IT1111676B - 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants - Google Patents
1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressantsInfo
- Publication number
- IT1111676B IT1111676B IT1945078A IT1945078A IT1111676B IT 1111676 B IT1111676 B IT 1111676B IT 1945078 A IT1945078 A IT 1945078A IT 1945078 A IT1945078 A IT 1945078A IT 1111676 B IT1111676 B IT 1111676B
- Authority
- IT
- Italy
- Prior art keywords
- substd
- opt
- alkyl
- derivs
- aryl
- Prior art date
Links
- SCKQUWRORFAPMX-UHFFFAOYSA-N 3-amino-1-phenoxy-1-phenylpropan-2-ol Chemical compound C=1C=CC=CC=1C(C(O)CN)OC1=CC=CC=C1 SCKQUWRORFAPMX-UHFFFAOYSA-N 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- WUGQZFFCHPXWKQ-UHFFFAOYSA-N Propanolamine Chemical compound NCCCO WUGQZFFCHPXWKQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Abstract
Propanolamine derivs. of formula (I) and their pharmaceutically acceptable salts are new: (n and n1 = 1-3; R and R1 are each same or different H, halo, 1-6C haloalkyl, OH, 1-6C alkoxy or opt. substd. alkyl, aryl(1-6C)-alkyl or aryl(1-6C)alkoxy (both opt. substd.), NO2, NR5R6, or two adjacent gps. are together OCH2O; R2 = H, opt. substd. 1-12C alkyl or aryl(1-6C)alkyl; R3 and R4 = H, 1-6C opt. substd. alkyl, 2-4C alkenyl or alkynyl, aryl(1-4C)alkyl (opt. substd.), 3-7C cycloalkyl (opt. substd.) or R3 + R4 complete a monocyclic 5 or 6 member heterocycle which may be unsatd. or satd. opt. substd. and or contain further O, S or N atoms; R2 and R4 may also together be CH2CH2; R5 and R6 = H or 1-6C alkyl).
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1945078A IT1111676B (en) | 1978-01-20 | 1978-01-20 | 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants |
IL56369A IL56369A (en) | 1978-01-20 | 1979-01-04 | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
US06/001,604 US4229449A (en) | 1978-01-20 | 1979-01-08 | Substituted morpholine derivatives and compositions |
GB7901130A GB2014981B (en) | 1978-01-20 | 1979-01-11 | Substituted propanolamine and morpholine derivatives |
CY1172A CY1172A (en) | 1978-01-20 | 1979-01-11 | Substituted propanolamine and morpholine derivatives |
DE1998175005 DE19875005I2 (en) | 1978-01-20 | 1979-01-12 | Substituted morpholine derivatives and their use |
AU43327/79A AU525954B2 (en) | 1978-01-20 | 1979-01-12 | Substituted propanolamine and morpholine derivatives |
DE2901032A DE2901032C2 (en) | 1978-01-20 | 1979-01-12 | Substituted morpholine derivatives and their use |
SI7910096A SI7910096A8 (en) | 1978-01-20 | 1979-01-17 | Process for preparing novel morpholine compounds |
NZ189418A NZ189418A (en) | 1978-01-20 | 1979-01-17 | Propanolamine and morpholine derivatives pharmaceutical compositions |
YU96/79A YU42094B (en) | 1978-01-20 | 1979-01-17 | Process for obtaining new morpnoline compounds |
NL7900412A NL190327C (en) | 1978-01-20 | 1979-01-18 | SUBSTITUTED 2- (PHENOXYMETHYL) MORPHOLINE DERIVATIVE WITH ANTI-DEPRESSIVE ACTION, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH A MORPHOLINE DERIVATIVE. |
DK022679A DK156565C (en) | 1978-01-20 | 1979-01-18 | ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED MORPHOLINE DERIVATIVES |
FI790177A FI71135C (en) | 1978-01-20 | 1979-01-19 | FRUIT PROCESSING OF PHARMACOLOGICAL ACTIVE SUBSTITUTES MORPHOLINDERIVAT |
CH582/79A CH650245A5 (en) | 1978-01-20 | 1979-01-19 | SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF. |
CA319,931A CA1128942A (en) | 1978-01-20 | 1979-01-19 | Substituted propanolamine and morpholine derivatives and process for their preparation |
NO790205A NO146953C (en) | 1978-01-20 | 1979-01-19 | ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES |
FR7901413A FR2442839A1 (en) | 1978-01-20 | 1979-01-19 | SUBSTITUTED MORPHOLINE DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESS FOR THEIR PREPARATION |
CS905179A CS207697B2 (en) | 1978-01-20 | 1979-01-19 | Method of makingthe substituted propanolamine and morpholine derivatives |
SE7900498A SE446727B (en) | 1978-01-20 | 1979-01-19 | SUBSTITUTED MORPHOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF |
AT0040679A AT371813B (en) | 1978-01-20 | 1979-01-19 | METHOD FOR PRODUCING NEW SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES AND THEIR ISOMERS AND SALTS |
JP449479A JPS54148739A (en) | 1978-01-20 | 1979-01-20 | Substituted propanolamine and morpholine derivative |
IE107/79A IE47727B1 (en) | 1978-01-20 | 1979-01-30 | Substituted propanolamine and morpholine derivatives |
FR7922678A FR2430412B1 (en) | 1978-01-20 | 1979-09-11 | SUBSTITUTED PROPANOLAMINE DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESS FOR THEIR PREPARATION |
SU802897011A SU980617A3 (en) | 1978-01-20 | 1980-03-20 | Process for producing morpholine derivatives or their acid-additive salts in the form of optical isomers or mixture of optical isomers |
US06/161,509 US4271160A (en) | 1978-01-20 | 1980-06-20 | Substituted morpholine derivatives and pharmaceutical compositions |
AT0419781A AT376964B (en) | 1978-01-20 | 1981-09-30 | METHOD FOR PRODUCING NEW SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR ISOMERS AND SALTS |
KE3243A KE3243A (en) | 1978-01-20 | 1982-10-25 | Substituted propanolamine and morpholine derivatives |
HK57/83A HK5783A (en) | 1978-01-20 | 1983-02-08 | Substituted propanolamine and morpholine derivatives |
MY8418A MY8400018A (en) | 1978-01-20 | 1984-12-31 | Substituted propanolamine and morpholine derivatives |
CS914133A CS413391A3 (en) | 1978-01-20 | 1991-12-30 | Substituted propanolamine and morpholine derivatives |
MX9203112A MX9203112A (en) | 1978-01-20 | 1992-06-22 | DERIVATIVES OF 2-PHENOXY-METHYL-MORPHOLINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
BG98513A BG61056B2 (en) | 1978-01-20 | 1994-02-22 | Substituted propanolamine and morpholine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1945078A IT1111676B (en) | 1978-01-20 | 1978-01-20 | 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7819450A0 IT7819450A0 (en) | 1978-01-20 |
IT1111676B true IT1111676B (en) | 1986-01-13 |
Family
ID=11158109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1945078A IT1111676B (en) | 1978-01-20 | 1978-01-20 | 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1111676B (en) |
MX (1) | MX9203112A (en) |
-
1978
- 1978-01-20 IT IT1945078A patent/IT1111676B/en active Protection Beyond IP Right Term
-
1992
- 1992-06-22 MX MX9203112A patent/MX9203112A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX9203112A (en) | 1992-07-01 |
IT7819450A0 (en) | 1978-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 599, 19971128; PHARMACIA UPJOHN SPA |
|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970124 |