GB1239679A - - Google Patents

Info

Publication number
GB1239679A
GB1239679A GB1239679DA GB1239679A GB 1239679 A GB1239679 A GB 1239679A GB 1239679D A GB1239679D A GB 1239679DA GB 1239679 A GB1239679 A GB 1239679A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
xcho
alkenyl
dec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1239679A publication Critical patent/GB1239679A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

1,239,679. Dihydropyridines. FARBENFABRIKEN BAYER A.G. 5 Dec., 1969 [7 Dec., 1968; 29 Jan., 1969], No. 59534/69. Heading C2C. Novel compounds I in which R is either 1-3C alkyl, alkenyl or alkynyl which may be substituted by OH or alkoxy or an optionally substituted benzyl radical; R<SP>1</SP> is H or 1-3C alkyl; R<SP>11</SP>' is straight or branched chain 1-6C alkyl, alkenyl or alkynyl optionally interrupted by one or more O or substituted by OH; and X is aryl substituted by at least one NH 2 or NO 2 and which may also be substituted by halo, alkyl, OH or alkoxy or X is α, # or γ-pyridyl are prepared by reaction of RNH 2 with XCHO and R<SP>1</SP>COCH 2 - COOR<SP>11</SP> or by reaction of XCHO with R<SP>1</SP>C- (NHR): CHCOOR<SP>11</SP>. Pharmaceutical compositions comprise a compound I together with a suitable carrier and are administered orally or intravenously as agents for treating coronary blood supply disturbances.
GB1239679D 1968-12-07 1969-12-05 Expired GB1239679A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1813436A DE1813436C3 (en) 1968-12-07 1968-12-07 N-substituted 2,6-dimethyl-1,4-dihydropyridines

Publications (1)

Publication Number Publication Date
GB1239679A true GB1239679A (en) 1971-07-21

Family

ID=5715623

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1239679D Expired GB1239679A (en) 1968-12-07 1969-12-05

Country Status (12)

Country Link
US (1) US3647807A (en)
AT (1) AT293389B (en)
BE (1) BE742737A (en)
CH (1) CH522646A (en)
DE (1) DE1813436C3 (en)
DK (1) DK136421B (en)
FI (1) FI52077C (en)
FR (1) FR2025618B1 (en)
GB (1) GB1239679A (en)
IL (1) IL33350A0 (en)
NL (1) NL164030C (en)
SE (1) SE366743B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216150B (en) * 1962-04-27 1966-05-05 Hans Sandkaulen K G Machine for grinding the wedge-shaped rising leaf surfaces of trowels
US3966948A (en) * 1970-01-24 1976-06-29 Bayer Aktiengesellschaft Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods
DE2005116C3 (en) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrical 1,4-dihydropyridine-3,5-dicarboxylic acid esters
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
US3922278A (en) * 1972-06-12 1975-11-25 Sterling Drug Inc 4-(3-Nitrophenyl)-3,5-pyridinedicarboxylic acid
FR2320750A1 (en) * 1975-08-12 1977-03-11 Hexachimie 1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION
SU798099A1 (en) * 1978-03-06 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp 1-benzyl-2,6-dimethyl-4-0- or -m-nitrophenyl-3,5-diethoxycarbonyl-1,4-dihydropyridines possessing coronarodilating activity
JPS58159490A (en) * 1982-02-23 1983-09-21 Nikken Kagaku Kk 1,4-dihydropyridne compound
US4689233A (en) * 1986-01-06 1987-08-25 Siegfried Aktiengesellschaft Coronary therapeutic agent in the form of soft gelatin capsules
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
DE3821334A1 (en) * 1988-06-24 1989-12-28 Bayer Ag 1,4-DIHYDROPYRIDINE-THREONINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, INTERMEDIATE PRODUCTS AND THEIR USE AS MEDICINAL PRODUCTS
EP0388482B1 (en) * 1989-03-20 1994-07-06 Siemens Aktiengesellschaft Light-sensitive composition
DE4011695A1 (en) * 1990-04-11 1991-10-17 Bayer Ag USE OF N-ALKYLATED 1,4-DIHYDROPYRIDE INDICARBOXIC ACID ESTERS AS DRUGS, NEW COMPOUNDS AND METHOD FOR THEIR PREPARATION
DE4133257A1 (en) * 1991-10-08 1993-04-15 Bayer Ag N-METHYL-NIMODIPINE, METHOD FOR THE PRODUCTION THEREOF AND ITS USE AS A CEREBRAL THERAPEUTIC
DE4430094A1 (en) * 1994-08-25 1996-02-29 Bayer Ag Use of 3,5-dicarboxylic acid ester-1,4-dihydropyridines as a drug

Also Published As

Publication number Publication date
CH522646A (en) 1972-06-30
FR2025618A1 (en) 1970-09-11
DE1813436B2 (en) 1978-04-20
DE1813436A1 (en) 1970-10-29
DK136421B (en) 1977-10-10
AT293389B (en) 1971-10-11
BE742737A (en) 1970-06-05
NL164030C (en) 1980-11-17
DE1813436C3 (en) 1979-01-11
DK136421C (en) 1978-03-13
IL33350A0 (en) 1970-01-29
NL6918261A (en) 1970-06-09
FI52077B (en) 1977-02-28
NL164030B (en) 1980-06-16
FI52077C (en) 1977-06-10
SE366743B (en) 1974-05-06
FR2025618B1 (en) 1973-04-06
US3647807A (en) 1972-03-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee