FR2411827A1 - Analogues de somatostatine - Google Patents
Analogues de somatostatineInfo
- Publication number
- FR2411827A1 FR2411827A1 FR7829260A FR7829260A FR2411827A1 FR 2411827 A1 FR2411827 A1 FR 2411827A1 FR 7829260 A FR7829260 A FR 7829260A FR 7829260 A FR7829260 A FR 7829260A FR 2411827 A1 FR2411827 A1 FR 2411827A1
- Authority
- FR
- France
- Prior art keywords
- gly
- ala
- analogues
- new
- somatostatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 3
- 229940075620 somatostatin analogue Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- KEULKIZRPKJGIH-RXMQYKEDSA-N 2-[[2-[[2-[[(2r)-2-aminopropanoyl]amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound C[C@@H](N)C(=O)NCC(=O)NCC(=O)NCC(O)=O KEULKIZRPKJGIH-RXMQYKEDSA-N 0.000 abstract 1
- RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 abstract 1
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 108010067216 glycyl-glycyl-glycine Proteins 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/860,279 US4122077A (en) | 1976-12-17 | 1977-12-13 | Somatostatin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2411827A1 true FR2411827A1 (fr) | 1979-07-13 |
| FR2411827B1 FR2411827B1 (enExample) | 1983-12-09 |
Family
ID=25332860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7829260A Granted FR2411827A1 (fr) | 1977-12-13 | 1978-10-13 | Analogues de somatostatine |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5484573A (enExample) |
| BE (1) | BE871051A (enExample) |
| CH (1) | CH634550A5 (enExample) |
| DE (1) | DE2843737A1 (enExample) |
| DK (1) | DK432878A (enExample) |
| FR (1) | FR2411827A1 (enExample) |
| GB (1) | GB2010280B (enExample) |
| IT (1) | IT1099705B (enExample) |
| LU (1) | LU80335A1 (enExample) |
| NL (1) | NL7810197A (enExample) |
| SE (1) | SE7810156L (enExample) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061608A (en) * | 1976-07-13 | 1977-12-06 | American Home Products Corporation | Arg 4 -somatostatin and analogues thereof |
| US4081433A (en) * | 1977-01-13 | 1978-03-28 | American Home Products Corporation | D-Nle4 -somatostatin and analogues thereof |
| FR2382433A1 (fr) * | 1977-02-22 | 1978-09-29 | American Home Prod | Analogues de somatostatine et leur preparation |
-
1978
- 1978-09-27 SE SE7810156A patent/SE7810156L/xx unknown
- 1978-09-29 DK DK432878A patent/DK432878A/da not_active Application Discontinuation
- 1978-10-05 GB GB7839504A patent/GB2010280B/en not_active Expired
- 1978-10-05 BE BE190944A patent/BE871051A/xx not_active IP Right Cessation
- 1978-10-06 LU LU80335A patent/LU80335A1/xx unknown
- 1978-10-06 DE DE19782843737 patent/DE2843737A1/de not_active Withdrawn
- 1978-10-10 NL NL7810197A patent/NL7810197A/xx not_active Application Discontinuation
- 1978-10-10 CH CH1052778A patent/CH634550A5/fr not_active IP Right Cessation
- 1978-10-12 IT IT28705/78A patent/IT1099705B/it active
- 1978-10-13 FR FR7829260A patent/FR2411827A1/fr active Granted
- 1978-10-17 JP JP12829678A patent/JPS5484573A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061608A (en) * | 1976-07-13 | 1977-12-06 | American Home Products Corporation | Arg 4 -somatostatin and analogues thereof |
| US4081433A (en) * | 1977-01-13 | 1978-03-28 | American Home Products Corporation | D-Nle4 -somatostatin and analogues thereof |
| FR2382433A1 (fr) * | 1977-02-22 | 1978-09-29 | American Home Prod | Analogues de somatostatine et leur preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7810156L (sv) | 1979-06-14 |
| IT7828705A0 (it) | 1978-10-12 |
| BE871051A (fr) | 1979-04-05 |
| NL7810197A (nl) | 1979-06-15 |
| GB2010280A (en) | 1979-06-27 |
| DE2843737A1 (de) | 1979-06-28 |
| DK432878A (da) | 1979-06-14 |
| IT1099705B (it) | 1985-09-28 |
| JPS5484573A (en) | 1979-07-05 |
| GB2010280B (en) | 1982-04-21 |
| LU80335A1 (fr) | 1979-03-16 |
| CH634550A5 (fr) | 1983-02-15 |
| FR2411827B1 (enExample) | 1983-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |