FR2449447A1 - ADDITIVE TO PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES IN THE DIGESTIVE APPARATUS - Google Patents

ADDITIVE TO PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES IN THE DIGESTIVE APPARATUS

Info

Publication number
FR2449447A1
FR2449447A1 FR8003909A FR8003909A FR2449447A1 FR 2449447 A1 FR2449447 A1 FR 2449447A1 FR 8003909 A FR8003909 A FR 8003909A FR 8003909 A FR8003909 A FR 8003909A FR 2449447 A1 FR2449447 A1 FR 2449447A1
Authority
FR
France
Prior art keywords
group
active substances
promote
absorption
therapeutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8003909A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Publication of FR2449447A1 publication Critical patent/FR2449447A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LES B-DICETONES AYANT LA FORMULE SUIVANTE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPE ALCOYLE SUBSTITUE PAR UN OU PLUSIEURS SUBSTITUANTS CHOISIS PARMI LES GROUPES HYDROXY, SULFO, CARBOXY, PHOSPHO ET AMINO, Y COMPRIS LEURS DERIVES, ET AMMONIO, OU UN GROUPE ARALCOYLE, ARYLE OU DES GROUPES HETEROCYCLIQUES QUI PEUVENT EVENTUELLEMENT ETRE SUBSTITUES PAR UN OU PLUSIEURS MEMBRES DU GROUPE DE SUBSTITUANTS MENTIONNE CI-DESSUS, OU UN GROUPE HETEROCYCLE-ALCOYLENE ALCOYLE; Y EST UN ATOME D'OXYGENE, UN ATOME DE SOUFRE OU UN GROUPE IMINO; R EST UN GROUPE ALCOYLE, FAVORISENT L'ABSORPTION DE SUBSTANCES THERAPEUTIQUEMENT ACTIVES PAR LE COURANT SANGUIN DANS L'APPAREIL DIGESTIF ET SONT CAPABLES D'AUGMENTER EFFICACEMENT LA CONCENTRATION DE CES SUBSTANCES ACTIVES DANS LE SANG MEME QUAND CES SUBSTANCES ACTIVES NE SONT ABSORBABLES DANS L'APPAREIL DIGESTIF QU'AVEC UNE DIFFICULTE CONSIDERABLE.THE B-DICETONES WITH THE FOLLOWING FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS AN ALCOHYL GROUP SUBSTITUTED BY ONE OR MORE SUBSTITUTES CHOSEN FROM THE HYDROXY, SULFO, CARBOXY, PHOSPHO AND AMINO GROUP, INCLUDING LEVEL, INCLUDING OR AN ARALCOYL, ARYL GROUP OR HETEROCYCLIC GROUPS WHICH COULD POSSIBLY BE SUBSTITUTED BY ONE OR MORE MEMBERS OF THE ABOVE-MENTIONED SUBSTITUTE GROUP, OR A HETEROCYCLE-ALCOYLENE ALCOYL GROUP; Y IS AN OXYGEN ATOM, A SULFUR ATOM OR AN IMINO GROUP; R IS AN ALKYL GROUP, PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES BY THE BLOOD CURRENT IN THE DIGESTIVE SYSTEM AND ARE CAPABLE OF EFFECTIVELY INCREASING THE CONCENTRATION OF THESE ACTIVE SUBSTANCES IN THE BLOOD EVEN WHEN THESE ABSORBES ARE NOT ACTIVE IN ITS ABSORBES. DIGESTIVE APPARATUS THAT WITH A CONSIDERABLE DIFFICULTY.

FR8003909A 1979-02-26 1980-02-22 ADDITIVE TO PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES IN THE DIGESTIVE APPARATUS Withdrawn FR2449447A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2244679A JPS55113723A (en) 1979-02-26 1979-02-26 Drug composition to be absorbed in digestive canal

Publications (1)

Publication Number Publication Date
FR2449447A1 true FR2449447A1 (en) 1980-09-19

Family

ID=12082929

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003909A Withdrawn FR2449447A1 (en) 1979-02-26 1980-02-22 ADDITIVE TO PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES IN THE DIGESTIVE APPARATUS

Country Status (3)

Country Link
JP (1) JPS55113723A (en)
FR (1) FR2449447A1 (en)
GB (1) GB2046091A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009145A1 (en) * 1993-09-30 1995-04-06 Eastman Chemical Company NUTRITIVE GLYCEROL ESTERS OF β-ACYLOXY BUTYRATES

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3171774D1 (en) * 1980-03-31 1985-09-19 Teijin Ltd Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom
US4582820A (en) * 1982-12-23 1986-04-15 Research Corporation Orally administered biologically active peptides and proteins
JPS6212746A (en) * 1985-07-11 1987-01-21 Hoechst Gosei Kk Production of acetoacetylated oligomer
WO1995009144A1 (en) * 1993-09-30 1995-04-06 Eastman Chemical Company Nutritive water soluble glycerol esters of hydroxy butyric acid
US5420335A (en) * 1993-09-30 1995-05-30 Birkhahn; Ronald H. Parenteral nutrients based on watersoluble glycerol bisacetoacetates
EP0881253A1 (en) * 1997-05-27 1998-12-02 Akcros Chemicals B-ketoesters for use as polymer stabilisers
JP7546828B2 (en) * 2019-06-12 2024-09-09 ケトリピックス セラポーティクス ゲーエムベーハー Method for producing polyol-based esters of ketocarboxylic acids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009609A2 (en) * 1978-08-26 1980-04-16 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract, pharmaceutical composition comprising said adjuvant and process for preparing said pharmaceutical composition; enamine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009609A2 (en) * 1978-08-26 1980-04-16 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract, pharmaceutical composition comprising said adjuvant and process for preparing said pharmaceutical composition; enamine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009145A1 (en) * 1993-09-30 1995-04-06 Eastman Chemical Company NUTRITIVE GLYCEROL ESTERS OF β-ACYLOXY BUTYRATES

Also Published As

Publication number Publication date
JPS55113723A (en) 1980-09-02
GB2046091A (en) 1980-11-12

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Legal Events

Date Code Title Description
ST Notification of lapse