FR2422665A1 - Procede de preparation de rifamycines, nouveaux composes obtenus et leur application therapeutique - Google Patents

Procede de preparation de rifamycines, nouveaux composes obtenus et leur application therapeutique

Info

Publication number
FR2422665A1
FR2422665A1 FR7832600A FR7832600A FR2422665A1 FR 2422665 A1 FR2422665 A1 FR 2422665A1 FR 7832600 A FR7832600 A FR 7832600A FR 7832600 A FR7832600 A FR 7832600A FR 2422665 A1 FR2422665 A1 FR 2422665A1
Authority
FR
France
Prior art keywords
rifamycins
preparing
new compounds
compounds obtained
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7832600A
Other languages
English (en)
Other versions
FR2422665B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holco Investment Inc
Original Assignee
Holco Investment Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holco Investment Inc filed Critical Holco Investment Inc
Publication of FR2422665A1 publication Critical patent/FR2422665A1/fr
Application granted granted Critical
Publication of FR2422665B1 publication Critical patent/FR2422665B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention est relative à un procédé de préparation de rifampicine, caractérisé en ce qu'on fait réagir la rifamycine S, dans un solvant aprotique dipolaire, avec une hexahydro-1,3,5-triazine trisubstituée en positions 1,3,5, à une température de 20 à 100 degrés C, puis on fait alors réagir avec la 1-amino-4-méthylpipérazine tout en maintenant le pH dans la gamme de 5 à 7, et enfin on isole la rifampicine formée Ce procédé permet également d'obtenir de nouveaux dérivés de rifamycine à activité antibiotique.
FR7832600A 1977-11-25 1978-11-20 Procede de preparation de rifamycines, nouveaux composes obtenus et leur application therapeutique Granted FR2422665A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB49148/77A GB1594134A (en) 1977-11-25 1977-11-25 Rifamycins

Publications (2)

Publication Number Publication Date
FR2422665A1 true FR2422665A1 (fr) 1979-11-09
FR2422665B1 FR2422665B1 (fr) 1983-12-16

Family

ID=10451344

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7832600A Granted FR2422665A1 (fr) 1977-11-25 1978-11-20 Procede de preparation de rifamycines, nouveaux composes obtenus et leur application therapeutique
FR7925577A Granted FR2438048A1 (fr) 1977-11-25 1979-10-15 Nouveaux derives de 1,3-oxazino (5,6-c) rifamycine doues d'une activite antibiotique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7925577A Granted FR2438048A1 (fr) 1977-11-25 1979-10-15 Nouveaux derives de 1,3-oxazino (5,6-c) rifamycine doues d'une activite antibiotique

Country Status (15)

Country Link
US (1) US4174320A (fr)
JP (1) JPS5479299A (fr)
AR (1) AR219549A1 (fr)
AT (1) AT362062B (fr)
AU (1) AU524481B2 (fr)
BE (1) BE872233A (fr)
CA (1) CA1095035A (fr)
DE (1) DE2846321A1 (fr)
FR (2) FR2422665A1 (fr)
GB (1) GB1594134A (fr)
GR (1) GR72969B (fr)
IN (2) IN149404B (fr)
IT (1) IT1100590B (fr)
PH (1) PH15017A (fr)
YU (2) YU40836B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308166D0 (en) * 1983-03-24 1983-05-05 Erba Farmitalia Preparation of azinomethyl-rifamycins
GB8318072D0 (en) * 1983-07-04 1983-08-03 Lepetit Spa Water-soluble rifampicin derivatives
GB8531887D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Rifamycin sv derivatives
CN100383143C (zh) * 2004-04-29 2008-04-23 薛荔 一锅烩合成利福平的方法
US20090275594A1 (en) * 2008-05-05 2009-11-05 Macielag Mark J 3-hydrazone piperazinyl rifamycin derivatives useful as antimicrobial agents
CN102660598B (zh) * 2012-05-31 2014-01-22 河南省南街村（集团）有限公司 一种提高利福霉素sv发酵产量的方法
CN103772413B (zh) * 2014-02-07 2016-01-20 天津大学 一种利福平ⅱ晶型的制备方法
CN111848639A (zh) * 2020-07-09 2020-10-30 华东理工大学 一种合成利福平的工艺方法
KR102688151B1 (ko) 2021-12-28 2024-07-24 주식회사 종근당바이오 Mnp가 저감된 리팜피신의 신규 제조방법
WO2023218419A1 (fr) 2022-05-13 2023-11-16 Olon S.P.A. Procédé de purification de rifampicine à partir de nitrosamines
WO2024009248A1 (fr) 2022-07-08 2024-01-11 Olon S.P.A. Procédé et ensemble pour la commande de la formation d'une impureté de nitrosamine dans un ingrédient pharmaceutique actif solide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR208F (fr) * 1964-07-31
NL145554B (nl) * 1967-06-07 1975-04-15 Lepetit Spa Werkwijze voor het bereiden van een 3-formylrifamycine sv-derivaat
IT1046627B (it) * 1970-06-01 1980-07-31 Lepetit Spa Composizioni antivirali contenenti derivati della rifaumicina sv
AR207762A1 (es) * 1973-07-25 1976-10-29 Archifar Ind Chim Trentino Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina
GB1478563A (en) * 1975-03-05 1977-07-06 Lepetit Spa Rifamycin derivatives

Also Published As

Publication number Publication date
FR2438048B1 (fr) 1982-12-03
GR72969B (fr) 1984-01-20
IN149404B (fr) 1981-11-28
YU40836B (en) 1986-06-30
IN151954B (fr) 1983-09-10
IT7830194A0 (it) 1978-11-24
US4174320A (en) 1979-11-13
PH15017A (en) 1982-05-10
JPS5740155B2 (fr) 1982-08-25
IT1100590B (it) 1985-09-28
AR219549A1 (es) 1980-08-29
FR2438048A1 (fr) 1980-04-30
BE872233A (fr) 1979-03-16
DE2846321A1 (de) 1979-05-31
CA1095035A (fr) 1981-02-03
AU4016878A (en) 1980-04-03
ATA833878A (de) 1980-09-15
YU273078A (en) 1983-01-21
YU211782A (en) 1983-01-21
DE2846321C2 (fr) 1991-04-25
FR2422665B1 (fr) 1983-12-16
AT362062B (de) 1981-04-27
JPS5479299A (en) 1979-06-25
GB1594134A (en) 1981-07-30
AU524481B2 (en) 1982-09-16

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