ATA833878A - Verfahren zur herstellung von 5,6,9,17,19,21- -hexahydro-23-methoxy-2,4,12,16,18,20,22- heptamethyl-8-(n-(4-methyl-1-piperazinyl)- formimidoyl)-2,7-(epoxypentadeca(1,11,13)- trienimino)-naphtho(2,1-b)furan-1,11(2h)-dion- 21-acetat - Google Patents
Verfahren zur herstellung von 5,6,9,17,19,21- -hexahydro-23-methoxy-2,4,12,16,18,20,22- heptamethyl-8-(n-(4-methyl-1-piperazinyl)- formimidoyl)-2,7-(epoxypentadeca(1,11,13)- trienimino)-naphtho(2,1-b)furan-1,11(2h)-dion- 21-acetatInfo
- Publication number
- ATA833878A ATA833878A AT833878A AT833878A ATA833878A AT A833878 A ATA833878 A AT A833878A AT 833878 A AT833878 A AT 833878A AT 833878 A AT833878 A AT 833878A AT A833878 A ATA833878 A AT A833878A
- Authority
- AT
- Austria
- Prior art keywords
- trienimino
- epoxypentadeca
- formimidoyl
- heptamethyl
- dion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB49148/77A GB1594134A (en) | 1977-11-25 | 1977-11-25 | Rifamycins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA833878A true ATA833878A (de) | 1980-09-15 |
| AT362062B AT362062B (de) | 1981-04-27 |
Family
ID=10451344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT833878A AT362062B (de) | 1977-11-25 | 1978-11-22 | Verfahren zur herstellung von 5,6,9,17,19,21- -hexahydro-23-methoxy-2,4,12,16,18,20,22- heptamethyl-8-(n-(4-methyl-1-piperazinyl)- formimidoyl) -2,7-(epoxypentadeca(1,11,13)- trienimino)-naphtho(2,1-b)furan-1,11(2h)-dion- 21-acetat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4174320A (de) |
| JP (1) | JPS5479299A (de) |
| AR (1) | AR219549A1 (de) |
| AT (1) | AT362062B (de) |
| AU (1) | AU524481B2 (de) |
| BE (1) | BE872233A (de) |
| CA (1) | CA1095035A (de) |
| DE (1) | DE2846321A1 (de) |
| FR (2) | FR2422665A1 (de) |
| GB (1) | GB1594134A (de) |
| GR (1) | GR72969B (de) |
| IN (2) | IN149404B (de) |
| IT (1) | IT1100590B (de) |
| PH (1) | PH15017A (de) |
| YU (2) | YU40836B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308166D0 (en) * | 1983-03-24 | 1983-05-05 | Erba Farmitalia | Preparation of azinomethyl-rifamycins |
| GB8318072D0 (en) * | 1983-07-04 | 1983-08-03 | Lepetit Spa | Water-soluble rifampicin derivatives |
| GB8531887D0 (en) * | 1985-12-30 | 1986-02-05 | Lepetit Spa | Rifamycin sv derivatives |
| CN100383143C (zh) * | 2004-04-29 | 2008-04-23 | 薛荔 | 一锅烩合成利福平的方法 |
| US20090275594A1 (en) * | 2008-05-05 | 2009-11-05 | Macielag Mark J | 3-hydrazone piperazinyl rifamycin derivatives useful as antimicrobial agents |
| CN102660598B (zh) * | 2012-05-31 | 2014-01-22 | 河南省南街村（集团）有限公司 | 一种提高利福霉素sv发酵产量的方法 |
| CN103772413B (zh) * | 2014-02-07 | 2016-01-20 | 天津大学 | 一种利福平ⅱ晶型的制备方法 |
| CN111848639A (zh) * | 2020-07-09 | 2020-10-30 | 华东理工大学 | 一种合成利福平的工艺方法 |
| KR102688151B1 (ko) | 2021-12-28 | 2024-07-24 | 주식회사 종근당바이오 | Mnp가 저감된 리팜피신의 신규 제조방법 |
| CN119173519A (zh) | 2022-05-13 | 2024-12-20 | 欧伦股份公司 | 从亚硝胺纯化利福平的方法 |
| WO2024009248A1 (en) | 2022-07-08 | 2024-01-11 | Olon S.P.A. | Method and assembly for the control of the formation of a nitrosamine impurity in a solid active pharmaceutical ingredient |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (de) * | 1964-07-31 | |||
| NL145554B (nl) * | 1967-06-07 | 1975-04-15 | Lepetit Spa | Werkwijze voor het bereiden van een 3-formylrifamycine sv-derivaat |
| IT1046627B (it) * | 1970-06-01 | 1980-07-31 | Lepetit Spa | Composizioni antivirali contenenti derivati della rifaumicina sv |
| AR207762A1 (es) * | 1973-07-25 | 1976-10-29 | Archifar Ind Chim Trentino | Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina |
| GB1478563A (en) * | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
-
1977
- 1977-11-25 GB GB49148/77A patent/GB1594134A/en not_active Expired
-
1978
- 1978-09-13 CA CA311,214A patent/CA1095035A/en not_active Expired
- 1978-09-25 AU AU40168/78A patent/AU524481B2/en not_active Expired
- 1978-09-27 AR AR273873A patent/AR219549A1/es active
- 1978-09-27 US US05/946,530 patent/US4174320A/en not_active Expired - Lifetime
- 1978-10-24 DE DE19782846321 patent/DE2846321A1/de active Granted
- 1978-11-04 JP JP13622578A patent/JPS5479299A/ja active Granted
- 1978-11-15 PH PH21809A patent/PH15017A/en unknown
- 1978-11-20 FR FR7832600A patent/FR2422665A1/fr active Granted
- 1978-11-22 YU YU2730/78A patent/YU40836B/xx unknown
- 1978-11-22 AT AT833878A patent/AT362062B/de not_active IP Right Cessation
- 1978-11-23 BE BE191899A patent/BE872233A/xx not_active IP Right Cessation
- 1978-11-23 GR GR57719A patent/GR72969B/el unknown
- 1978-11-24 IT IT30194/78A patent/IT1100590B/it active
- 1978-11-25 IN IN1275/CAL/78A patent/IN149404B/en unknown
-
1979
- 1979-10-15 FR FR7925577A patent/FR2438048A1/fr active Granted
-
1981
- 1981-08-28 IN IN966/CAL/81A patent/IN151954B/en unknown
-
1982
- 1982-09-23 YU YU02117/82A patent/YU211782A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2846321C2 (de) | 1991-04-25 |
| IT7830194A0 (it) | 1978-11-24 |
| JPS5479299A (en) | 1979-06-25 |
| PH15017A (en) | 1982-05-10 |
| FR2438048A1 (fr) | 1980-04-30 |
| FR2422665A1 (fr) | 1979-11-09 |
| IT1100590B (it) | 1985-09-28 |
| DE2846321A1 (de) | 1979-05-31 |
| US4174320A (en) | 1979-11-13 |
| JPS5740155B2 (de) | 1982-08-25 |
| YU211782A (en) | 1983-01-21 |
| FR2422665B1 (de) | 1983-12-16 |
| BE872233A (fr) | 1979-03-16 |
| CA1095035A (en) | 1981-02-03 |
| AR219549A1 (es) | 1980-08-29 |
| FR2438048B1 (de) | 1982-12-03 |
| AT362062B (de) | 1981-04-27 |
| AU4016878A (en) | 1980-04-03 |
| AU524481B2 (en) | 1982-09-16 |
| GR72969B (de) | 1984-01-20 |
| GB1594134A (en) | 1981-07-30 |
| IN149404B (de) | 1981-11-28 |
| YU273078A (en) | 1983-01-21 |
| YU40836B (en) | 1986-06-30 |
| IN151954B (de) | 1983-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |