JPS5731623A - Production of gamma-globulin for intravenous injection - Google Patents
Production of gamma-globulin for intravenous injectionInfo
- Publication number
- JPS5731623A JPS5731623A JP10561880A JP10561880A JPS5731623A JP S5731623 A JPS5731623 A JP S5731623A JP 10561880 A JP10561880 A JP 10561880A JP 10561880 A JP10561880 A JP 10561880A JP S5731623 A JPS5731623 A JP S5731623A
- Authority
- JP
- Japan
- Prior art keywords
- anticomplementary activity
- added
- gamma
- gamma globulin
- sufficiently low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: Specific amounts of L-arginine and L-lysine are added to a physiological saline silution of gamma-globuline that is effective for treatment and prevention of various microbial infections and sufficiently low in anticomplementary activity to produce the titled preparation of high stability for a long period of time.
CONSTITUTION: To a physilogical saline solution containing 5W15W/V% of gamma globulin with sufficiently low anticomplementary activity, are added L-alginine and L-lysine or their salts so that their amounts become in the range 0.2W0.3mol/l and the pH is adjusted to 6.4W7.2 to produce the objective gamma globulin preparation for intravenous injection. The gamma globulin with sufficiently low anticomplementary activity means a product that is made by treating naturally occurring human-originating gamma globulin with, e.g., low molecular dextran and a saccharide to remove impurities of high anticomplementary activity. However, when it is added directly, its anticomplementary activity rises again and so L-arginine or the like is added as a stabilizer to inhibit the rise.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10561880A JPS5731623A (en) | 1980-07-30 | 1980-07-30 | Production of gamma-globulin for intravenous injection |
US06/181,972 US4374763A (en) | 1979-09-17 | 1980-08-28 | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
CA000360104A CA1165236A (en) | 1979-09-17 | 1980-09-11 | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
EP80303246A EP0025719A3 (en) | 1979-09-17 | 1980-09-15 | Gamma-globulin preparation for intravenous administration, process for production thereof and process for preparation of gamma-globulin of low anticomplementary activity |
ES495527A ES8106653A1 (en) | 1979-09-17 | 1980-09-17 | Gamma-globulin preparation for intravenous administration, process for production thereof and process for preparation of gamma-globulin of low anticomplementary activity. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10561880A JPS5731623A (en) | 1980-07-30 | 1980-07-30 | Production of gamma-globulin for intravenous injection |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5731623A true JPS5731623A (en) | 1982-02-20 |
Family
ID=14412476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10561880A Pending JPS5731623A (en) | 1979-09-17 | 1980-07-30 | Production of gamma-globulin for intravenous injection |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5731623A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011034604A2 (en) | 2009-09-17 | 2011-03-24 | Baxter Healthcare, S.A. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
JP5485489B2 (en) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | Antibody-containing stabilized preparation |
US8906368B2 (en) | 2003-11-18 | 2014-12-09 | Zlb Behring Ag | Immunoglobulin preparations having increased stability |
US9241897B2 (en) | 2010-02-04 | 2016-01-26 | Csl Behring Ag | Immunoglobulin preparation |
US9422364B2 (en) | 2010-02-26 | 2016-08-23 | Csl Behring Ag | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
US10301376B2 (en) | 2008-03-17 | 2019-05-28 | Baxalta GmbH | Combinations and methods for subcutaneous administration of immune globulin and hyaluronidase |
-
1980
- 1980-07-30 JP JP10561880A patent/JPS5731623A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5485489B2 (en) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | Antibody-containing stabilized preparation |
US8906368B2 (en) | 2003-11-18 | 2014-12-09 | Zlb Behring Ag | Immunoglobulin preparations having increased stability |
US10301376B2 (en) | 2008-03-17 | 2019-05-28 | Baxalta GmbH | Combinations and methods for subcutaneous administration of immune globulin and hyaluronidase |
USRE49967E1 (en) | 2008-03-17 | 2024-05-14 | Takeda Pharmaceutical Company Limited | Combinations and methods for subcutaneous administration of immune globulin and hyaluronidase |
WO2011034604A2 (en) | 2009-09-17 | 2011-03-24 | Baxter Healthcare, S.A. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
US9241897B2 (en) | 2010-02-04 | 2016-01-26 | Csl Behring Ag | Immunoglobulin preparation |
US10137197B2 (en) | 2010-02-04 | 2018-11-27 | Csl Behring Ag | Process for preparing an immunoglobulin preparation |
US9422364B2 (en) | 2010-02-26 | 2016-08-23 | Csl Behring Ag | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
US10434176B2 (en) | 2010-02-26 | 2019-10-08 | Csl Behring Ag | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
US11419936B2 (en) | 2010-02-26 | 2022-08-23 | Csl Behring Ag | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
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