ES473982A1 - Benzylideneaniline and its Derivatives - Google Patents
Benzylideneaniline and its DerivativesInfo
- Publication number
- ES473982A1 ES473982A1 ES473982A ES473982A ES473982A1 ES 473982 A1 ES473982 A1 ES 473982A1 ES 473982 A ES473982 A ES 473982A ES 473982 A ES473982 A ES 473982A ES 473982 A1 ES473982 A1 ES 473982A1
- Authority
- ES
- Spain
- Prior art keywords
- benzylideneaniline
- alkyl
- represent
- compounds
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UVEWQKMPXAHFST-UHFFFAOYSA-N n,1-diphenylmethanimine Chemical compound C=1C=CC=CC=1C=NC1=CC=CC=C1 UVEWQKMPXAHFST-UHFFFAOYSA-N 0.000 title abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010015150 Erythema Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005035 acylthio group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 cyano, nitro, amino Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 231100000321 erythema Toxicity 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 239000000516 sunscreening agent Substances 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to benzylideneaniline derivatives of the general formula: < IMAGE > (wherein: R represents hydrogen or alkyl R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10, which may be the same or different, each represent hydrogen, alkyl, cyano, nitro, amino, haloalkoxy, haloalkyl, halo, alkoxy, acyl, acyloxy, thio, acylthio, alkylthio, alkyl-sulphinyl, alkylsulphonyl, or hydroxy, with the additional possibilities that either or both of R3 and R8 may also represent cycloalkyl, cycloalkenyl, aryl and heteroloweralkylidenyl, and that R6, R7, R8, R9 and R10 may each also represent carboxy and alkoxycarbonyl) for use in treating inflammation of the integument of warm-blooded animals by topical administration. Additionally, the benzylideneaniline compounds have been found to be effective sun- screening agents which may help to prevent radiation-induced erythemas. The invention also provides pharmaceutical compositions containing benzylideneaniline compounds, and certain of the new benzylideneaniline compounds per se.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/839,960 US4176198A (en) | 1977-10-06 | 1977-10-06 | Method of treatment |
US05/942,866 US4200648A (en) | 1977-10-06 | 1978-09-15 | Method of treatment |
US05/942,868 US4187317A (en) | 1977-10-06 | 1978-09-15 | Sunscreen and erythema treating with N-benzylidene anilenes |
US05/945,827 US4198349A (en) | 1977-10-06 | 1978-09-26 | Benzylideneaniline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES473982A1 true ES473982A1 (en) | 1980-01-16 |
Family
ID=27505893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES473982A Expired ES473982A1 (en) | 1977-10-06 | 1978-10-05 | Benzylideneaniline and its Derivatives |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS5470234A (en) |
DE (1) | DE2843467A1 (en) |
ES (1) | ES473982A1 (en) |
FR (1) | FR2405241A1 (en) |
GB (1) | GB2007648B (en) |
IT (1) | IT1160692B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3035921A1 (en) * | 1980-09-24 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | METHOD FOR THE PRODUCTION OF 3-BROMO-4FLUOR-BENZALDEHYDE ACETALS, NEW INTERMEDIATE PRODUCTS FOR THIS AND METHOD FOR THE PRODUCTION THEREOF |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2847473A (en) * | 1957-04-10 | 1958-08-12 | Dow Chemical Co | 2, 3-dichloro-nu-(omicron-chlorobenzylidene) aniline |
GB1171533A (en) * | 1967-09-05 | 1969-11-19 | Rech S Et D Applic Scient Soge | N-Benzylidene-Anisidine Derivatives, their preparation and Compositions containing them |
NL7008623A (en) * | 1969-06-25 | 1970-12-29 | ||
US3862833A (en) * | 1972-09-18 | 1975-01-28 | Rohm & Haas | Haloaniline derivatives as plant growth modifiers |
-
1978
- 1978-10-04 FR FR7828388A patent/FR2405241A1/en not_active Withdrawn
- 1978-10-05 GB GB7839398A patent/GB2007648B/en not_active Expired
- 1978-10-05 DE DE19782843467 patent/DE2843467A1/en not_active Withdrawn
- 1978-10-05 IT IT69302/78A patent/IT1160692B/en active
- 1978-10-05 JP JP12211778A patent/JPS5470234A/en active Pending
- 1978-10-05 ES ES473982A patent/ES473982A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2007648B (en) | 1982-08-25 |
FR2405241A1 (en) | 1979-05-04 |
JPS5470234A (en) | 1979-06-05 |
IT1160692B (en) | 1987-03-11 |
GB2007648A (en) | 1979-05-23 |
IT7869302A0 (en) | 1978-10-05 |
DE2843467A1 (en) | 1979-04-19 |
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