FR2426054A1 - Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament - Google Patents

Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament

Info

Publication number
FR2426054A1
FR2426054A1 FR7814597A FR7814597A FR2426054A1 FR 2426054 A1 FR2426054 A1 FR 2426054A1 FR 7814597 A FR7814597 A FR 7814597A FR 7814597 A FR7814597 A FR 7814597A FR 2426054 A1 FR2426054 A1 FR 2426054A1
Authority
FR
France
Prior art keywords
azabicyclo
hept
ene
heptane
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814597A
Other languages
English (en)
Other versions
FR2426054B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2426054A1 publication Critical patent/FR2426054A1/fr
Application granted granted Critical
Publication of FR2426054B1 publication Critical patent/FR2426054B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés chimiques nouveaux. Il s'agit d'un composé ayant la structure :
FR7814597A 1978-05-03 1978-05-17 Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament Granted FR2426054A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17493/78A GB1592224A (en) 1978-05-03 1978-05-03 Thienamycin derivatives their production and their use as antibiotics

Publications (2)

Publication Number Publication Date
FR2426054A1 true FR2426054A1 (fr) 1979-12-14
FR2426054B1 FR2426054B1 (fr) 1980-11-07

Family

ID=10096140

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7814597A Granted FR2426054A1 (fr) 1978-05-03 1978-05-17 Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament

Country Status (8)

Country Link
JP (1) JPS54151996A (fr)
CH (1) CH638522A5 (fr)
DE (1) DE2820055A1 (fr)
FR (1) FR2426054A1 (fr)
GB (1) GB1592224A (fr)
LU (1) LU79677A1 (fr)
NL (1) NL7804976A (fr)
SE (1) SE7805032L (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010317B1 (fr) * 1978-10-24 1983-12-21 Merck & Co. Inc. Acides 1-carbapen-2-em-3-carboxyliques 6-, 1- et 2-substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392996A1 (fr) * 1977-03-19 1978-12-29 Beecham Group Ltd Agent antibacterien a cycle b-lactame utilisable comme medicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
EP0002564B1 (fr) * 1977-11-12 1984-06-20 Beecham Group Plc Dérivés de l'acide 7-oxo-1-azabicyclo-(3.2.0)-hept-2-ène-2-carboxylique, leur préparation, compositions pharmaceutiques les contenant et produits intermédiaires

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392996A1 (fr) * 1977-03-19 1978-12-29 Beecham Group Ltd Agent antibacterien a cycle b-lactame utilisable comme medicament

Also Published As

Publication number Publication date
GB1592224A (en) 1981-07-01
SE7805032L (sv) 1979-11-03
JPS54151996A (en) 1979-11-29
FR2426054B1 (fr) 1980-11-07
NL7804976A (nl) 1979-11-13
LU79677A1 (fr) 1979-02-02
DE2820055A1 (de) 1979-11-22
CH638522A5 (en) 1983-09-30

Similar Documents

Publication Publication Date Title
FR2405950A1 (fr) Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
FR2403340A1 (fr) Derives imidazoliques utiles comme medicaments
FR2372818A1 (fr) Acide 5-(hydroxy (substitue) methyl)-2,3-dihydrobenzofuran-2-carboxylique et ses derives utiles comme medicaments
FR2428042A1 (fr) Procede de preparation d'analogues de cephalosporine et nouveaux produits ainsi obtenus, a activite antimicrobienne
FR2365567A1 (fr) Nouvelles piperazinylpyridines utiles comme medicaments
FR2400021A1 (fr) Preparation d'acide (1r,cis);caronaldehydique
FR2394546A1 (fr) Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments
FR2433504A1 (fr) Procede de preparation de derives du biphenyle
FR2392999A1 (fr) Nouveaux derives de l'acide 6-((aminosulfonyl)-phenyl)-1,2-dihydro-2-oxonicotinique utile comme medicament
FR2436150A1 (fr) Derives de 3'',4''-diacyltylosine utiles comme medicaments
FR2418240A1 (fr) Procede de preparation de composes de glucopyranose-nitrosouree et nouveaux composes ainsi obtenus
FR2358415A1 (fr) Derives peptidiques, leur preparation et leur application en tant que medicaments
FR2392958A1 (fr) Nouveaux amino-acides fluores utiles comme medicament
FR2381777A1 (fr) Procede de preparation d'oxazolinoazetidinones a partir d'acide 6-aminopenicillanique et nouveaux produits ainsi obtenus
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2386545A1 (fr) L'acide 3-(2-aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylique utile comme medicament
FR2380246A1 (fr) Nouveaux esters d'acide cyclopropane carboxylique utiles comme pesticides
FR2355011A1 (fr) 2-imino-3-aminothiazolidines utiles comme medicaments
FR2426054A1 (fr) Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament
FR2359154A1 (fr) Derives peptidiques utiles comme medicaments et procede pour leur preparation
FR2377382A1 (fr) Nouveaux phenylazacycloalcanes utiles comme medicaments
FR2380247A1 (fr) Nouveaux esters de l'acide cyclopropane carboxylique utiles comme pesticides
FR2378792A1 (fr) Nouveaux esters et amides d'ester d'acides pyrimidinone-((di)-thio)-phosphoriques (phosphoniques) substitues, leur procede de preparation et leur application comme insecticides, acaricides et nematicides
FR2380248A1 (fr) Nouveaux esters de l'acide cyclopropanecarboxylique utiles dans la lutte contre les parasites
FR2361341A1 (fr) Procede de preparation d'esters de l'acide anthranilique

Legal Events

Date Code Title Description
ST Notification of lapse