FR2395269A1 - Procede de preparation de 7,8-dihydro-14-hydroxynormorphinone - Google Patents

Procede de preparation de 7,8-dihydro-14-hydroxynormorphinone

Info

Publication number
FR2395269A1
FR2395269A1 FR7818206A FR7818206A FR2395269A1 FR 2395269 A1 FR2395269 A1 FR 2395269A1 FR 7818206 A FR7818206 A FR 7818206A FR 7818206 A FR7818206 A FR 7818206A FR 2395269 A1 FR2395269 A1 FR 2395269A1
Authority
FR
France
Prior art keywords
hydroxynormorphinone
dihydro
preparation
compound
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7818206A
Other languages
English (en)
French (fr)
Other versions
FR2395269B1 (nl
Inventor
Johannes Dr Hartenstein
Gerhard Dr Satzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of FR2395269A1 publication Critical patent/FR2395269A1/fr
Application granted granted Critical
Publication of FR2395269B1 publication Critical patent/FR2395269B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
FR7818206A 1977-06-21 1978-06-19 Procede de preparation de 7,8-dihydro-14-hydroxynormorphinone Granted FR2395269A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772727805 DE2727805A1 (de) 1977-06-21 1977-06-21 Verfahren zur herstellung von oxynormorphon

Publications (2)

Publication Number Publication Date
FR2395269A1 true FR2395269A1 (fr) 1979-01-19
FR2395269B1 FR2395269B1 (nl) 1983-06-10

Family

ID=6011952

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7818206A Granted FR2395269A1 (fr) 1977-06-21 1978-06-19 Procede de preparation de 7,8-dihydro-14-hydroxynormorphinone

Country Status (7)

Country Link
JP (1) JPS549300A (nl)
DE (1) DE2727805A1 (nl)
FI (1) FI781962A (nl)
FR (1) FR2395269A1 (nl)
GB (1) GB2000137B (nl)
HU (1) HU177923B (nl)
NL (1) NL7806658A (nl)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562072A1 (fr) * 1984-03-27 1985-10-04 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
FR2564838A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Procede de dealkylation d'alcaloides et intermediaires
EP2705040A1 (en) * 2011-05-06 2014-03-12 Brock University Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
HU197750B (en) * 1984-07-17 1989-05-29 Alkaloida Vegyeszeti Gyar Process for n-demethylation of morphine alkaloids
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
GB2471803B (en) * 2006-05-25 2011-02-16 Alpharma Chemical process
GB2438401A (en) * 2006-05-25 2007-11-28 Alpharma Aps Preparation of morphinan derivatives comprising N-demethylation, reductive amination and O-demethylation steps
GB2438400A (en) * 2006-05-25 2007-11-28 Alpharma Aps N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
MX2020008706A (es) 2018-02-23 2020-09-25 Rhodes Tech Nuevos compuestos de opioides y sus usos.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/74 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562072A1 (fr) * 1984-03-27 1985-10-04 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
EP0158476B1 (en) * 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Preparation of noroxymorphone from morphine
FR2564838A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Procede de dealkylation d'alcaloides et intermediaires
EP0164290A1 (fr) * 1984-05-25 1985-12-11 Sanofi S.A. Procédé de déalkylation d'alcaloides et intermédiaires
EP2705040A1 (en) * 2011-05-06 2014-03-12 Brock University Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer
US8946214B2 (en) 2011-05-06 2015-02-03 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
EP2705040A4 (en) * 2011-05-06 2015-03-11 Univ Brock METHOD FOR THE PRODUCTION OF MORPHINE ANALOGS BY METAL-CATALYZED N-DEMETHYLATION / FUNCTIONALIZATION AND INTRAMOLECULAR GROUP TRANSMISSION
US9108967B2 (en) 2011-05-06 2015-08-18 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US9533993B2 (en) 2011-05-06 2017-01-03 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer

Also Published As

Publication number Publication date
JPS549300A (en) 1979-01-24
NL7806658A (nl) 1978-12-27
GB2000137A (en) 1979-01-04
DE2727805A1 (de) 1979-01-04
HU177923B (en) 1982-01-28
FR2395269B1 (nl) 1983-06-10
FI781962A (fi) 1978-12-22
GB2000137B (en) 1982-01-06

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Legal Events

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