Compositions containing Ergot Alkaloids |
| FR2390959A1 (fr) * | 1977-05-16 | 1978-12-15 | Prugnaud Robert | Association therapeutique a visee anti-agregante et regularisatrice de la duree de vie plaquettaire a base de pyrimido-pyrimidine et d'acide acetyl salycilique |
-
1979
- 1979-04-12 FR FR7909270A patent/FR2453642A1/fr active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1347413A (fr) * | 1963-01-29 | 1963-12-27 | Italnysco S P A | Sphérules ou globules à action étalée et procédé pour leur préparation |
| GB1175430A (en) * | 1966-04-07 | 1969-12-23 | Sandoz Ltd | Pharmaceutical Compositions containing Ergot Alkaloids |
| FR2390959A1 (fr) * | 1977-05-16 | 1978-12-15 | Prugnaud Robert | Association therapeutique a visee anti-agregante et regularisatrice de la duree de vie plaquettaire a base de pyrimido-pyrimidine et d'acide acetyl salycilique |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2477015A1 (fr) * | 1980-03-03 | 1981-09-04 | Fabre Sa Pierre | Composition pharmaceutique a base d'un alcaloide de l'ergot de seigle, a activite regulatrice sur le tonus vasculaire |
| EP0036350A1 (fr) * | 1980-03-03 | 1981-09-23 | Pierre Fabre Medicament | Composition pharmaceutique à activité régulatrice sur le tonus vasculaire |
| WO1985002114A1 (fr) * | 1983-11-14 | 1985-05-23 | Societe Anonyme Ethypharm | Nouvelles formes galeniques du sulpiride utlisables par voie orale |
| EP0145558A3 (en) * | 1983-11-14 | 1985-08-07 | Ethypharm, Societe Anonyme | Galenic forms of sulpiride for oral administration |
| EP0147244A1 (fr) * | 1983-12-23 | 1985-07-03 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Nouvelles formes galéniques du sulpiride utilisables par voie orale |
| GB2151920A (en) * | 1983-12-23 | 1985-07-31 | Ile De France | Oral compositions containing sulpiride |
| AU569516B2 (en) * | 1983-12-23 | 1988-02-04 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Galenic forms of sulpiride for oral use |
| WO1986001717A1 (en) * | 1984-09-14 | 1986-03-27 | Pharmatec S.P.A. | Controlled release nifedipine preparation |
| EP0188309A3 (en) * | 1985-01-03 | 1987-09-02 | Connaught Laboratories Limited | Microencapsulation of living cells |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2453642B1 (enExample) | 1982-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| CA | Change of address | ||
| CD | Change of name or company name | ||
| ST | Notification of lapse |