FR2434151A1 - PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE - Google Patents

PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE

Info

Publication number
FR2434151A1
FR2434151A1 FR7914907A FR7914907A FR2434151A1 FR 2434151 A1 FR2434151 A1 FR 2434151A1 FR 7914907 A FR7914907 A FR 7914907A FR 7914907 A FR7914907 A FR 7914907A FR 2434151 A1 FR2434151 A1 FR 2434151A1
Authority
FR
France
Prior art keywords
ones
pyrroline
producing
pyrrolidine
necessary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7914907A
Other languages
French (fr)
Other versions
FR2434151B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mundipharma AG
Original Assignee
Mundipharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma AG filed Critical Mundipharma AG
Publication of FR2434151A1 publication Critical patent/FR2434151A1/en
Application granted granted Critical
Publication of FR2434151B3 publication Critical patent/FR2434151B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne la synthèse de composés hétérocycliques doués d'une activité biologique. On soumet des N-aroylméthylacétamides à une cyclisation sous N2 en milieu basique pour obtenir des 3-pyrroline-2-ones qu'une hydrogénation catalytique transforme en les pyrrolidine-2-ones correspondantes. Les composés ainsi obtenus agissent sur le système nerveux central ou ont une action analogue à celle des prostaglandines.The invention relates to the synthesis of heterocyclic compounds endowed with biological activity. N-aroylmethylacetamides are subjected to cyclization under N2 in a basic medium to obtain 3-pyrrolin-2-ones which catalytic hydrogenation transforms into the corresponding pyrrolidine-2-ones. The compounds thus obtained act on the central nervous system or have an action analogous to that of prostaglandins.

FR7914907A 1978-06-12 1979-06-11 PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE Granted FR2434151A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91468278A 1978-06-12 1978-06-12
US1249679A 1979-02-15 1979-02-15

Publications (2)

Publication Number Publication Date
FR2434151A1 true FR2434151A1 (en) 1980-03-21
FR2434151B3 FR2434151B3 (en) 1982-04-30

Family

ID=26683628

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7914907A Granted FR2434151A1 (en) 1978-06-12 1979-06-11 PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE

Country Status (19)

Country Link
AR (1) AR222997A1 (en)
AT (1) ATA386679A (en)
AU (1) AU529479B2 (en)
CA (1) CA1108628A (en)
CH (1) CH650772A5 (en)
DE (3) DE2923553A1 (en)
DK (1) DK157847C (en)
ES (1) ES481315A1 (en)
FI (1) FI70209C (en)
FR (1) FR2434151A1 (en)
GB (1) GB2028307B (en)
GR (1) GR68438B (en)
IL (1) IL57266A (en)
IT (1) IT1116891B (en)
NL (1) NL7904584A (en)
NO (1) NO791943L (en)
NZ (1) NZ190705A (en)
PT (1) PT69716A (en)
SE (1) SE431644B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943640A (en) * 1983-10-14 1990-07-24 The Dow Chemical Company Preparation of 5-(1-alkyl-carbonyloxy)alkylpyrrolidin-2-one
AU4809390A (en) * 1988-12-27 1990-08-01 Ici Americas Inc. Process for the preparation of 3-carboalkoxypyrrolidones
US5021587A (en) * 1990-01-24 1991-06-04 Petrolite Corporation Synthesis of N,3,4-trisubstituted-3-azoline-2-ones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272842A (en) * 1965-06-25 1966-09-13 Lilly Co Eli Novel pyrrolinones
GB1350582A (en) 1970-07-24 1974-04-18 Ucb Sa Cerivatives of 2-pyrrolidinone
DE2413935A1 (en) * 1974-03-20 1975-10-16 Schering Ag 4- (POLYALCOXY-PHENYL) -2-PYRROLIDONE

Also Published As

Publication number Publication date
GB2028307A (en) 1980-03-05
IT7949373A0 (en) 1979-06-11
FI70209C (en) 1986-09-15
ES481315A1 (en) 1980-08-16
IL57266A (en) 1982-12-31
GR68438B (en) 1981-12-30
FI70209B (en) 1986-02-28
FI791866A (en) 1979-12-13
DK241779A (en) 1979-12-13
SE7905079L (en) 1979-12-13
AU529479B2 (en) 1983-06-09
SE431644B (en) 1984-02-20
DE2954237C2 (en) 1989-09-21
DE2923553C2 (en) 1988-06-01
DK157847B (en) 1990-02-26
DK157847C (en) 1990-09-17
NZ190705A (en) 1981-10-19
AU4767079A (en) 1979-12-20
CH650772A5 (en) 1985-08-15
CA1108628A (en) 1981-09-08
PT69716A (en) 1979-07-01
DE2954236C2 (en) 1988-10-06
ATA386679A (en) 1983-12-15
DE2923553A1 (en) 1979-12-20
AR222997A1 (en) 1981-07-15
NL7904584A (en) 1979-12-14
NO791943L (en) 1979-12-13
GB2028307B (en) 1983-01-19
IT1116891B (en) 1986-02-10
IL57266A0 (en) 1979-09-30
FR2434151B3 (en) 1982-04-30

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Legal Events

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