FR2426045A2 - 5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents - Google Patents

5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents

Info

Publication number
FR2426045A2
FR2426045A2 FR7814899A FR7814899A FR2426045A2 FR 2426045 A2 FR2426045 A2 FR 2426045A2 FR 7814899 A FR7814899 A FR 7814899A FR 7814899 A FR7814899 A FR 7814899A FR 2426045 A2 FR2426045 A2 FR 2426045A2
Authority
FR
France
Prior art keywords
alkoxy
formula
antihypertensive agents
useful
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814899A
Other languages
French (fr)
Other versions
FR2426045B2 (en
Inventor
Takemi Koeda
Takashi Tsuruoka
Uichi Shibata
Hiroyasu Asaoka
Mitsugu Hachisu
Osamu Itoh
Yasuhary Sekizawa
Shineharu Inouve
Taro Niida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to FR7814899A priority Critical patent/FR2426045A2/en
Publication of FR2426045A2 publication Critical patent/FR2426045A2/en
Application granted granted Critical
Publication of FR2426045B2 publication Critical patent/FR2426045B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

5-Alkoxy-picolic acid esters of formula (I) are new In the formula R1 is 1-6C alkyl; R2 is (substd.) phenyl, phthalyzyl, alkoxyalkyl, alkoxyalkoxyalkyl, or acyloxyalkyl of formula -CHR3-O-CO-R4 (where R3 is H or methyl; R4 is 1-6C alkyl, (substd.) phenyl, 1-4C alkoxy or aralkyl). The cpds. are antihypertensive agents, prepd. by esterification of 5-alkoxy-picolic acid (or its salt) by reaction with acyloxyalkyl halide, alkoxy alkyl halide or 3-bromo-phthalide of formula X-CR3H-O-C-OR4 in the presence of base or with (substd.) phenol of formula: and in the presence of condensing agent, (where X is halogen; and R5, R6 and R7 are H, lower alkyl, lower alkoxy or halogen).
FR7814899A 1978-05-19 1978-05-19 5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents Granted FR2426045A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7814899A FR2426045A2 (en) 1978-05-19 1978-05-19 5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7814899A FR2426045A2 (en) 1978-05-19 1978-05-19 5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents

Publications (2)

Publication Number Publication Date
FR2426045A2 true FR2426045A2 (en) 1979-12-14
FR2426045B2 FR2426045B2 (en) 1982-01-22

Family

ID=9208460

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7814899A Granted FR2426045A2 (en) 1978-05-19 1978-05-19 5-Alkoxy-picolic acid ester cpds. - useful as antihypertensive agents

Country Status (1)

Country Link
FR (1) FR2426045A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181568A2 (en) * 1984-10-30 1986-05-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181568A2 (en) * 1984-10-30 1986-05-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds
EP0181568A3 (en) * 1984-10-30 1989-04-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds

Also Published As

Publication number Publication date
FR2426045B2 (en) 1982-01-22

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