FR2432025A1 - Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities - Google Patents

Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities

Info

Publication number
FR2432025A1
FR2432025A1 FR7822352A FR7822352A FR2432025A1 FR 2432025 A1 FR2432025 A1 FR 2432025A1 FR 7822352 A FR7822352 A FR 7822352A FR 7822352 A FR7822352 A FR 7822352A FR 2432025 A1 FR2432025 A1 FR 2432025A1
Authority
FR
France
Prior art keywords
alkyl
fluoranthene
fluorene
anoxia
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822352A
Other languages
French (fr)
Other versions
FR2432025B1 (en
Inventor
Regis Dupont
Patrick Lardenois
Claude Morel
Jonathan Frost
Gabor-Istvan Koletar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7822352A priority Critical patent/FR2432025A1/en
Priority to EP79400459A priority patent/EP0008249B1/en
Priority to DE7979400459T priority patent/DE2960689D1/en
Priority to AT79400459T priority patent/ATE165T1/en
Priority to ZA00793796A priority patent/ZA793796B/en
Priority to AU49278/79A priority patent/AU524307B2/en
Priority to PT69988A priority patent/PT69988A/en
Priority to US06/060,857 priority patent/US4277476A/en
Priority to CA332,589A priority patent/CA1107729A/en
Priority to NO792476A priority patent/NO792476L/en
Priority to DK316279A priority patent/DK316279A/en
Priority to JP9664279A priority patent/JPS5520796A/en
Priority to FI792366A priority patent/FI65250C/en
Priority to NZ191141A priority patent/NZ191141A/en
Priority to ES482889A priority patent/ES482889A1/en
Publication of FR2432025A1 publication Critical patent/FR2432025A1/en
Priority to GR59709A priority patent/GR75070B/el
Application granted granted Critical
Publication of FR2432025B1 publication Critical patent/FR2432025B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

Triaza-fluorene and fluoranthene derivs. of formula (I) and intermediates in their prepn. of formula (II) are new: (n is 1 or 2; m is 0 or 1; R1 is H, halogen, alkyl or alkoxy; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, benzyl, halobenzyl, alkylbenzyl, alkoxybenzyl, acyl, alkoxycarbonyl or alkylaminocarbonyl; R'2 is alkyl, cycloalkyl, cycloalkylalkyl, benzyl, halobenzyl, alkylbenzyl or alkoxybenzyl; R3 is H or alkyl; R4 is H, alkyl, acyl or aroyl; all alkyl and alkoxy gps. being of 1-4C). (I) have antianoxic and psychotropic props. and are useful for treating e.g. behavioural troubles caused by cerebrovascular damage or geriatric cerebral sclerosis.
FR7822352A 1978-07-28 1978-07-28 Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities Granted FR2432025A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR7822352A FR2432025A1 (en) 1978-07-28 1978-07-28 Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities
EP79400459A EP0008249B1 (en) 1978-07-28 1979-07-05 Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application
DE7979400459T DE2960689D1 (en) 1978-07-28 1979-07-05 Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application
AT79400459T ATE165T1 (en) 1978-07-28 1979-07-05 FLUORENE AND FLUORANTHENE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
ZA00793796A ZA793796B (en) 1978-07-28 1979-07-25 Derivatives of fluorenes and fluoranthenes and process for their preparation
NO792476A NO792476L (en) 1978-07-28 1979-07-26 PROCEDURE FOR MANUFACTURING ORGANIC COMPOUNDS
US06/060,857 US4277476A (en) 1978-07-28 1979-07-26 Derivatives of fluorenes and fluoranthenes and process for their preparation
CA332,589A CA1107729A (en) 1978-07-28 1979-07-26 Preparation of derivatives of fluorenes and fluoranthenes
AU49278/79A AU524307B2 (en) 1978-07-28 1979-07-26 Derivatives of fluorenes and fluoranthrenes
DK316279A DK316279A (en) 1978-07-28 1979-07-26 THEIR FLUORANTS AND FLUORANTS ANALYSIS OF THEIR PREPARATION AND USE IN THERAPEUTIC PREPARATIONS AND INTERMEDIATES
PT69988A PT69988A (en) 1978-07-28 1979-07-26 PROCESS FOR THE PREPARATION OF FLUORENE AND FLUORANTHENE DERIVATIVES
FI792366A FI65250C (en) 1978-07-28 1979-07-27 PROCEDURE FOR THERAPEUTIC USE OF THERAPEUTIC ANVAENDBARA 3-CETYL-1,2,3,3A, 4,5,6,7-OCTAHYDRO-3,6,7A-TRIAZA-CYCLOHEPTA (J) FLUORENDERIVAT
NZ191141A NZ191141A (en) 1978-07-28 1979-07-27 2,3,3a,4,5,6-hexahydro-3,5,6a-triazafluoranthenes and 1,2,3,3a,4,5,6,7-octahydro-3,6,7a-triazacyclohepta (j,k)-fluorenes
ES482889A ES482889A1 (en) 1978-07-28 1979-07-27 Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application.
JP9664279A JPS5520796A (en) 1978-07-28 1979-07-27 Fluorene and fluoranthene derivative
GR59709A GR75070B (en) 1978-07-28 1981-01-05

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7822352A FR2432025A1 (en) 1978-07-28 1978-07-28 Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities

Publications (2)

Publication Number Publication Date
FR2432025A1 true FR2432025A1 (en) 1980-02-22
FR2432025B1 FR2432025B1 (en) 1982-01-15

Family

ID=9211302

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822352A Granted FR2432025A1 (en) 1978-07-28 1978-07-28 Tri:aza-fluorene and -fluoranthene cpds. - with anti:anoxia and psychotropic activities

Country Status (3)

Country Link
JP (1) JPS5520796A (en)
FR (1) FR2432025A1 (en)
ZA (1) ZA793796B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1737461T3 (en) 2004-03-15 2013-03-18 Ptc Therapeutics Inc CARBOLIN DERIVATIVES FOR INHIBITING ANGIOGENESES
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases

Also Published As

Publication number Publication date
FR2432025B1 (en) 1982-01-15
ZA793796B (en) 1980-07-30
JPS5520796A (en) 1980-02-14

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