FR2408615A1 - 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents - Google Patents

4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Info

Publication number
FR2408615A1
FR2408615A1 FR7733890A FR7733890A FR2408615A1 FR 2408615 A1 FR2408615 A1 FR 2408615A1 FR 7733890 A FR7733890 A FR 7733890A FR 7733890 A FR7733890 A FR 7733890A FR 2408615 A1 FR2408615 A1 FR 2408615A1
Authority
FR
France
Prior art keywords
antiinflammatory
analgesic
thiazino
imino
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7733890A
Other languages
French (fr)
Other versions
FR2408615B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7733890A priority Critical patent/FR2408615A1/en
Priority to SU782677515A priority patent/SU797580A3/en
Priority to CA314,858A priority patent/CA1112642A/en
Priority to OA56648A priority patent/OA06082A/en
Priority to NL7810922A priority patent/NL7810922A/en
Priority to YU02594/78A priority patent/YU259478A/en
Priority to IL55903A priority patent/IL55903A/en
Priority to AU41471/78A priority patent/AU521104B2/en
Priority to PL1978210788A priority patent/PL113229B1/en
Priority to ZA00786297A priority patent/ZA786297B/en
Priority to GR57611A priority patent/GR66033B/el
Priority to JP13684978A priority patent/JPS5476596A/en
Priority to US05/958,617 priority patent/US4189480A/en
Priority to PL1978215703A priority patent/PL113230B1/en
Priority to NZ188865A priority patent/NZ188865A/en
Priority to CS787273A priority patent/CS203934B2/en
Priority to LU80497A priority patent/LU80497A1/en
Priority to DK499878A priority patent/DK499878A/en
Priority to SE7811595A priority patent/SE7811595L/en
Priority to GB7843907A priority patent/GB2007660B/en
Priority to PT68769A priority patent/PT68769A/en
Priority to IT29635/78A priority patent/IT1100206B/en
Priority to NO783770A priority patent/NO783770L/en
Priority to CH1153278A priority patent/CH635590A5/en
Priority to AR274400A priority patent/AR218943A1/en
Priority to HU78RO1000A priority patent/HU175414B/en
Priority to BE191632A priority patent/BE871890A/en
Priority to AT0806378A priority patent/AT365601B/en
Priority to ES474986A priority patent/ES474986A1/en
Priority to ES474985A priority patent/ES474985A1/en
Priority to FI783440A priority patent/FI63588C/en
Priority to DE2848926A priority patent/DE2848926C3/en
Publication of FR2408615A1 publication Critical patent/FR2408615A1/en
Priority to SU792790355A priority patent/SU867312A3/en
Priority to CS796081A priority patent/CS203935B2/en
Priority to AR278146A priority patent/AR220228A1/en
Priority to AT32881A priority patent/AT365602B/en
Application granted granted Critical
Publication of FR2408615B1 publication Critical patent/FR2408615B1/fr
Priority to YU02298/82A priority patent/YU229882A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Isoquinoline derivs. of formula (I) are new (where A is 3-pyridyl, 3-isoquinolyl, or 3-alkyl-isoquinolyl, the alkyl group having 1-10C). Also their (R) and (S) isomers, mixts. of isomers and their acid-addition salts. I) are Analgesic, antiinflammatory and antipyretic agents, active at 0.25-100 mg/kg orally in animals. Acute LD50 orally in mice 500-5000 mg/kg.
FR7733890A 1977-11-10 1977-11-10 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents Granted FR2408615A1 (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
FR7733890A FR2408615A1 (en) 1977-11-10 1977-11-10 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents
SU782677515A SU797580A3 (en) 1977-11-10 1978-10-26 Method of preparing isoquinoline derivatives, their salts, racemates or optical isomers
CA314,858A CA1112642A (en) 1977-11-10 1978-10-30 Isoquinoline derivatives, process for preparing same and compositions thereof
OA56648A OA06082A (en) 1977-11-10 1978-11-01 New isoquinoline derivatives and their preparation process.
NL7810922A NL7810922A (en) 1977-11-10 1978-11-02 NEW ISOCHINOLINE DERIVATIVES, THEIR PREPARATION, AND PREPARATIONS CONTAINING THE ISOCHINOLINE DERIVATIVES.
YU02594/78A YU259478A (en) 1977-11-10 1978-11-07 Process for obtaining new isoquinoline derivatives
IL55903A IL55903A (en) 1977-11-10 1978-11-08 4,4a,5,10-tetrahydro-1-(pyrid-3-yl)(or 1-(isoquinol-5-yl)) imino-1h,3h-(1,3)-thiazino(3,4-b)isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them
PL1978210788A PL113229B1 (en) 1977-11-10 1978-11-08 Process for preparing novel derivatives of isoquinoline
ZA00786297A ZA786297B (en) 1977-11-10 1978-11-08 Isoquinoline derivatives
GR57611A GR66033B (en) 1977-11-10 1978-11-08
JP13684978A JPS5476596A (en) 1977-11-10 1978-11-08 Isoquinoline derivative*its manufacture and use
US05/958,617 US4189480A (en) 1977-11-10 1978-11-08 Isoquinoline derivatives
PL1978215703A PL113230B1 (en) 1977-11-10 1978-11-08 Process for preparing novel derivatives of isoquinoline
NZ188865A NZ188865A (en) 1977-11-10 1978-11-08 Isoquinoline derivatives and pharmaceutical compositions
CS787273A CS203934B2 (en) 1977-11-10 1978-11-08 Process for preparing new derivatives of 1,3 thiazino/ /3,4-b/isoquinolines
AU41471/78A AU521104B2 (en) 1977-11-10 1978-11-08 (1,3-thiazino) (3,4-b)-isoquinolines
GB7843907A GB2007660B (en) 1977-11-10 1978-11-09 Isoquinoline derivatives
SE7811595A SE7811595L (en) 1977-11-10 1978-11-09 NEW DERIVATIVES OF ISOKINOLIN
LU80497A LU80497A1 (en) 1977-11-10 1978-11-09 NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
PT68769A PT68769A (en) 1977-11-10 1978-11-09 NOVEL DERIVATIVES OF ISOQUINOLINE PREPARATION AND COMPOSITIONS CONTAINING SAME
IT29635/78A IT1100206B (en) 1977-11-10 1978-11-09 ISOKINOLINE DERIVATIVES, THEIR PREPARATION, AND COMPOSITIONS CONTAINING THEM
NO783770A NO783770L (en) 1977-11-10 1978-11-09 NEW DERIVATIVES OF ISOKINOLIN.
CH1153278A CH635590A5 (en) 1977-11-10 1978-11-09 ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AR274400A AR218943A1 (en) 1977-11-10 1978-11-09 PROCEDURE FOR THE PREPARATION OF TIAZIN-1,3- (3,4-B) -ISOQUINOLEIN DERIVATIVES
HU78RO1000A HU175414B (en) 1977-11-10 1978-11-09 Process for preparing new thiazino-isoquinoline derivatives
BE191632A BE871890A (en) 1977-11-10 1978-11-09 NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
DK499878A DK499878A (en) 1977-11-10 1978-11-09 PROCEDURE FOR THE PREPARATION OF ISOQUINOLINE DERIVATIVES
ES474986A ES474986A1 (en) 1977-11-10 1978-11-10 Isoquinoline derivatives
AT0806378A AT365601B (en) 1977-11-10 1978-11-10 METHOD FOR PRODUCING NEW DERIVATIVES OF 4-
ES474985A ES474985A1 (en) 1977-11-10 1978-11-10 Isoquinoline derivatives
FI783440A FI63588C (en) 1977-11-10 1978-11-10 PROCEDURE FOR THE FRAME STATION OF THERAPEUTIC ANVAENDBARA HETEROSYCLYLIMINO-1,6,11,11A-TETRAHYDRO- (1,3-THIAZINO) (3,4-B) ISOQUINOLINE
DE2848926A DE2848926C3 (en) 1977-11-10 1978-11-10 Derivatives of 1,6,11,11a-tetrahydro- [1,3-thiazino] [3,4-b] isoquinoline, their preparation and the compositions containing them
SU792790355A SU867312A3 (en) 1977-11-10 1979-08-01 Method of preparing derivatives of isoquinoline,their isomers,isomer mixture or salts
CS796081A CS203935B2 (en) 1977-11-10 1979-09-07 Process for preparing new /1,3-thiazino//3,4-b/isoqunolines
AR278146A AR220228A1 (en) 1977-11-10 1979-09-20 PROCEDURE FOR THE PREPARATION OF TIAZIN-1,3- (3,4-B) -ISOQUINOLEIN DERIVATIVES
AT32881A AT365602B (en) 1977-11-10 1981-01-26 METHOD FOR PRODUCING NEW DERIVATIVES OF
YU02298/82A YU229882A (en) 1977-11-10 1982-10-12 Process for obtaining new isoquinoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7733890A FR2408615A1 (en) 1977-11-10 1977-11-10 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Publications (2)

Publication Number Publication Date
FR2408615A1 true FR2408615A1 (en) 1979-06-08
FR2408615B1 FR2408615B1 (en) 1981-12-18

Family

ID=9197483

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733890A Granted FR2408615A1 (en) 1977-11-10 1977-11-10 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Country Status (3)

Country Link
BE (1) BE871890A (en)
FR (1) FR2408615A1 (en)
ZA (1) ZA786297B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2635516A1 (en) * 1975-08-06 1977-02-17 Rhone Poulenc Ind NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2635516A1 (en) * 1975-08-06 1977-02-17 Rhone Poulenc Ind NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Also Published As

Publication number Publication date
FR2408615B1 (en) 1981-12-18
BE871890A (en) 1979-05-09
ZA786297B (en) 1979-10-31

Similar Documents

Publication Publication Date Title
FR2320310A1 (en) COPOLYMERISATES CONTAINING SUCCINIC HYDRAZIDE PATTERNS
DK33286D0 (en) 6-THIOXANTHIN DERIVATIVES AND THEIR USE
FR2408615A1 (en) 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents
FR2433023A2 (en) 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents
IE780126L (en) Thiazoloisoquinoline derivatives
IE44294L (en) 5-thiazole methane amine derivatives
ES445944A1 (en) 8-Amino-theophylline derivatives and therapeutic applications thereof
JPS5436235A (en) 4-n-alkyl-delta'-cyclohexene-1-carboxylic acids
IT8047847A0 (en) 3-TRICHLOROMETHYL-5-CYCLIC AMINE-1,2,4,-THIADIAZOLE COMPOUNDS WITH ACTIVITY TO INHIBIT THE NITRIFICATION OF AMMONIUM IN THE SOIL
GB1297035A (en)
ES474985A1 (en) Isoquinoline derivatives
BE842899A (en) NEUTRAL ELECTROLYTIC PICKLING OF STEELS
ES450206A1 (en) 1,2,3,4-Tetrahydroisoquinolines and the preparation thereof
IE44449L (en) Morphanthridines
JPS5238506A (en) Detergent composition
JPS548627A (en) 2-alkoxyalkoxy-5-nitrobenzenesulfonic acid and its salt
JPS5295674A (en) Preparation of 4#-substituted-2-methyl-2-piperidinopropiophenone and i ts salts
JPS52151175A (en) Gamma-pyrone and gamma-pyridone derivatives
JPS52106837A (en) Substituted benzoic acid amides and their preparation
JPS5363347A (en) Substd. benzoic acid amide and process for preparing them
SE8601938D0 (en) GLOVE
JPS5384935A (en) N-substitute benzanilides and bactericides containing the same
FR2421612A1 (en) (3)-Chloro-(4)-cyclopropyl methoxy-phenyl-propionic acid - antiinflammatory, analgesic and antipyretic with lower toxicity and superior activity than alclofenac
JPS5371096A (en) Novel penicilline derivs.
JPS5271427A (en) Preparation of benzylalcohol derivatives

Legal Events

Date Code Title Description
ST Notification of lapse