FR2432032A1 - Resines echangeuses d'ions du type anionique, possedant des proprietes hypocholesterolemiantes - Google Patents

Resines echangeuses d'ions du type anionique, possedant des proprietes hypocholesterolemiantes

Info

Publication number
FR2432032A1
FR2432032A1 FR7903703A FR7903703A FR2432032A1 FR 2432032 A1 FR2432032 A1 FR 2432032A1 FR 7903703 A FR7903703 A FR 7903703A FR 7903703 A FR7903703 A FR 7903703A FR 2432032 A1 FR2432032 A1 FR 2432032A1
Authority
FR
France
Prior art keywords
polymer
weight
properties
water
hypocholesterolemiant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7903703A
Other languages
English (en)
Other versions
FR2432032B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texcontor
Original Assignee
Texcontor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texcontor filed Critical Texcontor
Publication of FR2432032A1 publication Critical patent/FR2432032A1/fr
Application granted granted Critical
Publication of FR2432032B1 publication Critical patent/FR2432032B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyethers (AREA)
  • Steroid Compounds (AREA)

Abstract

Ces résines sont en particulier des résines styroliques, acryliques et époxydiques non toxiques, dotées de propriétés fortement hypocholestérolémiantes. Elles ont des densités apparentes dans l'eau comprises entre 0,18 et 0,20 g de matière sèche/ml avec une capacité d'absorption d'eau comprise entre 69 et 73 % en poids par rapport au poids du polymère; leur procédé de préparation, consistant à polymériser à faible vitesse un mélange de monomères contenant un pourcentage critique de monomère réticulant, de manière à donner au polymère un degré de réticulation déterminé de façon impérative et distribué uniformément, correspondant à une densité apparente dans l'eau comprise entre 0,18 et 0,20 g de matière sèche/ml avec une capacité d'absorption d'eau comprise entre 69 et 73 % en poids par rapport au poids du polymère est caractérisé en ce qu'on utilise, en tant que catalyseur de polymérisation, un peroxyde organique dans des concentrations comprises entre 0,2 et 3 % et, en tant qu'agent réticulant, un composé divinylique dans des concentrations comprises entre 1,5 et 12 %, et en ce qu'on applique une température de polymérisation comprise entre 50 degrés et 80 degrés C.
FR7903703A 1978-07-24 1979-02-14 Resines echangeuses d'ions du type anionique, possedant des proprietes hypocholesterolemiantes Granted FR2432032A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2601478A IT1097396B (it) 1978-07-24 1978-07-24 Resine scambiatrici di ioni del tipo anionico con proprieta' ipocolesterolemizzanti

Publications (2)

Publication Number Publication Date
FR2432032A1 true FR2432032A1 (fr) 1980-02-22
FR2432032B1 FR2432032B1 (fr) 1983-11-18

Family

ID=11218412

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7903703A Granted FR2432032A1 (fr) 1978-07-24 1979-02-14 Resines echangeuses d'ions du type anionique, possedant des proprietes hypocholesterolemiantes

Country Status (12)

Country Link
JP (1) JPS5521480A (fr)
AU (1) AU529979B2 (fr)
BE (1) BE877101A (fr)
CA (1) CA1141892A (fr)
DE (1) DE2924893C2 (fr)
ES (1) ES482755A1 (fr)
FR (1) FR2432032A1 (fr)
GB (1) GB2026501B (fr)
IT (1) IT1097396B (fr)
NL (1) NL182568C (fr)
NZ (1) NZ190878A (fr)
YU (1) YU179079A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7653081A (en) * 1980-10-20 1982-04-29 Dow Chemical Company, The T-butylstyrene copolymers for controlling body weight of animals
GB8730010D0 (en) * 1987-12-23 1988-02-03 Smith Kline French Lab Compounds
US5230885A (en) * 1987-12-23 1993-07-27 Smith Kline & French Laboratories Limited Polystyrene anion exchange polymer pharmaceutical composition
GB8911719D0 (en) * 1989-05-22 1989-07-05 Smith Kline French Lab Compounds
GB8913699D0 (en) * 1989-06-14 1989-08-02 Smith Kline French Lab Compounds
GB8913700D0 (en) * 1989-06-14 1989-08-02 Smith Kline French Lab Compounds
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
CA1141892A (fr) 1983-02-22
BE877101A (fr) 1979-10-15
JPS6218218B2 (fr) 1987-04-22
NL182568B (nl) 1987-11-02
YU179079A (en) 1982-10-31
DE2924893A1 (de) 1980-02-14
DE2924893C2 (de) 1983-08-04
NL182568C (nl) 1988-04-05
IT7826014A0 (it) 1978-07-24
FR2432032B1 (fr) 1983-11-18
AU4834179A (en) 1980-02-07
ES482755A1 (es) 1980-04-16
IT1097396B (it) 1985-08-31
NL7905353A (nl) 1980-01-28
JPS5521480A (en) 1980-02-15
AU529979B2 (en) 1983-06-30
GB2026501B (en) 1982-12-08
NZ190878A (en) 1982-05-31
GB2026501A (en) 1980-02-06

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse