FR2401135A1 - NEW DERIVATIVES OF AMINOALKYL-BENZENES AND METHODS FOR THEIR PREPARATION - Google Patents

NEW DERIVATIVES OF AMINOALKYL-BENZENES AND METHODS FOR THEIR PREPARATION

Info

Publication number
FR2401135A1
FR2401135A1 FR7814594A FR7814594A FR2401135A1 FR 2401135 A1 FR2401135 A1 FR 2401135A1 FR 7814594 A FR7814594 A FR 7814594A FR 7814594 A FR7814594 A FR 7814594A FR 2401135 A1 FR2401135 A1 FR 2401135A1
Authority
FR
France
Prior art keywords
benzenes
aminoalkyl
preparation
methods
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814594A
Other languages
French (fr)
Other versions
FR2401135B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB20660/77A external-priority patent/GB1604674A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of FR2401135A1 publication Critical patent/FR2401135A1/en
Application granted granted Critical
Publication of FR2401135B1 publication Critical patent/FR2401135B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32N-nitroguanidines
    • C07C279/36Substituted N-nitroguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/06Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/06Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne de nouveaux aminoalkyl benzènes. Les composés conformes à l'invention répondent à la formule générale suivante :The invention relates to novel aminoalkyl benzenes. The compounds in accordance with the invention correspond to the following general formula:

FR7814594A 1977-05-17 1978-05-17 NEW DERIVATIVES OF AMINOALKYL-BENZENES AND METHODS FOR THEIR PREPARATION Granted FR2401135A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB20660/77A GB1604674A (en) 1977-05-17 1977-05-17 Aminoalkyl-benzene derivatives
GB4012977 1977-09-27
GB1744478 1978-05-03

Publications (2)

Publication Number Publication Date
FR2401135A1 true FR2401135A1 (en) 1979-03-23
FR2401135B1 FR2401135B1 (en) 1983-08-19

Family

ID=27257503

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7814594A Granted FR2401135A1 (en) 1977-05-17 1978-05-17 NEW DERIVATIVES OF AMINOALKYL-BENZENES AND METHODS FOR THEIR PREPARATION
FR7828239A Granted FR2398718A1 (en) 1977-05-17 1978-10-03 NEW PRIMARY AMINES USEFUL FOR THE PREPARATION OF AMINOALKYL BENZENE DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7828239A Granted FR2398718A1 (en) 1977-05-17 1978-10-03 NEW PRIMARY AMINES USEFUL FOR THE PREPARATION OF AMINOALKYL BENZENE DERIVATIVES

Country Status (13)

Country Link
JP (1) JPS53149936A (en)
AU (2) AU523496B2 (en)
CH (2) CH643238A5 (en)
DE (1) DE2821410A1 (en)
DK (1) DK214878A (en)
ES (1) ES469953A1 (en)
FI (1) FI781490A (en)
FR (2) FR2401135A1 (en)
IE (1) IE46886B1 (en)
IT (1) IT1156755B (en)
NL (1) NL7805344A (en)
NZ (1) NZ187235A (en)
SE (1) SE443558B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477537A1 (en) * 1980-03-07 1981-09-11 Francaise Sucrerie NOVEL ACYLATED GUANIDINES, UREAS AND SUBSTITUTED UREAS, THEIR MANUFACTURING PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
AR228941A1 (en) * 1978-04-26 1983-05-13 Glaxo Group Ltd PROCEDURE FOR PREPARING NEW DERIVATIVES OF 3,5-DIAMINO-1,2,4-TRIAZOLE WHICH ARE ACTIVE AGAINST HISTAMINIC RECEPTORS
NO800583L (en) * 1979-03-02 1980-09-03 Glaxo Group Ltd PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE TRIAZOLD DERIVATIVES
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4293557A (en) 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
JPS609750B2 (en) * 1979-07-03 1985-03-12 帝国臓器製薬株式会社 Novel N-substituted phenoxypropylamide compounds
DE3070073D1 (en) * 1979-10-22 1985-03-14 Glaxo Group Ltd 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
EP0057981A3 (en) * 1981-02-09 1982-08-25 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
EP0071434B1 (en) * 1981-07-24 1987-01-28 Glaxo Group Limited Heterocyclic derivatives
US4411899A (en) * 1981-12-21 1983-10-25 Merck & Co., Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
JPS5988458A (en) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd Amine derivative and its salt
JPH0639466B2 (en) * 1987-08-03 1994-05-25 杏林製薬株式会社 Urea derivative
JPH01131172A (en) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd Amine derivative and salt thereof and antiulcer agent containing said derivative and salt
US5574054A (en) * 1992-05-12 1996-11-12 Zeria Pharmaceutical Co., Ltd. Quaternary ammonium salts and use thereof as medicine
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
CA2704199C (en) 2007-11-01 2016-01-19 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636468A (en) *
US2785201A (en) * 1953-12-24 1957-03-12 Personnes A Responsabilite Lim Compounds of bis quaternary ammonium derivatives of phenylethylamine
US3047628A (en) * 1957-02-19 1962-07-31 Hoffmann La Roche Benzylamine derivatives
US3099599A (en) * 1960-03-03 1963-07-30 Burroughs Wellcome Co Method for treating infestations of nematodes
FR2128505A1 (en) * 1971-03-09 1972-10-20 Smith Kline French Lab
FR2229417A1 (en) * 1973-05-17 1974-12-13 Smith Kline French Lab

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5227757A (en) * 1975-08-26 1977-03-02 Kyowa Hakko Kogyo Co Ltd Preparation of 6-aminomethylnaphthalene derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636468A (en) *
US2785201A (en) * 1953-12-24 1957-03-12 Personnes A Responsabilite Lim Compounds of bis quaternary ammonium derivatives of phenylethylamine
US3047628A (en) * 1957-02-19 1962-07-31 Hoffmann La Roche Benzylamine derivatives
US3099599A (en) * 1960-03-03 1963-07-30 Burroughs Wellcome Co Method for treating infestations of nematodes
FR2128505A1 (en) * 1971-03-09 1972-10-20 Smith Kline French Lab
FR2229417A1 (en) * 1973-05-17 1974-12-13 Smith Kline French Lab

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477537A1 (en) * 1980-03-07 1981-09-11 Francaise Sucrerie NOVEL ACYLATED GUANIDINES, UREAS AND SUBSTITUTED UREAS, THEIR MANUFACTURING PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP0035945A2 (en) * 1980-03-07 1981-09-16 Compagnie Francaise De Sucrerie Acyl guanidines, ureas and substituted ureas, their preparation and their use as medicaments
EP0035945A3 (en) * 1980-03-07 1981-12-02 Compagnie Francaise De Sucrerie Acyl guanidines, ureas and substituted ureas, their preparation and their use as medicaments

Also Published As

Publication number Publication date
FR2398718A1 (en) 1979-02-23
CH643233A5 (en) 1984-05-30
JPS53149936A (en) 1978-12-27
AU541144B2 (en) 1984-12-20
IE46886B1 (en) 1983-10-19
DK214878A (en) 1978-11-18
IT7849419A0 (en) 1978-05-17
ES469953A1 (en) 1979-09-16
AU8411782A (en) 1982-08-26
AU523496B2 (en) 1982-07-29
AU3606778A (en) 1979-11-15
FI781490A (en) 1978-11-18
FR2401135B1 (en) 1983-08-19
JPH0112744B2 (en) 1989-03-02
SE443558B (en) 1986-03-03
SE7805591L (en) 1978-11-18
DE2821410A1 (en) 1978-11-30
CH643238A5 (en) 1984-05-30
IE780940L (en) 1978-11-17
FR2398718B1 (en) 1982-10-15
NL7805344A (en) 1978-11-21
IT1156755B (en) 1987-02-04
NZ187235A (en) 1981-10-19

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