FR2433023A2 - 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents - Google Patents

4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Info

Publication number
FR2433023A2
FR2433023A2 FR7823469A FR7823469A FR2433023A2 FR 2433023 A2 FR2433023 A2 FR 2433023A2 FR 7823469 A FR7823469 A FR 7823469A FR 7823469 A FR7823469 A FR 7823469A FR 2433023 A2 FR2433023 A2 FR 2433023A2
Authority
FR
France
Prior art keywords
antiinflammatory
analgesic
thiazino
imino
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7823469A
Other languages
French (fr)
Other versions
FR2433023B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7823469A priority Critical patent/FR2433023A2/en
Priority to SU782677515A priority patent/SU797580A3/en
Priority to CA314,858A priority patent/CA1112642A/en
Priority to OA56648A priority patent/OA06082A/en
Priority to NL7810922A priority patent/NL7810922A/en
Priority to YU02594/78A priority patent/YU259478A/en
Priority to PL1978215703A priority patent/PL113230B1/en
Priority to US05/958,617 priority patent/US4189480A/en
Priority to CS787273A priority patent/CS203934B2/en
Priority to AU41471/78A priority patent/AU521104B2/en
Priority to JP13684978A priority patent/JPS5476596A/en
Priority to IL55903A priority patent/IL55903A/en
Priority to PL1978210788A priority patent/PL113229B1/en
Priority to NZ188865A priority patent/NZ188865A/en
Priority to GR57611A priority patent/GR66033B/el
Priority to NO783770A priority patent/NO783770L/en
Priority to HU78RO1000A priority patent/HU175414B/en
Priority to AR274400A priority patent/AR218943A1/en
Priority to PT68769A priority patent/PT68769A/en
Priority to IT29635/78A priority patent/IT1100206B/en
Priority to LU80497A priority patent/LU80497A1/en
Priority to GB7843907A priority patent/GB2007660B/en
Priority to SE7811595A priority patent/SE7811595L/en
Priority to CH1153278A priority patent/CH635590A5/en
Priority to DK499878A priority patent/DK499878A/en
Priority to ES474985A priority patent/ES474985A1/en
Priority to DE2848926A priority patent/DE2848926C3/en
Priority to AT0806378A priority patent/AT365601B/en
Priority to ES474986A priority patent/ES474986A1/en
Priority to FI783440A priority patent/FI63588C/en
Priority to SU792790355A priority patent/SU867312A3/en
Priority to CS796081A priority patent/CS203935B2/en
Priority to AR278146A priority patent/AR220228A1/en
Publication of FR2433023A2 publication Critical patent/FR2433023A2/en
Priority to AT32881A priority patent/AT365602B/en
Application granted granted Critical
Publication of FR2433023B2 publication Critical patent/FR2433023B2/fr
Priority to YU02298/82A priority patent/YU229882A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Isoquinoline derivs. of formula (I) are new (where A is 3-pyridyl, 3-isoquinolyl, or 3-alkyl-isoquinolyl, the alkyl group having 1-10C). Also their (R) and (S) isomers, mixts. of isomers and their acid-addition salts. I) are Analgesic, antiinflammatory and antipyretic agents, active at 0.25-100 mg/kg orally in animals. Acute LD50 orally in mice 500-5000 mg/kg.
FR7823469A 1977-11-10 1978-08-09 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents Granted FR2433023A2 (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
FR7823469A FR2433023A2 (en) 1978-08-09 1978-08-09 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents
SU782677515A SU797580A3 (en) 1977-11-10 1978-10-26 Method of preparing isoquinoline derivatives, their salts, racemates or optical isomers
CA314,858A CA1112642A (en) 1977-11-10 1978-10-30 Isoquinoline derivatives, process for preparing same and compositions thereof
OA56648A OA06082A (en) 1977-11-10 1978-11-01 New isoquinoline derivatives and their preparation process.
NL7810922A NL7810922A (en) 1977-11-10 1978-11-02 NEW ISOCHINOLINE DERIVATIVES, THEIR PREPARATION, AND PREPARATIONS CONTAINING THE ISOCHINOLINE DERIVATIVES.
YU02594/78A YU259478A (en) 1977-11-10 1978-11-07 Process for obtaining new isoquinoline derivatives
PL1978215703A PL113230B1 (en) 1977-11-10 1978-11-08 Process for preparing novel derivatives of isoquinoline
CS787273A CS203934B2 (en) 1977-11-10 1978-11-08 Process for preparing new derivatives of 1,3 thiazino/ /3,4-b/isoquinolines
AU41471/78A AU521104B2 (en) 1977-11-10 1978-11-08 (1,3-thiazino) (3,4-b)-isoquinolines
JP13684978A JPS5476596A (en) 1977-11-10 1978-11-08 Isoquinoline derivative*its manufacture and use
IL55903A IL55903A (en) 1977-11-10 1978-11-08 4,4a,5,10-tetrahydro-1-(pyrid-3-yl)(or 1-(isoquinol-5-yl)) imino-1h,3h-(1,3)-thiazino(3,4-b)isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them
PL1978210788A PL113229B1 (en) 1977-11-10 1978-11-08 Process for preparing novel derivatives of isoquinoline
NZ188865A NZ188865A (en) 1977-11-10 1978-11-08 Isoquinoline derivatives and pharmaceutical compositions
GR57611A GR66033B (en) 1977-11-10 1978-11-08
US05/958,617 US4189480A (en) 1977-11-10 1978-11-08 Isoquinoline derivatives
IT29635/78A IT1100206B (en) 1977-11-10 1978-11-09 ISOKINOLINE DERIVATIVES, THEIR PREPARATION, AND COMPOSITIONS CONTAINING THEM
AR274400A AR218943A1 (en) 1977-11-10 1978-11-09 PROCEDURE FOR THE PREPARATION OF TIAZIN-1,3- (3,4-B) -ISOQUINOLEIN DERIVATIVES
PT68769A PT68769A (en) 1977-11-10 1978-11-09 NOVEL DERIVATIVES OF ISOQUINOLINE PREPARATION AND COMPOSITIONS CONTAINING SAME
NO783770A NO783770L (en) 1977-11-10 1978-11-09 NEW DERIVATIVES OF ISOKINOLIN.
LU80497A LU80497A1 (en) 1977-11-10 1978-11-09 NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
GB7843907A GB2007660B (en) 1977-11-10 1978-11-09 Isoquinoline derivatives
SE7811595A SE7811595L (en) 1977-11-10 1978-11-09 NEW DERIVATIVES OF ISOKINOLIN
CH1153278A CH635590A5 (en) 1977-11-10 1978-11-09 ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK499878A DK499878A (en) 1977-11-10 1978-11-09 PROCEDURE FOR THE PREPARATION OF ISOQUINOLINE DERIVATIVES
HU78RO1000A HU175414B (en) 1977-11-10 1978-11-09 Process for preparing new thiazino-isoquinoline derivatives
ES474985A ES474985A1 (en) 1977-11-10 1978-11-10 Isoquinoline derivatives
DE2848926A DE2848926C3 (en) 1977-11-10 1978-11-10 Derivatives of 1,6,11,11a-tetrahydro- [1,3-thiazino] [3,4-b] isoquinoline, their preparation and the compositions containing them
AT0806378A AT365601B (en) 1977-11-10 1978-11-10 METHOD FOR PRODUCING NEW DERIVATIVES OF 4-
ES474986A ES474986A1 (en) 1977-11-10 1978-11-10 Isoquinoline derivatives
FI783440A FI63588C (en) 1977-11-10 1978-11-10 PROCEDURE FOR THE FRAME STATION OF THERAPEUTIC ANVAENDBARA HETEROSYCLYLIMINO-1,6,11,11A-TETRAHYDRO- (1,3-THIAZINO) (3,4-B) ISOQUINOLINE
SU792790355A SU867312A3 (en) 1977-11-10 1979-08-01 Method of preparing derivatives of isoquinoline,their isomers,isomer mixture or salts
CS796081A CS203935B2 (en) 1977-11-10 1979-09-07 Process for preparing new /1,3-thiazino//3,4-b/isoqunolines
AR278146A AR220228A1 (en) 1977-11-10 1979-09-20 PROCEDURE FOR THE PREPARATION OF TIAZIN-1,3- (3,4-B) -ISOQUINOLEIN DERIVATIVES
AT32881A AT365602B (en) 1977-11-10 1981-01-26 METHOD FOR PRODUCING NEW DERIVATIVES OF
YU02298/82A YU229882A (en) 1977-11-10 1982-10-12 Process for obtaining new isoquinoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7823469A FR2433023A2 (en) 1978-08-09 1978-08-09 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Publications (2)

Publication Number Publication Date
FR2433023A2 true FR2433023A2 (en) 1980-03-07
FR2433023B2 FR2433023B2 (en) 1982-02-05

Family

ID=9211728

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7823469A Granted FR2433023A2 (en) 1977-11-10 1978-08-09 4-Imino-thiazino:isoquinoline derivs. - useful as antiinflammatory, analgesic and antipyretic agents

Country Status (1)

Country Link
FR (1) FR2433023A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2635516A1 (en) * 1975-08-06 1977-02-17 Rhone Poulenc Ind NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2635516A1 (en) * 1975-08-06 1977-02-17 Rhone Poulenc Ind NEW DERIVATIVES OF THE THIAZOLO-SQUARE BRACKET ON 3.4-ANGLE BRACKET TO -ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Also Published As

Publication number Publication date
FR2433023B2 (en) 1982-02-05

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