FR2450109A1 - Controlling menstruation and preventing or terminating pregnancy - by admin. of luteinising hormone releasing hormone or its agonists after ovulation - Google Patents

Controlling menstruation and preventing or terminating pregnancy - by admin. of luteinising hormone releasing hormone or its agonists after ovulation

Info

Publication number
FR2450109A1
FR2450109A1 FR7733558A FR7733558A FR2450109A1 FR 2450109 A1 FR2450109 A1 FR 2450109A1 FR 7733558 A FR7733558 A FR 7733558A FR 7733558 A FR7733558 A FR 7733558A FR 2450109 A1 FR2450109 A1 FR 2450109A1
Authority
FR
France
Prior art keywords
leu
otbu
boc
lys
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7733558A
Other languages
French (fr)
Other versions
FR2450109B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7733558A priority Critical patent/FR2450109B1/en
Priority to AU41402/78A priority patent/AU522739B2/en
Priority to BE191582A priority patent/BE871826A/en
Publication of FR2450109A1 publication Critical patent/FR2450109A1/en
Application granted granted Critical
Publication of FR2450109B1 publication Critical patent/FR2450109B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Method for controlling the menstrual cycle and pregnancy comprises administering after ovulation a luteolytic amt. of LH-RH(leuteinising hormone releasing hormone) or its agonists of formula p-Glu-His-Trp-Ser-Tyr-X-Y-Arg-Pro-Z (I). In (I), either (a) Z=GlyNH2, Y=Leu and X is DN Leu, DN Val, D Abu (alpha-aminobutyric acid), D Phe, D Ser, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N Val, Met, Phe, D Leu, D Arg, D Ser (t-Bu), D Thr (t Bu), D Cys (t Bu), DAsp (OtBu), D Glu (OtBu), D Orn (boc), D Lys (boc), D Trp, Trp, 2-methyl-ala, D Tyr, D Met, epsilon-(lauryl or dextran)-D Lys; or (b) Z=NHQ (Q=1-3C alkyl or cyclopropyl), Y=Leu, and X is D Ser (tBu), DThr (tBu), DAsp (OtBu), D Glu (OtBu), D Orn (boc) or D Lys (boc); or (c) X=Gly; Y=Leu and Z is NHQ', pyrrolidino or morpholino, with Q'=methyl, ethyl, n-propyl or 2-hydroxyethyl; or (d) X=D Trp, D Leu, D Ala, D Ser (tBu) D Tyr, D Lys or Ala; Y=Leu and Z=ethylamino; or (e) X=Gly; Y=N-alpha-Me Leu and Z=GlyNH2 or ethylamino; or (f) X=D Leu, Y=Leu and Z=cyclopropylamino, or (g) X=Gly; Y=Ser(tBu), Cys(tBu), Asp(OtBu), Glu(OtBu), Orn(boc), or Lys(boc); Z=GlyNH2 or NHCL. Used for advancing the time of menstruation (e.g. before a sporting event); as postcoital contraceptives, or for terminating a pregnancy.
FR7733558A 1977-11-08 1977-11-08 NOVEL TREATMENT METHOD USING LH-RH, OR AGONISTS Expired FR2450109B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR7733558A FR2450109B1 (en) 1977-11-08 1977-11-08 NOVEL TREATMENT METHOD USING LH-RH, OR AGONISTS
AU41402/78A AU522739B2 (en) 1977-11-08 1978-11-07 Treatment using lh-rh or agonists thereof
BE191582A BE871826A (en) 1977-11-08 1978-11-07 NEW TREATMENT METHOD USING LH-RH OR AGONISTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7733558A FR2450109B1 (en) 1977-11-08 1977-11-08 NOVEL TREATMENT METHOD USING LH-RH, OR AGONISTS

Publications (2)

Publication Number Publication Date
FR2450109A1 true FR2450109A1 (en) 1980-09-26
FR2450109B1 FR2450109B1 (en) 1986-03-28

Family

ID=9197385

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733558A Expired FR2450109B1 (en) 1977-11-08 1977-11-08 NOVEL TREATMENT METHOD USING LH-RH, OR AGONISTS

Country Status (3)

Country Link
AU (1) AU522739B2 (en)
BE (1) BE871826A (en)
FR (1) FR2450109B1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137294A2 (en) * 1983-09-08 1985-04-17 Hoechst Aktiengesellschaft Gonadoliberin and gonadoliberin agonists in the treatment of metabolic diseases due to too small a parathormone level
EP0158987A2 (en) * 1984-04-18 1985-10-23 Hoechst Aktiengesellschaft Use of gonadoliberin and its antagonists for preparing a medicament for treating menopause disorders
EP0171477A2 (en) * 1984-06-18 1986-02-19 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245375A1 (en) * 1973-09-29 1975-04-25 Takeda Chemical Industries Ltd
FR2281132A1 (en) * 1974-08-09 1976-03-05 Hoechst Ag PEPTIDES WITH HIGH ACTIVITY OF HORMONE RELEASING HUMANIZING HORMONE OR FOLLICULOSTIMULATING HORMONE RELEASING HORMONE (HL-HL / HL-HFS) AND THEIR PREPARATION PROCESS AND THEIR APPLICATION
FR2307543A1 (en) * 1975-04-15 1976-11-12 Ici Australia Ltd NEW PEPTIDIC AMIDES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2313940A1 (en) * 1975-06-12 1977-01-07 Schally Andrew NEW PEPTIDES AND THEIR PREPARATION
US4010261A (en) * 1974-11-25 1977-03-01 Abbott Laboratories Method to prevent reproduction with [Des-Gly]10 -GN-RH nonadeptide amide analogs in position
FR2340928A1 (en) * 1976-02-11 1977-09-09 Abbott Lab Preventing reproduction in females with nonapeptides - in a safe treatment causing premature ovulation and inhibiting implantation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245375A1 (en) * 1973-09-29 1975-04-25 Takeda Chemical Industries Ltd
FR2281132A1 (en) * 1974-08-09 1976-03-05 Hoechst Ag PEPTIDES WITH HIGH ACTIVITY OF HORMONE RELEASING HUMANIZING HORMONE OR FOLLICULOSTIMULATING HORMONE RELEASING HORMONE (HL-HL / HL-HFS) AND THEIR PREPARATION PROCESS AND THEIR APPLICATION
US4010261A (en) * 1974-11-25 1977-03-01 Abbott Laboratories Method to prevent reproduction with [Des-Gly]10 -GN-RH nonadeptide amide analogs in position
FR2307543A1 (en) * 1975-04-15 1976-11-12 Ici Australia Ltd NEW PEPTIDIC AMIDES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2313940A1 (en) * 1975-06-12 1977-01-07 Schally Andrew NEW PEPTIDES AND THEIR PREPARATION
FR2340928A1 (en) * 1976-02-11 1977-09-09 Abbott Lab Preventing reproduction in females with nonapeptides - in a safe treatment causing premature ovulation and inhibiting implantation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137294A2 (en) * 1983-09-08 1985-04-17 Hoechst Aktiengesellschaft Gonadoliberin and gonadoliberin agonists in the treatment of metabolic diseases due to too small a parathormone level
EP0137294A3 (en) * 1983-09-08 1987-04-15 Hoechst Aktiengesellschaft Use of gonadoliberin and gonadoliberin agonists in the treatment of metabolic diseases due to too small a parathormone level
EP0158987A2 (en) * 1984-04-18 1985-10-23 Hoechst Aktiengesellschaft Use of gonadoliberin and its antagonists for preparing a medicament for treating menopause disorders
EP0158987A3 (en) * 1984-04-18 1987-04-15 Hoechst Aktiengesellschaft Use of gonadoliberin and its antagonists in the treatment of menopause
EP0171477A2 (en) * 1984-06-18 1986-02-19 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds
EP0171477A3 (en) * 1984-06-18 1987-10-14 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds

Also Published As

Publication number Publication date
BE871826A (en) 1979-05-07
AU4140278A (en) 1979-05-17
AU522739B2 (en) 1982-06-24
FR2450109B1 (en) 1986-03-28

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Legal Events

Date Code Title Description
DR Decision of the appeal court due to an appeal at law against decisions of the director of the inpi, except decision of lapse
CA Change of address
CD Change of name or company name