FR2447908A1 - Phenyl-alkyl-sulphone hypocholesterolaemics - and hypo:tri:glyceridaemics, which also have CNS activity as tranquillisers, anticonvulsants, antiemetics and antiulcerogenics - Google Patents

Phenyl-alkyl-sulphone hypocholesterolaemics - and hypo:tri:glyceridaemics, which also have CNS activity as tranquillisers, anticonvulsants, antiemetics and antiulcerogenics

Info

Publication number
FR2447908A1
FR2447908A1 FR7902573A FR7902573A FR2447908A1 FR 2447908 A1 FR2447908 A1 FR 2447908A1 FR 7902573 A FR7902573 A FR 7902573A FR 7902573 A FR7902573 A FR 7902573A FR 2447908 A1 FR2447908 A1 FR 2447908A1
Authority
FR
France
Prior art keywords
alkyl
phenyl
hypocholesterolaemics
glyceridaemics
antiulcerogenics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7902573A
Other languages
French (fr)
Other versions
FR2447908B1 (en
Inventor
Philippe Loiseau
Jean-Paul Fournier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7902573A priority Critical patent/FR2447908B1/en
Publication of FR2447908A1 publication Critical patent/FR2447908A1/en
Application granted granted Critical
Publication of FR2447908B1 publication Critical patent/FR2447908B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

(A) Phenyl-methylsulphone derivs. of formula (I) are new: (where R2-R6 = H, halo, methyl, methoxy, nitro or amino (opt. substd. by 1 or 2 1-3C alkyl gps.); R7 = H, 1-3C alkyl or 1-3C alkylene; and R8 = H, hydroxyalkyl, hydroxycycloalkyl or hydroxyalkylaryl (the hydroxy groups of which may be esterified and the aryl group may be substituted in the aromatic ring especially by halo); provided that (1) when R8 = H, then R2 = alkoxy or nitro; (2) when R7 = R8 = H, then R2 = nitro or R2 = R3 = R4 = alkoxy; (3) when R8 = -CHOH-C6H5, then at least one of R2-R6 is not = H; (4) when R8 = -CH2CH2OH or its esterified derivs. then at least one of R2-R7 is not = H; and (5) when R7 = -CH2OH or esterified deriv., then R6 is not = H). (B) Medicaments contg. cpds. of formula (I), where the groups are as defined above but without the restrictive conditions, are new.
FR7902573A 1979-01-31 1979-01-31 NOVEL BENZENESULFONE TYPE COMPOUNDS AND PROCESS FOR THEIR PREPARATION Expired FR2447908B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7902573A FR2447908B1 (en) 1979-01-31 1979-01-31 NOVEL BENZENESULFONE TYPE COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7902573A FR2447908B1 (en) 1979-01-31 1979-01-31 NOVEL BENZENESULFONE TYPE COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Publications (2)

Publication Number Publication Date
FR2447908A1 true FR2447908A1 (en) 1980-08-29
FR2447908B1 FR2447908B1 (en) 1986-03-21

Family

ID=9221457

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7902573A Expired FR2447908B1 (en) 1979-01-31 1979-01-31 NOVEL BENZENESULFONE TYPE COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Country Status (1)

Country Link
FR (1) FR2447908B1 (en)

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB544849A (en) * 1940-09-27 1942-04-30 Manchester Oxide Co Ltd Improvements in the manufacture of aromatic compounds containing sulphur
GB661783A (en) * 1948-04-01 1951-11-28 British Celanese Manufacture of vinyl sulphones
DE949054C (en) * 1954-02-19 1956-09-13 Hoechst Ag Process for the preparation of phenylsulphone compounds chlorinated or brominated in the 2,3,5,6-position
GB792045A (en) * 1954-02-18 1958-03-19 Boots Pure Drug Co Ltd New sulphur containing compounds
FR1297775A (en) * 1961-05-04 1962-07-06 Hickson & Welch Ltd Process for the preparation of stilbyl sulfones and resulting products
US3124447A (en) * 1964-03-10 Herbicidal ratingxco n nveesion scale
FR1359602A (en) * 1959-04-15 1964-04-30 Centre Nat Rech Scient New aryl alkyl sulfones, their preparation and applications
US3186904A (en) * 1961-02-03 1965-06-01 Boots Pure Drug Co Ltd Fungicidal sulphones and sulphoxides
FR1442292A (en) * 1963-09-30 1966-06-17 Shell Int Research Alkoyl-nitroaryl-sulfones as herbicides
NL7116796A (en) * 1970-12-07 1972-06-09
US3699171A (en) * 1970-08-28 1972-10-17 Shell Oil Co Process for the oxidation of aryl alkyl sulfoxides to aryl alkyl sulfones
FR2141749A1 (en) * 1971-06-05 1973-01-26 Cassella Farbwerke Mainkur Ag
FR2240201A1 (en) * 1973-08-10 1975-03-07 Anvar
FR2313061A1 (en) * 1975-06-03 1976-12-31 Yoshitomi Pharmaceutical PIPERAZINE DERIVATIVES AND THEIR PREPARATION PROCESS

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124447A (en) * 1964-03-10 Herbicidal ratingxco n nveesion scale
GB544849A (en) * 1940-09-27 1942-04-30 Manchester Oxide Co Ltd Improvements in the manufacture of aromatic compounds containing sulphur
GB661783A (en) * 1948-04-01 1951-11-28 British Celanese Manufacture of vinyl sulphones
GB792045A (en) * 1954-02-18 1958-03-19 Boots Pure Drug Co Ltd New sulphur containing compounds
DE949054C (en) * 1954-02-19 1956-09-13 Hoechst Ag Process for the preparation of phenylsulphone compounds chlorinated or brominated in the 2,3,5,6-position
FR1359602A (en) * 1959-04-15 1964-04-30 Centre Nat Rech Scient New aryl alkyl sulfones, their preparation and applications
US3186904A (en) * 1961-02-03 1965-06-01 Boots Pure Drug Co Ltd Fungicidal sulphones and sulphoxides
FR1297775A (en) * 1961-05-04 1962-07-06 Hickson & Welch Ltd Process for the preparation of stilbyl sulfones and resulting products
FR1442292A (en) * 1963-09-30 1966-06-17 Shell Int Research Alkoyl-nitroaryl-sulfones as herbicides
US3699171A (en) * 1970-08-28 1972-10-17 Shell Oil Co Process for the oxidation of aryl alkyl sulfoxides to aryl alkyl sulfones
NL7116796A (en) * 1970-12-07 1972-06-09
FR2141749A1 (en) * 1971-06-05 1973-01-26 Cassella Farbwerke Mainkur Ag
FR2240201A1 (en) * 1973-08-10 1975-03-07 Anvar
FR2313061A1 (en) * 1975-06-03 1976-12-31 Yoshitomi Pharmaceutical PIPERAZINE DERIVATIVES AND THEIR PREPARATION PROCESS

Also Published As

Publication number Publication date
FR2447908B1 (en) 1986-03-21

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