FR2413089A1 - HYPERTENSION TREATMENT COMPOSITION - Google Patents

HYPERTENSION TREATMENT COMPOSITION

Info

Publication number
FR2413089A1
FR2413089A1 FR7834359A FR7834359A FR2413089A1 FR 2413089 A1 FR2413089 A1 FR 2413089A1 FR 7834359 A FR7834359 A FR 7834359A FR 7834359 A FR7834359 A FR 7834359A FR 2413089 A1 FR2413089 A1 FR 2413089A1
Authority
FR
France
Prior art keywords
group
treatment composition
hypertension treatment
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7834359A
Other languages
French (fr)
Other versions
FR2413089B1 (en
Inventor
Zola P Horovitz
Bernard Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25343256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2413089(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2413089A1 publication Critical patent/FR2413089A1/en
Application granted granted Critical
Publication of FR2413089B1 publication Critical patent/FR2413089B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSITIONS ANTI-HYPERTENSION QUI CONTIENNENT UNE COMBINAISON D'UN COMPOSE DIURETIQUE ET D'UN COMPOSE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPEMENT HYDROXY, ALCOXY INFERIEUR OU NH; R ET R SONT CHACUN DES ATOMES D'HYDROGENE OU DES GROUPEMENTS ALKYLE INFERIEUR OU PHENYLALKYLE INFERIEUR; R EST UN ATOME D'HYDROGENE OU UN GROUPEMENT R-CO; R EST UN ATOME D'HYDROGENE OU UN GROUPEMENT HYDROXY OU ALKYLE INFERIEUR; R EST UN GROUPEMENT ALKYLE INFERIEUR, PHENYLE OU PHENYLALKYLE INFERIEUR; ET N VAUT 0, 1 OU 2.THE INVENTION CONCERNS ANTI-HYPERTENSION COMPOSITIONS WHICH CONTAIN A COMBINATION OF A DIURETIC COMPOUND AND A COMPOUND OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS A HYDROXY, LOWER ALCOXY OR NH GROUP; R AND R ARE EACH HYDROGEN ATOMS OR LOWER ALKYL OR LOWER PHENYLALKYL GROUPS; R IS A HYDROGEN ATOM OR AN R-CO GROUP; R IS A HYDROGEN ATOM OR A LOWER HYDROXY OR ALKYL GROUP; R IS A LOWER ALKYL, PHENYL OR LOWER PHENYLALKYL GROUP; AND N IS VALUE 0, 1 OR 2.

FR7834359A 1977-12-27 1978-12-06 HYPERTENSION TREATMENT COMPOSITION Granted FR2413089A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86442877A 1977-12-27 1977-12-27

Publications (2)

Publication Number Publication Date
FR2413089A1 true FR2413089A1 (en) 1979-07-27
FR2413089B1 FR2413089B1 (en) 1980-12-26

Family

ID=25343256

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7834359A Granted FR2413089A1 (en) 1977-12-27 1978-12-06 HYPERTENSION TREATMENT COMPOSITION

Country Status (30)

Country Link
JP (1) JPS54110333A (en)
AR (1) AR230378A1 (en)
AU (1) AU526239B2 (en)
BE (1) BE873092A (en)
CA (1) CA1120400A (en)
CH (1) CH642542A5 (en)
DE (1) DE2854316C3 (en)
DK (1) DK578778A (en)
EG (1) EG14178A (en)
FI (1) FI783991A (en)
FR (1) FR2413089A1 (en)
GB (1) GB2010675B (en)
GR (1) GR72951B (en)
HK (1) HK45483A (en)
HU (1) HU178747B (en)
IE (1) IE48306B1 (en)
IL (1) IL56281A (en)
IT (1) IT1202811B (en)
KE (1) KE3235A (en)
LU (1) LU80709A1 (en)
MY (2) MY8300240A (en)
NL (2) NL192870C (en)
NO (1) NO784357L (en)
NZ (1) NZ189159A (en)
PH (1) PH22111A (en)
PL (1) PL212188A1 (en)
PT (1) PT68983A (en)
SE (1) SE445173B (en)
SG (1) SG41482G (en)
ZA (1) ZA786948B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829950B2 (en) * 1978-10-05 1983-06-25 ウェルファイド株式会社 Cyclic iminocarboxylic acid derivatives and their salts
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4898729A (en) * 1983-12-09 1990-02-06 Euroceltique, S.A. Treatment of hypertension, compounds and compositions for antihypertension and diuresis
DE3532036A1 (en) * 1985-09-09 1987-03-26 Hoechst Ag PHARMACEUTICAL PREPARATION FOR TREATING HIGH PRESSURE
DK9200258U4 (en) * 1992-03-11 1993-07-23 Merck & Co Inc Pharmaceutical preparation containing enalapril for use in hypertension
WO1996024358A1 (en) * 1995-02-10 1996-08-15 G.D. Searle & Co. Use of low dose amount of spironolactone for treatment of cardiovascular disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340932A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340932A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Also Published As

Publication number Publication date
SE7813277L (en) 1979-06-28
AU526239B2 (en) 1982-12-23
IL56281A0 (en) 1979-03-12
SE445173B (en) 1986-06-09
PT68983A (en) 1979-01-01
IL56281A (en) 1983-05-15
LU80709A1 (en) 1979-04-13
IE782413L (en) 1979-06-27
IT1202811B (en) 1989-02-09
ZA786948B (en) 1980-04-30
DE2854316C3 (en) 1994-12-22
JPS647045B2 (en) 1989-02-07
DE2854316A1 (en) 1979-07-05
FI783991A (en) 1979-06-28
AR230378A1 (en) 1984-04-30
HK45483A (en) 1983-10-28
FR2413089B1 (en) 1980-12-26
EG14178A (en) 1984-06-30
IE48306B1 (en) 1984-12-12
MY8300240A (en) 1983-12-31
PH22111A (en) 1988-06-01
HU178747B (en) 1982-06-28
CA1120400A (en) 1982-03-23
DK578778A (en) 1979-06-28
KE3235A (en) 1982-11-05
GB2010675B (en) 1982-06-16
DE2854316C2 (en) 1989-08-10
NL192870C (en) 1998-04-02
AU4204178A (en) 1979-07-05
BE873092A (en) 1979-06-27
NZ189159A (en) 1984-12-14
PL212188A1 (en) 1980-02-11
CH642542A5 (en) 1984-04-30
GB2010675A (en) 1979-07-04
SG41482G (en) 1985-01-11
JPS54110333A (en) 1979-08-29
NL980017I1 (en) 1998-07-01
NL192870B (en) 1997-12-01
IT7831266A0 (en) 1978-12-22
GR72951B (en) 1984-01-17
NO784357L (en) 1979-06-28
MY102991A (en) 1993-03-31
NL7812164A (en) 1979-06-29

Similar Documents

Publication Publication Date Title
FR2439790A1 (en) PHOSPHINYLALCANOYL PROLINES WITH THERAPEUTIC ACTION, AND METHODS OF PREPARING THEM
FR2409992A1 (en) NEW 2-HALOMETHYL-5-VINYL-1,3,4-OXADIAZOLES
GB1164825A (en) New N-Substituted Nitro-Anilines
FR2372219A1 (en) ANTI-SUN COMPOSITIONS
FR2413089A1 (en) HYPERTENSION TREATMENT COMPOSITION
FR2412569A1 (en) STEROIDS, THEIR PREPARATION AND THERAPEUTIC USE
FR2361328A1 (en) NEW BENZOPHENONES USEFUL IN PARTICULAR FOR THE PREPARATION OF OXIMES AND HYDRAZONES
TW335334B (en) Compositions having synergistic fungitoxic effects
FR2409988A1 (en) PYRAZOLES SUBSTITUTED IN POSITION 4, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2411810A1 (en) ADDITIVE COMPOSITIONS FOR MIXTURES BASED ON GYPSUM PLASTER OR ANHYDRITE
FR2385760A1 (en) HIGHLY CONDUCTIVE ORGANOMETALLIC POLYMERS
FR2636946A1 (en) ((DIARYLMETHOXY) ALCOYL) -1 PYRROLIDINES AND PIPERIDINES, METHODS OF PREPARATION AND MEDICAMENTS CONTAINING THEM
DK341985D0 (en) ANTIHOST AND SMELL REGULATORY 2-SUBSTITUTED THIAZOLIDINES
FR2358141A1 (en) NEW LOCAL ANESTHESICS
ATE50773T1 (en) ALKYLRESORCINOPHOSPHITES.
FR2411843A1 (en) NEW 6-DEOXYNEAMINES POSSIBLY 1-N-ALKYLATED AND INTERMEDIARIES NECESSARY FOR THEIR PREPARATION
EP0815111A4 (en) Analogues of n-acetylardeemin, method of preparation and uses thereof
FR2381746A1 (en) NEW ENCEPHALINIC DERIVATIVES OF METHIONINE
FR2364204A1 (en) NEW METAAMINOPHENOLS AND TINCTORIAL COMPOSITIONS CONTAINING THEM
FR2407941A1 (en) NEW CHOLESTEROL DERIVATIVES
GB1045031A (en) Dentifrice
FR2447375A1 (en) PROSTAGLANDIN E1 ANALOGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2423479A1 (en) COMPOSITION INCLUDING A PLATINUM COORDINATING COMPOUND FOR THE TREATMENT OF MALIGNANT TUMORS AND NEOPLASMS
FR2355500A1 (en) ANTIMICROBIAL COMPOSITION BASED ON 1-ACYLOXY-2-IMIDAZOLYL-1-PHENYLETHANES
FR2447383A1 (en) MERCAPTOACYLPYRROLIDINE- AND MERCAPTOACYLPIPERIDINE-PHOSPHONIC ACIDS, WITH ANTIHYPERTENSIVE ACTION

Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0095, 920424

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0095, 781206

CL Concession to grant licences