FR2417505A1 - Nouvelles aminoalcoyl-cyanoguanidines acyclees contenant un radical heterocyclique et leur application comme medicaments inhibant la secretion gastrique, possedant un effet antihistaminique puissant ainsi qu'une action ulcerotherapique - Google Patents

Nouvelles aminoalcoyl-cyanoguanidines acyclees contenant un radical heterocyclique et leur application comme medicaments inhibant la secretion gastrique, possedant un effet antihistaminique puissant ainsi qu'une action ulcerotherapique

Info

Publication number
FR2417505A1
FR2417505A1 FR7903880A FR7903880A FR2417505A1 FR 2417505 A1 FR2417505 A1 FR 2417505A1 FR 7903880 A FR7903880 A FR 7903880A FR 7903880 A FR7903880 A FR 7903880A FR 2417505 A1 FR2417505 A1 FR 2417505A1
Authority
FR
France
Prior art keywords
action
ulcerotherapic
aminoalcoyl
acycled
cyanoguanidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7903880A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of FR2417505A1 publication Critical patent/FR2417505A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Ces composés sont représentés par la formule I ci-après ; pour les préparer, on fait par exemple réagir un composé de formule avec un composé de formule III, puis les produits de la réaction sont éventuellement alcoylés. Les composés de formule I inhibent par exemple la sécrétion gastrique, notamment celle de l'acide gastrique et ils possèdent un effet antihistaminique puissant du type des << bloqueurs de H2 >>. En outre, ils ont une action ulcérothérapique.
FR7903880A 1978-02-17 1979-02-15 Nouvelles aminoalcoyl-cyanoguanidines acyclees contenant un radical heterocyclique et leur application comme medicaments inhibant la secretion gastrique, possedant un effet antihistaminique puissant ainsi qu'une action ulcerotherapique Withdrawn FR2417505A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB636778 1978-02-17

Publications (1)

Publication Number Publication Date
FR2417505A1 true FR2417505A1 (fr) 1979-09-14

Family

ID=9813213

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7903880A Withdrawn FR2417505A1 (fr) 1978-02-17 1979-02-15 Nouvelles aminoalcoyl-cyanoguanidines acyclees contenant un radical heterocyclique et leur application comme medicaments inhibant la secretion gastrique, possedant un effet antihistaminique puissant ainsi qu'une action ulcerotherapique

Country Status (13)

Country Link
US (1) US4256752A (fr)
JP (1) JPS54125666A (fr)
AT (1) ATA123879A (fr)
BE (1) BE874260A (fr)
DD (1) DD142049A5 (fr)
DE (1) DE2905134A1 (fr)
DK (1) DK69379A (fr)
FR (1) FR2417505A1 (fr)
GB (1) GB2017084A (fr)
IL (1) IL56686A0 (fr)
NL (1) NL7901255A (fr)
PL (1) PL115911B1 (fr)
SE (1) SE7901404L (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US5081154A (en) * 1984-01-10 1992-01-14 Aktiebolaget Hassle Metoprolol succinate
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
WO1989010745A1 (fr) * 1988-05-02 1989-11-16 Pomerantz, Edwin Compositions et procedes in situ pour la formation de pellicules sur des tissus du corps
GB0121444D0 (en) * 2001-09-05 2001-10-24 Univ Strathclyde Sensor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950333A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
FR2389508A1 (fr) * 1977-05-02 1978-12-01 Dana Corp

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
US4060621A (en) * 1972-09-05 1977-11-29 Smith Kline & French Laboratories Limited Pyridyl alkylguanidine compounds
US3979398A (en) * 1973-02-08 1976-09-07 Smith Kline & French Laboratories Limited Sulphoxides
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1602458A (en) 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950333A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
FR2389508A1 (fr) * 1977-05-02 1978-12-01 Dana Corp

Also Published As

Publication number Publication date
BE874260A (fr) 1979-08-16
DD142049A5 (de) 1980-06-04
IL56686A0 (en) 1979-05-31
DE2905134A1 (de) 1979-08-23
NL7901255A (nl) 1979-08-21
GB2017084A (en) 1979-10-03
PL115911B1 (en) 1981-05-30
US4256752A (en) 1981-03-17
SE7901404L (sv) 1979-08-18
DK69379A (da) 1979-08-18
ATA123879A (de) 1980-12-15
PL213474A1 (fr) 1980-03-10
JPS54125666A (en) 1979-09-29

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Legal Events

Date Code Title Description
RE Withdrawal of published application